This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
Table of Contents
|Public Summary & Executive Summary||1-18|
|1 Background Information||19-42|
|2 Molecular and Cellular Responses to Ionizing Radiation||43-64|
|3 Radiation-Induced Cancer: Mechanisms, Quantitative Experimental Studies and the Role of Genetic Factors||65-90|
|4 Heritable Genetic Effects of Radiation in Human Populations||91-131|
|5 Background for Epidemiologic Methods||132-140|
|6 Atomic Bomb Survivor Studies||141-154|
|7 Medical Radiation Studies||155-188|
|8 Occupational Radiation Studies||189-206|
|9 Environmental Radiation Studies||207-238|
|10 Integration of Biology and Epidemiology||239-258|
|11 Risk Assessment Models and Methods||259-266|
|12 Estimating Cancer Risk||267-312|
|13 Summary and Research Needs||313-324|
|Appendix A: Basic Biological and Genetic Concepts||325-328|
|Appendix B: Commetary on "Radiation from Medical Procedures in the Pathogenesis of Cancer and Ischemic Heart Disease: Dose-Response Studies with Physicians per 100,000 Populations"||329-329|
|Appendix C: Issues Raised by the Institute for Energy and Environment Research (IEER)||330-331|
|Appendix D: Hormesis||332-335|
|Appendix E: Fifteen-Country Workers Study||336-336|
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