Click for next page ( 48


The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement



Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page 47
APPENDIX E Background Tables E2 Core Grant Obligations for Cancer Centers in Current and Constant Dollars, Fiscal Years 1972-1990 Companson of Selected Funding Mechanisms of the National Cancer Institute, Fiscal Years 1979-1990 E3 History of Cancer Center Core. Grant Awards, Fiscal Years 1976-1988 E4 E6 E7 Total Cancer Centers Research Support by Source, Fiscal Year 1988 or 1989 Comparison of NCT Grant Awards to Institutions With Centers and Institutions Without Centers, Fiscal Year 1987 NCI Grant Awards to Institutions With Cancer Centers, Fiscal Year 1988 . .. Amount and Proportion of NCI Grant Funding to Institutions With Cancer Centers, by Type or Mechanism, Fiscal Years 1981-1988 E8 Cancer Center Core Grant Awards by Authorized Budget Categories, Fiscal Years 1985-1987 - ... . . E9 Percentage Growth of Core Grant Awards, Research Project- Grant Awards, and Total NCI Obligations, Fiscal Years 1973-1990 El0 Cancer Centers Core Grants as a Share of NCI's Overall Budget, Fiscal Years: 1972-1990 Ell Percentage Distribution of NCT Obligations by Mechanism, Fiscal Years 1977-~.988 El2 Amount and Number of Cancer Center Core Grant Awards by Type of Application, Fiscal Years 1976-1988 47

OCR for page 47
TABLE E1 Core Grant Obligations for Cancer Centers in Current and Constant Dollars (dollars in thousands), Fiscal Years 1972-1990 a/ Cancer Centers Cancer Centers BRDPI 100/ Core Support Core Support Never Year (19&8=100) BRDPI (current dollars) (1988 dollars) of Centers 1972 33.22 3.01 10,090 30,373 40 1973 34.81 2.87 13,002 37,351 44 1974 37.02 2.70 17,575 47,474 52 1975 40.98 2.44 30,096 73,441 56 1976 44.04 2.27 47,803 108,545 64 1977 47.55 2.10 55,132 115,945 56 1978 51.06 1.96 60,348 118,190 67 1979 55.26 1.81 64,364 116,475 68 1980 60.66 1.65 . 67,421 111,146 64 1981 66.98 1.49 71,408 106,611 57 1982 72.75 1.37 74,996 103,087 56 1983 77.28 1.29 77,372 100,119 60 1984 81.86 1.22 79,211 96,764 59 1985 86.47 1.16 84,957 98,250 57 t986 90.26 1.11 88,426 97,968 59 1987 95.02 1.05 95,819 100,841 60 1988 100.00 1.00 100,427 100,427 59 1989 105.92 0.94 101,345 95,681 54 b/ 1990 111.85 0.89 101,345 90,608 49 b/ a/ b/ The Biomedical Research and Development Price Index (BRDPI) was developed by the Department of Commerce's Bureau of Economic Analysis to measure the effects of price changes in the inputs to research supported by NIH (Holloway and Reed, 1989). The values for 1987-1990 are Time Ah: n FOR r~r^;~*i^~^ of the implicit price deflator for changes in the BRDPI. ~ ~ ~ ~~ ~ ~ ~W Vl l ~JI'ID ~~ U] ~~ L ~ vr~~ . GNP and its historical relationship with Projected by NCI, assuming that no additional funding beyond $101,345,000 each year is forthcoming. SOURCE: The BRDPI was provided by the Office of Economic and Resource Statistics, NIH. The cancer centers core grant obligations and number of centers came from the NCI Fact Book (various years) for 1972-1978, from the Financial Management Branch, NCI, for 1979-1990. 48

OCR for page 47
4 0 a, Q. 0 - ~ 0 ~: 0 ob ~ 0 E _ UJ o - 0 0 al 0 - 0 ._ - 0 o C ._ CO 0 - - o ._ - 4, C - C o ._ a' z o U) E ._ ac' :E: cn ._ C L} - o oC a, ._ al 0~ C~ IU J CO 0 0 0 e U. ~ ~ X 0 ~o o. ~o _ ~ ~ - u' 0 0 ~r r~ ~o u ~ 0 ~ ~o _ ~ _ 0 _ _ ~ U' - r~ ~ r~ X 0 0 U~ r~ r~ 0 ~ o~ 0 U~ ~o _ ~o ~ - 0` ~ O X O 0 :) _ 0~ ~ 0 : _ ~o ~0 %? X o~ ~ 0 o~ 0 _ L, 0 U' _ -: U' ~ _ r~ X U' 0 o~ ~ 0 o~ ~ ~ ~o _ L, 0 ~ U' _ - 0 o~ _ ~ r~ a' 0 o~ _ ru a o~ _ _ ~ ~ ~ o~ _ ~ o~ U r~ r~ 0 o~ _ ~ 0 - ~ ~ - 0 o ~o ~ - 0 ~ ~ ~o ~ a) x ru 0 ~o o' ~ 0 o~ ~ ob 0 ~ 0 ~ ' ~ b 0 u, ~ x ~ % - ~ ~ ' ~ oh r~ ~o %0 ~ r~ ~ - 0 ~ u ~ o~ o rO - ~ $ o' - ~ ~o 0 ~ r~ ~ c o c ~ , v) 4- . - 4, s ~ 4 - ~ ~ c ~ o ~ ~ ~ o ~ ~ c ~ c~ ~ - ~ - ~ z ~ ~ o ~ z a, _ ~ _ a, ~ ~ ~ ~ 0 ~ C U) ~ C ~ F O ~ O ~ Z 49 C. c 4, . - s - a, 4" c o . c o 4 4" . 4, ~C c o . a, z o ~, c . 3 E a, o o - o ._ X O ~ ~ C _ C o ._ ~ ~ C Z cn C ~ _ _ a~ ~ ._ X ~ 4, C r~ C a:~ ._ _ 1 CeO ~ ~ O' ~ _ Z o Q - ~o ._ > O o - c~) ~ z ~ - 0 - 0~ LLI o z cy c ~ ._ ~n

