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MANY OF THE ~1 lhe Soiree for Ye Stay of PA for Clinical Investigation was coast by Be Institute of Medicine In Dense to a Quest by the National Aim; of Herald for an art of Be availability of appropriate Err for Rae relate to patients. In the heals acid, Here are many ~ni~1 advance Cat offer considerable hope for the future if appropriate Rae are available for clinical investigation. Major cordons have been raised about He future of clinics investigation ~ e Bite States because of (a) final changes In He organization of health Ore In the Undo Statics (b) major efforts at cost containment in all areas of clinical Medicine, (c) rapidly Elating expenses Assyria ~1 with drug devel ~ nt in this country, and (~) a reduction in the number of individuals pursuing a career in clinical investigation. In its mandate, the Committee was asked to consider the following questions: 1. What changes in the health care system have had an impact on the environment for clinical investigation or the resources necessary for such Roth? How should furring for Dali and cad be in Great ad? 2. How can the NIH increase ~n~=rest in clinical investigation among medical students and residents? How can the training of young clinical investigators be improved to optimize their c ~ s of sur--cc in the peer review process? 3. What might the NIH do to stimulate and facilitate the translation of basic research advances to clinical practice? 4. How might the NIH foster interaction between industry and clinical investigators involved in federally-funded research in order to exploit scientific opportunities while safeguarding federal stewardship of public monies? 5. How should research involving patient care be organized to provide optimal scientific return? 6. How can the NIH stimulate ingress In outdone aunt of new and established treatment programs? Ye National Astir; of Health do the ~nrni~ee to palace expeditiously, relying on Herons to provide their collective j~nt on Be challenges facing clinical investigation. Soiree ma; were ask ~ to su ~ it papers which were considered at the boo meetings of the Committee (and reprinted herein as Appendixes) and, along with the data supplied by the National Institutes of Health, contributed to the findings and recommendations in this report. 1