Research supported by scientific ocean drilling has fundamentally transformed our understanding of the planet with key contributions to the discovery and theory of plate tectonics; the formation and destruction of ocean crust; the reconstruction of extreme greenhouse and icehouse climates; the identification of major extinctions; and the discovery of a diverse community of microbes living deep ocean seafloor. With the retirement in 2024 of the JOIDES Resolution-- the U.S. dedicated drilling vessel for deep sea research and the workhorse for the international scientific ocean drilling community-- the scientific ocean drilling landscape will change. At this critical juncture, the National Science Foundation (NSF) is looking to identify the most urgent research questions that can only be answered with scientific ocean drilling and what infrastructure is needed to progress those priorities.
This interim report that is the first part of a broader study of decadal survey of ocean science provides a broad perspective of future research and associated infrastructure needs. The report concludes that the rapid pace of climate change, related extreme events, sea level rise, changes in ocean currents, chemistry threatening ocean ecosystems, and devastating natural hazards are among the greatest challenges facing society. By coring the past to inform the future, U.S. based scientific ocean drilling research continues to have unique and essential roles in addressing these vital and urgent challenges.
Topics: Earth Sciences
The use of immune modulator therapeutics, a type of immunotherapy enhancing the body immune system response to cancer, was perceived as the beginning of a new era in cancer care. While still important and frequently used, some of these therapeutics produce uneven response rates, disease resistance, and serious side effects. The National Academies National Cancer Policy Forum, in collaboration with the Forum on Drug Discovery, Development, and Translation, hosted a public workshop to discuss challenges related to immunotherapy treatment resistance, as well as potential policy opportunities to improve the development of immunotherapies for cancer treatment.
Topics: Health and Medicine
To consider how an Earth system science approach can inform research on climate intervention, The National Academies of Sciences, Engineering, and Medicine held a virtual workshop on June 20-22, 2023 titled Climate Intervention in an Earth Systems Science Framework. Individuals with a wide range of physical, ecological, and social sciences expertise explored climate interventions within the context of convergent research and the capacities of the National Science Foundation (NSF). The workshop drew on the National Academies report Next Generation Earth Systems Science at the National Science Foundation, which called upon NSF to pursue an Earth systems science initiative that emphasizes research on interconnections and feedback between natural and social processes; focuses on real-world problems; enhances the participation of social, engineering, and data scientists; and strengthens efforts to include diverse perspectives in research.
Topics: Environment and Environmental Studies | Earth Sciences
The Food and Nutrition Board of the National Academies of Sciences, Engineering, and Medicine convened a virtual workshop series that gathered researchers, government officials, and other global leaders in nutrition research and policy. The event, sponsored by the U.S. Food and Drug Administration (FDA), carefully considered meta-analysis methodologies that could in turn be used to advance nutrition research, develop policy, and inform regulatory decision-making.
Topics: Food and Nutrition
The Survey of Income and Program Participation (SIPP) is one of the U.S. Census Bureau’s major surveys with features making it a uniquely valuable resource for researchers and policy analysts. However, the Census Bureau faces the challenge of protecting the confidentiality of survey respondents which has become increasingly difficult because numerous databases exist with personal identifying information that collectively contain data on household finances, home values, purchasing behavior, and other SIPP-relevant characteristics.
A Roadmap for Disclosure Avoidance in the Survey of Income and Program Participation addresses these issues and how to make data from SIPP available to researchers and policymakers while protecting the confidentiality of survey respondents. The report considers factors such as evolving privacy risks, development of new methods for protecting privacy, the nature of the data collected through SIPP, the practice of linking SIPP data with administrative data, the types of data products produced, and the desire to provide timely access to SIPP data. The report seeks to balance minimizing the risk of disclosure against allowing researchers and policymakers to have timely access to data that support valid inferences.
Topics: Behavioral and Social Sciences
Smart manufacturing technologies - from advanced sensors to new computing capabilities - have the potential to greatly improve the productivity, energy efficiency, and sustainability of the U.S. manufacturing sector. Successfully implementing these technologies is essential for ensuring U.S. competitiveness and providing new job opportunities for the U.S. workforce.
Options for a National Plan for Smart Manufacturing explores promising technologies transforming the manufacturing sector and identifies the research and resources needed to accelerate smart manufacturing adoption industry wide. This report also identifies critical needs for education and workforce development for smart manufacturing and makes actionable recommendations to support and train the next-generation manufacturing workforce.
Topics: Industry and Labor | Engineering and Technology
Approximately 3.6 million live births occur every year in the United States. Between 8 and 9 percent of infants are born with low birth weight (LBW), defined by the medical community as less than 2,500 grams or 5.5 pounds at birth. While most infants born with LBW are not impacted by severe developmental disabilities or major or multiple health conditions, research indicates that these infants often do experience elevated rates of mild to moderate chronic health conditions that have meaningful functional impacts throughout an individuals life course.
The Social Security Administration (SSA) asked the National Academies of Sciences, Engineering, and Medicine to convene an expert committee to provide an overview of the current status of the identification, treatment, and prognosis of LBW babies, including trends in survivability, in the U.S. population under age 1 year. SSA also asked the committee to provide information on the short- and long-term functional outcomes associated with and the most common conditions related to LBW, available treatments and services, and other considerations. The resulting report, Low Birth Weight Babies and Disability, presents the committees conclusions.
Topics: Health and Medicine
Artificial intelligence (AI), machine learning (ML), and deep learning (DL) are promising tools that can be used to develop algorithms to better understand and predict interactions between food- and nutrition-related data and health outcomes. Understanding that additional research is needed to identify areas where AI/ML is likely to have an impact, the National Academies Food and Nutrition Board hosted a public workshop in October 2023 to explore the future benefits and limitations of integrating big data and AI/ML tools into nutrition research. Participants also discussed issues related to diversity, equity, inclusion, bias, and privacy and the appropriate use of evidence generated from these new methods.
Topics: Food and Nutrition | Computers and Information Technology
Antarctica hosts some of the harshest and most remote environments on Earth - and it is a region of vital importance for scientific research. The environment and position of Antarctica on the globe mean that research conducted there can offer unique insights on important Earth processes, including rising sea level, the carbon cycle, ecosystem structure. As the climate warms, data gathered from Antarctic research will be essential to understanding how Earth processes are changing and the potential social, economic, and health impacts on both U.S. and global populations.
This report identifies the highest priorities for research in the Southern Ocean and nearshore and coastal Antarctica, as well as gaps in current capabilities to support this research. Global sea level rise, heat and carbon budgets, and changing ecosystems are the three highest-priority science drivers for research in the region. To address those drivers and maintain a robust U.S. research presence in this vitally important region, investments are needed in the U.S. Antarctic program and its research platforms, including the development of new technologies and the replacement of aging icebreaking research vessels. Additionally, the U.S. should strengthen relationships with other nations’ Antarctic programs that can help support these essential science drivers.
Topics: Earth Sciences
The United States is experiencing a decline in life expectancy despite high health care spending due to a multitude of factors, including the COVID-19 pandemic, opioid epidemic, high burden of chronic disease, and systemic and structural inequities.
A response proportional to this crisis is required. Valuing America's Health: Aligning Financing to Reward Better Health and Well-Being explores opportunities to transform the current health and health care system to one that promotes whole person and whole population health. The publication emphasizes the need for a bold vision and sustainable financing strategies to prioritize health and well-being for all. Authors of the publication highlight the importance of building a movement to prioritize health, repairing systemic failures, holding stakeholders accountable, controlling health care costs, incentivizing health promotion, adopting collaborative financing and policy-making approaches, and empowering individuals and communities in health decision-making.
The way is clear; what is needed now is the will to move forward. Learn more about how to ensure our nation's health and health care system can support optimal health for all.
Topics: Health and Medicine
Fisheries are essential to the global economy and feed billions around the world; they, support individuals and communities, and sustain cultural heritages and livelihoods. Although U.S. fisheries have been managed for commercial fishing historically, there has been an interest more recently in better accounting for and meeting the needs of the diverse individuals, groups, and communities that rely on and participate in fisheries, or aspire to do so.
At the request of the National Marine Fisheries Service, this report considers information needs and data collection for assessing the distribution of fisheries management benefits. Assessing Equity in the Distribution of Fisheries Management Benefits identifies information needs, obstacles to collecting information, and potential methodologies for assessing where and to whom the primary benefits of commercial and for-hire fishery management accrue.
Topics: Agriculture | Environment and Environmental Studies
Protecting privacy and ensuring confidentiality in data is a critical component of modernizing our national data infrastructure. The use of blended data - combining previously collected data sources - presents new considerations for responsible data stewardship. Toward a 21st Century National Data Infrastructure: Managing Privacy and Confidentiality Risks with Blended Data provides a framework for managing disclosure risks that accounts for the unique attributes of blended data and poses a series of questions to guide considered decision-making.
Technical approaches to manage disclosure risk have advanced. Recent federal legislation, regulation and guidance has described broadly the roles and responsibilities for stewardship of blended data. The report, drawing from the panel review of both technical and policy approaches, addresses these emerging opportunities and the new challenges and responsibilities they present. The report underscores that trade-offs in disclosure risks, disclosure harms, and data usefulness are unavoidable and are central considerations when planning data-release strategies, particularly for blended data.
Topics: Behavioral and Social Sciences
The National Academies Forum on Microbial Threats and Forum on Neuroscience and Nervous System Disorders hosted a hybrid public workshop in June 2023 to explore opportunities to advance research and treatment of infection-associated chronic illnesses. The illnesses discussed in this workshop, including COVID-19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), persistent or posttreatment Lyme disease syndrome (PTLDS), and multiple sclerosis (MS), share overlapping mechanisms and symptoms and have been inadequately researched. Recognizing these commonalities, speakers identified the need to advance research more comprehensively, translating to improved diagnostic and treatment options for patients across multiple conditions.
Topics: Health and Medicine
Member agencies of the intelligence community (IC) collect, maintain, and store large amounts of data. There is a profusion of sensors and communications options that has led to a dramatic escalation in the amount of data readily available for a wide variety of purposes. Much more data are being created than are being deleted. But a large fraction, as much as 30 to 35 percent of enterprise data, is data that are rarely accessed (with weeks to years elapsing between uses) and may sit for a long period of time. This poses a challenge because it means that, worldwide, a massive number of exabytes of data need to be securely maintained, managed, and administered in some sort of way. Additionally, the amount of data that will need to be archived for short- and long-term use will continue to rise. In particular, the IC has the potential to be one of the largest customers for cold data storage because of its wide-ranging need for information.
