Workshop on Perspectives on the Medical Use of Marijuana:
Basic and Clinical Science |
|
December 14—16, 1997
Beckman Center, Irvine, California |
|
AGENDA |
|
Sunday, December 14, 1997 |
| 2:00 p.m. |
Introduction |
| |
|
Constance Pechura, IOM Division Director, Neuroscience and Behavioral Health |
| 2:30 p.m. |
Public Input Session, 5 minutes per person |
| |
|
Moderator: Stanley Watson, Jr., IOM Study Investigator, University of Michigan |
| 5:30 p.m. |
ADJOURN |
|
Monday, December 15, 1997 |
CANNABINOID NEUROSCIENCE |
| 8:30 a.m. |
Moderator: Stanley Watson, IOM Study Investigator, University of Michigan |
| 8:45 a.m. |
Neuropharmacology of Cannabinoids and Their Receptors |
| |
|
Steven R. Childers, Wake Forest University School of Medicine |
| 9:15 a.m. |
Precipitated Cannabinoid Withdrawal and Sensory Processing of Painful Stimuli |
| |
|
J. Michael Walker, Brown University |
| 9:45 a.m. |
Role of Cannabinoids in Movement |
| |
|
Clara Sanudo, Brown University |
| 10:15 a.m. |
Tolerance and Cannabinoid-Opioid Interactions |
| |
|
Sandra P. Welch, Medical College of Virginia |
| 10:45 a.m. |
BREAK |
MEDICAL USES OF MARIJUANA: CLINICAL DATA AND BASIC BIOLOGY |
| 11:10 a.m. |
Moderator: John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University |
| 11:15 a.m. |
Profile of Medical Marijuana Users |
| |
|
John Mendelson, University of California at San Francisco |
| 11:45 a.m. |
Immune Modulation by Cannabinoids |
| |
|
Norbert Kaminski, Michigan State University |
| 12:15 p.m. |
Psychological Effects of Marijuana Use |
| |
|
Charles R. Schuster, Wayne State University |
| 12:45 p.m. |
LUNCH |
| 1:45 p.m. |
Marijuana and Glaucoma |
| |
|
Paul Kaufman, University of Wisconsin |
| 2:15 p.m. |
Effects of Marijuana and Cannabinoids in Neurological Disorders |
| |
|
Paul Consroe, University of Arizona Health Sciences Center |
| 2:45 p.m. |
Neural Mechanisms of Cannabinoid Analgesia |
| |
|
Howard Fields, University of California at San Francisco |
| 3:15 p.m. |
Pain Management |
| |
|
Michael Rowbotham, University of California at San Francisco |
| 3:45 p.m. |
Wasting Syndrome Pathogenesis and Clinical Markers |
| |
|
Donald Kotler, St. Luke's-Roosevelt Hospital |
| 4:15 p.m. |
Clinical Experience with Marijuana |
| |
|
Stephen O'Brien, East Bay AIDS Center |
| 4:45 p.m. |
ADJOURN |
|
Tuesday, December 16, 1997 |
MEDICAL USES OF MARIJUANA: CLINICAL DATA AND BASIC BIOLOGY |
| 8:30 a.m. |
Moderator: John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University |
| 8:45 a.m. |
Marijuana in AIDS Wasting: Tribulations and Trials |
| |
|
Donald I. Abrams, University of California at San Francisco |
| 9:15 a.m. |
Nausea and Vomiting: Underlying Mechanisms and Upcoming Treatments |
| |
|
Alan D. Miller, The Rockefeller University |
| 9:45 a.m. |
Postchemotherapy Nausea and Antiemetics |
| |
|
Richard J. Gralla, Ochsner Cancer Center |
| 10:15 a.m. |
BREAK |
SUMMARY VIEWS |
| 10:30 a.m. |
Marijuana Is Different from THC: A Review of Basic Research and State Studies of Antiemesis |
| |
|
Richard E. Musty, University of Vermont |
| 11:00 a.m. |
Medical Uses of Crude Marijuana: Medical and Social Issues |
| |
|
Eric A. Voth, The International Drug Strategy Institute |
| 11:30 a.m. |
General Questions |
| |
|
Moderator: John A. Benson, Jr., IOM Study Investigator |
| 12:00 noon |
ADJOURN |
|
Workshop on Acute and Chronic Effects of Marijuana Use |
|
January 22—23, 1998
New Orleans Marriott Hotel
New Orleans, Louisiana |
|
AGENDA |
|
Thursday, January 22, 1998 |
| 2:00 p.m. |
Introduction |
| |
|
Constance Pechura, IOM Division Director, Neuroscience and Behavioral Health |
| 2:30 p.m. |
