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Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×

Appendix A
Priority Lists of Chemicals

A master list of approximately 1,000 acutely toxic chemicals was initially compiled through the integration of individual priority lists of chemicals submitted by each U.S. federal agency placing a representative on the NAC/AEGL Committee. The master list was subsequently reviewed by individuals from certain state agencies and representatives from organizations in the private sector and modified as a result of comments and suggestions received. The various priority chemical lists were compiled separately by each federal agency based on their individual assessments of the hazards, potential exposure risk, and relevance of a chemical to their programmatic needs.

On May 21, 1997, a list of 85 chemicals was published in the Federal Register. This list identified those chemicals to be of highest priority across all U.S. federal agencies and represented the selection of chemicals for AEGL development by the NAC/AEGL Committee for the first 2–3 years of the program. The committee has now addressed most of these chemicals, and they are currently in the “proposed,” “interim,” or “final” stages of development. Certain chemicals did not contain an adequate database for AEGL development and, consequently, are on hold pending decisions regarding further toxicity testing. This initial “highest” priority list of 85 chemicals is shown in Table A-1.

A second “working list” of approximately 100 priority chemicals is being selected from the original master list or from new high-priority candidate chemicals submitted by U.S. agencies and organizations and by member coun-

Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×

tries of the Organization for Economic Cooperation and Development (OECD) that are planning to participate in the AEGL Program. Although “working lists” will be published in the Federal Register and elsewhere from time to time to indicate the NAC/AEGL Committee’s agenda, the priority of chemicals addressed, and, hence, the “working list,” is subject to modification if priorities of the NAC/AEGL Committee or individual stakeholder organizations, including international members, change during that period.

INITIAL LIST OF 85 PRIORITY CHEMICALS FOR AEGL DEVELOPMENT

Organization Lists Used to Compile the Master List and The Initial List of 85 Priority Chemicals1

ATSDR Medical Managment

U.S. Agency for Toxic Substances and Disease Registry

M=Chemicals with an ATSDR Medical Management Guideline

T=Chemicals with an ATSDR Toxicology Profile

DOD

U.S. Department of Defense

A=Army Toxicity Summary Chemical

C=Chemical Weapons Convention Schedule 3. A Toxic Chemical

Cs=Chemical Stockpile Emergency Preparedness Program (CSEPP) Chemical

1  

The initial list of 85 priority chemicals shown in Table A-1 has been created by identifying the highest priority hazardous chemicals from the Master List. This initial list is a starting point for the development of AEGL values by the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Chemicals (NAC/AEGL). However, the list of chemicals is subject to modification, pending changes in priorities recommended by the various stakeholders that make up the NACa/AEGL. While it is anticipated that most of these chemicals will remain as high priority for AEGL development, changes to the list could occur. The NAC/AEGL Committee hopes to select 30 to 40 chemicals per year to address in the AEGL development process. Consequently, the initial list will expand as the NAC/AEGL Committee continues to address chemicals of interest to its member organizations.

Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×

 

I=Air Force Installation Restoration Program Chemical

N=Navy Chemical

S=Strategic Environmental Research and Development Program (SERDP) Chemical

DOE SCAPA

U.S. Department of Energy Subcommittee for Consequence Assessment and Protective Action Chemical

DOT ERP

U.S. Department of Transportation Emergency Response Guidebook

P=Priority DOT ERG Chemical

O=Other ERG Chemical

EPA CAA 112b

U.S. Environmental Protection Agency Clean Air Act 112b Chemical

EPA CAA 112r

U.S. Environmental Protection Agency Clean Air Act 112b Chemical (+=SARA s.302 also)

EPA Superfund

U.S. Environmental Protection Agency Superfund Chemical

OSHA PSM

U.S. Occupational Safety and Health Administration Process Safety Management Chemical

OSHA STEL

U.S. Occupational Safety and Health Administration Short-term Exposure Limit Chemical

NIOSH IDLH

NIOSH Immediately Dangerous to Life or Health Chemical

Seveso Annex III

International Seveso Convention List

Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×

TABLE A-1 Priority List of Chemicals

CAS No.