OCR for page 47
t p o~ ~ ;L 3 - ~ X a ~o - ~0 o~ o. o 0 - = o 3 4" o C~ a, C~ L~ o o 4 - CO ._ UJ o ._ :' ._ o' - 0 0 0 _ _ 0 ~ u~ ~ o~ ~ ~ ~ r~ ~ r~ 0 ~ 0 ~ ~o o. ~ u~ _ _ _ ~ _ _ _ _ _ ~ ~ _ 0 ~ _ _ _ _ 0 0 ~ O 0 ~ O 0 0. 0 0 ~C ^1 ~ ~ ~ 0 0% 0 ~ ~o r~ u' r~ ~o ~ ~ ~c _ _ _ _ _ _ ru r~ 0 ~0 a 0 O~ 0. ~ O O _ O O O U. O' O O C ~J ~ ~ _ ~ ~ ~J r~ u, ~ ~ ~ ' _ r~ , _ 0 o ~ o ~ ~ o. o~ _ ~ ru u~ r~ _ 0 _ ~ ~ ~ O u~ ~ ~ 0~ 1~ u~ ~0 r~ _ _ r~ ~ ~ u~ o ~o ~o r~ r~ r~ %0 ~ _ _ _ _ ~ ~ _ ~ _ ~ ~ ~ 0 _ _ _ ~ _ 0 ~ ~ ~ u~ ~ 0 _ _ 0~ %0 r~ ~ ~ ~ U' 0 0 0 0` 0 0 ~ 0~ ~ U' O 0 ~ 0h ~ ~ O ~ ~ U~ `0 _ %0 0 _ ~ ~ U~ _ ~ _ _ _ _ _ _ ~ ~ _ _ _ _ r~ ~ _ _ 0 `0 0~ ~ ~ m0 ~J 1` ~ 0 M) ~ ~ r~ ~o 0 0 06 `0 ~ ~ ~ %d u~ ~ 0 0 ~ r~ u~ 0 `0 ~ ~ ~ ~ U' ~ ~ ' ~ ~ ~ ~ ~ r~ ~ ~ ~o _ ~o _ u~ O ~ r~ u' ~ ~Q ~ ~ ~ ~ ~ r' a~ ~ . ~ ~ 0 ~o u~ ~ c~: ~ _ ~ _ _ _ _ ~J 1^ N `0 ^1 _ . . _ ~ ~o r~ r~ ~ u~ 0` 0 `0 ~ U' ~ %0 O ~ J U~ U~ ~ ~t _ _, _ _ ~ _ ~ ~ U~ ~ ~ ~ ~ _ O ~ 0~ ~ O 0 0 %0 0 ~ r~ r~ ~ o~ _ _ _ _ _ _ r~ ~o r~ ~o r~ _ ~o 0 r~ ru ~ o~ U~ ~ r~ 0 ~ ~o r~ ~ ~ r~ o~ ~o r~ ~o ~ o~ ru ~ c - 0 ~ O mt O C~ ~J 0% ~ a' ~ 0 ^1 ~ 11~ 0 %0 0 _ _ r~ U~ 0~ 0 0 0 0~ u~ _ ~ ~ ~ _ _ u, r~ c 0 _ ~ r~ r~ ~ 0 ~ 0 ~ ~ _ _ _ ~ _ ~ ~ _ ~ ~ ~ r~ ~ r~ ~ _ _ r~ r~ _~ . _ ~ ~ ~ ~ ru o~ ~? ~ ~ 0 ~ U~ 0 U~ %0 O ~ _ ~ ~ ~ O ~ CO ~ _ CO 0 ~ ~ _ ~ _ _ ~ ~ ~ ~ ~ ~80 ~ h~ ~ ~ ~ ~J ~J~ ~ ~ U~ ~ %0 0 r~ ~ r~ ~ ~ u~ _ ~ ru ~ r~ ~ ~o %0 ~ _ _ _ _ ~ ~ _ _ O 0~ 0 Ut ~ IO ~ ~ 0 0 ~ O ~ 1^ ~ N ~ _ _ _ r~ _ 0 ~ U, u' 0 ~ r~ ~ u, _ ~ U~ ~ U' ~ ~ _ _ r~ r~. _ rw O O ~ 0 ~ `0 ~ _ ~ _ 1` 1^ 0 ~o r~ 0 ~ r~ ~ ~ %0 ~ ~ ~ ~ 0 ~0 0% _ ~ 0 ~ ~;r In U~ ~ _ 0 ~o 0 r~ 0 ~ ~ ~ _ r~ r~ ~ _ ~0 0% 0 O O O . ~ ~ ~ 0 ~ 0~ 0 U' r~ ~ 0 _ ~ _ ~ _ ^. ' U~ 0 ~ O ~ 0 - 0 0 ~ U, 0 0 O O ~ U' C~ O ~ 1^ 0 ~ _ - _ O _ 0 r~ 00 ~ 0 ~ ~ 0 ~1 ~1 `0 ~ ~ ~ ~ ~J tf' ~J N ~ t~J 1O 1^ O `0 _ U~ ~ ~ ~ ~0 ~0 ~J _ CO ~ ~ ~J 0 0 0 ~J ~ 0` `0 0` ~J 0% ~ 0~ ~ ~ t~ 1^ 0 `0 t~ 0 0% 0 U~ 0% ~ U, ~J O 1` %0 ~ ~ 0` %0 _ _ _ ~ h_ ~ ~ ; _ - ) ~J ~J O U.' ' Z O u m - . ,~ ~ a, ) _ ~ Z ~ CY _ ~ C~ ' ~ LLI ' ~ Z ~: UJ ~ ~ X Z ~ ~ ~ ~ ~ Z CY ~ 0 0 ~ UJ ~ ~ tY >~ C~ C~ > ~ ~ J >~ O ~ U.l U' Z ~ O 1~ ~ C' CY Z Y : U, O ~ 1" ~ CO 2 l]J Y (r) (J) O ~ 2 _ Z ~ 1D ~ Z ~ CY ~ (Y : tY CD O ~ ~ ~ Ul ~ ~ U~ ~ ~ tY ~ O Z UJ ~ O ~ C C~ CD CY q: <: _ U~ CC - : Z O ~ ~ ~ ~ ~ ~ ~ z x ~ ~ ~n ~ ~ ~ ~ m 3 <: O O ~ z 0 u~ O z _ ~ C. u~ ~ ~ ~ ~ m ~ 3 ~ ~ z ~ ~ ~ u, ~o ~ 0 c~ 0 r~ 50 ~o ~ c~ 0 0 r~ 0 ~ 0 ~ ~ ~ ~ ~ _ u a) ~ ~ ~o ~ ~ 0 - ~ `0 ~ ~ O O ~ O 0 0b ~ `0 ~ ~ _ u~ 0 ~ ~ `0 ~ ~ 0 - u~ ~ ~ ~ ~ ~ ~0 u~ O ~ ~ ~ ~ ~ 0~ rO _ ~ r~ _ `0 ~ ~ ~ ~ ~ O ~ u' ~ o~ ~ ~o ~ c~ ~o r~ ~ ~ 0 ro ~ ~o r~~ o~ ~ ~ _ r~ ~ . ~ ~ _ _ ~ u~ ~ u~ ~ 0 u' ~ 0 0 ~ ~ ~ r~ ~ u' ~ ~ 0b 06 ~ u~ ~o ~0 0 ~ ~ ~ ~ ~ _ ~ _ 0 0 0. 0 ~ ~ 0` 0 ~ o~ u~ ~ c~ r~ r~ 0. ~ ~ ~ ~ 0. ~ 0~ u~ 0~ ~ ~ 0b ~ O `0 u~ ~ 0 ~ u~ ~ t~ 0. 1~ ~ O `0 `0 r~ _ ~ _ _ U~ 0b 0 r~ U) _ 0~ ~ O O 0 ~ ~ 0. r~ U~ 0 0 ~ ~ U' 0 ~ ~ . ~ 0 . ~ ~ ~ _ _ u, r~ 0 o~ ~ r~ ~ 0 ~ U~ 0b ~ 0b U~ 0 ~ _ _ 1 0 ~ In _ u~ %0 U~ U~ ~ ~ _ ~ 0~ ~ O ~ 0 `0 _ r~ r~ r~ ~ u~ ru ~o o r~ _ _ o 0 r~ _ 0 ~ o o~ 0% ~ ~ U~ ~ ~ 0 0~ ~ %0 0 `0 ~ ~ _ _ _ ~ _ _ ~ _ u' ~n In 0 ~ ~ O U, 0 0 _ ~ ~ O _ ~ ~ `0 U~ 0~ U~ ~ ~ ~ `0 _ _ ~ ~ r~ O 0% 0 0~ ru ~ ~ _ ~o ~ ~ ~ %0 r~ ~ ~