At the request of the Office of the Director of National Intelligence (ODNI), this Rapid Expert Consultation (REC) explores options for technologies for archival data storage, focusing primarily on current data storage technologies, particularly magnetic storage, Flash, MRAM, and optical storage. While not all of these technologies are well suited to archival storage applications, the ODNI indicated a desire to hear about all possible options. Brief overviews of emerging technologies are included. Finally, the REC offers comments on the importance of non-technological aspects of archiving, including policies and personnel, which should be considered in the design and acquisition of long-term data storage systems.
Topics: Computers and Information Technology | Conflict and Security Issues
Facial recognition technology is increasingly used for identity verification and identification, from aiding law enforcement investigations to identifying potential security threats at large venues. However, advances in this technology have outpaced laws and regulations, raising significant concerns related to equity, privacy, and civil liberties.
This report explores the current capabilities, future possibilities, and necessary governance for facial recognition technology. Facial Recognition Technology discusses legal, societal, and ethical implications of the technology, and recommends ways that federal agencies and others developing and deploying the technology can mitigate potential harms and enact more comprehensive safeguards.
Topics: Computers and Information Technology | Behavioral and Social Sciences | Engineering and Technology
Between 1980 and mid-2023, 232 billion-dollar disasters occurred in the U.S. Gulf Coast region, with the number of disasters doubling annually since 2018. The variety and frequency of storms have exacerbated historic inequalities and led to cycles of displacement and chronic stress for communities across the region. While disaster displacement is not a new phenomenon, the rapid escalation of climate-related disasters in the Gulf increases the urgency to develop pre-disaster policies to mitigate displacement and decrease suffering. Yet, neither the region nor the nation has a consistent and inclusionary process to address risks, raise awareness, or explore options for relocating communities away from environmental risks while seeking out and honoring their values and priorities.
Community-Driven Relocation: Recommendations for the U.S. Gulf Coast Region and Beyond examines how people and infrastructure relocate and why community input should drive the planning process. This report provides recommendations to guide a path for federal, state, and local policies and programs to improve on and expand existing systems to better serve those most likely to be displaced by climate change.
Topics: Behavioral and Social Sciences
Between 2020-2023, many health systems and organizations created formal positions to improve diversity, equity, and inclusion (DEI) and health equity in response to social and health injustices and public demands for diversity and equity among executive level leadership. The National Academies Roundtable on the Promotion of Health Equity hosted an October 2023 public hybrid workshop to explore the successes and challenges of DEI and health equity C-suites, dimensions of DEI and health equity commitments, strategies for achieving internal and external goals, and potential metrics for measuring success.
Topics: Health and Medicine
A National Academies committee was tasked with identifying essential health care services for women related to intimate partner violence (IPV) during steady state conditions, determining whether the essential health care services related to IPV differ during public health emergencies (PHEs), and identifying strategies to sustain access to those essential health care services during PHEs. This report, Essential Health Care Services Addressing Intimate Partner Violence, presents findings from research and deliberations and lays out recommendations for leaders of health care systems, federal agencies, health care providers, emergency planners, and those involved in IPV research.
Topics: Health and Medicine
The proper disposal of unused or expired prescription drugs, particularly controlled substances such as opioids, may help to prevent serious risk of nonmedical use or overdose. In June 2023, the National Academies Forum on Drug Discovery, Development, and Translation hosted a hybrid public workshop to examine the scientific merit and practical implementation of drug disposal options to remove opioid analgesics from the home. Workshop participants considered potential strategies for encouraging and assessing the development and efficacy of in-home drug disposal systems that support the public health goal of mitigating the risk of nonmedical use or overdose associated with opioids.
Topics: Health and Medicine
Research shows that that children learn science and engineering subjects best by engaging from an early age in the kinds of practices used by real scientists and engineers. By doing science and engineering, children not only develop and refine their understanding of the core ideas and crosscutting concepts of these disciplines, but can also be empowered to use their growing understanding to make sense of questions and problems relevant to them. This approach can make learning more meaningful, equitable, and lasting.
Using cases and shorter examples, Rise and Thrive with Science shows what high-quality teaching and learning in science and engineering can look like for preschool and elementary school children. Through analyses of these examples and summaries of research findings, the guide points out the key elements of a coherent, research-grounded approach to teaching and learning in science and engineering. This guide also discusses the kinds of support that educators need to implement effective and equitable instruction for all children. This book will provide inspiration for practitioners at the preschool and elementary levels to try new strategies for science and engineering education, whatever their level of experience.
Rise and Thrive with Science will be an essential guide for teachers as they organize instruction to enable young children to carry out their own science investigations and engineering design projects, determine the kinds of instruction that lead to meaningful learning, and try to engage every one of their students.
Topics: Education
Critical Issues in Transportation for 2024 and Beyond calls for reassessing the role of transportation in addressing major societal challenges and the research that informs the choices that society will need to make in 2024 and coming years. This reassessment is driven by large-scale environmental, public health, and socioeconomic forces, including:
For the latest edition of Critical Issues in Transportation, the Transportation Research Board’s Executive Committee chose to focus on five societal goals to address these and other dynamic forces and the challenges in accentuating transportation’s role in achieving them.
Topics: Transportation and Infrastructure
Advances in biomedical science, data science, engineering, and technology are leading to high-pace innovation with potential to transform health and medicine. These innovations simultaneously raise important ethical and social issues, including how to fairly distribute their benefits and risks. The National Academies of Sciences, Engineering, and Medicine, in collaboration with the National Academy of Medicine, established the Committee on Creating a Framework for Emerging Science, Technology, and Innovation in Health and Medicine to provide leadership and engage broad communities in developing a framework for aligning the development and use of transformative technologies with ethical and equitable principles. The committees resulting report describes a governance framework for decisions throughout the innovation life cycle to advance equitable innovation and support an ecosystem that is more responsive to the needs of a broader range of individuals and is better able to recognize and address inequities as they arise.
Topics: Health and Medicine
Research in biological and physical sciences in space provides the critical scientific and technological foundations that make space exploration possible. As humanity looks towards the Moon and Mars for future missions, this work is needed to help astronauts adapt and live in the harsh environments of space. Thriving in Space provides a roadmap for increasing national investment in biological and physical science research, from experiments to infrastructure to education. This report identifies key scientific questions, priorities, and ambitious research campaigns that will enable human space exploration and transform our understanding of how the universe works.
Thriving in Space reviews the state of knowledge in the current and emerging areas of space-related biological and physical sciences research and generates recommendations for a comprehensive vision and strategy for a decade of transformative science at the frontiers of biological and physical sciences research in space. This report will help NASA define and align biological and physical sciences research to uniquely advance scientific knowledge, meet human and robotic exploration mission needs, and provide terrestrial benefits.
Topics: Space and Aeronautics
Across multiple domains of science, engineering, and medicine, excitement is growing about the potential of digital twins to transform scientific research, industrial practices, and many aspects of daily life. A digital twin couples computational models with a physical counterpart to create a system that is dynamically updated through bidirectional data flows as conditions change. Going beyond traditional simulation and modeling, digital twins could enable improved medical decision-making at the individual patient level, predictions of future weather and climate conditions over longer timescales, and safer, more efficient engineering processes. However, many challenges remain before these applications can be realized.
This report identifies the foundational research and resources needed to support the development of digital twin technologies. The report presents critical future research priorities and an interdisciplinary research agenda for the field, including how federal agencies and researchers across domains can best collaborate.
Topics: Computers and Information Technology | Math, Chemistry, and Physics
This booklet provides key insights from Oil in the Sea IV: Inputs, Fates, and Effects, published in 2022, which benefited from significant advancements in scientific methods to detect the input and fates of oil in the sea, and from lessons learned from the Deepwater Horizon explosion and oil spill in 2010. Going beyond previous reports, Oil in the Sea IV includes analysis of human health impacts of oil in the sea, oil in the Arctic marine environment, and prevention and response efforts that can help to both reduce the amount of oil reaching the sea and minimize its effects. The booklet is meant to serve as a reference guide to all those involved in oil spill research and response.
Topics: Environment and Environmental Studies | Earth Sciences
Social media has been fully integrated into the lives of most adolescents in the U.S., raising concerns among parents, physicians, public health officials, and others about its effect on mental and physical health. Over the past year, an ad hoc committee of the National Academies of Sciences, Engineering, and Medicine examined the research and produced this detailed report exploring that effect and laying out recommendations for policymakers, regulators, industry, and others in an effort to maximize the good and minimize the bad. Focus areas include platform design, transparency and accountability, digital media literacy among young people and adults, online harassment, and supporting researchers.
Topics: Health and Medicine
Pediatric subspecialists are critical to ensuring quality care and pursuing research to improve prevention, diagnosis, and treatment for children. However, there are substantial disincentives to pursuing a career as a pediatric subspecialist, which are often heightened for individuals from groups underrepresented in medicine, and more effective collaboration with primary care clinicians is needed. Changing health care needs, increasing care complexity, and access barriers to pediatric subspecialty care have raised concerns about the current and future availability of pediatric subspecialty care and research.
In response, the National Academies, with support from a coalition of sponsors, formed the Committee on the Pediatric Subspecialty Workforce and Its Impact on Child Health and Well-Being to recommend strategies and actions to ensure an adequate pediatric subspecialty physician workforce to support broad access to high quality subspecialty care and a robust research portfolio to advance the health and health care of infants, children, and adolescents. This report outlines recommendations that, if fully implemented, can improve the quality of pediatric medical subspecialty care through a well-supported, superbly trained, and appropriately used primary care, subspecialty, and physician-scientist workforce.
Topics: Behavioral and Social Sciences | Health and Medicine
While there is a limited data on safety-sensitive professionals, substance use disorders potentially affect pilots and flight attendants at the same rate as the general population - around 15 percent - but due to the high-risk nature of their jobs, aircraft operators are held to a higher standard for substance misuse on the job.
To protect the safety of the public and the aviation workforce, the Human Intervention Motivation Study (HIMS) and the Flight Attendant Drug and Alcohol Program (FADAP) were launched to help treat critical aviation workers - pilots and flight attendants, respectively - who misuse substances. In response to a congressional mandate, this new report reviews available evidence on the effectiveness of HIMS and FADAP and offers recommendations for improving these programs.
Topics: Health and Medicine | Transportation and Infrastructure
The predominant way of making steel in the United Sates is by using an electric arc furnace (EAF) to melt scrap steel, which results in the formation of a rock-like material called slag. Among its various applications, EAF slag is used in a loose or unencapsulated form as ground cover material for residential landscaping. However, the slag generated from the EAF process can contain toxic metals, which can be hazardous to human and environmental health.
