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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Table of Contents Papers from a National Academy of Sciences Colloquium: Genetic Engineering of Viruses and Viral Vector* Genetic engineering of viruses and of virus vectors:11287 A preface Peter Palese and Bernard Roizman Site-specific integration by adeno-associated virus11288-11294 R. Michael Linden, Peter Ward, Catherine Giraud, Ernest Winocour, and Kenneth I. Berns Oncogenic potential of the adenovirus E4Orf6 protein11295-11301 Mary Moore, Nobuo Horikoshi, and Thomas Shenk Adenovirus-mediated interleukin-12 gene therapy for11302-11306 metastatic colon carcinoma Manuel Caruso , Khiem Ph. am-Nguyen , Yok-Lam Kwong, Bisong Xu, Ken-Ichiro Kosai, Milton Finegold, Savio L. C. Woo, and Shu-Hsia Chen The function of herpes simplex virus genes: A primer11307-11312 for genetic engineering of novel vectors Bernard Roizman The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors Samita S. Andreansky, Bin He, G. Yancey Gillespie, Liliana Soroceanu, James Markert, Joany Chou, Bernard Roizman, and Richard J. Whitley 11313-11318 i Replication-defective herpes simplex virus vectors for 11319-11390 gene transfer in vivo Peggy Marconi, David Krisky, Thomas Oligino, Pietro L. Poliani, Ramesh Ramakrishnan, William F. Goins, David J. Fink, and Joseph C. Glorioso A deletion mutant in the human cytomegalovirus 11321-11326 gene encoding IE149~aa is replication defective due to a failure in autoregulation Edward S. Mocarski, George W. Kemble, John M. Lyle, and Richard F. Greaves buman cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains Thomas R. Jones, Emmanuel J. H. J. Wiertz, Lei Sun, Kenneth N. Fish, Jay A. Nelson, and Hidde L. Ploegh Epstein-Barr virus vectors for gene delivery 11334-11340 to B lymphocytes Erle S. Robertson, Taclamasa Ooka, and Elliott D. Kieff Genetically engineered poxviruses for recombinant 11341-11348 gene expression, vaccination, and safety Bernard Moss Applications of pox virus vectors to vaccination: An update Enzo Paoletti 11349-11353
Contents Negative-strand RNA viruses: Genetic engineering 11354-11358 and applications Peter Palese, Hongyong Zheng, Othmar G. Engelhardt, Stephan Pleschka, and Adolfo Garc~a-Sastre Foreign glycoproteins expressed from recombinant 11359-11365 vesicular stomatitis viruses are incorporated efficiently into virus particles Matthias J. Schnell, Linda Buonocore, Evelyne Kretzschmar, Erik Johnson, and John K. Rose Specific infection of CD4+ target cells by recombinant 11366-11370 rabies virus pseudotypes carrying the HIV-1 envelope spike protein Teshome Mebatsion and Karl-Klaus Conzelmann Alphavirus-based expression vectors: Strategies 11371-11377 and applications Ilya Frolov, Thomas A. Hoffman, Bela M. Pragai, Sergey A. Dryga, Henry V. Huang, Sondra Schlesinger, and Charles M. Rice Early events in poliovirus infection: Virus-receptor interactions Vincent R. Racaniello 11378-11381 Efficient transfer, integration, and sustained long-term 11382-11388 expression of the transgene in adult rat brains injected with a lentiviral vector Luigi Naldini, Ulrike Blomer, Fred H. Gage, Didier Trono, and Inder M. Verma Use of virion DNA as a cloning vector for the 11389-11394 construction of mutant and recombinant herpesviruses S. Monroe Duboise, Jie Guo, Ronald C. Desrosiers, and Jae U. Jung Development of HIV vectors for anti-HIV 11395-11399 gene therapy Eric Poeschla, Pierre Corbeau, and Flossie Wong-Staal A stable human-derived packaging cell line for 11400-11406 production of high titer retrovirus/vesicular stomatitis virus G pseudotypes Daniel S. Ory, Beverly A. Neugeboren, and Richard C. Mulligan Cell-surface receptors for retroviruses and 11407-11413 implications for gene transfer A. Dusty Miller Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B. alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease William L. McClements, Marcy E. Armstrong, Robert D. Keys, and Margaret A. Liu 11414-11420 Fusigenic viral liposome for gene therapy in 11421-11425 cardiovascular diseases Victor J. Dzau, Michael J. Mann, Ryuichi Morishita, and Yasufumi Kaneda . . 11