OCR for page 47
al ~ x ~ ~ He to ~ - ~ x C9 or or 0= so - - to ~ - o~ 0 - ~ - ce a, (D N 0 . 0~ _ _ a' ._ ~ US 0 0` _ _ C~ . 0 ~ 0 ~ _ C" U. ._ 0 C~ U', _ - ~ %0 _ _ CD 0 3 0 ~C 4 C ~ 0 C~ ~ _ o { a' C o 0` O ._ U) ._ ~ 4 - ._ . ~ r~ ce C ~ - m - : u~ ~ ~ 0b 0 0 co _ u~ o~ u~ ~ r~ 0 0 0 ~ ~ r~ ~ ~ ~ r~ ~ ~ ~ ~ ~ r~ ~ ~ ~ ru ~ ~ ~n r~ _ u~ ru ~ C~ ~ ~ ~ 0 ~o ~ 0 0 ~o _ 0 o~ o ~ r~ 0 0 0 o~ _ ~ ~ 0 U~ ~o ~ o. 0 ~o ~ ~ ~ ~ _ . ~ ~ ~o 0 ~ ~ a' ~ ~o ~ u' _ ~ U' ~ ~ ~ r~ ~ u, ~ Lr~ _ _ _ _ Ut _ o~ _ ~ ~ ~ ~ C~ o~ ~ ~ ~ `0 0 0 ~ 0 `0 0 ~ ~ 0 _ _ u, ~ _ ~ o~ r~ ~ r~ 0 ~ ~ u' ~ 0 ~ ~ ~ 0~ ~ ~ 0~ ~ ~ ~ U~ ~0 U~ `0 ~ ~ N `0 1 ~ ~ ~ J _ _ _ _ N O ~ _ ~ ~ O ~^ ~ ~J ~ ~ ~ ~ 0~ C~ ~ ~0 0 0 0 0 0 0 0 0 `0 0 0 ~ ~ ,U' ~ ~ ~ ~ _ ~ ~ ~ ~ ~ ~ ~ ~ ~ C~ ~ ~ ~ ~0 0 ~ 0 In .0 ~ ~ ~ ~o _ r_ ~ ~J ~ u~ LO r~ _ _ O O O ~ ~ ~ _ ~ ~ ~ ~ ~ 0 0 0 ~ 0 ~ ~ ~ ~ ~ O ~ O O O O O 0 ~ I~ 1^ 0 U~ ~J U~ 0~ 0b ~ . 0 U~ 0~ 0 %0 ~ . - ~ ~J 1^ ~J O 0 ~ ~ C~ `0 0 ~ `0 _ 11~ 0 %;t ~S ~ `0 t~ ~ ~ ~J 11~ U N _ _ C' O O O O O O O ~0 LO 0` ~ ~J ^1 0 ~ 0 C~ ~ r~ ~ O `0 `0 ~ 0 0 ~ ~0 0 0 0 0 0 0 _ , o~ 0 u~ 0 ~ ~ ~ 0 0 ~ 0 ~ ~ u~ ~ u~ r~ ~ ~ r~ 0 ~ ~ O O ~ 0~ ~0 ~ U, ~ `0 0 ~ ~ ~ 0 N 0 ~ ~ `0 1^ U~ ~ In _ ~ _ ~ _ _ u~ ~ u~ ~ ~ ~0 0 %0 0h ~ ~ ~ 0~ ~ 0 0 0~ r~ ~ In ~ 0 0 ~ ~ 0 0 0 0 0 a' ~ ~ r~ 0 o~ o~ r~ ~ U' o~ ~ o. o~ ~ ~ r~ ~ ~o r~. 0 ~ 0 u' 0 0 C~ ~ ~ ~ ~ ~o ru ~ 0 u, c~ ~ 0 ~ 0~ ~ r~ ~ ~ ~ ~o ~ u~ _ ~ _ r~ ~ ~ _ ~ ~o r~ 0 ~ ~ 0 ~ ~ r~ ~ o~ In ~ u~ 0 o. u~ ~ . r~ ~ 0 ~ u, 0 0 ~ ~ ~ r~ r~ r~ ~ _ ~ ~ 0 U' r~ r~ ~ 0 o u, o ~ ~ C?~ r~ r~ O _ 0 ~ ~ ~J ~ 0 ~J ~0 N Ut 0~ N 0~ t~J O ~ 0 ~ 1~ `0 0 ~ ~ O O ~ ~1 ~I N _ _ ~ _ _ 1~ ^1 ~0 ~ ~ 0 (~J 0~ ~ ~ 0 0 0 ~ ~ 0 0 ~ %0 0 _ ~ ~ ~ ~ ~0 _ 1^ _ C~ ~ ~ ~ 0~ 0 0 ~ ~ _ ~ 0 ~ u' Ch 0 ~ u~ ru ~ r~ 0 ~ 0 r~ ~:r _ O U~ U' ~ ~ %0 0 ~ ~ O ~ 0% ~ 0 U' 0 ~0 0 0 0 U~ ~ U' O ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ . ~ ~ ~ ~ _ _ _ _ ~ ~ _ _ _ ~ ~ _ u, ra ~ 0 r~ ~ r~ _ o~ ~o _ ~ 0 0 0 ~ 0 0 ~ 0 o~ ~ u' 0~ 0 0 o~ r~ 0 r~ ~o ~ ~ ~ ~ ~ 0 _ _ u~ ~ O ~ %0 ~ %0 %0 ~ ~ ~ ~ ~ O ~ 0h ~J ru o~ If~ ~ o~ c~ u~ r_ _ l~ 0 ~ 0 ~ ctl ~ ~ ~ ~ ~ ~ u~. ~ -r ~ In ~ o~ 51

OCR for page 47
~ lo ~ x x 0 - 0 0 o. 0 0 0 0 ~ ~ ru ~o 0 _ 0 0 ~ ~ ~ 0 0~ ~ 0 ra 0 0 0 ~ 0% o. _ r~ ~ ~o ~ r~ ~o o. r~ ~ ~o 0 u u' r~ 0 ~ Od ~ _ ~ O O O O O ~ ~ ~ O O _ 0 0 0~ 1~) 0 0 ~ ~0 O O O N ~ ~ o~ u' ru ~ ~ a 0 ~ u~ ~ ~ ~ ~ ~ _ 0 _ v' r~ ~ _ a ~ ~ _ ~ _ ~ ~ ~ u~ ~ ~ _ 0 ~_ 0 0 0 0 0 r~ 0 r~ 0 _ u~ O ~ ~n o. 0 _ ~ r~ u~ 0 c~ o~ ~o ~0 0 o~ ~ u' r~ ~ o~ ~ ~ ~ u~ 0 u' r~ ~ ~ 0 u' ~ _ _ ~o ~ _ 0 ~ ~ ~ ~ r~ _ ~ ~ ~ U~ _ ~ _ _ ~ O O o 0 ~ 0+ ~ 0 0 ~ ~ ~ _ ~ 0 0 ~ ~ 0 ~ ~ 0 0 0 0 o~ r~ ~o ~ ~ ~ 0 ~ u~ ~0 ~ 0 ~r 0 _ ~ ~ _ _ ~ u, ~o ~ ~ ~ ~ _ ~ ~ _ In _ 0 0 - ie 0- _ o~ 0 >- o~ ~ _ ._ 0 ~ _ 7 -0 ~ o~ o ~ 4" f~ U. a, 0 4" o c o o 0 - - a' O O O O U1 U, ~ ~ O O ~ O _ ~ 0 0 ~ `- U~ 0 0 ~ O O O O r~ ~ ~ ~ ~ r~ r~ 0 ~ ~ ~ ~ ~ ~ 0 u' ~ ~ - ~o ~o ~ ~ ~ ~ r~ ~ ~ O O O 0 0 ~ ~ 0 0 ~ ~ U' N `0 ~ _ O O O O O O O O O O O ~ `0 _ 0 06 0~ _ ~J O ~ h_ u' r~ u~ ~ 0 ~ ~o r~ O O O O ~ ~ _ `0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 U, %0 0 U' O U~ In ~ ~ t~ ~r O >~ Z ~ d: O O ~ CY ILI ~C C) > Z _ ~ Z CY O O U" m tY ~ ~ UJ tr ~ , - ~ . . _ 8 ~ CY _ _ ~: ~3 ~ _ _ cn c~ =. - : z ~ ~n C~ _ ~: o Z _ S ~ _ tr Ul ~C _ ~ C] _ Z ~ ~ tY O UJ Z O J ~ tY Cl ~ ~ o _ _ UJ ~ C~ ~ -~ I3J Z Z t~ :: ~ UJ "I C~ J CY >~ L) ~ <: U] ~ Y U) C3 X _ U' ~ UJ _ O ~ x: Z .CY cn .u, _ LU ~ ~ ,_ ,,, o _ _ O o~ x: Z CIC CO U) _ -- IlI ~ ~ O ot ~ ~ Z CO ~ Ul ~C UJ ~ 3 cn IIJ 0 ~ ~ z ~r z ~ ~ z z Y u' ~ cn z ~ O z cY ~: ._ ~ ~ m ~ 3 ~r 0 3 z u~ ~ ~ c~ z z `~ 3 ~ ~ ~ Z Z ~ ~) ~ aC UJ {~ t~l O ~ 2 0 J ~ O ~ ~ IIJ IIJ C~ ~ @) ~ O ~ ~ ~ ~ O 3 C~ ~ ~ ~ Y ~ 1~1 Z ~ CJ) ~ Z 4" cr _ ~ Z ~ Ir ~ ~ l~ ILI _ ul z x 0 ._ c~ 0 ~ ~ u~ ~ ~ (Y ~ z ~ cn _ ~ ~ ~ u" Y ~ ~: ~ ~ u' ~ - : C~ ~ C:) 0 3 0 ~ O O Z ~ `L ~1 0 0 0 0 ~ O C5 ~ 1u ~ ~ ~ ~ ~ ~ ~ _ ~ c~ C ~ ~ > ~ ~ ~ ~ z ~ z s ~ c~ 3 >~ ~ ~ ~ 3 ~ cY ~ ~ z ~ _ _ _ ~ ~ _ ~ ti] z ~ ~c ~ ~ ~ tY tn ~ _ _ _ _ ~ O O Z z z aC ~ u~ z ~ ~C ~ O ~ O z z z z ~ ~ ~: Z ~ Z ~ =) =) ~ =) ~ ~ t~ ~ {J) 3 ~ -- ~ ~ C~ ~ ~ =, ~ ~ [LI O) UJ ~ ~ ~ O -: ~J 1~ ~ ~ ~0 ~ 0 0. 0 _ - 1 ~ ~ 1^ `0 ~ 0 0~ 0 CXJ ~ ~ 1^ %0 ~ `0 `0 %0 `0 ~ `0 %0 `0 `0 ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ 00 CO 0000 52

