microgliocytosis and cerebellar degeneration

 

Mouse

24 wk

 

1.9

Paralysis

MacDonald and Harbison 1977

Mouse (C57B1/6)

17 d

6 d

 

4

8

Increased auditory brainstem response thresholds

Wassick and Yonovitz 1985

Mouse (B6C3F1) 2 yr

2 yr

 

0.6

Paralysis, neuropathy

Mitsumori et al. 1990

Rabbit (New Zealand)

7 d

 

30

Ataxia, decreased muscle tone, reduced splay reflex

Jacobs et al. 1977

Cat

   

0.05

Ataxia

Khera et al. 1974

Cat

60 wk

 

0.046

Impaired hopping

Charbonneau et al. 1976

Abbreviations: NOAEL, no-observed-adverse-effect level; LOAEL, lowest-observed-adverse-effect level; NS, not stated.



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