Information Level

Information Level 1

Information Level 2

Information Level 3

Information Level 4

Database output

Linked databases of chemical information and effects on signaling pathways, molecular-stress pathways, and conversions by DMEs.

SAR (structure-activity relationship) database for chemical effects on developmental and signaling pathways, end points, and susceptibility factors.

Developmental toxicity database with both qualitative and quantitative information.

Mode-of-action database for developmental toxicants.

Risk assessment information available from each assay type

Identification of potentially vulnerable signaling pathways.

Identification of chemical properties associated with potential to alter signaling and stress pathways.

Improvement of SAR data for developmentally relevant impacts.

Identification of potentially sensitive target organs.

Information on periods of sensitivity.

Dose-response characterization.

Mammalian relevancy information.

Special toxicant sensitivity of genetic variants.

Improved mechanistic understanding.

Quantitative information for predicting human susceptibility.

Better validation of animal-to-human extrapolation.

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