Rat

75–300

Gavage

5×/week for 13 weeks

NA

None

Bucci and Parker, 1992; Bucci et al., 1992

Mouse

5 mg/m3

Inhalation

20 min for 10 days

None

Slight ataxiac

Husain et al., 1993

Cat

1,000

s.c.

Physostigmine and atropine

None

Goldstein et al., 1987

 

3.5

s.c.

1×/day for 10 days

None

Noned

 

 

7

s.c.

1×/day for 5 days

None

Noned

 

NOTE: DN = delayed neuropathy; i.m. = intramuscular; i.p. = intraperitoneal; i.v. = intravenous; s.c. = subcutaneous; NA = not available; PAD = dodecyl iodide salt of P2S; 2-PAM = pralidoxime chloride; P2S = pralidoxime mesylate, 2-hydroxyiminomethyl-N-methylpyridinium methyl methanesulfonate.

aNo hens were ataxic at 500 μg/kg. Figures not provided for doses higher than 1,000 μg/kg.

bStudy does not report how many of five dosed animals developed moderate ataxia.

cStudy does not report how many of six dosed animals developed slight ataxia.

dNo behavioral signs of neurotoxicity, but sarin decreased conduction velocity of muscle spindle afferents and altered the frequency response of primary and secondary nerve endings.



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