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Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference (2000)
Institute for Laboratory Animal Research (ILAR)

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. "Opening Remarks, Shin-Ichi Ota." Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press, 2000.

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Microbial Status and Genetic Evaluation of Mice and Rats: PROCEEDINGS OF THE 1999 US/JAPAN CONFERENCE

at the National Academy of Sciences, where the Institute for Laboratory Animal Research has been our host. I sincerely hope that we will continue having these meetings and will expand our discussion topics in the future. Since 1980, this meeting has been held only in the United States. For the US/Japan Science and Technology Cooperative Program to pursue the mutual benefit for which it was established, I believe that some future meetings should be held in Japan or, if Japan is not possible, in Hawaii.

Finally, I sincerely thank Dr. Judith Vaitukaitis and Dr. Ralph Dell as well as all US participants for their efforts in organizing this meeting.

REFERENCES

Nomura T, Potkay S. 1991. Establishment and Preservation of Reference Inbred Strains of Rats for General Purpose Use: Report on U.S.-Japan Non-Energy Research and Development Cooperation: Laboratory Animal Science. ILAR News 33(3):42-44.

USPHS/NIH [US Public Health Service/National Institutes of Health] . 1986. Manual of Microbiologic Monitoring of Laboratory Animals. 1st ed. (NIH Publication No. 86-2498). Washington, DC: GPO.

USPHS/NIH [US Public Health Service/National Institutes of Health] . 1994. Manual of Microbiologic Monitoring of Laboratory Animals. 2nd ed. (NIH Publication No. 94-2498). Washington, DC: GPO.

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Front Matter (R1-R16)
Opening Remarks, Judith Vaitukaitis (1-3)
Opening Remarks, Shin-Ichi Ota (4-5)
Introductory Comments on Microbiologic Testing of Laboratory Mice and Rats: Uniformity of Results (6-6)
Development of a Performance Assessment Program for Research Animal Diagnostic Laboratories and Defining Microbiologic Testing Standards (7-10)
Standardization of Rodent Health Surveillance: Regulation Versus Competition (11-15)
Factors Causing Difficulties in Uniformity of Results Among Testing Facilities in Microbiologic Monitoring of Laboratory Animals (16-20)
Necessity of Reexamining the Pathogenicity and Elimination of Parasites in Rats and Mice (21-26)
Emerging (and Reemerging) Viruses of Laboratory Mice and Rats (27-34)
Emerging Infections as a Cause of Concern (35-39)
Emerging Diseases in Mice and Rats (40-43)
Survey of Heliobacter Species in Laboratory Mice and Gerbils in Japan (44-46)
Genetic Evaluation of Outbred Rats (47-50)
Genetic Evaluation of Outbred Rats from the Breeder's Perspective (51-64)
Concept for Establishment of Rat Outbred Global Standard Strains (65-76)
Necessity of Genetic and Microbiologic Quality Network from the Pharmaceutical Industry's Perspective (77-84)
International Harmonization of Laboratory Animals (85-96)
Rat Genetics and Toxicology (97-104)
A Phenotype-driven Approach to the Molecular and Functional Analysis of the Mouse Genome (105-115)
Evaluation of Targeted Mutations (116-118)
Defining Behavioral Phenotypes in Transgenic and Knockout Mice (119-129)
Defining Phenotype in Genetically Engineered Mice (130-131)
Development of the Mouse Model Dramatype for Human Clinical Benefit (132-136)
Concluding Remarks (137-137)
Implication of Wild-derived Genes, Mitochondria, and Chromosomes in the Genetic Background of Mouse Models for Diseases and Biologic Functions (138-141)
Concluding Comments, John Strandberg (142-143)
Concluding Remarks, John Vandenbergh (144-146)
Appendix A (147-148)
Appendix B (149-150)