OCR for page 47
t ~ 4 D ~o `0 L. 3 0 ~1 0 0 - - >~ - a' 0 ._ - U) a' o ._ U) 0 = o - U, o 4" c o o ._ UJ ~ o ~ ~ ~ `0 0 ~O 0 0 0` 0~ 0 U~ o o o o o _ ~ - _ C, 0b - o 0 . - r~ - CO' 0h 0 0% ^1 0 _ ~ _ 0~ _ 0h o _ ~ o r~ o. _ ~ ~ ~ o. _ U~ ~ _ ~ ~ ~ 0~ ~ ~ O o o O O O _ o~ a:~ ~ _ _ O o o O o o o' o o o O o O o O o O o ~ O o O O o O o o o C~ o O O O O O O o o O O O O O O o O O o o O o o O o o o o o O o o o o o o 0 - ~0 a, 0 0 0` 0 0 o ._ 4 - ._ 4 - - O o o O O o o O O O o O O O o O O o O o o o O o o o ~ CO z UJ :~ ~ U~ J J cn z UJ CL ~ ~ ~ tY Q ~ z z ~ >~ Z ~ ~ ~C ~ ~ ~n ~ O ~ ~ ~ tY ~ cn z co L> ~ CY Ul ~ O ~C ~ ~ z ~ u, ~ ~ J ~ LU J ~ >~ ~ ~ z m ~ -: z - : 0 ~ cn ul c~ O z cY _ C~] U) ~ Ir ~ CY aC ~ ~ ~n ~ 0 ~ ~ 0 L~ Z 0 ~ ~ ~r 0 z ~ ~ ~ ~ > ~ _ _ ~ ~ 0 CL ~ ._ >, . , _ ~ ~ ~ O _ O ~ 0 O L. O ~ _ ~ O C ~ ~ ._ ._ { ~ 0 ._ ~ ~ D o ~ ~ . ~ ~ CL ~ , ~ "C ~ 0 :c ~ ~ C C t_ _ 0 to 3 O _ `0 C O 0 ._ _ 4 - 0 _ cn 0 0 C C ._ ~o ~ O 4J ~ D 10 ~C cn C - - _ C C ._ - C~ z ._ o Q - D ~o 4 E a, 4 C) . o

OCR for page 47
~ ~ JO 0 _ ~ ~ ~ 0 _ ~ 0 0 ~ ~ rat ~ rot _ rat ~ co us 0 ~ ~ ~ or 0 ~ ~ ~ ~ _ u' 0 ~ ~ rat 0 ~ ~ or ~ ~ ~ 0 0 _ 0 Fat _ ~ ~ _ 0 or ~ 0 0 ~ ~ ~ rat lo us ret ~ ~ ~ 0 ~ ~ rat ~ 0 ~ ~ us e_ ~ 0~ 0 ~0 ~0 ~ o or ~ 0 ~ ~ ~ us us us . ~ so _ ~ 0 so 0 ret o o ~ o ~ ~ rot o lo so ~ ~ o ~ ~ ~ lo ~ m 06 0 0 ~ 0 ~ 0h u) ~ 0 r~ 0 r~ 0 r~ ~ 0 0 r~ ~ ~ ~o ~ ~J ~ 1O N ~ ~ 1^ ~J ~J ~ '0 ~ ^1 ~ ~1 ^1 , . 0 ~ 0h ~ ~ ~o ra ~ 0 _ u' r~ _ u' _ 0 ~ ~ ~ ~ ~ ~ o~ ~o 0 0 u~ ~ _ ~ _ 0 _ ~ ~ u, u~ 0 o~ 0 _ ~ ~ u~ ~ ~ ru ~ _ 0 u~ u' o ~ ~ r~ _ o. r~ ~ r~ ~o ~ 0 _ u~ ~ ~ a' u, r~ ~ o 0 ~ 0 r~ o~ o~ u, 0 0 rO r~ 0 ~o `0 r~ 0 ru ~ _ u~ o~ ru 0 0 ~o ~ ~ _ r~ ~ 0 ~ ~ o ~ 0 ~ u~ ~ 0 0 r~ u~ r~ 0 ~ ~ r~ r~ C~ . ~ ~ 0 0 u~ ~ o. r~ ~ r~ ~ ~ r~ ~ _ ~ 0 0 _ ~ r~ ,_ 0 _ ~ _ ~ ~ u~ r~ 0 u~ ~ ~ _ u~ u~ _ r~ ~ 0 ~ ~ ~ 0 ''t0 0 0 ~ 0 ~ 0 ~o ~ ~ 0 ~ ~ ~ ~o -? ~ ~ ~ ~ ~ ~ ~ ~ ~ O ~ ~ ~ 0 X ~ ~ ~ ~ 0 0 0 ~ ~ 0 r~ 0 $ ~ _ (Q ~ r~i ~ ~o ~o _ 0 oh 0 r~ ~ 0~ 0 0 ~ 0 r~ 0 0 ~o ~ o:' r~ 0 u~ r~ 0 _ u~ o. ~ 0 0 _ 0 ~ ~o ~ r~ r~ ~o _ _ 0 0 u~ ob 0 ~ _ _ _ 0 0 ~ r~ c~ 0 o~ ~o ~ ~ O 0 0 0 N ~ 0 ~ 0 ~J ~ 0 1^ ~ Itl ^1 U1 ~ ~ `0 0 U' ~J _ t~l ~ ~J ~ ~J N ~J ~ ~ _ ~J tO ~ ~J ~J ~1 ~J 0 0 0 0 0 0 0 0 0 0 ~ ~n ~1 0 ~ O U' 0 0 0 0 ~ ~J O 0 u, 0 _ o~ _ r~ 0 ~ u~ 0 ~o 0 u~ ~ O 0` o ~ o txJ o 1~ U~ 1*~ 0 N O 0~ ~ ~ ~ ~ - ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ r~ 0 _ 0 ~ r~ N O 0 ~0 ~ O ~ ~ O' 0` ~ ~ ~ ~ ~ N ~ O U' N ~ ~ ~ ~ _ 0 P_ ~J ~ N _ _ r~ C `0 0 0 `0 0 0 ~ O O U~ 0K 0 0 0 0h ~ O' 0 O' O 11~ 0 ~ ~J O O _ _ ~ ~ O O ~ O O O O 4~ ~ ~ r~ 0 co 0~ o ~ r~ u~ ~ ~ U~ u~ _ o~ o o ~ _ ~ ~ ca ~ o~ c _ ~o u~ _ ~ o~ ~ r~ 0 ~ 0 u~ ~ _ ~ ~ ~ u~ 0~ 0 rn ~ u~ ~ .o ~r ~ ~ ~ ~ ~ ~ ~ ~ O~ ~ ~ O' N 0 ~ ~ ~ ~ ~ ~ ~ N ~ ~ N N ~ c U O O ~ 0 0~ r ~ _ ~ 0 _ ~ ~ 1` ~ _ h- O O O ~J ~ 0 ~ ~n ~ _ _ _ ~ ~ _ ~ _ _ N ~ ~ u~ 0 a~ U~ _ ~ O O O ~ ~0 0 0 O' 0~ 0 ~ ~ ~ O' 0' 0 ~ ~ ~ ~ ~ ~ 0 ~ ~ N O ~ ~ O ~ ~ ~ O ~ 0~ ,1 C ~ ~ O ~ ._ Z ~ > IY 4, _ a, ~ ~ ._ ~n 0 >' aC _ O 4) ._ C O C ._ 4~ ._ _ z ~n 0 4 - C a~ u ._ _ C C ~ O ~ ~ ._ ._ ~ C ~ 4J Q ~ ~ ._ U CO ~ ~1 0 1 4~ ~ Cl) ' ~ ~ 4, ~ U ~ ~ ~ C C ~ S ~ C U) ~ ~ ~ ~ C C ~ ~ ~ ~ ~ ~ . C O ~ U C ~ 0 0 4, ~ ~ ' ~ u ~ ~ g, 4, E ~ ~ C ~ ~ ~ 0 4, ~o 0 0 3 3 'c ~ 'c ~ 0 0 ~ ~ ~ ~ ~ O ~ ~ ~ `~` ~ ~ 54 d]

