EKG:

electrocardiogram

ESA:

European Space Agency

EVA:

extravehicular activity

FBRP:

Fundamental Biology Research Program, formerly Gravitational Biology and Ecology (GB&E)

fMRI:

functional magnetic resonance imaging

GB&E:

Gravitational Biology and Ecology, recently renamed the Fundamental Biology Research Program (FBRP)

GH:

growth hormone

HEDS:

Human Exploration and Development of Space (NASA)

HPA:

hypothalamus-pituitary-adrenal

HZE:

high atomic number, high energy

IGF-I:

insulin-like growth factor-I

IPT:

integrated product team

ISS:

International Space Station

ITR:

Integrated Testing Regimen

JSC:

Johnson Space Center (NASA)

LBNP:

lower-body negative pressure

LEO:

low Earth orbit

LET:

linear energy transfer

MARES:

Muscle Atrophy Research and Exercise System

MORD:

Medical Operations Requirements Document

MRI:

magnetic resonance imaging

NASA:

National Aeronautics and Space Administration

NIH:

National Institutes of Health

Front Matter (R1-R16)

Executive Summary (1-6)

1 Introduction (7-10)

2 Sensorimotor Integration (11-18)

3 Bone Physiology (19-25)

4 Muscle Physiology (26-32)

5 Cardiovascular and Pulmonary Systems (33-39)

6 Endocrinology and Nutrition (40-45)

7 Immunology and Microbiology (46-50)

8 Radiation Biology (51-57)

9 Behavior and Performance (58-67)

10 Setting Priorities in Research (68-71)

11 Programmatic and Policy Issues (72-80)

Appendix A: A Strategy for Research in Space Biology and Medicine in the New Century, Executive Summary (81-99)

Appendix B: Letter of Request from NASA (100-102)

Appendix C: Glossary (103-106)

Appendix D: Acronyms (107-109)

Appendix E: Biographies of Committee Members (110-112)