NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.
Support for this project was provided by Contract NASW 96013 between the National Academy of Sciences and the National Aeronautics and Space Administration. Any opinions, findings, conclusions, or recommendations expressed in this report are those of the authors and do not necessarily reflect the views of the sponsor.
Copyright 2000 by the National Academy of Sciences. All rights reserved.
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THE NATIONAL ACADEMIES
National Academy of Sciences
National Academy of Engineering
Institute of Medicine
National Research Council
The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Bruce M. Alberts is president of the National Academy of Sciences.
The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. William A. Wulf is president of the National Academy of Engineering.
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COMMITTEE ON SPACE BIOLOGY AND MEDICINE
MARY JANE OSBORN,
University of Connecticut Health Center,
Chair
NORMA M. ALLEWELL,
Harvard University
JAY C. BUCKEY, JR.,
Dartmouth-Hitchcock Medical Center
LYNETTE JONES,
Massachusetts Institute of Technology
ROBERT A. MARCUS,
VA Palo Alto Health Care System
LAWRENCE A. PALINKAS,
University of California at San Diego
KENNA D. PEUSNER,
George Washington University Medical Center
STEVEN E. PFEIFFER,
University of Connecticut Medical School
DANNY A. RILEY,
Medical College of Wisconsin
RICHARD SETLOW,
Brookhaven National Laboratory
GERALD SONNENFELD,
Morehouse School of Medicine
T. PETER STEIN,
University of Medicine and Dentistry of New Jersey
JUDITH L. SWAIN,
Stanford University School of Medicine
Staff
SANDRA J. GRAHAM, Study Director
ANNE K. SIMMONS, Senior Program Assistant
SPACE STUDIES BOARD
CLAUDE R. CANIZARES,
Massachusetts Institute of Technology,
Chair
MARK R. ABBOTT,
Oregon State University
FRAN BAGENAL,
University of Colorado
DANIEL N. BAKER,
University of Colorado
ROBERT E. CLELAND,
University of Washington
MARILYN L. FOGEL,
Carnegie Institution of Washington
BILL GREEN,
former member, U.S. House of Representatives
JOHN H. HOPPS, JR.,
Morehouse College
CHRIS J. JOHANNSEN,
Purdue University
ANDREW H. KNOLL,*
Harvard University
RICHARD G. KRON,
University of Chicago
JONATHAN I. LUNINE,
University of Arizona
ROBERTA BALSTAD MILLER,
Columbia University
GARY J. OLSEN,
University of Illinois at Urbana-Champaign
MARY JANE OSBORN,
University of Connecticut Health Center
GEORGE A. PAULIKAS,
The Aerospace Corporation (retired)
JOYCE E. PENNER,
University of Michigan
THOMAS A. PRINCE,
California Institute of Technology
PEDRO L. RUSTAN, JR.,
U.S. Air Force (retired)
GEORGE L. SISCOE,
Boston University
EUGENE B. SKOLNIKOFF,
Massachusetts Institute of Technology
MITCHELL SOGIN,
Marine Biological Laboratory
NORMAN E. THAGARD,
Florida State University
ALAN M. TITLE,
Lockheed Martin Advanced Technology Center
RAYMOND VISKANTA,
Purdue University
PETER W. VOORHEES,
Northwestern University
JOHN A. WOOD,
Harvard-Smithsonian Center for Astrophysics
JOSEPH K. ALEXANDER, Director
COMMISSION ON PHYSICAL SCIENCES, MATHEMATICS, AND APPLICATIONS
PETER M. BANKS,
Veridian ERIM International, Inc.,
Co-chair
W. CARL LINEBERGER,
University of Colorado,
Co-chair
WILLIAM F. BALLHAUS, JR.,
Lockheed Martin Corporation
SHIRLEY CHIANG,
University of California at Davis
MARSHALL H. COHEN,
California Institute of Technology
RONALD G. DOUGLAS,
Texas A&M University
SAMUEL H. FULLER,
Analog Devices, Inc.
JERRY P. GOLLUB,
Haverford College
MICHAEL F. GOODCHILD,
University of California at Santa Barbara
MARTHA P. HAYNES,
Cornell University
WESLEY T. HUNTRESS, JR.,
Carnegie Institution of Washington
CAROL M. JANTZEN,
Westinghouse Savannah River Company
PAUL G. KAMINSKI,
Technovation, Inc.