This report, conducted at the request of the U.S. EPA, discusses the relative hazard of key EAF slag constituents, the extent to which they may be released into the environment, and important aspects in assessing human exposures and risk. Due to uncertainties in the current evidence stream, the report was unable to make an overall characterization of risk related to unencapsulated EAF slag use in the United States and cautions against making generalizations from conclusions in published risk assessments. The report also identifies research needs to better understand factors considered to have the potential to contribute to the highest risks from the use of unencapsulated EAF slag, such as human exposure to dust particles that may be released over time from applied slag.
Topics: Environment and Environmental Studies
Complementary feeding refers to the introduction of foods other than human milk or formula to an infants diet. In response to a request from the Centers for Disease Control and Prevention, the National Academies Health and Medicine Division convened the Committee on Complementary Feeding Interventions for Infants and Young Children under Age 2 to conduct a consensus study scoping review of peer-reviewed literature and other publicly available information on interventions addressing complementary feeding of infants and young children. The interventions studied took place in the U.S. and other high-income country health care systems; early care and education settings; university cooperative extension programs; the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC); home visiting programs; and other settings. This consensus study report summarizes evidence and provides information on interventions that could be scaled up or implemented at a community or state level.
Topics: Food and Nutrition | Health and Medicine
The next decade of planetary science and astrobiology holds tremendous promise. This booklet highlights key science questions, identifies priority missions, and presents a research strategy that includes both planetary defense and human exploration.
Topics: Space and Aeronautics
Since 1790, the U.S. census has been a recurring, essential civic ceremony in which everyone counts; it reaffirms a commitment to equality among all, as political representation is explicitly tied to population counts. Assessing the 2020 Census looks at the quality of the 2020 Census and its constituent operations, drawing appropriate comparisons with prior censuses. The report acknowledges the extraordinary challenges the Census Bureau faced in conducting the census and provides guidance as it plans for the 2030 Census. In addition, the report encourages research and development as the goals and designs for the 2030 Census are developed, urging the Census Bureau to establish a true partnership with census data users and government partners at the state, local, tribal, and federal levels.
Topics: Behavioral and Social Sciences
We live in a time of extraordinary discovery and progress in astronomy and astrophysics. The next decade will transform our understanding of the universe and humanity's place in it. Every decade the U.S. agencies that provide primary federal funding for astronomy and astrophysics request a survey to assess the status of, and opportunities for the Nation's efforts to forward our understanding of the cosmos. Pathways to Discovery in Astronomy and Astrophysics for the 2020s identifies the most compelling science goals and presents an ambitious program of ground- and space-based activities for future investment in the next decade and beyond. The decadal survey identifies three important science themes for the next decade aimed at investigating Earth-like extrasolar planets, the most energetic processes in the universe, and the evolution of galaxies. The Astro2020 report also recommends critical near-term actions to support the foundations of the profession as well as the technologies and tools needed to carry out the science.
Topics: Space and Aeronautics
Formaldehyde is widely present in the environment and is one of the highest production chemicals by volume, used in manufactured goods including wood products, permanent press fabrics, and household products. It is also formed by combustion sources and is present in smoke from cigarettes and other tobacco products, and in emissions from gas stoves and open fireplaces. In carrying out its mission to protect human health, the U.S. Environmental Protection Agency (EPA) identifies and characterizes the health hazards of chemicals found in the environment through its Integrated Risk Information System (IRIS) Program, which has reviewed the human health hazards resulting from formaldehyde exposure in several assessments.
This report is a continuation of guidance from the National Academies on draft IRIS assessments of formaldehyde and other aspects of the IRIS program. This report reviews the 2022 Draft Assessment with regard to its adequacy and transparency in evaluating the scientific literature, use of appropriate methods to synthesize the current state-of-the science, and presentations of conclusions that are supported by the scientific evidence. The report concludes that the 2022 Draft Assessment follows the advice of prior National Academies reports and that its findings on hazard and quantitative risk are supported by the evidence identified. However, revisions are needed to ensure that users can find and follow the methods used in each step of the assessment for each health outcome.
Topics: Environment and Environmental Studies
The next decade of planetary science and astrobiology holds tremendous promise. New research will expand our understanding of our solar system's origins, how planets form and evolve, under what conditions life can survive, and where to find potentially habitable environments in our solar system and beyond. Origins, Worlds, and Life: A Decadal Strategy for Planetary Science and Astrobiology 2023-2032 highlights key science questions, identifies priority missions, and presents a comprehensive research strategy that includes both planetary defense and human exploration. This report also recommends ways to support the profession as well as the technologies and infrastructure needed to carry out the science.
Topics: Space and Aeronautics
The field of quantum information science (QIS) has witnessed a dramatic rise in scientific research activities in the 21st century as excitement has grown about its potential to revolutionize communications and computing, strengthen encryption, and enhance quantum sensing, among other applications. While, historically, QIS research has been dominated by the field of physics and computer engineering, this report explores how chemistry - in particular the use of molecular qubits - could advance QIS. In turn, researchers are also examining how QIS could be used to solve problems in chemistry, for example, to facilitate new drug and material designs, health and environmental monitoring tools, and more sustainable energy production.
Recognizing that QIS could be a disruptive technology with the potential to create groundbreaking products and new industries, Advancing Chemistry and Quantum Information Science calls for U.S. leadership to build a robust enterprise to facilitate and support research at the intersection of chemistry and QIS. This report identifies three key research areas: design and synthesis of molecular qubit systems, measurement and control of molecular quantum systems, and experimental and computational approaches for scaling qubit design and function. Advancing Chemistry and Quantum Information Science recommends that the Department of Energy, National Science Foundation, and other funding agencies should support multidisciplinary and collaborative research in QIS, the development of new instrumentation, and facilities, centralized and open-access databases, and efforts to create a more diverse and inclusive chemical workforce.
Topics: Math, Chemistry, and Physics
The world confronts an existential challenge in responding to climate change, resulting in an urgent need to reduce greenhouse gas emissions from all sectors of the economy. What will it take for new and advanced nuclear reactors to play a role in decarbonization? Nuclear power provides a significant portion of the worlds low-carbon electricity, and advanced nuclear technologies have the potential to be smaller, safer, less expensive to build, and better integrated with the modern grid. However, if the United States wants advanced nuclear reactors to play a role in its plans for decarbonization, there are many key challenges that must be overcome at the technical, economic, and regulatory levels.
Laying the Foundation for New and Advanced Nuclear Reactors in the United States discusses how the United States could support the successful commercialization of advanced nuclear reactors with a set of near-term policies and practices. The recommendations of this report address the need to close technology research gaps, explore new business use cases, improve project management and construction, update regulations and security requirements, prioritize community engagement, strengthen the skilled workforce, and develop competitive financing options.
Topics: Environment and Environmental Studies | Energy and Energy Conservation
Addressing climate change is essential and possible, and it offers a host of benefits - from better public health to new economic opportunities. The United States has a historic opportunity to lead the way in decarbonization by transforming its current energy system to one with net-zero emissions of carbon dioxide. Recent legislation has set the nation on the path to reach its goal of net zero by 2050 in order to avoid the worst consequences of climate change. However, even if implemented as designed, current policy will get the United States only part of the way to its net-zero goal.
Accelerating Decarbonization in the United States provides a comprehensive set of actionable recommendations to help policymakers achieve a just and equitable energy transition over the next decade and beyond, including policy, technology, and societal dimensions. This report addresses federal and subnational policy needs to overcome implementation barriers and gaps with a focus on energy justice, workforce development, public health, and public engagement. The report also presents a suite of recommendations for the electricity, transportation, built environment, industrial, fossil fuels, land use, and finance sectors.
Topics: Environment and Environmental Studies | Earth Sciences
Many young children in the United States are thriving and have access to the conditions and resources they need to grow up healthy. However, a substantial number of young children face more challenging conditions such as: poverty; food insecurity; exposure to violence; and inadequate access to health care, well-funded quality schools, and mental health care. In many cases, the historical origins of unequal access to crucial supports for children's physical, emotional, and cognitive development are rooted in policies that intentionally segregated and limited various populations' access to resources and create opportunity gaps that intertwine and compound to affect academic, health, and economic outcomes over an individual's life course and across generations.
Closing the Opportunity Gap for Young Children, identifies and describes the causes, costs, and effects of the opportunity gap in young children and explores how disparities in access to quality educational experiences, health care, and positive developmental experiences from birth through age eight intersect with key academic, health, and economic outcomes. The report identifies drivers of these gaps in three key domains—education, mental health, and physical health—and offers recommendations for policy makers for addressing these gaps so that all children in the United States have the opportunity to thrive. In addition, the report offers a detailed set of recommendations for policy makers, practitioners, community organizations, and philanthropic organizations to reduce opportunity gaps in education, health, and social-emotional development.
Topics: Behavioral and Social Sciences
Racially and ethnically minoritized populations and tribal communities often face preventable inequities in health outcomes due to structural disadvantages and diminished opportunities around health care, employment, education, and more. Federal Policy to Advance Racial, Ethnic, and Tribal Health Equity analyzes how past and current federal policies may create, maintain, and/or amplify racial, ethnic, and tribal health inequities. This report identifies key features of policies that have served to reduce inequities and makes recommendations to help achieve racial, ethnic, and tribal health equity.
Topics: Health and Medicine
Experiencing poverty during childhood can lead to lasting harmful effects that compromise not only children’s health and welfare but can also hinder future opportunities for economic mobility, which may be passed on to future generations. This cycle of economic disadvantage weighs heavily not only on children and families experiencing poverty but also the nation, reducing overall economic output and placing increased burden on the educational, criminal justice, and health care systems.
Reducing Intergenerational Poverty examines key drivers of long- term, intergenerational poverty, including the racial disparities and structural factors that contribute to this cycle. The report assesses existing research on the effects on intergenerational poverty of income assistance, education, health, and other intervention programs and identifies evidence-based programs and policies that have the potential to significantly reduce the effects of the key drivers of intergenerational poverty. The report also examines the disproportionate effect of disadvantage to different racial/ethnic groups. In addition, the report identifies high-priority gaps in the data and research needed to help develop effective policies for reducing intergenerational poverty in the United States.
Topics: Behavioral and Social Sciences
Much of the statistical information currently produced by federal statistical agencies - information about economic, social, and physical well-being that is essential for the functioning of modern society - comes from sample surveys. In recent years, there has been a proliferation of data from other sources, including data collected by government agencies while administering programs, satellite and sensor data, private-sector data such as electronic health records and credit card transaction data, and massive amounts of data available on the internet. How can these data sources be used to enhance the information currently collected on surveys, and to provide new frontiers for producing information and statistics to benefit American society?