Chemical

ATSDR

DOD

DOE SCAPA

DOT ERG

EPA CAA 112b

EPA CAA 112r

EPA Superfund

OSHA PSM

OSHA STEL

NIOSH IDLH

Seveso Annex III

56–23–5

Carbon tetrachloride

T

AIS

 

 

X

 

X

 

 

X

 

57–14–7

1,1-Dimethyl hydrazine

 

P

X

X+

 

X

X

60–34–4

Methyl hydrazine

P

X

X+

X

X

X

62–53–3

Aniline

M

 

P

X

+

X

 

X

67–66–3

Chloroform

T

AIS

 

X

X+

X

X

68–12–2

Dimethylformamide

 

X

X

 

71–43–2

Benzene

X

AIS

X

X

 

X

 

71–55–6

1,1,1-Trichloroethane

T

X

X

X

 

X

74–90–8

Hydrogen cyanide

M

C

 

P

X

X+

 

X

 

X

X

74–93–1

Methyl mercaptan

T

 

P

 

X+

 

X

X

 

75–09–2

Methylene chloride

MT

AIS

X

 

X

 

X

 

75–21–8

Ethylene oxide

MT

 

P

X

X+

 

X

 

X

X

75–44–5

Phosgene

M

C

 

P

X

X+

 

X

 

X

X

75–55–8

Propyleneimine

 

X

X+

 

X

X

75–56–9

Propylene oxide

X

X+

X

X

75–74–1

Tetramethyllead

X

X+

 

X

 

X

X

75–77–4

Trimethychlorosilane

 

X+

 

75–78–5

Dimethyldichlorosilane

 

X

 

X+

 

X

 

75–79–6

Methyltrichlorosilane

 

X+

 

X

78–82–0

Isobutyronitrile

X+

 

79–01–6

Trichloroethylene

MT

AIS

X

 

X

 

X

 

Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×

79–21–0

Peracetic acid

 

X+

 

X

 

X

79–22–1

Methy chloroformate

X+

 

91–08–7

Toluene 2,6-diisocyanate

M

 

X+

106–89–8

Epichlorohydrin

 

X

X+

 

X

 

107–02–8

Acrolein

T

 

P

X

X+

X

X

X

X

X

107–11–9

Allyl amine

 

P

 

X+

 

X

 

X

107–12–0

Propionitrile

 

X+

 

107–15–3

Ethylenediamine

X+

 

X

 

107–18–6

Allyl alcohol

 

P

 

X+

 

X

X

X

107–30–2

Chloromethyl methyl ether

O

X

X+

 

X

 

X

108–23–6

Isopropyl chloroformate

P

 

X+

 

108–88–3

Toluene

MT

AINS

 

X

 

X

 

108–91–8

Cyclohexylamine

 

X+

 

109–61–5

Propyl chloroformate

 

O

 

X+

110–00–9

Furan

 

X+

X

X

 

110–89–4

Piperidine

X+

 

123–73–9

Crotonaldehyde, (E)

X+

 

X

 

126–98–7

Methacrylonitrile

 

O

 

X+

 

X

 

127–18–4

Tetrachloroethylene

T

AIS

X

 

X

 

X

 

151–56–4

Ethyleneimine

 

P

X

X+

 

X

X

X

302–01–2

Hydrazine

T

I

X

 

X

X+

 

X

 

353–42–4

Boron triflouride compound with methyl ether (1:1)

 

X+

 

X

506–77–7

Cyanogen chloride

X+

 

X

 

509–14–8

Tetranitromethane

X+

 

X

Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×

CAS No.