KENNETH H. KELLER,
University of Minnesota
JOHN R. KREICK,
Sanders, a Lockheed Martin Company (retired)
MARSHA I. LESTER,
University of Pennsylvania
DUSA M. McDUFF,
State University of New York at Stony Brook
JANET L. NORWOOD,
Former Commissioner, U.S. Bureau of Labor Statistics
M. ELISABETH PATÉ-CORNELL,
Stanford University
NICHOLAS P. SAMIOS,
Brookhaven National Laboratory
ROBERT J. SPINRAD,
Xerox PARC (retired)
MYRON F. UMAN, Acting Executive Director
Preface
In 1998, the Committee on Space Biology and Medicine (CSBM) completed a comprehensive report, A Strategy for Research in Space Biology and Medicine in the New Century (National Academy Press, Washington, D.C., 1998), that reviewed the status of space life sciences research in all of the disciplines funded by the National Aeronautics and Space Administration’s (NASA’s) life sciences program and laid out a detailed strategy for research during the International Space Station era. In that report, numerous biomedical research questions related to astronaut health and safety were identified as critical to NASA’s long-duration flight program. Shortly after the report’s publication, NASA requested that CSBM assess the agency’s entire current program in biomedical research, both intramural and extramural, in light of the recommendations of the Strategy report.
After a series of discussions with NASA’s Life Sciences Division, the committee began reviewing NASA’s entire biomedical research program in December 1998 in order to assess the degree to which the program seemed likely to meet research needs over the next 10 years. The research priorities given in the 1998 Strategy report were to be used as a point of departure when considering future needs and priorities. Specifically, the committee agreed to examine the relationship between intramural and extramural biomedical research activities sponsored by the agency and to review the content and program organization of both. The roles of the NASA Specialized Centers of Research and Training and the National Space Biomedical Research Institute, in the biomedical program, were also to be examined. The review was to cover all NASA biomedical research activities, including those currently conducted in conjunction with operational medical and aerospace medicine programs.
Some of the specific points the committee considered in developing its recommendations were the following:
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The balance of discipline areas emphasized in the current program;
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The degree to which studies of fundamental cellular and physiological mechanisms are addressed in each discipline program;
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The balance between ground and flight investigations;
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NASA plans for the development and validation of physiological and psychological countermeasures;
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Plans for epidemiology and monitoring;
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Plans for validation of animal models; and
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The extent to which programs are supporting new, advanced technologies and methodologies.
The committee made use of a variety of sources in gathering information for this study. Documents available to the committee included FY 1998 and FY 1999 life sciences budget information, the 1998 and 1999 Life Sciences Task Book, the first annual report of the National Space Biomedical Research Institute (NSBRI) and 1998 and 1999 program budget information, the Countermeasure Evaluation and Validation Project Plan, the International Space Station Medical Operations Requirements Document and relevant sections of the Astronaut Medical Evaluation Requirements Document, and NASA Research Announcements for 1998 and 1999. In addition, the Proceedings of the First Biennial Biomedical Investigators’ Workshop, held in January 1999, provided valuable current information. In addition to receiving briefings from NASA and NSBRI spokespersons, the committee as a whole held one meeting at Johnson Space Center, and a subgroup visited Ames Research Center to learn about the activities at that site relevant to biomedical research. These visits provided a vast amount of useful information, and the committee wishes to express its considerable appreciation of the hard work that went into the centers’ preparation for the visits and the thoroughness and candor of the briefings and discussions.
Acknowledgment of Reviewers
This report has been reviewed by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Research Council’s (NRC’s) Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the authors and the NRC in making the published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The contents of the review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. The committee wishes to thank the following individuals for their participation in the review of this report:
James Bagian, Environmental Protection Agency,
Norman Bell, Medical University of South Carolina,
Robert A. Greenes, Harvard Medical School,
Robert Langer, Massachusetts Institute of Technology,
Robert Nerem, Georgia Institute of Technology,
Gary Paige, University of Rochester, and
Edward Schultz, University of Wisconsin Medical School.
Although the individuals listed above have provided many constructive comments and suggestions, responsibility for the final content of this report rests solely with the authoring committee and the NRC.