OCR for page 47
4" 4" - ~ ~ ~ ~ o 4~ a_ Q O O Q ~ In 'a ~ . _ ~ :e 4, ~4 ~ ._ O TIC _ O ~ ~ ._ O C ._ ~ ._ 40 ~ ~ z In 0 u' ~ _ ret 0 _ 0 ~ ~ ~ 0 0 to 0 ret 0 `0 `0 ~ ~ O O `0 ~ ~ 0 0 ~ 00~ ~~ 0 0~ ~ 0~ r~ ~0 ~ 0 ~ _ r~ ~ ~ ~ o~ ~s ~ r~ ~ ~o ~ o~ ~ ~ 0 O ~ ~ ~ 0 ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ' ~ ~ ~ ~ ~ ~ ~ ~ ~ `0 ~ 0 0 r~ 0 ~ ~ ~ _ 0 ~ u~ ~Q 0 _ ~ In u~ ~ 0~ ~ 0~ 0 _ u' r~ r~ ~o 0` 0 0 ~ ~ 0 o~ 0 o~ ,~ r~ r~ ~ ~ ~ ~ ~ ~ ___~___~0 0 `0 ~ U~ O ~ ~ U~ ~ 0 _ _ U. ~ 0 _ _ ~ _ U~ ~J ~ 0~ 0 ~ ~ 0 tO U~ 0 `0 ~ ~ 0 ~ ~ U~ ~ ~ O ~ . q0 `0 _ 0 ~ a~ ~o _ ~o ~ ~ ~ ~J ~ J ~ 0 t~ r~ _ ~ 0 ~ ~ 0 ~ 0 ~ _ 0 _ ~ ~ r~ ~ 0 0 ~ O ~ ~ 0 ~ _ ~ ~ U~ ~ U~ _ 0 ~ ~ _ ~ ~ ~ ~ ~ ~ ~ - , ~ ~ ~ ~ ~ ~ l~ O ~J `0 t~ 1` In ~ ~ 80 1 - 0 ~ ~ O 0~ _ t~ _ _ _ _ _ _ _ ~I N t~ ^1 o o o u' o o o o o ~ ~ o o ~ ~ o ~ ~ ~ 0 u~ r~ oh - ~ ~ ~ ~ 0 ~ ~ o~ u~ o. r~ ~ ~o ~ w - rO ~ u~ ~ - ~ u~ o - u~ o $ o u' u~ ~ o o ~Q ~o ~ ~o o ~ o r~ ~o ~o 0 ~ o ~ ~ co ~ ~ ~r o. 0 u~ u' o. o~ o~ - a' - - o~ o r~ r~ 0 o t" 0 o - u~ o u' - ~- 0 o `` ~ 0 ~r ~ ~ ~- ~~ o2 -' N _ ~0 0 ~ ~ ~ ~ ~ O 1^ ^1 "1 ~ ~ ~J ~J o~ ~ 0 0 a~ _ r_ ob u~ o ~ _ .^ ~ ~ _ u ~ 0 ~o _ ~ u~ ~ ~ r~ ~o ~ ~ ~ ~ ~ ~ 0~ O r~i ~ 0 u~ r~ ~ r~i r~ ~ 0 0 ~ ~ ~ `0 0 ~o ~ ~ O ~ ~ 0 ~ 0 ~ ~ _ 0 0` U~ ~ O _ ~ ~J ~ _ ~ ~ ~ ~0 0 ~ N O 0 0 1 0 _ 0 ~ O O U~ N t~ t~l ~ 1^ 0` ~ ~1 _ t~l __ _ _ _ ~0 O O ~ 0 ~ `0 ~ 0 _ ~ O ~J ~J 1~ ~ 0 ~J ~ 0 ~J 1^ 0 ~ U~ U~ O U~ 5 ~J ~ ~ ~ 1^ 0 ~1 0 ~J 0~ ~ 0 ~ 1^ ~ ~ ~ ~ ~ . - ~ ~ -. ~ ~ ~ ~ ~ ~ ~ ~ ~J ~ ~J 0` - 1 0 ~ ~J ~J 1^ 0 0~ _ y~ ~ U~ ~ ~ ~ 0 ~J ~ `0 0 O 0~ ~J ~ ~ %0 In ~ U, ~ ~ CO ~ O 04 ~ ~ 0. ~ ~ t~J O ~ ~ ~ ~ . ~ ~ ~ _ _ ~ ._ _ _ _ 0 - O 1^ ~ ~ ~J ~ <) O 0` ~ O ~ ~J %0 ~ 0` 0 ~ ~ In 0 ~o ~ a, ~ ~ ~o o~ ~ ~ ~ O ~ %0 0 `0 0% ~ .~ 0 0~ 0~ 0` ~ O 0 ~ _ ~ ~ ~ ~ ~ O ~ ~ ~ ~ ~ ~ ~ ~ ~ 0 ~ _ ~ 0 ~ _ ~ ~n o 0 ~ o~ ~ u~ ~ 0 0 r~ o 0~ ~ z u~ ~ u~ ~ u~ ~ r~ r~ u~ u~ r~ 0 ~o _ O ~ ~, ~0 In ~ ~J _ ~ ~ ~J ~ ~1 ~ ~0 %0 ~0 a, .. _ _ _ _ - <' ~ ~ C ' O ~ ~ O ~ Z _ ~ _ L, o cn 4 <~ a, 4, cn 4, C~ - o 0 ~ ~ -0 O 3 C~ aC U' J m ~: o 0 r~ _ ~ r~ 0 o~ r~ ~ _ _ r~ o o~ _ U~ O O r~ ~ 0` ~ ~0 0 `0 _ ~ ~ O 0 `0 0 0 _ ~r z LU C~ L~ C~ z C~ OV} ._ 4> C C ~ Ll ~ t~ ~ ~ ~ cn ._ ._ 4~ ~ ~ ~ ~ C C ~ ~ C a, a' ~ ~ ._ ~ ~ ~ ~ ~ ~ c ~ ~r _ ~ ~ ~ ~ ' C C O O ~ C to O ~ ~ ~ 4~~ ~ ~ ~ c.~ ~~ ~ ~ E ~ C C C ~ O C C ~ ~ ~ ~ ~ o ._ CL, ~ ~ ~ ~ < ~ ~ L, ~ 4" ~ ~ c~ . ~ a, c ~ c 0 ~ ~ ~ tn c o o O ~ ~ ~ O o O L) u~ ~ cn ~ ~ I_ t~ o, .~ ~ ~ ~ ~ o ~ ~ tr a, ~ ~ ~ 0 ~ ~ 4., ~ ._ ._ ._ cn C ~ ~ ~n ~n cn ~ ~ C~ O Z ~ . ~ ~ ~ ~ ~ ~ ._ _ _ ~ ~ _ _ ~ ~ _ C ~ ~ a, C C O O ~ ~ =, ~: t/) .> 3 ~ ~ ~ Z ~ 55

