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This activity was supported by Contract/Grant No. S-ISNCT-14-CA-1013 between the National Academy of Sciences and the Department of State. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.

International Standard Book Number-13: 978-0-309-39220-4
International Standard Book Number-10: 0-309-39220-9
Digital Object Identifier: 10.17226/21918

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Copyright 2016 by the National Academy of Sciences.
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Suggested citation: National Academies of Sciences, Engineering, and Medicine. (2016). Chemical Laboratory Safety and Security: A Guide to Developing Standard Operating Procedures. Committee on Chemical Management Toolkit Expansion: Standard Operating Procedures. Washington, DC: The National Academies Press. doi: 10.17226/21918.

The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Ralph J. Cicerone is president.

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COMMITTEE ON CHEMICAL MANAGEMENT TOOLKIT EXPANSION: STANDARD OPERATING PROCEDURES

Members

NED D. HEINDEL (Chair), Lehigh University

MONTGOMERY ALGER, Pennsylvania State University

WILLIAM BULLOCK, Bristol-Myers Squibb

MARK C. CESA, INEOS USA LLC (Ret.)

THOMAS F. EDGAR, University of Texas, Austin

PATRICK J. LIM, University of San Carlos

KENNETH G. MOLOY, National Science Foundation

SUPAWAN TANTAYANON, Chulalongkorn University

Staff

CAMLY TRAN, Study Director (as of January 1, 2016)

KATHRYN HUGHES, Senior Program Officer (through January 1, 2016)

CLAIRE BALLWEG, Program Coordinator (as of January 1, 2016)

CARL-GUSTAV ANDERSON, Research Associate (through January 1, 2016)

COTILYA BROWN, Senior Program Assistant (through January 1, 2016)

BOARD ON CHEMICAL SCIENCES AND TECHNOLOGY

Members

DAVID BEM (Co-Chair), PPG Industries

DAVID WALT (Co-Chair), Tufts University

HÉCTOR D. ABRUÑA, Cornell University

JOEL C. BARRISH, Achillion Pharmaceuticals, Inc.

MARK A. BARTEAU, University of Michigan

JOAN BRENNECKE, University of Notre Dame

MICHELLE V. BUCHANAN, Oak Ridge National Laboratory

DAVID W. CHRISTIANSON, University of Pennsylvania

JENNIFER S. CURTIS, University of California, Davis

RICHARD EISENBERG, University of Rochester

SAMUEL H. GELLMAN, University of Wisconsin-Madison

SHARON C. GLOTZER, University of Michigan

MIRIAM E. JOHN, Sandia National Laboratories (Ret.)

FRANCES S. LIGLER, University of North Carolina, Chapel Hill and North Carolina State University

SANDER G. MILLS, Merck Research Laboratories (Ret.)

JOSEPH B. POWELL, Shell, Houston

PETER J. ROSSKY, Rice University

TIMOTHY SWAGER, Massachusetts Institute of Technology

Staff

TERESA FRYBERGER, Director

DOUGLAS FRIEDMAN, Senior Program Officer

CAMLY TRAN, Associate Program Officer

CLAIRE BALLWEG, Program Coordinator

ACKNOWLEDGMENT OF REVIEWERS

This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the process. We wish to thank the following individuals for their review of this report:

John Brauman, Stanford University

Muhammad Iqbal Choudary, University of Karachi

Kimberly Jeske, Oak Ridge National Laboratory

Royce Murray, University of North Carolina at Chapel Hill

Russell W. Phifer, WC Environmental, LLC

Lori Seiler, The Dow Chemical Company

Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse the report’s conclusions or recommendations, nor did they see the final draft of the report before the release. The review of this report was overseen by Stephen Berry of the University of Chicago. He was responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring committee and the institution.

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The Guide to Developing Standard Operating Procedures is meant to be used with the Chemical Laboratory Safety and Security: A Guide to Prudent Chemical Management and the accompanying toolkit.

These materials are available on the Internet at www.dels.nas.edu/global/bcst/Chemical-Management.

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CONTENTS

1 STANDARD OPERATING PROCEDURES FOR CHEMICAL SAFETY

Introduction

What Is a Standard Operating Procedure?

Who Is Responsible for Developing Standard Operating Procedures?

Guide to Developing Standard Operating Procedures

2 RISK ASSESSMENT FLOWCHART

Introduction

Management and Storage

Process Risk Mitigation

Assessment of Chemicals

Assessment of Process Conditions

3 CHEMICAL STORAGE MATRIX

Introduction

Primary Storage Requirement

Secondary Storage Requirement

Labeling

Inventory of Chemicals

4 STANDARD OPERATING PROCEDURE FORMS

Introduction

Moderate Risk Standard Operating Procedure

High Risk Standard Operating Procedure

5 APPLICATION OF THE GUIDE TO DEVELOPING STANDARD OPERATING PROCEDURES

Scenario 1: Neutralization of Carbonate by Acid

Scenario 2: Use and Filtration of a Pyrophoric Catalyst

Scenario 3: Toxic and Explosive Gases: Handling Diazomethane and Alternatives

Scenario 4: Reagent Storage

6 FORMS

Risk Assessment Flowchart

Chemical Storage Matrix

Moderate Risk Standard Operating Procedure Form

High Risk Standard Operating Procedure Form

APPENDIXES

A Charge to the Committee

B Available Resources

C Segregation List

D Flammable List

E Security List

F Committee and Staff Biographies