In the laboratory, testing the toxic effects for a single compound is a straightforward process. However, many common harmful substances occur naturally as mixtures and can interact to exhibit greater toxic effects as a mixture than the individual components exhibit separately. Complex Mixtures addresses the problem of identifying and classifying complex mixtures, investigating the effect of exposure, and the research problems inherent in testing their toxicity to human beings. A complete series of case studies is presented, including one that examines the cofactors of alcohol consumption and cigarette smoke.
Table of Contents
|2. Concepts for Analyzing Human Exposure to Complex Chemical Mixtures||10-38|
|3. Testing Strategies and Methods||39-64|
|4. Sampling and Chemical Characterization||65-98|
|5. Interpretation and Modeling of Toxicity-Test Results||99-124|
|Appendix A: Origins of Complex Mixtures||125-132|
|Appendix B: Case Studies Establishing Active Agents and/or Interactions in Complex Mixtures||133-167|
|Appendix C: Case Studies on Strategies for Testing the Toxicity of Complex Mixtures||168-178|
|Appendix D: Predicting the Joint Risk of a Misture in Terms of the Component Risks||179-184|
|Appendix E: Cancer Models||185-201|
|Appendix F: Developmental Toxicology||202-208|
|Appendix G: Empirical Modeling of the Toxicity of Mixtures||209-220|
The National Academies Press and the Transportation Research Board have partnered with Copyright Clearance Center to offer a variety of options for reusing our content. You may request permission to:
For most Academic and Educational uses no royalties will be charged although you are required to obtain a license and comply with the license terms and conditions.
For information on how to request permission to translate our work and for any other rights related query please click here.
For questions about using the Copyright.com service, please contact:
Copyright Clearance Center
22 Rosewood Drive
Danvers, MA 01923
Tel (toll free): 855/239-3415 (select option 1)
Loading stats for Complex Mixtures: Methods for In Vivo Toxicity Testing...