Public Input Session, 5 minutes per person |
| |
|
Moderator: Stanley Watson, Jr., IOM Study Investigator, University of Michigan |
| 4:30 p.m. |
ADJOURN |
|
Friday, January 23, 1998 |
| 8:30 a.m. |
Moderator: John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University |
HEALTH CONSEQUENCES OF MARIJUANA USE |
| 9:00 a.m. |
Health Consequences of Marijuana Use: Epidemiological Studies |
| |
|
Stephen Sidney, Kaiser Permanente, Oakland, CA |
| 9:30 a.m. |
Immunity, Infections, and Cannabinoids |
| |
|
Thomas Klein, University of South Florida |
| 10:00 a.m. |
Pulmonary Effects of Smoked Marijuana |
| |
|
Donald Tashkin, Unversity of California at Los Angeles |
| 10:30 a.m. |
BREAK |
| 10:45 a.m. |
Is Marijuana Carcinogenic?: Epidemiological and Biological Evidence |
| |
Panel Discussion |
| |
|
Stephen Sidney |
| |
|
Donald Tashkin |
| 12:00 noon |
LUNCH |
EFFECTS OF MARIJUANA ON BEHAVIOR |
| 1:30 p.m. |
Marijuana: Addictive and Amotivational States, the Scientific Evidence |
| |
|
John Morgan, City University of New York Medical School |
| 2:00 p.m. |
Marijuana's Acute Behavioral Effects in Humans |
| |
|
Richard Foltin, Columbia University |
| 2:30 p.m. |
Tolerance and Dependence Following Chronic Administration of Oral THC or Smoked Marijuana to Humans |
| |
|
Margaret Haney, Columbia University |
| 3:00 p.m. |
Patterns of Continuity and Discontinuity of Marijuana Use in Relationship to Other Drugs |
| |
|
Robert Pandina, Rutgers University |
| 3:30 p.m. |
ADJOURN |
|
Workshop on Prospects for Cannabinoid Drug Development |
|
February 23—24, 1998
National Academy of Sciences Building
Washington, D.C. |
|
AGENDA |
|
Monday, February 23, 1998 |
| 1:30 p.m. |
Introduction |
| |
|
Constance Pechura, IOM Division Director, Neuroscience and Behavioral Health |
| 2:00 p.m. |
Public Input Session, 5 minutes per person |
| |
Moderator: John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University |
| 5:30 p.m. |
ADJOURN |
|
Tuesday, February 24, 1998 |
| 8:30 a.m. |
Introduction |
| |
|
Constance Pechura, IOM Division Director |
| |
|
Neuroscience and Behavioral Health |
| |
Moderator: Stanley J. Watson, Jr., IOM Study Investigator<\I>, University of Michigan |
OVERVIEWS OF PRECEDING WORKSHOPS |
| 8:45 a.m. |
Acute and Chronic Effects of Marijuana |
| |
|
Billy R. Martin, Medical College of Virginia |
| 9:25 a.m. |
Perspectives on the Medical Use of Marijuana |
| |
|
Eric B. Larson, University of Washington Medical School |
| 9:55 a.m. |
The Neurobiology of Cannabinoid Dependence |
| |
|
George F. Koob, Scripps Research Institute |
| 10:25 a.m. |
BREAK |
DRUG DEVELOPMENT |
| 10:45 a.m. |
Regulatory Requirements Affecting Marijuana |
| |
|
J. Richard Crout, Crout Consulting |
| 11:15 a.m. |
Marinol and the Market |
| |
|
Robert E. Dudley, Unimed Pharmaceuticals, Inc. |
| 11:45 a.m. |
Development of Cannabis-based Therapeutics |
| |
|
Dave Pate, HortaPharm, B.V. |
| 12:15 p.m. |
LUNCH |
DRUG DELIVERY |
| 1:30 p.m. |
Alternative Drug Delivery Technologies for the Therapeutic Use of Marijuana |
| |
|
Phyllis I. Gardner, ALZA Corporation, Stanford University |
| 2:00 p.m. |
Delivery of Analgesics via the Respiratory Track |
| |
|
Reid M. Rubsamen, Aradigm Corporation |
| 2:30 p.m. |
Current Concepts for Delivery of THC |
| |
|
Mahendra G. Dedhiya, Roxanne Laboratories, Inc. |
| 3:00 p.m. |
 9-THC-Hemisuccinate in Suppository Formulation: An Alternative to Oral and Smoked THC |
| |
|
Mahmoud A. ElSohly, University of Mississippi, ElSohly Laboratories, Inc. |
| 3:30 p.m. |
Concluding Remarks |
| |
|
John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University |
| 3:45 p.m. |
ADJOURN |