OCR for page 47
4 i, o o ~ : o 0 .~x mo to Z CL > N to ~ ~ ~ ~ ~ ~ 0 ~ o ~ X ~ 8 ~ 0 ~ ~ ~ 0 or _ 0 ~ to us ~ 06 ~ ~ O rat U. ~ _ 0 ret 0 cat O ~ ~ ~ ~ ~ O u~ ~ _ ~ ~ O 0 u~ ~ _ r~ r~ ~o o. o ~o o 0 o~ _ o ~ ~o ~ 0 ~ ~ ~ ~ _ ~ U _ _ _ _ _ _ ~o ~ ~ ~ ~ ~ o, ~ o ~ ~ ~ ~ Ut ~ ~ ~o ~o ~ o~ _ U~ U~ ~o ~ ~ Ch ~ o~ % ~ ~ ~ 0 ~ N _ ~; y o ._ ~ ~ ._ ~ ._ ~ O C ._ > C 4 _ ~ ~ ~ .~ O ~ ._ :" _ ._ a' 0 ~ 0 a' t: . ~ _ 0 > O ._ D ~ ~ C ._ ~ 0 ~ 0 C~ ~ J C ~ U, O C' _ C ~ ~ L" ~ ~ ~ O ~ CY ~ ~ 4} >~ ~S O ~ ~ ~ ~ ~n - 0 ~ 0 ~ ~ ~ ~ ~ Z ~ _ L, ~ 4" ~ ~ C 0 ~0 ._ U' ~ ~ 4, ~ C 0 > ~ t0 C Y C ~ ~ 0 W ~ _ ~ ~ _ _ ~ ~ O L ~ ~ ~ t :' ~ 0 C~ _ 56 CO 0 >~ D 0 O Z - O C O O 0 C~ ~ O O G, D > 411 ~ ~ 4" C >. ~ ~ ~ ~ _ Q ._ O ~ D 4 CO C O ._ Q 0 ~ a, C ._ ~ ~ ._ C O O >- 0 ._ ~ _ ~ _ ~ 4 0 ~ [L O UJ ~ U, ~ `-0 ~ r~ In O 0. N 0 _ ~ N O 0 ~ N 0 ~ O _ `0 O O ~ _ O ~0 ~ r~ ~ ~ . ru O C 0~ e 1 0~ `0 ~ 0` 0 _ ~S 0` ~ 00 0 _ r~ O U~ `0 U, U~ `0 0~ O _ _ ~C - ._ 4" t ~0 4" 4" ._ o D o al - ._ - e~ 4~ 07 U) o CO 4 L} Q - ._ 4- - o 4 CL 4, 0 0 0 ~ C _ O ._ 4J C ~ A5 ~ O C ._ 0 4~ E 4" cn o 4" Q X LU 0 ~C C~ Q a, 4" 0 Cl 0 - ._ o > ._ 4~ ~n ._ ._ E 4 o = a' 0 m 4 C) - ._ c c ._ - - 4~ x z E o C o U C ._ 4~ O o' C 4, cn ~ L, R 0 c_ a ~J ~ m e U) U.! C ~r ~ ~ C

OCR for page 47
z o I ~ Z L~ ~ 57 x ~ ~o o~ _ ~ _ ~C ~ Z o o ~ _ Z ~ ~ _ oc ~ UJ Z ~ _ o o~ o ~o x 0 ~n o~ ~o o _ ~ o~ ~o x _ o~ - r~ U~ . 0 o o U~ N X _ _ ~ ~0 _ _ 0 O ~ _ ~ `0 ~ _ 0~ o ~ 1^ 0 X O O 0% O _ 0 O U~ 0` o "o o 0 `0 . o ~0 ra X 0 `0 IJ~ ^1 X ~ '~ 0 ~o o~ ~ ~ r~ o u, o o ~o LO o~ - 0 ~n z 111 J Z ~ W O _ Z Z O IV J S ~ OCR for page 47
I UJ o z o CY o 4. ICO ~C Z o q~ IU. o 0 0 o ~8 >~ - <) cn . cn c L) c a 4" . CO o . . c o 3 4" - z ~0 UJ - `0 0 0 _ ~ 0 ~ 0 1 ~ ~ ~ ~J N. 0 ~ ~0 ~J -O ~ O _ ~ u~ ~ ~o ~0 r~ r~ u~ u' O ~ ~ ~ ~ U~ U~ ~ O ru O O O _ h~ 0- ~O ~ %O O i~ 0 ~ ~ ~ N ~ O U~ ~ N IJ~ %0 tn ~ ~ ~ ~ u~ ~ ~ l~ _ ~ U' `0 0 . . Cl) 1 0 ~C) ~ o a, _ ~o _ r~ ~ 0 O co c~ r~ ~ ~ _ ~ ~ ~: - ~ _ ~ 0% ~ O 1^ 0` 0 =, ~ O U' 0b 0 0 ~ C:' ~ ~ ~J ~ U) U' O O Z O! OC : CL ~ CY C~ _. t~l _ O O O _ ~J ~ U~ O 1~1 N ~ O O N O O ~ m _ O O O t~ O 0 0 ~J U~ ~ l~ N U~ 0 0 0~ ~ ~ _ ~ 0~ ~) ru u~ 0 _ r~ ~ r~ ~ o~ 0 0 r~ ~ ~ C~ ~ u~ r~ 0 ~ ~ ~ O ~ ~ ~ h~ 0~ 0 ~ ~ r. _ ~ ~ N 0 ~ o~ ~ ~o 0 ~ u' ~ r~ a) 0 0 0 o' u, ~0 - 0 ~ - 0 t~~ ~- ~~ ~ %~ ~ ~ ~ ~ ~ ~ ~ r~ 0 o~ 0 r~ _ _ ~ r~ ~o 0 ~ u~ r~ _ ~ 0 ~ ~ r~ 0 o 0 ~ ~ _ ~ _ . _ ~ ~ ru ~ ~ - J ~ ~ ~ ~ ~ y ~ o o ct: c} z ~ - ~ uJ o o ~ ~: c~ ~c ~ ~ ~ z L~~ ~r Z ~ ~ 0 3 ~ t~ ~ O CD U. CO ~ >~ UJ J - : Z Z Z ~ ~ UJ :~ <~ J ~ Z >~ ~r 0 tY 58 , Y Cy <$ _ . ~ o o ~ o ~ ~ z :" ~ ~ ~ c~ ~r =) Ul UJ ~ o o , ~ ~ ~ ~ ~ ~ ~ z

OCR for page 47
tY s o ~ o Ul <~ ~ z z ~ o L, o - o ~o o~ 4, >~ - a, - L~ 0 4" 4, ~o 4J - 0 o ~ - 4J 4J - 4J o 4 :~: ec z ~o J qt ~q q' # # ~ 1 z # [u ~ ~ z o - : ~ tr - o ~ ~n C] ~ UJ >~ ~ O cn ~ ~ ~ s - : tY ~ U.l ~ J Z ~ ~ o J z ~U S tY z aS ~ O ~ U) ~ Z Z . e a: ~n z - o q J ~ O ~ - : _ _ tY C~ S J S O Ir J U] J C~ ~ _ O Z S m `~ t~ J U] J Z <: ~ Z ~ S - : ~ UJ ~ _ Z Z ~: ~r Y 0 _ ~ _ ~ ~ r~ ~ ~ ~ .1 ~ ~ c~ ~ ~n U' s ~ ~n S ~ ~ ~ ~ ~ =' X X 0 0 ~ UJ or 0 0 o 0 0 . . ~ ~ ~ > ~ _ _ _ _ _ Z Z Z Z Z o <~ o8 z o S ~: ~ tY 0 0 _ _ Z Z

