During the 1950s, with the Cold War looming, military planners sought to know more about how to keep fighting forces fit and capable in the harsh Alaskan environment. In 1956 and 1957, the U.S. Air Force's former Arctic Aeromedical Laboratory conducted a study of the role of the thyroid in human acclimatization to cold. To measure thyroid function under various conditions, the researchers administered a radioactive medical trace, Iodine-131, to Alaska Natives and white military personnel; based on the study results, the researchers determined that the thyroid did not play a significant role in human acclimatization to cold.
When this study of thyroid function was revisited at a 1993 conference on the Cold War legacy in the Arctic, serious questions were raised about the appropriateness of the activity—whether it posed risks to the people involved and whether the research had been conducted within the bounds of accepted guidelines for research using human participants. In particular, there was concern over the relatively large proportion of Alaska Natives used as subjects and whether they understood the nature of the study. This book evaluates the research in detail, looking at both the possible health effects of Iodine-131 administration in humans and the ethics of human subjects research. This book presents conclusions and recommendations and is a significant addition to the nation's current reevaluation of human radiation experiments conducted during the Cold War.
Table of Contents
|2 Health Effect of I131 Administration in Humans||26-42|
|3 The Ethics of Human Subjects Research||43-61|
|4 Conclusions and Recommendations||62-66|
|A. Thyroid Function in Health and Disease||75-80|
|B. Summary of the Public Session||81-86|
|C. Thyroid Radaition Dose Estimates for I131||87-87|
|D. Secretary of Defense Letter||88-91|
|E. Informed Consent Elements of Disclosure||92-94|
|F. Principles for the Conduct of Research in the Arctic||95-98|
|G. Biographical Sketches of Committee Members||99-100|
The National Academies Press and the Transportation Research Board have partnered with Copyright Clearance Center to offer a variety of options for reusing our content. You may request permission to:
For most Academic and Educational uses no royalties will be charged although you are required to obtain a license and comply with the license terms and conditions.
For information on how to request permission to translate our work and for any other rights related query please click here.
For questions about using the Copyright.com service, please contact:
Copyright Clearance Center
22 Rosewood Drive
Danvers, MA 01923
Tel (toll free): 855/239-3415 (select option 1)
Loading stats for The Arctic Aeromedical Laboratory's Thyroid Function Study: A Radiological Risk and Ethical Analysis...