RAS/GAP

Mid-gestation

CNS, heart, allantois

Disorganized, organogenesis defects

 

Henkemeyer et al. 1995

RAS-GRF

Viable

CNS

Impaired long-term memory

Brambilla et al. 1997

VAV

Viable

T cells

Defective selection of thymocytes

Turner et al. 1997

Target Proteins

 

C-FOS

Viable

Osteoclasts

Osteopetrosis, toothless

 

Johnson et al. 1992; Wang et al. 1992

FOSB

Viable

Mammary gland

Failure to nurture offspring

Gruda et al. 1996; Brown et al. 1996

C-JUN

Mid-gestation

Fibroblasts and others

Altered response to mitogens

Hilberg et al. 1993; Johnson et al. 1993

aSources: Online Mendelian Inheritance in Man (<ww3.ncbi.nlm.nih.gov/Omim/>) and reference no. 2.

bPossible association between gene and syndrome.

cVariable phenotype depending on genetic background.

Note: Null phenotypes of mice produced by gene targeting for some genes involved in one signaling pathway, the receptor tyrosine kinase pathway, and human syndromes or diseases associated with mutations or deletions in these genes. In addition to the entries in this table, many of the mouse mutations have been combined to make double or triple mutants. Additional follow-up studies, some using hypomorphic alleles and chimeras, have been reported (see Mouse Knockout Database: <http://tbase.jax.org>).



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