OCR for page 47
I ~S Z ~r o tY o z 0 ~r >~ - - C. 0 C~ 4, 0 ~ oo" ~ C C~ ~ ~ o ~ ~ Z o 3 0 ~ S _ Z Z O `0 . _ Z ~ Z O I UJ o ~C UJ ~ . ~ o o Z tY ~ ~ tY s o u' ~ ~ 0 `0 ru ~ ~ o~ O N F" ~ ~~- ~ ~ 0 ~ ~ ~ ~ ~ ~ ~ ~ _ _ U~ ~ ^' ~o ~ 0 ~ N ~ 06 ~ _ ~ O ~ ~ ~ ~ ~ ~ ~ ~ _ _ N N `0 _ ~ 0 _ ~ ~0 N _ _ U' 0 ~ r~ 0~ ~ ~ ~ N O r ~ O O N N _ 0 N ~ N 0~ U' 0 0 `0 0 ~ 0 r~ _ _ 0 O ~ 1^ N 0~ ~ O _ 0 0 0 N - C~ U~ O N r~ O `0 U~ r~ 0 ~ F~ It' N 0~ - ~o u~ ~ - 0 r~ _ ~ o o o o o ~ - o~ o O In ~ 0 r~ 0 0 ~ b r~ r~ o o o o o o ~ ~ ~ o ~ - - co o o u~ ~ ~ o~ o o o~ N ~0 ~ It' N _ N `0 ~ N ~ U' O 0 ~ ~ 0 U~ U, ~ 0 ~ ~ O ~ _ _ ~Q ~ ~ 0 ~ ~Q ~Q ~ `0 ~ ~ ~ ~ ~ _ _ N 0 0 0 0 0 - $ 1 Ul . I ~ _ ~ O O _ 0 `0 ~ ~ `0 `0 W 1^ N `0 ^1 `0 ~ 1^ 0 N ~ O ~ N ~ C~ O eo 0 16- _ ~ N O O 0 N _ ~ _ Y1 ru 0~ 0 _ N N ~0 U~ `0 0 O' C>~ ru _ ~0 U' N r~ 0 ~J CO U' ~0 r~ O O `0 ~ ~ O 0` 0 O O U~ 0 ~ `0 N N O o 0 - ~0 r~ o - U' 0 ~0 O U~ _ O _ ~ U' 0 `0 W _ 0 0 O r~ o O ~r ~ _ CO ~ C] _ z ~r Z ~C UJ CL o _ _ ~n ~n ~c a~ r 0 W [U ~ Z 3 :- ~ ~C Z ~ O Z Z ~ Z :~ ~ ~ 0 =' ~ O O ~n ~C Z ~ : ~ O Z ~ tY ~ UJ ~C UJ ~ ~ Z 0t Y :- ~ ~ 3 60 r~ U' U' 0 o~ - o 0 o o' 0 ~ rO ~ o ~S N ~ CY _ U) Ct: _ _ ~ z ~r _ ~ S J ~ ~ UJ ~ >_ 0% _ m 4~ ~ mC ~ . ~ as `0 ac, ~ ~: o~ _ a' ._ 0 ~ CO C _ ~ _ C ._ cn - z ._ o OCR for page 47
TABLE E7 Amount and Proportion of NCI Grant Funding to Institutions With Cancer Centers, By Type of Mechanism (dollars in thousands), Fiscal Years 1981-1988 Fiscal Years NCI Grant Programs ~ 81 82 83 84 85 86 87 88 Traditional Research Grants ~ 113~0 112~5 125~0 144~1 156~4 168~6 181~0 194~2 (R01s) % 1 34.0% 34~6% 36~7% 38.rX 38.2% 39~0% 36~6% 35~6% Program Project Grants ~ 76~0 71~9 74~1 79~0 85.0 90~6 106~8 117~7 (P01s) % 1 22~9% 22~1% 21~7% 21~2% 20.7% 21.0% 21~6% 21.6% . ._ 1 Core Grants ~ 70~8 71~7 76~1 79~2 84~9 88~4 95~8 101.4 X 1 21~3% 22~0% 22~3% 21~3% 20.r/o 20~5% 19~3% 18.6% _1 Manpower 1 21~6 18~3 18~2 18~0 21.9 22~5 24~2 25~7 % 1 6~5% 5~6% 5.3% 4~8% 5.3% 5~2% 4~9X 4.r/o Construction 1 1.1 0.9 1~5 1.0 5.5 ~~ 2~0 ~~ % 1 0~3% 0~3% 0~4% 0~3% 1.3% 0~0% 0~4% 0.0% Cancer Control ~ 13~9 13~9 9~6 14~8 15~0 10~5 13~2 13.2 % 1 4~2% 4~3X 2~8% 4~0;` 3.r/O 2~4% 2er~e 2.4% Other Grants ~ 36~2 36~0 36~3 35~9 41~1 51~1 72~3 93~2 % 1 10~9% 11~1% 10~73; 9~7% 10.0% 11~8% 146X 17~1% I Total Grants ~ 332~6 325~2 340.8 372~0 409~8 431~8 495~2 545~4 % 1 100~0% 100~0% 100~0% 100.0X 100~0% 100~0% 100~0% 100~0Yo SOURCE: Data provided by NCI's Financial Management Branch. 61

OCR for page 47
TABLE E8 Cancer Center Core Grant Awards by.Authorized Budget Categories, Fiscal Years 1985-1987 Fiscal Year Budget Category 1985 1986 1987 Senior Leaders 5,660,245 5,669,202 s,a47,537 Major Program Directors 2,935,601 3,069,551 3,064,796 Staff Investigators 10,051,693 9,538,912 9,377,276 Administration 6,198,620 . 6,644,402 6,759,058 Planning and Evaluation 276,653 282,224 277,348 Shared Resources Developmental Funds 26,851,824 27,732,057 31,230,837 4,507,578 4,636,293 5,074,085 Alteration and Renovation . 67,831. 132,500 135,000 .. Research Costs of Patient Care 0 0 0 Total Direct Costs 56,550,045 57,705,141 61,765,937 Indirect Costs Total Costs (Direct and Indirect) 29,681,842 31,734,842 33,513,006 86,231,887 89,439,983 95,278,943 NOTE: The figures are based on authorized direct costs, exclusive of supplements in 1986 and 1987 for IL-2 LAK studies; and excluding minority satellite supplements and the effects of administrative adjustments to direct and indirect costs. The data are voluntarily reported by centers and may cross the Federal fiscal year or be omitted when a-center did not submit information. SOURCE: Data provided by the Cancer Centers Branch, NCI, from the Cancer Centers Administrative Profile Database. 62

