Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens: A Workshop Summary (2005)

Chapter: Appendix C Abbreviations

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Suggested Citation:"Appendix C Abbreviations." National Research Council. 2005. Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11335.

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Appendix C
ABBREVIATIONS

Ahr

aryl hydrocarbon receptor

ADH

alcohol dehydrogenase

cDNA

complementary deoxyribonucleic acid

CYP1B1

cytochrome P450, isozyme 1B1

CYP2A6

cytochrome P450, isozyme 2A6

CYP2E1

cytochrome P450, isozyme 2E1

CYP3A4

cytochrome P450, isozyme 3A4

DNA

deoxyribonucleic acid

EH

epoxide hydrolase

EPA

U.S. Environmental Protection Agency

E₂

Estrogen

FDA

U.S. Food and Drug Administration

GAO

U.S. Government Accountability Office

GST

glutathione S-transferase

IARC

International Agency for Research on Cancer

IGFbp5

insulin-like growth factor-binding protein-5

LOX

lysyl oxidase

MOA

mode-of-action

mRNA

messenger ribonucleic acid

MTD

maximal tolerated dose

Page 55 Cite

Suggested Citation:"Appendix C Abbreviations." National Research Council. 2005. Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11335.

×

NIEHS

National Institute of Environmental Health Sciences

NIH

National Institutes of Health

NOAEL

no-observed-adverse-effects level

OHT

4-hydroxytamoxifen

OPN

osteopontin

PCR

polymerase chain reaction

PGME

propylene glycol monomethyl ether

RNA

ribonucleic acid

SAR

structure-activity relationship

SNP

single-nucleotide polymorphisms

Page 56 Cite

Suggested Citation:"Appendix C Abbreviations." National Research Council. 2005. Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11335.

×

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Page 54 Cite

Suggested Citation:"Appendix C Abbreviations." National Research Council. 2005. Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11335.

×

Page 55 Cite

Suggested Citation:"Appendix C Abbreviations." National Research Council. 2005. Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11335.

×

Page 56 Cite

Suggested Citation:"Appendix C Abbreviations." National Research Council. 2005. Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11335.

×

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Toxicogenomics is a discipline that combines expertise in toxicology, genetics, molecular biology, and environmental health to help understand the response of living organisms to stressful environments. The National Research Council convened a workshop to discuss how toxicogenomic data could be applied to improve risk assessments, particularly cancer risk from environmental exposure to chemicals. Risk assessments serve as the basis of many public-health decisions in environmental, occupational, and consumer protection from chemicals. The workshop provided a forum for communities of experts, including those working in "-omics" and those in the policy arena, to discuss where their fields intersect, and how toxicogenomics could address critical knowledge gaps in risk assessments.

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