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TABLE 7 Proposals for Establishing a Quality Network

  1. Novartis requests breeders to establish:

    • Adequate breeding scheme to avoid genetic drifting/bottleneck by generation/site

    • Embryo preservation for risk management

    • Sharing of minimum health profile

    • Sharing of reference substances for reliable screen

    • Genetic/microbiological monitoring for data-oriented quality assessment

    • Quality network between breeding sites/group breeders

  2. Novartis requests reference organizations to provide:

    • Evaluation standard for genetic drifting of outbred stock

    • Harmonized minimum health profile

    • Supply of reference substances

REFERENCES

Katoh, H., S. Wakana, S. Utsu, and J. Yamada. 1991. Studies on the genetic monitoring of outbred mice and rats: A survey granted by the Ministry of Education, Science and Culture [text in Japanese]. Tokyo, Japan.

Saitoh, M., and K. Esaki. 1985. Multi-cross hybrid animals [in Japanese]. Jikken-igaku 3:564-566.



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