Chemical

ATSDR

DOD

DOE SCAPA

DOT ERG

EPA CAA 112b

EPA CAA 112r

EPA Superfund

OSHA PSM

OSHA STEL

NIOSH IDLH

Seveso Annex III

540–59–0

1,2-Dichloroethylene

T

 

X

 

X

 

540–73–8

1,2-Dimethylhydrazine

 

P

X

X+

 

X

 

X

584–84–9

Toluene 2,4-diisocyanate

M

 

X

X+

X

 

X

X

594–42–3

Perchloromethyl-mercaptan

 

X+

 

X

 

X

X

624–83–9

Methyl isocyanate

 

P

X

X+

 

X

 

X

X

811–97–2

HFC 134A (1,1,1,2-

Tetrafluoroethane)

 

N

 

814–68–6

Acrylyl chloride

 

X+

 

X

 

1330–20–7

Xylenes (mixed)

X

AIN

 

X

 

X

 

1717–00–6

HCFC 141b (1,1-Dichloro-1-fluoroethane)

 

N

 

4170–30–3

Crotonaldehyde cis & trans mixture

 

P

 

X+

 

X

 

6423–43–4

Propylene glycol dinitrate (Otto Fuel II)

T

Navy

 

7446–09–5

Sulfur dioxide

 

P

 

X+

 

X

X

X

X

7446–11–9

Sulfur trioxide

P

 

X+

 

X

 

X

7647–01–0

Hydrogen chloride

P

X

X+

X

X

X

X

X

7647–01–0

Hydrochloric acid

P

X

X+

X

X

X

X

 

7664–39–3

Hydrogen fluoride

M

 

P

X

X+

 

X

X

X

X

7664–41–7

Ammonia

MT

 

X+

X

X

 

X

X

7664–93–9

Sulfuric acid

 

P

 

+

X

 

X

 

7697–37–2

Nitric acid

 

X

P

 

X+

 

X

X

X

 

Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×

7719–12–2

Phosphorus trichloride

 

P

 

X+

 

X

X

X

 

7726–95–6

Bromine

P

X+

X

X

X

X

7782–41–4

Fluorine

P

X+

X

 

X

 

7782–50–5

Chlorine

M

 

P

X

X+

X

X

X

X

X

7783–06–4

Hydrogen sulfide

M

 

X

X+

 

X

 

7783–60–0

Sulfur tetrafluoride

 

P

 

X+

 

7783–81–5

Uranium hexafluoride

 

X

 

7784–34–1

Arsenous trichloride

 

P

 

X+

 

7784–42–1

Arsine

M

 

X

P

X

X+

X

X

 

X

X

7790–91–2

Chlorine trifluoride

 

X

O

 

X

 

X

 

7803–51–2

Phosphine

M

 

X

P

X

X+

 

X

X

X

X

8014–95–7

Oleum

 

P

 

X+

X

 

10025–87–3

Phosphorus oxychloride

O

X+

X

10049–04–4

Chlorine dioxide

 

X

X

X

X

 

10102–43–9

Nitric oxide

P

X+

X

 

X

 

10102–44–0

Nitrogen dioxide

 

X

X

X

X

 

10294–34–5

Boron trichloride

 

P

X+

X

13463–39–3

Nickel carbonyl

P

X

X+

X

X

 

X

13463–40–6

Iron, pentacarbonyl-

P

 

X+

X

X

 

19287–45–7

Diborane

 

X

P

 

X+

X

 

X

 

25323–89–1

Trichloroethane

T

AS

X

 

X

 

X

 

70892–10–3

Jet fuels (JP-5 and JP-8)

 

N

 

163702–07–6

Methyl nonafluorobutyl ether (HFE 7100 component)

N

163702–08–7

Methyl nonafluorobutyl ether (HFE 7100 component)

N

Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×

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Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×
Page 165
Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×
Page 166
Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×
Page 167
Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×
Page 168
Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×
Page 169
Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×
Page 170
Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×
Page 171
Suggested Citation:"A Priority Lists of Chemicals." National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. doi: 10.17226/10122.
×
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Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures.

The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment.

It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routes—both oral and dermal—as well as risk assessors in the government, academe, and private industry.

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