Appendix D
Patents
Since 1990, the Naval Medical Research Center (NMRC) and the Walter Reed Army Institute of Research (WRAIR) malaria vaccine programs have had six and eight patents granted, respectively. One further WRAIR patent is expected to be assigned a patent number in the coming months. The titles of approved patents are listed below.
NMRC PATENTS GRANTED TO DATE
U.S. Patent Issue No. 5,095,093 on March 10, 1992
Title: Protective four amino acid epitope against Plasmodium vivax malaria
Inventors: Hoffman, Charoenvit, and Jones
U.S. Patent Issue No. 5,198,535 on March 30, 1993
Title: Protective malaria sporozoite surface protein immunogen and gene
Inventors: Hoffman, Charoenvit, Hedstrom, Khusmith, and Rogers
U.S. Patent Issue No. 5,599,543 on February 4, 1997
Title: Protective four amino acid epitope against Plasmodium vivax malaria
Inventors: Hoffman, Charoenvit, and Jones
U.S. Patent Issue No. 5,814,617 on September 29, 1998
Title: Protective 17 kDa malaria hepatic and erythrocytic stage immunogen and gene
Inventors: Hoffman, Charoenvit, Hedstrom, and Doolan
U.S. Patent Issue No. 6,066,623 on May 23, 2000
Title: Polynucleotide vaccine protective against malaria, methods of protection and vector for delivering polynucleotide vaccines
Inventors: Hoffman, Hedstrom, and Sedegah
U.S. Patent Issue No. 6,399,062 on June 4, 2002
Title: Murine monoclonal antibody protective against Plasmodium vivax malaria
Inventors: Charoenvit, Hoffman, and Beaudoin
WRAIR PATENTS GRANTED TO DATE
U.S. Patent Issue No. 4,906,564 on March 6, 1990
Title: Antigenic determinants recognized by antibodies obtained using a pathogenic agent or derivative thereof that presents a restricted set of antigens
Inventors: Lyon, Chulay, Thomas, Howard, Weber
EUROPEAN PATENT OFFICE Patent Issue No. 0192626 on July 29, 1992
Title: Malaria circumsporozoite vaccine
Inventors: Ballou, Gross, Hockmeyer, Young
GERMAN Patent Issue No. P3686178.2 on July 29, 1992
Title: Malaria circumsporozoite vaccine
Inventors: Ballou, Gross, Hockmeyer, Young
SOUTH AFRICAN Patent Issue No. 86/0874 on December 30, 1996
Title: Malaria circumsporozoite vaccine
Inventors: Ballou, Gross, Hockmeyer, Young
U.S. Patent Issue No. 6,310,046 on October 30, 2001
Title: Sequestrin of Plasmodium falciparum
Inventors: Duffy, Ockenhouse
U.S. Patent Issue No. 6,541,815 on November 4, 2003
Title: Sequestrin
Inventors: Duffy, Ockenhouse
U.S. Patent Issue No. 6,855,322 on February 15, 2005
Title: Isolation and purification of P. falciparum merozoite protein-142 vaccine
Inventors: Lyon, Angov