It would be helpful to obtain more comprehensive nutritional data from all three populations as well as single-strand hair analyses to address more effectively the issue of spiking or bolus dose. A reanalysis of the 5.5-year SCDS data controlling statistically for examiner might also be useful.
Most of the MeHg exposure standards currently in effect are based on extrapolations from the Iraqi MeHg poisoning episode, in which exposure was due to the consumption of highly contaminated grain and resulted in body burdens that greatly exceeded those found in the general population of fish consumers. Given the availability of data from three well-designed epidemiological studies in which prenatal MeHg exposures were in the range of general-population exposures, exposure standards should be based on data from these newer studies.
Bellinger, D. 1995. Interpreting the literature on lead and child development: The neglected role of the “experimental system” . Neurotoxicol. Teratol. 17(3):201-212.
Bonthius, D.J., and J.R. West. 1990. Alcohol-induced neuronal loss in developing rats: Increased brain damage with binge exposure. Alcohol Clin. Exp. Res. 14(1):107-118.
Budtz-Jørgensen, E., N. Keiding, P. Grandjean, and R. White. 1999. Methylmercury neurotoxicity independent of PCB exposure. [Letter]. Environ. Health Perspect. 107(5):A236-A237.
Crump, K.S., T. Kjellström, A.M. Shipp, A. Silvers, and A. Stewart . 1998. Influence of prenatal mercury exposure upon scholastic and psychological test performance: benchmark analysis of a New Zealand cohort. Risk Anal. 18(6):701-713.
Goodlett, C.R., S.J. Kelly, and J.R. West. 1987. Early postnatal alcohol exposure that produces high blood alcohol levels impairs development of spatial navigation learning. Psychobiology 15(1):64-74.
Grandjean, P., P. Weihe, P.J. Jørgensen, T. Clarkson, E. Cernichiari, and T. Videro. 1992. Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead. Arch. Environ. Health 47:185-195
Grandjean, P., E. Budtz-Jørgensen, R.F. White, P.J. Jørgensen, P. Weihe, F. Debes, and N. Keiding . 1999. Methylmercury exposure biomarkers as