Toward a 21st Century National Data Infrastructure: Enhancing Survey Programs by Using Multiple Data Sources, the second report in a series funded by the National Science Foundation, discusses how use of multiple data sources can improve the quality of national and subnational statistics while promoting data equity. This report explores implications of combining survey data with other data sources through examples relating to the areas of income, health, crime, and agriculture.
Topics: Behavioral and Social Sciences
This new publication presents highlights of a June 2023 workshop that focused on a new geospatial tool developed by the White House Council on Environmental Quality to identify communities experiencing climate and economic burdens. The tool, called the Climate and Economic Justice Screening Tool, will be used to guide federal investments to further the White House’s Justice40 Initiative. The workshop explored how well data in the tool represents the lived experiences of historically marginalized and overburdened communities in the United States.
Participants included researchers, policy makers and community members from a wide range of regional, cultural, ethnic, and socioeconomic backgrounds. Topics discussed included potential data gaps, the impact of climate and economic burdens, regional differences in data, historical factors that affect community health and wellbeing, and other inputs to the tool that might help it accurately identify disadvantaged communities.This publication summarizes the presentation and discussion of the workshop.
Topics: Environment and Environmental Studies
The COVID-19 pandemic has had an unprecedented impact on the lives of children and their families, who have faced innumerable challenges such as illness and death; school closures; social isolation; financial hardship; food insecurity; deleterious mental health effects; and difficulties accessing health care. In almost every outcome related to social, emotional, behavioral, educational, mental, physical, and economic health and well-being, families identifying as Black, Latino, and Native American, and those with low incomes, have disproportionately borne the brunt of the negative effects of the pandemic.
The effects of the COVID-19 pandemic on children and families will be felt for years to come. While these long-term effects are unknown, they are likely to have particularly significant implications for children and families from racially and ethnically minoritized communities and with low incomes.
Addressing the Long-Term Effects of the COVID-19 Pandemic on Children and Families identifies social, emotional, behavioral, educational, mental, physical, and economic effects of the COVID-19 pandemic and looks at strategies for addressing the challenges and obstacles that the pandemic introduced for children and families in marginalized communities. This report provides recommendations for programs, supports, and interventions to counteract the negative effects of the pandemic on child and family well-being and offers a path forward to recover from the harms of the pandemic, address inequities, and prepare for the future.
Topics: Behavioral and Social Sciences
What can be more vital to each of us than our health? Yet, despite unprecedented health care spending, the U.S. health system is substantially underperforming, especially with respect to what should be possible, given current knowledge. Although the United States is currently devoting 18% of its Gross Domestic Product to delivering medical care—more than $3 trillion annually and nearly double the expenditure of other advanced industrialized countries—the U.S. health system ranked only 37 in performance in a World Health Organization assessment of member nations. In Vital Directions for Health & Health Care: An Initiative of the National Academy of Medicine, the National Academy of Medicine (NAM), which has long stood as the nation’s most trusted independent source of guidance in health, health care, and biomedical science, has marshaled the wisdom of more than 150 of the nation’s best researchers and health policy experts to assess opportunities for substantially improving the health and well-being of Americans, the quality of care delivered, and the contributions of science and technology. This publication identifies practical and affordable steps that can and must be taken across eight action and infrastructure priorities, ranging from paying for value and connecting care, to measuring what matters most and accelerating the capture of real-world evidence. Without obscuring the difficulty of the changes needed, in Vital Directions, the NAM offers an important blueprint and resource for health, policy, and leaders at all levels to achieve much better health outcomes at much lower cost.
Topics: Health and Medicine
In 2016, the National Academy of Medicine (NAM) hosted a series of meetings, which was sponsored by the Patient-Centered Outcomes Research Institute, with support from NAM's Executive Leadership Network. The series underscored the importance of partnerships between researchers and health system leadership and considered opportunities to build institutional capacity, cross-institutional synergy, and system-wide learning. During these meetings, health system executives, researchers, and others discussed building infrastructure that simultaneously facilitates care delivery, care improvement and evidence development. The vision is a digital system-wide progress toward continuous and seamless learning and improvement throughout health and health care. This publication aims to answer the following questions:
Topics: Health and Medicine
As a result of a collaboration between the National Academy of Medicine (NAM) and the Office of the National Coordinator for Health Information Technology, this NAM Special Publication summarizes and builds on a meeting series in which a multi-stakeholder group of experts discussed the potential of clinical decision support (CDS) to transform care delivery by ameliorating the burden that expanding clinical knowledge and care and choice complexity place on the finite time and attention of clinicians, patients, and members of the care team. This summary also includes highlights from discussions to address the barriers to realizing the full benefits of CDS-facilitated value improvement. Optimizing Strategies for Clinical Decision Support identifies the need for a continuously learning health system driven by the seamless and rapid generation, processing, and practical application of the best available evidence for clinical decision making and lays out a series of actionable collaborative next steps to optimize strategies for adoption and use of CDS.
Topics: Health and Medicine
Social factors, signals, and biases shape the health of our nation. Racism and poverty manifest in unequal social, environmental, and economic conditions, resulting in deep-rooted health disparities that carry over from generation to generation. In Perspectives on Health Equity and Social Determinants of Health, authors call for collective action across sectors to reverse the debilitating and often lethal consequences of health inequity. This edited volume of discussion papers provides recommendations to advance the agenda to promote health equity for all. Organized by research approaches and policy implications, systems that perpetuate or ameliorate health disparities, and specific examples of ways in which health disparities manifest in communities of color, this Special Publication provides a stark look at how health and well-being are nurtured, protected, and preserved where people live, learn, work, and play. All of our nation’s institutions have important roles to play even if they do not think of their purpose as fundamentally linked to health and well-being. The rich discussions found throughout Perspectives on Health Equity and Social Determinants of Health make way for the translation of policies and actions to improve health and health equity for all citizens of our society. The major health problems of our time cannot be solved by health care alone. They cannot be solved by public health alone. Collective action is needed, and it is needed now.
Topics: Health and Medicine
There is no question that opioid use disorder has become the fastest growing, serious, and far-reaching public health crisis facing our nation today. The growing and unprecedented opioid epidemic is a critical issue for public health and medical care throughout the country. Provisional estimates suggest that nearly 65,000 Americans died from a drug overdose in 2016, a 21% increase from the previous year and at a level higher than occurred during the peak years for deaths from HIV infection and automobile fatalities.
Nearly half of opioid overdose deaths are related to medications obtained legally by prescription, sparking deep concern among leaders in the health care sector. The need is clear for clinicians, as the "gatekeepers" of opioid prescriptions, and as the front line in facilitating access to treatment for addiction, to work together with state and community leaders to reduce the impact of opioid misuse on American communities.
At the request of the National Governors Association, the National Academy of Medicine convened a group of experts and field leaders to explore clinicians' roles in addressing opioid misuse and addiction. The resulting Special Publication is informed by, and builds on, initiatives and guidelines that have been stewarded by various stakeholder organizations providing leadership in addressing these issues. In the midst of evolving understanding of and experience in pain management and substance abuse, the authors offer to clinicians a set of axioms applicable both to responsible, appropriate opioid prescribing practices, and to recognition and treatment of substance use disorder. Also underscored are actions that clinicians can take to improve their skills and effectiveness in the face of the growing need, including leadership engagement to ensure that communities have the resources and tools that clinicians require to fulfill their responsibilities.
Topics: Health and Medicine
To advance insights and perspectives on how to better manage the care of the high-need patient population, the National Academy of Medicine, with guidance from an expert planning committee, was tasked with convening three workshops held between July 2015 and October 2016. The resulting special publication, Effective Care for High-Need Patients: Opportunities for Improving Outcomes, Value, and Health, summarizes the presentations, discussions, and relevant literature.
Topics: Health and Medicine
Health services research is "the multidisciplinary field of scientific investigation that studies how social factors, financing systems, organizational structures and processes, health technologies, and personal behaviors affect access to health care and the quality and cost of health care." Since the 1960s, health services research has provided the foundation for progress, effectiveness, and value in health care. Ironically, at a time in which appreciation has never been higher for both the need and potential from health services research, the political and financial support for sustenance and growth appear to be weakening.
With funding support from AcademyHealth, the American Association of Colleges of Nursing, the American Board of Family Medicine, the American Society of Anesthesiologists, the Association of American Medical Colleges, the Federation of American Hospitals, and the Robert Wood Johnson Foundation, this National Academy of Medicine Special Publication identifies the range of issues that health services research must consider, address, and potentially overcome to transform the field to meet the needs of a 21st-century health care system. These issues are broad, multidisciplinary, and will require a coordinated effort to address—as well as dedicated and sustainable funding. Federal support for health services research has never been more critical. Now is a critical time for the field to articulate its priorities, demonstrate its utility, and transform to meet the needs of a 21st-century health care system. The physical and financial health of the nation is at stake.
Topics: Health and Medicine
Realizing the promise of digital technology will depend on the ability to share information across time and space from multiple devices, sources, systems, and organizations. The major barrier to progress is not technical; rather, it is in the failure of organizational demand and purchasing requirements. In contrast to many other industries, the purchasers of health care technologies have not marshaled their purchasing power to drive interoperability as a key requirement. Better procurement practices, supported by compatible interoperability platforms and architecture, will allow for better, safer patient care; reduced administrative workload for clinicians; protection from cybersecurity attacks; and significant financial savings across multiple markets.
With funding support from the Gordon and Betty Moore Foundation, this National Academy of Medicine Special Publication represents a multi-stakeholder exploration of the path toward achieving large-scale interoperability through strategic acquisition of health information technology solutions and devices. In this publication, data exchanges over three environments are identified as critical to achieving interoperability: facility-to-facility (macro-tier); intra-facility (meso-tier); and at point-of-care (micro-tier). The publication further identifies the key characteristics of information exchange involved in health and health care, the nature of the requirements for functional interoperability in care processes, the mapping of those requirements into prevailing contracting practices, the specification of the steps necessary to achieve system-wide interoperability, and the proposal of a roadmap for using procurement specifications to engage those steps. The publication concludes with a series of checklists to be used by health care organizations and other stakeholders to accelerate progress in achieving system-wide interoperability.
Topics: Health and Medicine
Evidence-based medicine arose from a clear need and represents a major advance in the science of clinical decision making. Despite broad acceptance of evidence-based medicine, however, a fundamental issue remains unresolved: evidence is derived from groups of people, yet medical decisions are made by and for individuals. Despite persistent assertions from clinicians that determining the best therapy for each patient is a more complicated endeavor than just picking the best treatment on average, traditional approaches have been overly reliant on the average effects estimated from the outcomes of clinical trials.
