TY - BOOK AU - Institute of Medicine A2 - Molla S. Donaldson A2 - Laneta Dorflinger A2 - Sarah S. Brown A2 - Leslie Z. Benet TI - Clinical Applications of Mifepristone (RU486) and Other Antiprogestins: Assessing the Science and Recommending a Research Agenda SN - 978-0-309-04949-8 DO - 10.17226/2203 PY - 1993 UR - https://nap.nationalacademies.org/catalog/2203/clinical-applications-of-mifepristone-ru486-and-other-antiprogestins-assessing-the PB - The National Academies Press CY - Washington, DC LA - English KW - Health and Medicine AB - Mifepristone (RU486), the first clinically available antiprogestin, has generated great interest since its discovery in the early 1980s. Today, it is recognized that mifepristone, along with other antiprogestins, has a potentially significant therapeutic role in human health and disease, with likely applicability to a variety of pregnancy-related conditions (e.g., management of labor) and to contraception, endometriosis, and cancer, among others. But because mifepristone has been studied and used most widely as a means of nonsurgical abortion, political issues have thus far limited research on the drug and prevented its introduction into the U.S. market. This book provides an unbiased evaluation of current knowledge about both the fundamental nature of antiprogestins as well as their possible use in treating numerous diseases and conditions, and it contains recommendations for future research. ER -