. "Necessity of Genetic and Microbiologic Quality Network from the Pharmaceutical Industry's Perspective." Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press, 2000.
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Microbial Status and Genetic Evaluation of Mice and Rats: PROCEEDINGS OF THE 1999 US/JAPAN CONFERENCE
TABLE 7 Proposals for Establishing a Quality Network
Novartis requests breeders to establish:
Adequate breeding scheme to avoid genetic drifting/bottleneck by generation/site
Embryo preservation for risk management
Sharing of minimum health profile
Sharing of reference substances for reliable screen
Genetic/microbiological monitoring for data-oriented quality assessment
Quality network between breeding sites/group breeders
Novartis requests reference organizations to provide:
Evaluation standard for genetic drifting of outbred stock
Harmonized minimum health profile
Supply of reference substances
REFERENCES
Katoh, H., S. Wakana, S. Utsu, and J. Yamada. 1991. Studies on the genetic monitoring of outbred mice and rats: A survey granted by the Ministry of Education, Science and Culture [text in Japanese]. Tokyo, Japan.
Saitoh, M., and K. Esaki. 1985. Multi-cross hybrid animals [in Japanese]. Jikken-igaku 3:564-566.