This Special Publication is based on a workshop, held by the National Academy of Medicine, that considered patient and stakeholder perspectives on the importance of understanding heterogeneous treatment effects (HTE) and best practices for implementing clinical programs that take HTE into account. For evidence to be more applicable to individual patients, we need to combine methods for strong causal inference (first and foremost, randomization) with methods for prediction that permit inferences about which particular patients are likely to benefit and which are not. Better population-based outcomes will only be realized when we understand more completely how to treat patients as the unique individuals they are.
Topics: Health and Medicine
The emergence of artificial intelligence (AI) in health care offers unprecedented opportunities to improve patient and clinical team outcomes, reduce costs, and impact population health. While there have been a number of promising examples of AI applications in health care, it is imperative to proceed with caution or risk the potential of user disillusionment, another AI winter, or further exacerbation of existing health- and technology-driven disparities.
This Special Publication synthesizes current knowledge to offer a reference document for relevant health care stakeholders. It outlines the current and near-term AI solutions; highlights the challenges, limitations, and best practices for AI development, adoption, and maintenance; offers an overview of the legal and regulatory landscape for AI tools designed for health care application; prioritizes the need for equity, inclusion, and a human rights lens for this work; and outlines key considerations for moving forward.
AI is poised to make transformative and disruptive advances in health care, but it is prudent to balance the need for thoughtful, inclusive health care AI that plans for and actively manages and reduces potential unintended consequences, while not yielding to marketing hype and profit motives.
Topics: Health and Medicine | Computers and Information Technology
The effective use of data is foundational to the concept of a learning health system—one that leverages and shares data to learn from every patient experience, and feeds the results back to clinicians, patients and families, and health care executives to transform health, health care, and health equity. More than ever, the American health care system is in a position to harness new technologies and new data sources to improve individual and population health.
Learning health systems are driven by multiple stakeholders—patients, clinicians and clinical teams, health care organizations, academic institutions, government, industry, and payers. Each stakeholder group has its own sources of data, its own priorities, and its own goals and needs with respect to sharing that data. However, in America’s current health system, these stakeholders operate in silos without a clear understanding of the motivations and priorities of other groups. The three stakeholder working groups that served as the authors of this Special Publication identified many cultural, ethical, regulatory, and financial barriers to greater data sharing, linkage, and use. What emerged was the foundational role of trust in achieving the full vision of a learning health system.
This Special Publication outlines a number of potentially valuable policy changes and actions that will help drive toward effective, efficient, and ethical data sharing, including more compelling and widespread communication efforts to improve awareness, understanding, and participation in data sharing. Achieving the vision of a learning health system will require eliminating the artificial boundaries that exist today among patient care, health system improvement, and research. Breaking down these barriers will require an unrelenting commitment across multiple stakeholders toward a shared goal of better, more equitable health.
We can improve together by sharing and using data in ways that produce trust and respect. Patients and families deserve nothing less.
Topics: Health and Medicine | Computers and Information Technology
In response to a growing national awareness that the development and use of new diagnostic, therapeutic, and preventive interventions had been occurring at a quickening pace—one far outstripping the evidence necessary to make informed decisions about their comparative advantage—the Patient-Centered Outcomes Research Institute (PCORI) was established in 2010 as part of the Affordable Care Act legislation. PCORI is guided by the imperative to help patients, families, clinicians, and other health care stakeholders make better informed health care decisions and improve care and outcomes. To inform the next steps in its organizational strategy, PCORI enlisted the National Academy of Medicine (NAM) to leverage its deep experience in convening experts on matters of significant national importance, including its long-standing thought leadership role in the realization of a learning health system. The NAM formed a multi-stakeholder workgroup and held two virtual convenings with the objective of engaging with patients, clinicians, health system leaders, researchers, and other stakeholders from the broader health community to identify and discuss high-priority emerging issues in health, health care, and biomedical science and technology. The key messages from these meetings are outlined in the Special Publication Priorities on the Health Horizon: Informing PCORI's Strategic Plan.
Given the breadth of the domains considered in the Priorities on the Health Horizon meetings—emerging technologies, social and environmental factors, optimizing value, and infrastructure—a formidable set of pressing health and health care research needs were reviewed and discussed. In addition, certain fundamental strategic priorities emerged as basic and critical to progress in the field: (1) the need to reorient research perspectives and activities to patient and family priorities and values, and in particular, those conditions that drive inequities; (2) the need to foster strategic learning partnerships across groups, organizations, and sectors; and (3) the need to build the continuous learning infrastructure to produce new insights at the pace and scale necessary for health and health care improvement.
Moving forward, building the capacity to continuously improve learning and sharing throughout the system will entail stakeholders working together as seamlessly as possible. The NAM and PCORI worked together to facilitate an expansive dialogue with key stakeholders and engender trust through a focus on shared commitments to progress on improving health for all Americans in the decade ahead.
Topics: Health and Medicine
The United States is in the midst of an urgent and complex opioid crisis. To address how education and training can more effectively respond to this crisis, we must have a better understanding of problems in practice—or professional practice gaps—for health professionals and teams in practice. A coordinated response requires identifying and addressing professional practice gaps (PPGs) related to pain management, opioid use disorder, and other substance use disorder (SUD) care, as well as integrating evidence-based best practices into health professional education and training curricula across the continuum from undergraduate training into post-graduate continuing education This Special Publication presents two information-gathering efforts to assess persisting PPGs pertaining to pain management and SUD care and to better understand the current health professional education environment: the first is a comprehensive literature review, and the second is a survey of the regulatory landscape.
The results underscore the need to collaboratively develop a harmonized interprofessional, person- and family-centered approach for the continuum of health professions education to more effectively address the opioid crisis.
In this Special Publication, the Health Professional Education and Training Workgroup of the National Academy of Medicine’s Action Collaborative on Countering the U.S. Opioid Epidemic identified five action-oriented priorities to support this goal:
With due effort and support, these approaches will amplify effective practices while harmonizing and improving the environment for health care professionals to best serve the needs of their patients and communities.
Topics: Health and Medicine
Sharing health data and information across stakeholder groups is the bedrock of a learning health system. As data and information are increasingly combined across various sources, their generative value to transform health, health care, and health equity increases significantly. Health data have proven their centrality in guiding action to change the course of individual and population health, if properly stewarded and used.
In the context of the COVID-19 pandemic, both data and a lack of data illuminated profound shortcomings that affected health care and health equity. Yet, a silver lining of the pandemic was a surge in collaboration among data holders in public health, health care, and technology firms, suggesting that an evolution in health data sharing is visible and tangible.
This Special Publication features some of these novel data-sharing collaborations, and has been developed to provide practical context and implementation guidance that is critical to advancing the lessons learned identified in its parent NAM Special Publication, Health Data Sharing: Building a Foundation of Stakeholder Trust. The focus of this publication is to identify and describe exemplar groups to dispel the myth that sharing health data more broadly is impossible and illuminate the innovative approaches that are being taken to make progress in the current environment. It also serves as a resource for those waiting in the wings, showing how barriers were addressed and harvesting lessons and insights from those on the front lines.
In the meantime, knowledge is already available to foster better health care and health outcomes. The examples described in this volume suggest how intentional attention to health data sharing can enable unparalleled advances, securing a healthier and more equitable future for all.
Topics: Health and Medicine | Computers and Information Technology
An accurate measure of poverty is necessary to fully understand how the economy is performing across all segments of the population and to assess the effects of government policies on communities and families. In addition, poverty statistics are essential in determining the size and composition of the population whose basic needs are going unmet and to help society target resources to address those needs.
An Updated Measure of Poverty: (Re)Drawing the Line recommends updating the methodology used by the Census Bureau to calculate the Supplemental Poverty Measure (SPM) to reflect household basic needs. This report recommends that the more comprehensive SPM replace the current Official Poverty Measure as the primary statistical measure of poverty the Census Bureau uses. The report assesses the strengths and weaknesses of the SPM and provides recommendations for updating its methodology and expanding its use in recognition of the needs of most American families such as medical care, childcare, and housing costs.
Topics: Behavioral and Social Sciences
As part of its core mission, the U.S. Environmental Protection Agency (EPA) is tasked with assessing the hazards and risks to human health from exposure to pollutants. While some pollutants are well studied, there are little or no data on the potential health effects for many thousands of chemicals that can make their way into the environment, such as PFAS. EPA still relies on laboratory mammalian studies as the foundation of most human health risk assessments, which are limited by high costs, long timelines, and other concerns. New approach methods (NAMs) in toxicology, for example new in vivo and in vitro strategies and computational systems biology, offer opportunities to inform timely decision-making when no data are available from laboratory mammalian toxicity tests or epidemiological studies. NAMs may also help inform efforts to protect susceptible and vulnerable populations by characterizing subtle health perturbations, better encompassing genetic diversity, and accounting for nonchemical stressors.
While the promise and need for NAMs is clear, many barriers to their use remain. This report aims to bridge the gap between the potential of NAMs and their practical application in human health risk assessment. Building Confidence in New Evidence Streams for Human Health Risk Assessment draws lessons learned from laboratory mammalian toxicity tests to help inform approaches for building scientific confidence in NAMs and for incorporating such data into risk assessment and decision-making. Overall, the report recommendations aim to ensure a seamless handoff from the evaluation of NAM-based testing strategies in the laboratory to the incorporation of NAM data into modern, systematic-review-based risk assessments.
Topics: Biology and Life Sciences
Behavioral economics - a field based in collaborations among economists and psychologists - focuses on integrating a nuanced understanding of behavior into models of decision-making. Since the mid-20th century, this growing field has produced research in numerous domains and has influenced policymaking, research, and marketing. However, little has been done to assess these contributions and review evidence of their use in the policy arena.
Behavioral Economics: Policy Impact and Future Directions examines the evidence for behavioral economics and its application in six public policy domains: health, retirement benefits, climate change, social safety net benefits, climate change, education, and criminal justice. The report concludes that the principles of behavioral economics are indispensable for the design of policy and recommends integrating behavioral specialists into policy development within government units. In addition, the report calls for strengthening research methodology and identifies research priorities for building on the accomplishments of the field to date.
Topics: Industry and Labor | Behavioral and Social Sciences
One strategy cells use for regulation is modifying proteins, DNA, and RNA to control their structure, function, and stability. For years, research has focused on the reversible modifications to proteins and DNA. However, RNA can also be highly modified, and more than 170 types of modification to RNA have been identified so far. Current methods for mapping and sequencing RNA and its modifications - also known as the epitranscriptome - are limited, partly because available sequencing technologies can detect only a small number of them. This limits the understanding of different molecular processes and leaves a gap in knowledge related to human diseases and disorders.
