Monkeyss (macaque and squirrel)

135-1,000 d (variable dosing)

NS

NS

Ataxia, tremor, constriction of visual field

Evans et al. 1977

Monkeys (macaque)

20-73 wk (variable dosing)

NS

NS

Tremor, constriction of visual field

Merigan et al. 1983

Monkeys (Macaca fascicularis)

177-392 d

0.05

0.09

Ataxia, tremor, blindness

Burbacher et al. 1988

Rat

29 d

2.4

Ataxia, paralysis

Hunter et al. 1940

Rat

1-6 wk

0.8

Ataxia, degeneration of cerebellum and dorsal root ganglia

Chang and Hartmann 1972

Rat

3-12 wk

0.84

1.68

Ataxia, edema and necrosis of cerebellum

Magos and Butler 1972

Rat (Wistar)

2 d

10

Impaired performance in tilting plane test

Fehling et al. 1975

Rat (Wistar)

9, 13, or 21 d

2

4

Hindlimb crossing

Inouye and Murakami 1975

Rat (Wistar)

Gestation d 7-14

4

6

Spasms, gait disturbances

Fuyuta et al. 1978

Rat (Sprague-Dawley)

2 d

1.32

4

Altered sleep cycles

Arito and Takahashi

Rat

15 d (dosed every 3 d)

10

Hindlimb crossing, flailing

Leyshon and Morgan 1991