Development of new vaccines against important bacterial infections of infants and children, including Hemophilus influenzae type B, pertussis, and typhoid.
Development of a curative therapy for cystinosis, an inborn error of metabolism.
Discovery of AZT as an effective agent against human immunodeficiency virus (HIV or AIDS virus).
Development of chemotherapy to preserve kidney function in patients with systemic lupus erythematosus.
Development of effective treatments for alpha 1-antitrypsin deficiency state which have additional application to biochemical abnormalities in emphysema.
Advances in surgical treatment of hypertrophic cardiomyopathy.
Development of new strategies for use of coronary bypass surgery in treatment of chronic stable angina.
Significant contributions to technical and theoretical development of nuclear magnetic resonance and optical spectroscopy.
Demonstration that the drug, 5-azacytidine, increased fetal hemoglobin synthesis thus exerting beneficial effects in patients with severe beta thalassemia or sickle cell anemia.
Development of treatments which lessen the symptoms of malignant pheochromocytoma and identification of a marker, neuropeptide Y, which distinguishes this tumor from other pathological conditions.
Development of methods to assess the tone of the sympathetic nervous system; these have been useful in diagnosis and treatment of hypertension.
Demonstration that the drug, cyclophosphamide, induces long-term remission of symptoms in systemic vasculitis.