Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference

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Table of Contents
Front Matter R1-R16
Opening Remarks, Judith Vaitukaitis 1-3
Opening Remarks, Shin-Ichi Ota 4-5
Introductory Comments on Microbiologic Testing of Laboratory Mice and Rats: Uniformity of Results 6-6
Development of a Performance Assessment Program for Research Animal Diagnostic Laboratories and Defining Microbiologic Testing Standards 7-10
Standardization of Rodent Health Surveillance: Regulation Versus Competition 11-15
Factors Causing Difficulties in Uniformity of Results Among Testing Facilities in Microbiologic Monitoring of Laboratory Animals 16-20
Necessity of Reexamining the Pathogenicity and Elimination of Parasites in Rats and Mice 21-26
Emerging (and Reemerging) Viruses of Laboratory Mice and Rats 27-34
Emerging Infections as a Cause of Concern 35-39
Emerging Diseases in Mice and Rats 40-43
Survey of Heliobacter Species in Laboratory Mice and Gerbils in Japan 44-46
Genetic Evaluation of Outbred Rats 47-50
Genetic Evaluation of Outbred Rats from the Breeder's Perspective 51-64
Concept for Establishment of Rat Outbred Global Standard Strains 65-76
Necessity of Genetic and Microbiologic Quality Network from the Pharmaceutical Industry's Perspective 77-84
International Harmonization of Laboratory Animals 85-96
Rat Genetics and Toxicology 97-104
A Phenotype-driven Approach to the Molecular and Functional Analysis of the Mouse Genome 105-115
Evaluation of Targeted Mutations 116-118
Defining Behavioral Phenotypes in Transgenic and Knockout Mice 119-129
Defining Phenotype in Genetically Engineered Mice 130-131
Development of the Mouse Model Dramatype for Human Clinical Benefit 132-136
Concluding Remarks 137-137
Implication of Wild-derived Genes, Mitochondria, and Chromosomes in the Genetic Background of Mouse Models for Diseases and Biologic Functions 138-141
Concluding Comments, John Strandberg 142-143
Concluding Remarks, John Vandenbergh 144-146
Appendix A 147-148
Appendix B 149-150

1:15 – 2:45	Genetic Evaluation of Outbred Rats
	US Speakers: Joseph J. DeGeorge William J. White Howard Jacob Japanese Speakers: Tatsuji Nomura, Chair Naoko Kagiyama Hideki Katoh UK Speaker: Micheal F.W. Festing
2:45 – 3:00	Break
3:00 – 4:30	Defining Phenotype in Genetically Engineered Mice
	US Speakers: Dabney K. Johnson Eugenia Floyd Jacqueline N. Crawley Japanese Speakers: Norikazu Tamaoki, Chair Kazunori Nakajima Tatsuji Nomura Kazuo Moriwaki
4:30 – 5:00	Concluding Comments
	John Strandberg John Vandenbergh
5:00 – 6:00	Cocktails—Executive Dining Room
6:00	Dinner—Executive Dining Room

Table of Contents

Front Matter R1-R16

Opening Remarks, Judith Vaitukaitis 1-3

Opening Remarks, Shin-Ichi Ota 4-5

Introductory Comments on Microbiologic Testing of Laboratory Mice and Rats: Uniformity of Results 6-6

Development of a Performance Assessment Program for Research Animal Diagnostic Laboratories and Defining Microbiologic Testing Standards 7-10

Standardization of Rodent Health Surveillance: Regulation Versus Competition 11-15

Factors Causing Difficulties in Uniformity of Results Among Testing Facilities in Microbiologic Monitoring of Laboratory Animals 16-20

Necessity of Reexamining the Pathogenicity and Elimination of Parasites in Rats and Mice 21-26

Emerging (and Reemerging) Viruses of Laboratory Mice and Rats 27-34

Emerging Infections as a Cause of Concern 35-39

Emerging Diseases in Mice and Rats 40-43

Survey of Heliobacter Species in Laboratory Mice and Gerbils in Japan 44-46

Genetic Evaluation of Outbred Rats 47-50

Genetic Evaluation of Outbred Rats from the Breeder's Perspective 51-64

Concept for Establishment of Rat Outbred Global Standard Strains 65-76

Necessity of Genetic and Microbiologic Quality Network from the Pharmaceutical Industry's Perspective 77-84

International Harmonization of Laboratory Animals 85-96

Rat Genetics and Toxicology 97-104

A Phenotype-driven Approach to the Molecular and Functional Analysis of the Mouse Genome 105-115

Evaluation of Targeted Mutations 116-118

Defining Behavioral Phenotypes in Transgenic and Knockout Mice 119-129

Defining Phenotype in Genetically Engineered Mice 130-131

Development of the Mouse Model Dramatype for Human Clinical Benefit 132-136

Concluding Remarks 137-137

Implication of Wild-derived Genes, Mitochondria, and Chromosomes in the Genetic Background of Mouse Models for Diseases and Biologic Functions 138-141

Concluding Comments, John Strandberg 142-143

Concluding Remarks, John Vandenbergh 144-146

Appendix A 147-148

Appendix B 149-150