To address these limitations and develop a roadmap for the sequencing of RNA with the epitranscriptome, the National Academies of Sciences, Engineering, and Medicine convened an ad hoc committee to provide a consensus report. A workshop held on March 14-15, 2023 was one part of an information-gathering effort by the committee and is summarized in this proceedings.
Topics: Biology and Life Sciences
Each year, the Gulf Research Program (GRP) produces an annual report to summarize how funds were used. These reports review accomplishments, highlight activities, and, over time, will assess metrics to determine how the program is progressing in accomplishing its goals. The 2021 annual report is the eighth report in this series.
The GRP is an independent, science-based program founded in 2013. Through grants, fellowships, and other activities, it seeks to enhance oil system safety and the protection of human health and the environment in the Gulf of Mexico region and other areas along the U.S. outer continental shelf with offshore oil and gas operations.
Topics: Environment and Environmental Studies
In 2023, the National Academies held a series of facilitated workshops to gather information on progress to date on projects funded by the National Science Foundation (NSF) Understanding the Rules of Life (URoL) program. A fundamental goal of the URoL program is to identify the causal, predictive relationships that drive how life functions—a concept articulated as the "rules of life." Principal investigators of the URoL program shared findings from their research and how those findings might contribute to identifying rules of life that are generalizable across fields and scales. Participants also discussed how they have incorporated multidisciplinary, systems-level approaches into their work. This booklet highlights the program's focus areas and reach, major scientific breakthroughs, and lessons for research and education across scientific disciplines. This booklet is intended for policy and lay audiences interested in learning more about the goals and opportunities of NSF's URoL program.
Topics: Biology and Life Sciences
In December 2020, the National Reconnaissance Offices Geospatial Intelligence Directorate asked the National Academies of Sciences, Engineering, and Medicine to review the advancements and changes that have occurred since the production of the classified consensus study Acquisition Strategies for Future Space Based Optics in 2018. The resulting letter report and its contents are classified and cannot be summarized here. This publication is the unclassified summary of that report.
Topics: Space and Aeronautics
Extreme weather and wildfires, intensified by climate change, are damaging the native plant communities of landscapes across the United States. Native plant communities are foundational to thriving ecosystems, delivering goods and services that regulate the environment and support life, provide food and shelter for a wide range of native animals, and embody a wealth of genetic information with many beneficial applications. Restoring impaired ecosystems requires a supply of diverse native plant seeds that are well suited to the climates, soils, and other living species of the system.
This report examines the needs for native plant restoration and other activities, provides recommendations for improving the reliability, predictability, and performance of the native seed supply, and presents an ambitious agenda for action. An Assessment of Native Seed Needs and the Capacity for Their Supply considers the various challenges facing our natural landscapes and calls for a coordinated public-private effort to scale-up and secure a cost-effective national native seed supply.
Topics: Agriculture
Genetic and genomic information has become far more accessible, and research using human genetic data has grown exponentially over the past decade. Genetics and genomics research is now being conducted by a wide range of investigators across disciplines, who often use population descriptors inconsistently and/or inappropriately to capture the complex patterns of continuous human genetic variation.
In response to a request from the National Institutes of Health, the National Academies assembled an interdisciplinary committee of expert volunteers to conduct a study to review and assess existing methodologies, benefits, and challenges in using race, ethnicity, ancestry, and other population descriptors in genomics research. The resulting report focuses on understanding the current use of population descriptors in genomics research, examining best practices for researchers, and identifying processes for adopting best practices within the biomedical and scientific communities.
Topics: Health and Medicine | Behavioral and Social Sciences
This letter describes the work of the Committee on Assistance to the California Department of Food and Agriculture Pierces Disease/Glassy-Winged Sharpshooter Board on Grapevine Viruses and Grapevine Disease Research and critiques the California Department of Food and Agriculture Pierces Disease/Glassy-Winged Sharpshooter Board Request for Proposals that was issued in December 2022.
Topics: Agriculture
Individuals from minoritized racial and ethnic groups continue to face systemic barriers that impede their ability to access, persist, and thrive in science, technology, engineering, mathematics, and medicine (STEMM) higher education and workforce. Without actively dismantling policies and practices that disadvantage people from minoritized groups, STEMM organizations stand to lose much needed talent and innovation as well as the ideas that come from having a diverse workforce.
A new report from the Board on Behavioral, Cognitive, and Sensory Sciences examines the backdrop of systemic racism in the United States that has harmed and continues to harm people from minoritized groups, which is critical for understanding the unequal representation in STEMM. The report outlines actions that top leaders and gatekeepers in STEMM organizations, such as presidents and chief executive officers, can take to foster a culture and climate of antiracism, diversity, equity, and inclusion that is genuinely accessible and supportive to all.
Topics: Behavioral and Social Sciences
Artificial intelligence (AI), facial recognition, and other advanced computational and statistical techniques are accelerating advancements in the life sciences and many other fields. However, these technologies and the scientific developments they enable also hold the potential for unintended harm and malicious exploitation. To examine these issues and to discuss practices for anticipating and preventing the misuse of advanced data analytics and biological data in a global context, the National Academies of Sciences, Engineering, and Medicine convened two virtual workshops on November 15, 2022, and February 9, 2023. The workshops engaged scientists from the United States, South Asia, and Southeast Asia through a series of presentations and scenario-based exercises to explore emerging applications and areas of research, their potential benefits, and the ethical issues and security risks that arise when AI applications are used in conjunction with biological data. This publication highlights the presentations and discussions of the workshops.
Topics: Biology and Life Sciences
Nonhuman primates represent a small fraction of animals used in biomedical research, but they remain important research models due to their similarities to humans with respect to genetic makeup, anatomy, physiology, and behavior. Limitations in the availability of nonhuman primates have been exacerbated by the COVID-19 pandemic and recent restrictions on their exportation and transportation, impacting National Institutes of Health (NIH)-funded research necessary for both public health and national security. Additionally, there is continued interest in understanding whether and how nonanimal models can be used to answer scientific questions for which nonhuman primates are currently used.
At the direction of the U.S. Congress, NIH asked the National Academies of Sciences, Engineering, and Medicine to convene an expert committee to conduct a landscape analysis of current and future use of nonhuman primates in NIH-supported biomedical research, as well as opportunities for new approach methodologies to complement or reduce reliance on nonhuman primate models. This report provides the committee findings and conclusions.
Topics: Biology and Life Sciences | Health and Medicine
The Comprehensive Addiction and Recovery Act (CARA; P.L. 114-198) was signed into law in 2016 to help address the challenges of overdose deaths and opioid use disorder, and to expand access to evidence-based treatment. Among these efforts was the authorization of four grant programs to be overseen by the Substance Abuse and Mental Health Services Administration (SAMHSA).
In 2018, SAMHSA requested that the National Academies establish a committee to conduct a review of the four programs, which focus primarily on opioids, but occasionally include treatment and recovery services for co-occurring substance use disorders. The review resulted in three consensus study reports over five years. This third and final report aims to (1) understand the processes of the four grant programs; actions taken by grantees and their partners; impacts to clients, patients, the community, and public; and structural or environmental changes that might have resulted from grant funding, and (2) analyze how future congressionally mandated evaluations can be structured and carried out to better support policy makers.
Topics: Health and Medicine
High energy density (HED) science has critical applications for society from fusion energy to sustaining the US nuclear deterrent, while also contributing to broader scientific questions such as understanding planets and their origins.
The next decade of HED science will be instrumental to growing our understanding and in the development of new technologies and processes. Fundamental Research in High Energy Density Science identifies key challenges and science questions for the field for the coming decade and proposes ways to address them.
Topics: Math, Chemistry, and Physics | Energy and Energy Conservation
The history of the U.S. criminal justice system is marked by racial inequality and sustained by present day policy. Large racial and ethnic disparities exist across the several stages of criminal legal processing, including in arrests, pre-trial detention, and sentencing and incarceration, among others, with Black, Latino, and Native Americans experiencing worse outcomes. The historical legacy of racial exclusion and structural inequalities form the social context for racial inequalities in crime and criminal justice. Racial inequality can drive disparities in crime, victimization, and system involvement.
Reducing Racial Inequality in Crime and Justice: Science, Practice, and Policy synthesizes the evidence on community-based solutions, noncriminal policy interventions, and criminal justice reforms, charting a path toward the reduction of racial inequalities by minimizing harm in ways that also improve community safety. Reversing the effects of structural racism and severing the close connections between racial inequality, criminal harms such as violence, and criminal justice involvement will involve fostering local innovation and evaluation, and coordinating local initiatives with state and federal leadership.
This report also highlights the challenge of creating an accurate, national picture of racial inequality in crime and justice: there is a lack of consistent, reliable data, as well as data transparency and accountability. While the available data points toward trends that Black, Latino, and Native American individuals are overrepresented in the criminal justice system and given more severe punishments compared to White individuals, opportunities for improving research should be explored to better inform decision-making.
Topics: Behavioral and Social Sciences
Grapevine red blotch disease is a recently recognized disease of grapes that has been detected across some of the major grape-growing regions in the United States and poses a threat to the $162 billion U.S. grape industry. At the request of the state of California, this publication describes the work of the Committee on Assistance to the California Department of Food and Agriculture Pierces Disease/Glassy-Winged Sharpshooter Board on Grapevine Viruses and Grapevine Disease Research and transmits the final evaluation by the committee of the research proposals on grapevine virus diseases and their vectors.
Topics: Agriculture
Whole health is physical, behavioral, spiritual, and socioeconomic well-being as defined by individuals, families, and communities. Whole health care is an interprofessional, team-based approach anchored in trusted relationships to promote well-being, prevent disease, and restore health. It aligns with a person's life mission, aspiration, and purpose. It shifts the focus from a reactive disease-oriented medical care system to one that prioritizes disease prevention, health, and well-being. It changes the health care conversation from "What’s wrong with you?" to "What matters to you?"
The Department of Veterans Affairs (VA), the Samueli Foundation, and the Whole Health Institute commissioned the National Academies of Sciences, Engineering, and Medicine to establish a committee to provide guidance on how to fill gaps and create processes to accelerate the transformation to whole health care for veterans, both inside and outside the VA system, and the rest of the U.S. population. The resulting report presents findings and recommendations that provide a roadmap for improving health and well-being for veterans and the nation.
Topics: Health and Medicine
Cybersecurity for Level 0 and Level 1 devices - which include sensors, the Industrial Internet of Things, and operate on a time scales ranging from milliseconds to seconds - is underdeveloped. This Federal Facilities Council white paper addresses changes to improve cybersecurity, productivity, process safety, predictive maintenance, and resilience, while also breaking down cultural and organizational barriers.
