Advances in technologies and knowledge are creating new avenues for research and opportunities for the discovery and clinical development of innovative therapies and diagnostics. However, despite these opportunities, only a small fraction of investigational products are successfully developed into cures and therapies that can be accessed by patients. One response to the ever-widening gap between the number and promise of basic scientific discoveries and the translation of those discoveries into therapies is a renewed emphasis on collaborative approaches among federal agencies, academia, and industry, all directed at the advancement of the drug development enterprise.
The newly developed Cures Acceleration Network (CAN)-a part of the National Center for Advancing Translational Sciences (NCATS) within the National Institutes of Health (NIH)-has the potential to catalyze widespread changes in NCATS, NIH, and the drug development ecosystem in general.
On June 4-5, 2012, the IOM Forum on Drug Discovery, Development, and Translation held, at the request of NCATS, a workshop-bringing together members of federal government agencies, the private sector, academia, and advocacy groups-to explore options and opportunities in the implementation of CAN. Accelerating the Development of New Drugs and Diagnostics: Maximizing the Impact of the Cures Acceleration Network: Workshop Summary summarizes the workshop.
Table of Contents
|2 Approaches to Accelerating Translational Science||15-28|
|3 Application of Matching Authority||29-38|
|4 Application of Flexible Research Authority||39-50|
|5 Situating CAN Within the Drug Development Ecosystem||51-64|
|6 Final Reflections on Ways to Maximize the Goals of CAN||65-70|
|Appendix A: Workshop Agenda||73-86|
|Appendix B: Public Health Service Act, Title IV - National Institutes of Health||87-94|
|Appendix C: Participant Biographies||95-116|
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