OCR for page 47
TABLE E9 Percentage Growth of Core Grant Awards, Research Project Grant Awards, and Total NCI Obligations (dollars in thousands), Fiscal Years 1973-1990 CANCER PERCENTAGE RESEARCH PERCENTAGE TOTAL PERCENTAGE FISCAL CENTERS CHANGE PROJECT CHANGE NCI CHANGE YEAR CORE SUPPORT PER YEAR GRANT AWARDS PER YEAR OBLIGATIONS PER YEAR 1972 10,090 -- 97,622 -- 378,636 -- 1973 13,002 28.9 125,426 28.5 431,245 13.9 1974 17,575 35.2 171,412 36.7 581,149 34.8 1975 30,096 71.2 199,731 16.5 699,320 20.3 1976 47,803 58.8 210,662 5.5 760,751 8.8 1977 55,132 15.3 223,612 6.1 814,957 7.1 1978 60,348 9.5 246,774 10.4 872,380 7.0 1979 64,364 6.7 285,132 15.5 914,119 4.8 1980 67,421 4.7 321,325 12.7 958,163 4.8 1981 71,408 5.9 355,455 10.6 947,213 -1.1 1982 74,996 5.0 358,349 0.8 942,982 -0.4 1983 77,372 3.2 406,143 A', 13.3 986,811 4.6 1984 79,211 2.4 461,247 13.6 1,081,460 9.6 1985 84,957 7.3 516,475 12.0 1,177,853 8.9 1986 88,426 4.1 559,160 8.3 1,210,284 2.8 1987 95,819 8.4 643,153 15.0 1,402,790 15.9 1988 100,427 4.8 657,314 2.2 1,469,282 4.7 1989(Estimated) 101,345 0.9 712,020 8.3 1,571,460 7.0 1990(Requested) 101,345 0.0 749,747 5.3 1,646,073 4.7 SOURCE: For 1972-1978, NCI, 1979 NCI Fact Book. NIH Publication No. 80-512. April 1980. For 1979-1987, figures provided by Financial Management Branch, NCI (Table E1). For 1988-1990 NIH, Justification of Appropriation Estimates for ComTittee on Appropriations, Fiscal Year 1990. Volume III:36. 63

OCR for page 47
TABLE E10 Cancer Centers Core Grants as a Share of NCI's Overall Budget (dollars in thousands), Fiscal Years 1972-1990 FISCAL YEAR CANCER CENTERS CORE SUPPORT TOTAL NCI OBLIGATIONS PERCENTAGE OF NCI'S OVERALL BUDGET . 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989(Estimated) 1990(Required) 10,090 13,002 17,575 30,096 47,803 55,132 60,348 64,364 67,421 71,408 74,996 77,372 79,211 84,957 8S,426 95,819 100,427 101,345 101,345 378,636 431,245 581,149 699,320 760,751 814,957 872,380 914,119 958,163 947,213 942,982 986,811 1,081,460 1,177,853 1,210,284 1,402,790 1,469,282 1,571,460 1,646,073 2.7 3.0 3.0 4.3 6.3 6.8 6.9 7.0 7.0 7.5 8.0 7.8 7.3 7.2 7.3 6.8 6.8 6.4 6.2 NOTE: NCI figures for 1979-1982 exclude expenditures for the National Toxicology Program, which was transferred to the Institute for Environmental Health Sciences in 1983. Cancer Centers and NCI figures for 1988-1990 include AIDS funding ($3.6 million in 1988 and 1989 and S4.7 million in 1990 for cancer centers). SOURCE: See Table E9. 64

OCR for page 47
0 ~ oo ~ - o u, ~o 0 e ~ ~ Bb O~ Ut ~0 U~ ~ ~ ~_ ~3b ~~b _ ~ __ 0 O' 0 0h - - ~0 >~ U' 0 0b _ 0 0 cn _ ~b al o 4 - _ cn - - o - E ._ c ~: o :~: 0~ ~ _ Q o ._ a' - D z 0 0~ o b_ ._ ~ r~ 4~ ~ 'C~) 0` ._ _ C~ ~n a, L} 4, CL Ul - 0 - ru 0 - r~ 0~ ~0 b 0 0 0 1^ N ~ u~ ~0 0 ~ O 0~ ~ ~ ~ ~ ~ ~ ~ ~ O ~ O N ~ ~0 U~ ~J r~) ~ ~ ~ e ~ ~ O _ ~b ~ ~ o~ ~ 0 u' 0 u' r~ ~ b lb ~ ~b ~ U' ~ ~ U~ ~ ~ ~0 U~ U~ O 0 bb b _ _ r~ ~ o~ ~ 0 e ~0 ~ o ~ ~ t u~ m 0 3b ~ __ 0 bb r~ o r~ r~ u' r~ ~ ~ ~ _ ~ e _ 0 0 ~ - 1 ~ 0 1^ U' O b ~0 e cn 0 0~ U~ ~3b ~ ~ `0 ~ ~5 E ~o ~ ~ `, ~b`_ ^, ~ tn ~ Ui in O In ._ ~ 0` ~ ~ o5 Q V) _ ~ N _ ~o ~b t~ ~ t~J t_ _ 0 ~ %;t O O o~ u~ ~ ~ ru 0 u, ~ u' 0 ~ ~ ~ _ ~ ru _ ~ ._ 0^ Z O . ~ - 0 t~l 0 1^ ~ ^1 ~ O ~ |% C 0~ e ~ ~ O t~l %0 ~ ~J ~ ~ U~ `0 O O _ r~ _ ~ .~. ~ c, ~ Q _ O~ ~ o~ r~ _ 0 o~ 0 u' C~ 0 ~ .. 0~ o `0 ~ ~ ~ ~ U~ ~ _ _ ~ ~_ `0 O V) Z 0` BO Z- ~C . ~ o E _ o ~ ~ r~ ~ o ~ o O ~ ~ ~ 0 4) cn ~ r_ ~ N ~o ~ ~b 0 _ ~ 1O 1^ ~ ~ t~J ^1 ~ r- %0 ~ C ~ ~ _ ~n |` b . _ ~ ~ ~ Qo ~ ~ ._ 0 u~ ~o ~ ~o ~o r~ ~;r ~ u~ 0% ~ C c~ o ~ O ~ C 0 0` ~ t~l ~ r~ u~ ~ ru 0~ ~ ~ ~ ru r~ _ ~ ~ ~ c o C . . . . . . . . . 4~ ~ ~ o ~ C,0 . . CO ~ C CO . . . C o C ~ . . . ., - (D Q) ~ ._ a' a> ~ u, C ~ ~ ~ cn . q, a, 0 4" 4" ~ ._ a: ~ C . ~ > Q} ~ . . ~ 0 ~n . c ) ~ cn C C a _ a, ~ ~ 0 c o} ~ 0 ~ 0 _ _ _ 0 ~ ~ 0 ~ ~ _ cY ~ c~ 0 z _ r~ ~ cn 65

OCR for page 47
Q `0 t~ ~ N g ~ ~ O 0% ~ U' ~ - - . ~ , 06 _ ~ ~ ~ N _ r~ o~ ~o u~ ~ o ~ o. o~ 'O ~ ~ ~ O 0 ~ _ r~ r~ ~0 - C3 ~0 C~ a, o Q E n, 0` `0 0~ _+ a' ~I N ~ U. O o ~0 ~ ~, %d O 0% - 1 `0 O ~ C~ O o~ r~ _+ ^. U~ U r~ . 0 1^ ~ In o~ O C E Z ~: a' 4 N O O U~ %0 ~ N ra U' r~ - O O N a' O N N CO C~ - rn `0 ~0 N - - N ~0 N C. ._ ~ _ , _ C ~ Q _ Q _ ~ :5 ~ a' 0 3 C ~) a' a) 0 a, > OC _ _ ~ tJ) Q ~ 0 a' ~ ~ c ~ Z ,, ~ ~ . O ~ O 66 - Q ~0 ~ . 0 E C 0 a, L~ V) ~ L. a, 4 ~C L) - o ~ ._ CO _ ~ 4 C ~ E o cn o, C C :3 _ o E ~ 0 Q) 4 - 4) 4~ ~ ._ 4~ E .- ~ _ Q Z ~ D Q C a v) = o 1 = CO 0 Q O 4" O O 4- _ _ V) a' _ = O ~ 4} 1 ~ E 0 = ~ CO - 0 t~ cn ._ a V) a) ~ O _ C~ )< ~ ~ a, a, c a' L" 4> _ ~:n ~ ~ Q ~ ._ 1 _ CD ~ O a, ~ co a, Q) 4J C O ~ ~ ._ ._ C 4J CD ._ a, c co ~ a, D cn ~n 4 - a, c 0 v, c~ ~ a' 3 4 r~ a, :' a 4 ~ ~ {~~ _ 3 O _ `0 O C~ _ _ 4) ~ cn ._ ~ O C~ ~ _ '~ C~ ~ _ C~ ~ E a' cn - a' ._ r~ ._ a, - L) z a, ._ o Q - a, . ~n