This is not a publication of the National Academies of Sciences, Engineering, and Medicine. The views expressed in this publication are solely those of the author and do not necessarily reflect the views of the National Academies of Sciences, Engineering, and Medicine.
Topics: Computers and Information Technology
The COVID-19 pandemic spurred a rapid expansion of wastewater-based infectious disease surveillance systems to monitor and anticipate disease trends in communities.The Centers for Disease Control and Prevention (CDC) launched the National Wastewater Surveillance System in September 2020 to help coordinate and build upon those efforts. Produced at the request of CDC, this report reviews the usefulness of community-level wastewater surveillance during the pandemic and assesses its potential value for control and prevention of infectious diseases beyond COVID-19.
Wastewater-based Disease Surveillance for Public Health Action concludes that wastewater surveillance is and will continue to be a valuable component of infectious disease management. This report presents a vision for a national wastewater surveillance system that would track multiple pathogens simultaneously and pivot quickly to detect emerging pathogens, and it offers recommendations to ensure that the system is flexible, equitable, and economically sustainable for informing public health actions. The report also recommends approaches to address ethical and privacy concerns and develop a more representative wastewater surveillance system. Predictable and sustained federal funding as well as ongoing coordination and collaboration among many partners will be critical to the effectiveness of efforts moving forward.
Topics: Environment and Environmental Studies | Health and Medicine
The Dietary Reference Intakes (DRIs) are a set of reference values that encompass a safe range of intake and provide recommended nutrient intakes for the United States and Canada. The DRIs for energy are used widely to provide guidance for maintaining energy balance on both an individual and group level.
U.S. and Canadian governments asked the National Academies to convene an expert committee to examine available evidence and provide updated Estimated Energy Requirements (EERs) for their populations. The resulting report presents EER equations that provide a baseline for dietary planners and assessors who are estimating energy needs and monitoring energy balance to enhance the general health of individuals and populations.
Topics: Food and Nutrition |
Recent discoveries and emerging technologies in astronomy and astrophysics have sparked transformative new endeavors to understand the universe and our place in it. This booklet presents an ambitious vision for exploring the cosmos over the next decade and beyond. It outlines the investments needed to cultivate and sustain the people who drive innovation and discovery, the tools to carry out the science, and the research insights that will expand humanity’s horizons.
Topics: Space and Aeronautics
Historically, the U.S. national data infrastructure has relied on the operations of the federal statistical system and the data assets that it holds. Throughout the 20th century, federal statistical agencies aggregated survey responses of households and businesses to produce information about the nation and diverse subpopulations. The statistics created from such surveys provide most of what people know about the well-being of society, including health, education, employment, safety, housing, and food security. The surveys also contribute to an infrastructure for empirical social- and economic-sciences research. Research using survey-response data, with strict privacy protections, led to important discoveries about the causes and consequences of important societal challenges and also informed policymakers. Like other infrastructure, people can easily take these essential statistics for granted. Only when they are threatened do people recognize the need to protect them.
Toward a 21st Century National Data Infrastructure: Mobilizing Information for the Common Good develops a vision for a new data infrastructure for national statistics and social and economic research in the 21st century. This report describes how the country can improve the statistical information so critical to shaping the nation's future, by mobilizing data assets and blending them with existing survey data.
Topics: Behavioral and Social Sciences
In mid-2022, the United States has lost more than 1 million people to the COVID-19 pandemic. We have been real-time witnesses to scores of heroic responses to the disease, death, inequity, and economic strife unleashed by the virus, but have also experienced the consequences of poor pandemic preparedness and long-standing structural failures in our health system.
For decades, the U.S. health system has fallen far short of its potential to support and improve individual and population health. The COVID-19 pandemic has presented death and devastation—but also an unprecedented opportunity to truly transform U.S. health, health care, and health delivery.
To capitalize on this opportunity, the National Academy of Medicine gathered field leaders from across all of the major health system sectors to assess how each sector has responded to the pandemic and the opportunities that exist for health system transformation. The opportunity is now to capitalize on the hard-won lessons of COVID-19 and build a health care system that centers patients, families, and communities; cares for clinicians; supports care systems, public health, and biomedical research to perform at the best of their abilities; applies innovations from digital health and quality, safety, and standards organizations; and encourages health care payers and health product manufacturers and innovators to produce products that benefit all.
Topics: Health and Medicine
The Hanford Nuclear Reservation in Washington state, which produced plutonium for nuclear weapons from 1944-1987, is the site of the largest and most complex nuclear cleanup challenge in the United States. The U.S. Department of Energy's Office of Environmental Management (DOE-EM) is responsible for managing the cleanup of the radioactive and other hazardous wastes stored in 177 underground tanks at the site. DOE plans to use vitrification, or immobilization in glass waste forms, for all of the high-level radioactive waste at Hanford. However, because the volume of "low-activity waste" exceeds DOEs capacity limits for vitrification, DOE must decide how to treat the remaining "supplemental low-activity waste" (SLAW) so that it can be safely disposed in a near-surface disposal site. To help inform its decision, DOE contracted with a Federally Funded Research and Development Center (FFRDC), led by Savannah River National Laboratory, to analyze and report its findings about three potential alternative technologies.
At the request of Congress, the National Academies reviewed the FFRDC report in terms of its value for decision making and how well it meets various Congressional requirements related to Hanford cleanup. The review concludes that the FFRDC report is overall very strong, provides a useful framework for evaluating the technology options, and is responsive to guidance from the first National Academies review. The framework provides for structured side-by-side comparisons, using relevant criteria, of a limited number of alternatives for managing SLAW. Recommendations for strengthening the report include estimating a lifecycle cost profile for constructing and operating each alternative, and providing more in-depth discussion on potential challenges that may need to be addressed in obtaining the necessary various regulatory approvals.
Topics: Environment and Environmental Studies
Wildfires in America are becoming larger, more frequent, and more destructive, driven by climate change and existing land management practices. Many of these fires occur at the wildland-urban interface (WUI), areas where development and wildland areas overlap and which are increasingly at risk of devastating fires as communities continue to expand into previously undeveloped areas. Unlike conventional wildfires, WUI fires are driven in part by burning of homes, cars, and other human-made structures, and in part by burning vegetation. The interaction of these two types of fires can lead to public health effects that are unique to WUI fires.
This report evaluates existing and needed chemistry information that decision-makers can use to mitigate WUI fires and their potential health impacts. It describes key fuels of concern in WUI fires, especially household components like siding, insulation, and plastic, examines key pathways for exposure, including inhalation and ingestion, and identifies communities vulnerable to exposures. The report recommends a research agenda to inform response to and prevention of WUI fires, outlining needs in characterizing fuels, and predicting emissions and toxicants.
Topics: Math, Chemistry, and Physics | Earth Sciences | Environment and Environmental Studies
Oil and natural gas represent more than 50 percent of the worldwide energy supply, with high energy demand driven by population growth and improving standards of living. Despite significant progress in reducing the amount of oil in the sea from consumption, exploration, transportation, and production, risks remain. This report, the fourth in a series, documents the current state-of-knowledge on inputs, fates and effects of oil in the sea, reflecting almost 20 additional years of research, including long-term effects from spills such as the Exxon Valdez and a decade-long boom in oil spill science research following the Deepwater Horizon oil spill.
The report finds that land-based sources of oil are the biggest input of oil to the sea, far outweighing other sources, and it also notes that the effects of chronic inputs on the marine environment, such as land-based runoff, are very different than that from an acute input, such as a spill. Steps to prevent chronic land-based oil inputs include reducing gasoline vehicle usage, improving fuel efficiency, increasing usage of electric vehicles, replacing older vehicles. The report identifies research gaps and provides specific recommendations aimed at preventing future accidental spills and ensuring oil spill responders are equipped with the best response tools and information to limit oil’s impact on the marine environment.
Topics: Environment and Environmental Studies | Earth Sciences
The aging population of the United States has significant implications for the workforce - challenging what it means to work and to retire in the U.S. In fact, by 2030, one-fifth of the population will be over age 65. This shift has significant repercussions for the economy and key social programs. Due to medical advancements and public health improvements, recent cohorts of older adults have experienced better health and increasing longevity compared to earlier cohorts. These improvements in health enable many older adults to extend their working lives. While higher labor market participation from this older workforce could soften the potential negative impacts of the aging population over the long term on economic growth and the funding of Social Security and other social programs, these trends have also occurred amidst a complicating backdrop of widening economic and social inequality that has meant that the gains in health, improvements in mortality, and access to later-life employment have been distributed unequally.
Understanding the Aging Workforce: Defining a Research Agenda offers a multidisciplinary framework for conceptualizing pathways between work and nonwork at older ages. This report outlines a research agenda that highlights the need for a better understanding of the relationship between employers and older employees; how work and resource inequalities in later adulthood shape opportunities in later life; and the interface between work, health, and caregiving. The research agenda also identifies the need for research that addresses the role of workplaces in shaping work at older ages, including the role of workplace policies and practices and age discrimination in enabling or discouraging older workers to continue working or retire.
Topics: Behavioral and Social Sciences
Climate change, driven by increases in human-produced greenhouse gases and particles (collectively referred to as GHGs), is the most serious environmental issue facing society. The need to reduce GHGs has become urgent as heat waves, heavy rain events, and other impacts of climate change have become more frequent and severe. Since the Paris Agreement was adopted in 2015, more than 136 countries, accounting for about 80% of total global GHG emissions, have committed to achieving net-zero emissions by 2050. A growing number of cities, regional governments, and industries have also made pledges to reduce emissions. Providing decision makers with useful, accurate, and trusted GHG emissions information is a crucial part of this effort.
This report examines existing and emerging approaches used to generate and evaluate GHG emissions information at global to local scales. The report develops a framework for evaluating GHG emissions information to support and guide policy makers about its use in decision making. The framework identifies six criteria or pillars that can be used to evaluate and improve GHG emissions information: usability and timeliness, information transparency, evaluation and validation, completeness, inclusivity, and communication. The report recommends creating a coordinated repository or clearinghouse to operationalize the six pillars, for example, by providing timely, transparent, traceable information; standardized data formats; and governance mechanisms that are coordinated, trusted, and inclusive of the global community.
Topics: Environment and Environmental Studies
U.S. leadership in technology innovation is central to our nation’s interests, including its security, economic prosperity, and quality of life. Our nation has created a science and technology ecosystem that fosters innovation, risk taking, and the discovery of new ideas that lead to new technologies through robust collaborations across and within academia, industry, and government, and our research and development enterprise has attracted the best and brightest scientists, engineers, and entrepreneurs from around the world. The quality and openness of our research enterprise have been the basis of our global leadership in technological innovation, which has brought enormous advantages to our national interests.
