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Behavioral Measures of Neurotoxicity

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Exposure to toxic chemicals--in the workplace and at home--is increasing every day. Human behavior can be affected by such exposure and can give important clues that a person or population is in danger. If we can understand the mechanisms of these changes, we can develop better ways of testing for toxic chemical exposure and, most important, better prevention programs.

This volume explores the emerging field of neurobehavioral toxicology and the potential of behavior studies as a noninvasive and economical means for risk assessment and monitoring. Pioneers in this field explore its promise for detecting environmental toxins, protecting us from exposure, and treating those who are exposed.


Suggested Citation

National Research Council. 1990. Behavioral Measures of Neurotoxicity. Washington, DC: The National Academies Press.

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Publication Info

452 pages | 6 x 9
ISBN: 978-0-309-04047-1

Table of Contents

skim chapter
Front Matter i-xvi
Introduction 1-10
Are Neurotoxins Driving Us Crazy? Planetary Observations on the Causes of Neurodegenerative Diseases of Old Age 11-36
Part I. Assessment of Neurobehavioral Tests Now in Use 37-38
Methods in Behavioral Toxicology: Current Test Batteries and Need for Development 39-55
The Current Status of Test Development in Neurobehavioral Toxicology 56-68
Human Neurobehavioral Toxicology Testing 69-85
Neurobehavioral Tests: Problems, Potential, and Prospects 86-98
Part II. Assessment of Animal Models: What Has Worked and What Is Needed 99-100
Exposure to Neurotoxins Throughout the Life Span: Animal Models for Linking Neurochemical Effects to Behavioral Consequences 101-123
Animal Models of Dementia: Their Relevance to Neurobehavioral Toxicology Testing 124-136
Bridging Experimental Animal and Human Behavioral Toxicology Studies 137-158
Methods and Issues in Evaluating the Neurotoxic Effects of Organic Solvents 159-183
Animal Models: What Has Worked and What Is Needed 184-188
Part III. Chemical Time Bombs: Environmental Causes of Neurodegenerative Diseases 189-190
On the Identification and Measurement of Chemical Time Bombs: A Behavior Development Perspective 191-205
Neurobehavioral Time Bombs: Their Nature and Their Mechanisms 206-225
Neurobehavioral Toxicity of Selected Environmental Chemicals: Clinical and Subclinical Aspects 226-242
The Health Effects of Environmental Lead Exosure: Closing Pandora's Box 243-267
Chemical Time Bombs: Environmental Causes of Neurodegenerative Diseases 268-284
Part IV. Behavioral Aspects of Neurotoxicity: Regional Issues 285-286
Neurobehavioral Toxicity Testing in China 287-311
Regional Issues in the Development of the Neurobehavioral Core Test Battery 312-321
Issues in the Development of Neurobehavioral Toxicity Tests in India 322-336
Regional Issues in Neurobehavioral Testing: An Overview 337-344
Part V. Recommendations for Further Research and Testing 345-346
Environmental Modulation of Neurobehavioral Toxicity 347-358
Computerized Performance Testing in Neurotoxicology: Why, What, How, and Whereto? 359-394
The Scope and Promise of Behavioral Toxicology 395-414
Appendix: Symposium Agenda 415-418
Index 419-432

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