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Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate (2000)

Chapter: Appendix: Biographical Information on the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate

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Suggested Citation:"Appendix: Biographical Information on the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate." National Research Council. 2000. Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate. Washington, DC: The National Academies Press. doi: 10.17226/9901.
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Appendix

BIOGRAPHICAL INFORMATION ON THE SUBCOMMITTEE ON THE TOXICITY OF DIISOPROPYL METHYLPHOSPHONATE

JOHN A. MOORE (Chair) is president and chief executive officer of the Institute for Evaluating Health Risks, a nonprofit institution that serves government, industry, and the public on issues that address the health risks of chemicals. He received his D.V.M. from Michigan State University. Dr. Moore has held a number of distinguished positions in the government, including director of toxicology research and testing at the National Institute for Environmental Health Sciences, deputy director of the National Toxicology Program, and assistant administrator of the Office of Pesticides and Toxic Substances at the U.S. Environmental Protection Agency (EPA). He also served as acting deputy administrator of EPA for one year. Dr. Moore has held a number of elected positions in the Society of Toxicology, including president of the Risk Assessment Specialty Section. Among his many honors and achievements, Dr. Moore has received the highest federal award of Distinguished Executive.

MELVIN E. ANDERSEN is a professor in the Department of Environmental Health at Colorado State University. He received his Ph.D. in

Suggested Citation:"Appendix: Biographical Information on the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate." National Research Council. 2000. Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate. Washington, DC: The National Academies Press. doi: 10.17226/9901.
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biochemistry and molecular biology from Cornell University. He is widely known for his contributions in developing biologically realistic models of the uptake, distribution, metabolism, and biological effects of drugs and toxic chemicals and applying these models in safety assessments and quantitative health risk assessments.

PETER L. DeFUR is affiliate associate professor in the Center for Environmental Studies at Virginia Commonwealth University. Before his appointment at the university, he was a senior scientist at the Environmental Defense Fund. He received his Ph.D. in biology from the University of Calgary. His research interests include hormone disrupting chemicals in the environment and health and environmental risks from dioxin and related compounds.

PAUL M.D. FOSTER is a program director for endocrine, reproductive, and developmental toxicology at the Chemical Industry Institute of Toxicology. He received his Ph.D. in biochemistry and toxicology from Brunel University, Uxbridge, Middlesex, United Kingdom. His research interests include mechanisms of toxicity, target organ toxicity, and male reproductive physiology and its application to the study of toxic effects. Dr. Foster has served on a number of national and international committees reviewing reproductive toxicology, including committees of the U.S. National Toxicology Program, EPA, European Center for Ecotoxicology of Chemicals, and World Health Organization.

SIDNEY GREEN is associate professor of pharmacology at Howard University. He received his Ph.D. in pharmacology from Howard University. His research interests include genetic and systemic toxicology. Dr. Green was formerly director of toxicology at Covance Laboratories, Inc. He was also director of the Division of Toxicological Research at the U.S. Food and Drug Administration in the Center for Food Safety and Applied Nutrition and director of the Toxic Effects Branch in EPA 's Office of Toxic Substances.

DAVID H. MOORE is director of Medical Toxicology Programs at Battelle Memorial Institute, Battelle Edgewood Operations. Dr. Moore received his D.V.M. from the University of Georgia College of Veterinary Medicine, and his Ph.D. in physiology from Emory University School of Medicine. His research interests are in the clinical effects of chemical warfare agents.

Suggested Citation:"Appendix: Biographical Information on the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate." National Research Council. 2000. Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate. Washington, DC: The National Academies Press. doi: 10.17226/9901.
×
Page 31
Suggested Citation:"Appendix: Biographical Information on the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate." National Research Council. 2000. Re-evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate. Washington, DC: The National Academies Press. doi: 10.17226/9901.
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Page 32
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Diisopropyl Methylphosphonate (DIMP) is a groundwater contaminant at the U.S. Army's Rocky Mountain Arsenal in Colorado. DIMP is a by-product created from the manufacture and detoxification of the nerve agent GB which the arsenal produced from 1953 to 1957. For awhile the Army and the State of Colorado disagreed upon the appropriate drinking-water contaminant guideline for DIMP. A drinking-water guideline of 600 micrograms per liter was established by the U.S. Environmental Protection Agency (EPA) in 1989 but the State of Colorado promulgated a lower guideline of 8 micrograms per liter. The significant difference between the two suggested values arose from the fact that both sides used different studies to determine their values. Colorado used one-generation reproductive toxicity study in mink, whereas EPA used a subchronic toxicity study in dogs.

To resolve the disagreement, a two-generation reproductive study in mink was conducted. The Army asked the National Research Council (NRC) to independently evaluate the 1997 study and re-evaluate the drinking-water guideline for DIMP. This task was assigned to the Committee on Toxicology, which established the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate, a multidisciplinary group of experts. The subcommittee evaluated the two-generation reproductive study as well as other studies relevant to the task. Data on the use of mink as a predictive model in toxicology were also reviewed. Re-Evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate is the subcommittee's report which shows that neither party was corrected in their DIMP guidelines. The report includes the subcommittee's evaluation and recommendations concerning the topic.

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