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Suggested Citation:"Concluding Remarks, John Vandenbergh." National Research Council. 2000. Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press. doi: 10.17226/9987.
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Concluding Comments

John Vandenbergh

North Carolina State University

Raleigh, NC

I would like to share a number of recommendations that I heard without associating them with particular speakers. Many of the speakers presented very specific recommendations, which in some cases were new to me and probably were new to others.

One important discussion centered on the maintenance of genetic diversity in outbred stocks, avoiding drift and the various bottlenecks that can appear. We used terms such as rotation, or migration among colonies that are scattered about, and the technique of making crosses (such as four-way crosses).

We heard that colleagues in toxicology have not been taking advantage of information resulting from genetic analysis. I agree with that premise and refer to a recently published paper (Spearow and others 1999) showing that the strain of mice most frequently used by toxicologists, the CD1 strain, is also the least responsive to estrogen among all strains that have been tested. Yet, so much of environmental estrogen is now being tested on that particular strain of mouse. I believe it is necessary to reexamine that testing. One other suggestion that I believe requires additional thought is that of developing one or more global strains.

We learned that we can use the team approach to phenotyping. In addition, I think we can use simple but elegant behavioral assays that are available and have been described in some detail. It may be advisable to use genetically altered mice or rats as strains that can be used over a long time, rather than use only the selected strains we have. Finally, near the end of our discussion, the fascinating term dramatype was explained.

In closing and on behalf of the International Committee of the Council of the Institute for Laboratory Animal Research (ILAR), I want to thank all the speakers and Ralph Dell and the ILAR staff for hosting an excellent meeting. The Na

Suggested Citation:"Concluding Remarks, John Vandenbergh." National Research Council. 2000. Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press. doi: 10.17226/9987.
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tional Center for Research Resources of the National Institutes of Health has been very generous in providing some support for this program in addition to the Central Institute in Japan and the Japanese government. Finally, I thank Dr. Nomura who, with Dr. Held, started all of these discussions in the 1980s and who has been the driving force behind this meeting as well as the subject of normalization of animal use. Their good start and continued pressure in the area has made possible the success of this meeting.

REFERENCE

Spearow, J.L., P. Doemeny, R. Sera, R. Leffler, and M. Barkley. 1999. Genetic variation in susceptibility to endocrine disruption by estrogen in mice. Science 285:1259-1261.

Suggested Citation:"Concluding Remarks, John Vandenbergh." National Research Council. 2000. Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press. doi: 10.17226/9987.
×
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Suggested Citation:"Concluding Remarks, John Vandenbergh." National Research Council. 2000. Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press. doi: 10.17226/9987.
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Page 144
Suggested Citation:"Concluding Remarks, John Vandenbergh." National Research Council. 2000. Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press. doi: 10.17226/9987.
×
Page 145
Suggested Citation:"Concluding Remarks, John Vandenbergh." National Research Council. 2000. Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press. doi: 10.17226/9987.
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Page 146
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US/Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US/Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes. In addition to these publications, the meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.

In cooperation with the Comparative Medicine section of NCRR/NIH, the ILAR Council and staff are pleased to become the host for this important annual meeting and look forward to participating in future meetings. The support and sponsorship of NCRR (P40 RR 11611) in the United States and the Central Institute for Experimental Animals in Japan are gratefully acknowledged. Bringing together the leading scientists in the field of laboratory animal care has resulted in increased understanding of American and Japanese approaches to laboratory animal science and should continue to strengthen efforts to harmonize approaches aimed at resolving common challenges in the use of animal models for biomedical research and testing. This effort to improve understanding and cooperation between Japan and the United States should also be useful in developing similar interaction with other regions of the world including Europe, Australia, and Southeast Asia.

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