One of the holy grails in biology is the ability to predict functional characteristics from an organism’s genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism’s phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from “-omics” screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.
Table of Contents
|2 The GenotypePhenotype Challenge||4-12|
|3 Case Studies on Building Functional Genomics Tools in Diverse Systems||13-28|
|4 Understanding the Contributions of Non-Protein-Coding DNA to Phenotype||29-38|
|5 Advancing Research on the Environmental Regulation of Gene Function||39-54|
|6 Predicting Current and Future Sources of Variation in Quantitative Traits||55-62|
|7 Interpreting and Validating Results from High-Throughput Screening Approaches||63-76|
|8 Large Databases and Consortia||77-93|
|9 Big-Picture Challenges in Research, Education, and Training||94-105|
|10 Future of Functional Genomics||106-111|
|Appendix A: Statement of Task||121-122|
|Appendix B: Workshop Agenda||123-125|
|Appendix C: Planning Committee Biographies||126-128|
|Appendix D: Speaker Biographies||129-136|
|Appendix E: Acronyms and Abbreviations||137-138|
The National Academies Press and the Transportation Research Board have partnered with Copyright Clearance Center to offer a variety of options for reusing our content. You may request permission to:
For most Academic and Educational uses no royalties will be charged although you are required to obtain a license and comply with the license terms and conditions.
For information on how to request permission to translate our work and for any other rights related query please click here.
For questions about using the Copyright.com service, please contact:
Copyright Clearance Center
22 Rosewood Drive
Danvers, MA 01923
Tel (toll free): 855/239-3415 (select option 1)
Loading stats for Next Steps for Functional Genomics: Proceedings of a Workshop...