TABLE D.1 Gulf War Illnesses and Related Conditions

 

Unexplained Illnesses in Gulf War Veterans

Multiple Chemical Sensitivity (MCS)

Fibromyalgia (FB)

Chronic Fatigue Syndrome (CFS)

Most common symptoms

Fatigue

Headache

Muscle and joint pain

Skin rash

Impaired memorya

Fatigue, low energy

Inability to concentrate

Memory problems

Nasal congestion

Headache

Throat soreness

Joint discomfortb

Widespread muscle pain and stiffness

Tenderness at specified soft tissues sites

Fatigue

Sleep disturbance

Impaired cognitionc

Severe fatigue

Headaches

Postexertional fatigue

Impaired cognition

Muscle pain

Multijoint pain

Sore throat

Unrefreshing sleep

Sudden onset of symptoms with a flulike illnessd

Classification criteria

No widely accepted criteriae

No widely accepted criteriaf

1990 American College of Rheumatologyg

1988 CDC case definition, revised 1994h

ICD-10 listing

No

No

YesI

Yesj

Causes

Unknown

Unknown

Unknown

Unknown

Pathology or laboratory test

None

None

None

None

Animal model

None

Neurobehavioral sensitization and/or limbic kindlingk

None

None

Biological correlates

None yet identified

None yet identifiedl

HPA dysregulation

Alterations in pain mediators (substance P, dynorphin)

Growth hormone deficiencym

HPA dysregulation and other CNS abnormalities

Immune activation

Physical and cardiovascular de-conditioningn



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