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Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference (2000)
Institute for Laboratory Animal Research (ILAR)

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. "Rat Genetics and Toxicology." Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press, 2000.

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Microbial Status and Genetic Evaluation of Mice and Rats: PROCEEDINGS OF THE 1999 US/JAPAN CONFERENCE

Pohjanvirta, R., M. Viluksela, J.T. Tuomisto, M. Unkila, J. Karasinska, M.A. Franc, M. Holowenko, J.V. Giannone, P.A. Harper, J. Tuomisto, and A.B. Okey. 1999. Physicochemical differences in the AH receptors of the most TCDD-susceptible and the most TCDD-resistant rat strains. Toxicol. Appl. Pharmacol. 155:82-95.

Shellabarger, C.J., J.P. Stone, and S. Holtzman. 1978. Rat differences in mammary tumor induction with estrogen and neutron irradiation. J. Natl. Cancer Inst. 61:1505-1508.

Shirai, T., A. Nakamura, S. Fukushima, A. Yamamoto, M. Tada, and N. Ito. 1990. Different carcinogenic responses in a variety of organs, including the prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl . Carcinogenesis 11:793-797.

Tuomisto, J.T., M. Viluksela, R. Pohjanvirta, and J. Tuomisto. 1999. The AH receptor and a novel gene determine acute toxic responses to TCDD: Segregation of the resistant alleles to different rat lines . Toxicol. Appl. Pharmacol. 155:71-81.

Vorhees, C.V., L.L. Morford, S.L. Inman, T.M. Reed, M.A. Schilling, G.D. Cappon, M.S. Moran, and D.W. Nebert. 1999. Genetic differences in spatial learning between Dark Agouti and Sprague-Dawley strains: Possible correlation with the CYP2D2 polymorphism in rats treated neonatally with methamphetamine. Pharmacogenetics 9:171-181.

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104
Front Matter (R1-R16)
Opening Remarks, Judith Vaitukaitis (1-3)
Opening Remarks, Shin-Ichi Ota (4-5)
Introductory Comments on Microbiologic Testing of Laboratory Mice and Rats: Uniformity of Results (6-6)
Development of a Performance Assessment Program for Research Animal Diagnostic Laboratories and Defining Microbiologic Testing Standards (7-10)
Standardization of Rodent Health Surveillance: Regulation Versus Competition (11-15)
Factors Causing Difficulties in Uniformity of Results Among Testing Facilities in Microbiologic Monitoring of Laboratory Animals (16-20)
Necessity of Reexamining the Pathogenicity and Elimination of Parasites in Rats and Mice (21-26)
Emerging (and Reemerging) Viruses of Laboratory Mice and Rats (27-34)
Emerging Infections as a Cause of Concern (35-39)
Emerging Diseases in Mice and Rats (40-43)
Survey of Heliobacter Species in Laboratory Mice and Gerbils in Japan (44-46)
Genetic Evaluation of Outbred Rats (47-50)
Genetic Evaluation of Outbred Rats from the Breeder's Perspective (51-64)
Concept for Establishment of Rat Outbred Global Standard Strains (65-76)
Necessity of Genetic and Microbiologic Quality Network from the Pharmaceutical Industry's Perspective (77-84)
International Harmonization of Laboratory Animals (85-96)
Rat Genetics and Toxicology (97-104)
A Phenotype-driven Approach to the Molecular and Functional Analysis of the Mouse Genome (105-115)
Evaluation of Targeted Mutations (116-118)
Defining Behavioral Phenotypes in Transgenic and Knockout Mice (119-129)
Defining Phenotype in Genetically Engineered Mice (130-131)
Development of the Mouse Model Dramatype for Human Clinical Benefit (132-136)
Concluding Remarks (137-137)
Implication of Wild-derived Genes, Mitochondria, and Chromosomes in the Genetic Background of Mouse Models for Diseases and Biologic Functions (138-141)
Concluding Comments, John Strandberg (142-143)
Concluding Remarks, John Vandenbergh (144-146)
Appendix A (147-148)
Appendix B (149-150)