ADVANCES IN CLINICAL PRACTICE AND APPLICATIONS

  • Development of new vaccines against important bacterial infections of infants and children, including Hemophilus influenzae type B, pertussis, and typhoid.

  • Development of a curative therapy for cystinosis, an inborn error of metabolism.

  • Discovery of AZT as an effective agent against human immunodeficiency virus (HIV or AIDS virus).

  • Development of chemotherapy to preserve kidney function in patients with systemic lupus erythematosus.

  • Development of effective treatments for alpha 1-antitrypsin deficiency state which have additional application to biochemical abnormalities in emphysema.

  • Advances in surgical treatment of hypertrophic cardiomyopathy.

  • Development of new strategies for use of coronary bypass surgery in treatment of chronic stable angina.

  • Significant contributions to technical and theoretical development of nuclear magnetic resonance and optical spectroscopy.

  • Demonstration that the drug, 5-azacytidine, increased fetal hemoglobin synthesis thus exerting beneficial effects in patients with severe beta thalassemia or sickle cell anemia.

  • Development of treatments which lessen the symptoms of malignant pheochromocytoma and identification of a marker, neuropeptide Y, which distinguishes this tumor from other pathological conditions.

  • Development of methods to assess the tone of the sympathetic nervous system; these have been useful in diagnosis and treatment of hypertension.

  • Demonstration that the drug, cyclophosphamide, induces long-term remission of symptoms in systemic vasculitis.



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