In today’s rapidly changing landscapes of technology and competition, however, the assumption that the United States will continue to hold a dominant competitive position by depending primarily on its historical approach of identifying specific and narrow technology areas requiring controls or restrictions is not valid. Further challenging that approach is the proliferation of highly integrated and globally shared platforms that power and enable most modern technology applications.
To review the protection of technologies that have strategic importance for national security in an era of openness and competition, Protecting U.S. Technological Advantage considers policies and practices related to the production and commercialization of research in domains critical to national security. This report makes recommendations for changes to technology protection policies and practices that reflect the current realities of how technologies are developed and incorporated into new products and processes.
Topics: Conflict and Security Issues
As the coldest, most remote, and most extreme environment on Earth, Antarctica provides a unique vantage point for investigating life adaptations, understanding the health of the global climate, and peering into the depths of the Universe. For example, ecological studies in the Dry McMurdo Valley help explain how life survives in extremes, observations of the West Antarctic Ice Sheet reveal vital information about our changing climate, and the Ice Cube Neutrino Observatory provides insights into supernovae, black holes, and similar phenomenon. Since 1959, the Antarctic Treaty has ensured the continent remains a haven for scientific investigation, offering up an invaluable model of global cooperation with U.S. leadership provided by the U.S. Antarctic Program.
This booklet, drawing primarily from reports of the National Academies, captures a multitude of insights gained - and sought - from U.S. research investments in this remarkable place. A continued commitment to science, cooperation, and a shared vision for the future are required to build on this rich history of discovery and answer crucial questions in the decades ahead.
Topics: Earth Sciences
Regular use of sunscreens has been shown to reduce the risk of sunburn and skin cancer, and slow photoaging of skin. Sunscreens can rinse off into water where people are swimming or wading, and can also enter bodies of water through wastewater such as from bathing or showering. As a result, the ultraviolet (UV) filters - the active ingredients in sunscreens that reduce the amount of UV radiation on skin - have been detected in the water, sediment, and animal tissues in aquatic environments. Because the impact of these filters on aquatic ecosystems is not fully understood, assessment is needed to better understand their environmental impacts.
This report calls on the U.S. Environmental Protection Agency to conduct an ecological risk assessment of UV filters to characterize the possible risks to aquatic ecosystems and the species that live in them. EPA should focus on environments more likely to be exposed such as those with heavy recreational use, or where wastewater and urban runoff enter the water. The risk assessment should cover a broad range of species and biological effects and could consider potential interacting effects among UV filters and with other environmental stresses such as climate change. In addition, the report describes the role of sunscreens in preventing skin cancer and what is known about how human health could be affected by potential changes in usage. While the need for a risk assessment is urgent, research is needed to advance understanding of both risks to the environment from UV filters and impacts to human health from changing sunscreen availability and usage.
Topics: Environment and Environmental Studies | Health and Medicine
With unprecedented global aging, societies must undertake all-of-society efforts to maximize the benefits and minimize the burdens of aging populations. The Global Roadmap for Healthy Longevity (Global Roadmap) describes a realistic vision of healthy longevity that could be achieved by 2050. The vision includes full inclusion of people of all ages, regardless of health or functional status, in all aspects of society and societies characterized by social cohesion and equity.
To achieve the vision, Global Roadmap recommends changes that need to be made to health systems, social infrastructure, physical environments, education, work, and retirement. In some cases, the recommended changes benefit older people most directly, but when older people thrive, people of all ages benefit. If taken up, the recommendations of this report can support individuals of all ages in all corners of the globe to live long, meaningful, and purpose-driven lives by 2050.
Topics: Health and Medicine
This report evaluates submissions received in response to a Request for Proposals for Biomolecular Simulation Time on Anton 2, a supercomputer designed and built by D.E. Shaw Research (DESRES). Over the past 12 years, DERES has made an Anton or Anton 2 system housed at the Pittsburgh Supercomputing Center available to the non-commercial research community, based on the advice of previous committees of the National Academies of Sciences, Engineering, and Medicine. As in those prior rounds, the goal of the thirteenth Request for Proposals for simulation time on Anton 2 is to continue to facilitate breakthrough research in the study of biomolecular systems by providing a massively parallel system specially designed for molecular dynamics simulations. These capabilities allow multi-microsecond simulation timescales. The program seeks to continue to support research that addresses important and high impact questions demonstrating a clear need for the special capabilities of the Anton.
Topics: Math, Chemistry, and Physics
Ontologies in the Behavioral Sciences: Accelerating Research and the Spread of Knowledge describes how ontologies support science and its application to real-world problems. That report details how ontologies function, how they can be engineered to better support the behavioral sciences, and the resources needed to sustain their development and use to help ensure the maximum benefit from investment in behavioral science research. The full report published in May, 2022. This digest version summarizes the primary ideas presented in that report.
Topics: Behavioral and Social Sciences
Transportation is the largest source of greenhouse gas emissions in the United States, with petroleum accounting for 90 percent of transportation fuels. Policymakers encounter a range of questions as they consider low-carbon fuel standards to reduce emissions, including total emissions released from production to use of a fuel or the potential consequences of a policy. Life-cycle assessment is an essential tool for addressing these questions. This report provides researchers and practitioners with a toolkit for applying life-cycle assessment to estimate greenhouse gas emissions, including identification of the best approach to use for a stated policy goal, how to reduce uncertainty and variability through verification and certification, and the core assumptions that can be applied to various fuel types. Policymakers should still use a tailored approach for each fuel type, given that petroleum-based ground, air, and marine transportation fuels necessitate different considerations than alternative fuels including biofuels, hydrogen, and electricity. Ultimately, life-cycle assessments should clearly document what assumptions and methods are used to ensure transparency.
Topics: Environment and Environmental Studies
People spend the vast majority of their time inside their homes and other indoor environments where they are exposed to a wide range of chemicals from building materials, furnishings, occupants, cooking, consumer products, and other sources. Despite research to date, very little is known about how exposures to indoor chemicals across complex chemical phases and pathways affect human health. The COVID-19 pandemic has only increased public awareness of indoor environments and shed light on the many outstanding questions about how best to manage chemicals indoors. This report identifies gaps in current research and understanding of indoor chemistry and new approaches that can be applied to measure, manage, and limit chemical exposures. Why Indoor Chemistry Matters calls for further research about the chemical transformations that can occur indoors, pathways and timing of indoor chemical exposure, and the cumulative and long-term impacts of exposure on human health. Research priorities should consider factors that contribute to measurable environmental health disparities that affect vulnerable populations, such as the age, location, and condition of buildings that can alter exposures to indoor chemicals.
Topics: Math, Chemistry, and Physics | Environment and Environmental Studies
Chemistry plays a pivotal role in the strength of the U.S. economy and the advancement of humankind. Chemists' achievements include life-saving pharmaceuticals, advanced energy solutions, improved agricultural productivity, and novel materials used in products from clothing to electronic devices. The many sectors reliant on the U.S. chemical economy account for about 25% of the U.S. GDP and support 4.1 million U.S. jobs. However, a new and evolving chemistry landscape requires changes with regard to funding, training, and a focus on integrating sustainability into manufacturing, product usage, and product disposal.
This report identifies strategies and options for research investments that will support U.S. leadership while considering environmental sustainability and developing a diverse chemical economy workforce with equitable opportunities for all chemistry talent. The report recommends that funding agencies and philanthropic organizations who support the chemical sciences fund as large a breadth of fundamental research projects as possible. Chemical industry and their partners at universities, scientific research institutions, and national laboratories should align the objectives of fundamental research to directly assist with new practices toward environmental stewardship, sustainability, and clean energy. Additionally, the report recommends that funding agencies make substantial investment toward education research to enable innovative ways of teaching about emerging concepts, tools and technologies.
Topics: Math, Chemistry, and Physics | Industry and Labor
Heritable disorders of connective tissue (HDCTs) are a diverse group of inherited genetic disorders and subtypes. Because connective tissue is found throughout the body, the impairments associated with HDCTs manifest in multiple body systems and may change or vary in severity throughout an affected individual's lifetime. In some cases, these impairments may be severe enough to qualify an eligible child or adult for monetary benefits through the U.S. Social Security Administration's (SSA's) Social Security Disability Insurance or Supplemental Security Income program. SSA asked the National Academies of Sciences, Engineering, and Medicine to convene an expert committee that would provide current information regarding the diagnosis, treatment, and prognosis of selected HDCTs, including Marfan syndrome and the Ehlers-Danlos syndromes, and the effect of the disorders and their treatment on functioning. The resulting report, Selected Heritable Disorders of Connective Tissue and Disability, presents the committee's findings and conclusions.
Topics: Health and Medicine
The Department of Defense operates several ranges across all service branches to test the effectiveness of military systems in the land, sea, air, space, and cyberspace domains. These ranges and infrastructure represent a critical part of the DoD acquisition and systems development process.
The DoD's Office of Test and Evaluation (DOT&E) has asked the Board on Army Research and Development to assess how effectively these ranges fulfill DOT&E's mission to determine operational effectiveness and lethality of systems currently under development. This study will specifically evaluate whether these ranges are prepared to simulate threats, countermeasures, and operations against near-peer adversaries. This publication is the unclassified version of the classified report.
Topics: Conflict and Security Issues
Nearly 600,000 people are released from state and federal prisons annually. Whether these individuals will successfully reintegrate into their communities has been identified as a critical measure of the effectiveness of the criminal legal system. However, evaluating the successful reentry of individuals released from prison is a challenging process, particularly given limitations of currently available data and the complex set of factors that shape reentry experiences.
The Limits of Recidivism: Measuring Success After Prison finds that the current measures of success for individuals released from prison are inadequate. The use of recidivism rates to evaluate post-release success ignores significant research on how and why individuals cease to commit crimes, as well as the important role of structural factors in shaping post-release outcomes. The emphasis on recidivism as the primary metric to evaluate post-release success also ignores progress in other domains essential to the success of individuals returning to communities, including education, health, family, and employment.
In addition, the report highlights the unique and essential insights held by those who have experienced incarceration and proposes that the development and implementation of new measures of post-release success would significantly benefit from active engagement with individuals with this lived experience. Despite significant challenges, the report outlines numerous opportunities to improve the measurement of success among individuals released from prison and the report’s recommendations, if implemented, will contribute to policies that increase the health, safety, and security of formerly incarcerated persons and the communities to which they return.
Topics: Behavioral and Social Sciences