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Suggested Citation:"Major Issues." National Research Council. 2004. Tenth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/10894.
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Page 11

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TENTH INTERIM REPORT OF THE SUBCOMMITTEE ON ACUTE EXPOSURE GUIDELINE LEVELS 11 Additional References Rios-Blanco, M.N., Ranasinghe, A., Upton, P., Lee, M.S., Filser, J.G., and Swenberg, J.A. (2002). Exposure-dependent accumulation of N-(2- hydroxypropyl) valine in hemoglobin of F344 rats exposed to propylene oxide by the inhalation route. J. Chromatogr. B 778: 383– 396. Rios-Blanco, M.N., Yamaguchi, S., Dhawan-Robl, M., Kessler, W., Schoonhoven, R., Filser, J.G., and Swenberg, J.A. 2003a. Effects of propylene oxide exposure on rat nasal respiratory cell proliferation. Toxicol. Sci. in press. Rios-Blanco, M.N., Ranasinghe, A., Lee, M.S., Faller, T., Filser, J.G., and Swenberg, J.A. 2003b. Molecular dosimetry of N7-(2- hydroxypropyl) guanine in tissues of F344 rats after inhalation exposure to propylene oxide. Carcinogenesis 24:1233–1238. Schettgen, T., Eroding, H.C., Angerer, J., and Drexler, H. (2002). Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine. Toxicol Lett. 134:65–70. Segerback, D., Plna, K., Faller, T., Kreuzer, P.E., Hakansson, K., Filser, J.G., and Nilsson, R. (1998). Tissue distribution of DNA adducts in male Fischer rats exposed to 500 ppm of propylene oxide: quantitative analysis of 7-(2-hydroxypropyl) guanine by 32P-postlabeling. Chem.-Biol. Interact. 115:229–246. Thier, R., Wiebel, F.A. and Bolt, H.M. (1999). Differential substrate behaviors of ethylene oxide and propylene oxide towards human glutathione transferase theta hGSTT1–1. Arch. Toxicol. 73:489–492. COMMENTS ON IRON PENTACARBONYL At its July 21–23, 2003 meeting, the subcommittee reviewed the AEGL document on iron pentacarbonyl. The document was presented by Robert Young of Oak Ridge National Laboratory. The subcommittee recommends a number of revisions. The revised document will be reviewed by the subcommittee at its next meeting. Major Issues The NAC must explain how exposures might occur to the public and to what compound. It is stated iron pentacarbonyl, released into air, will either spontaneously combust or undergo decomposition to iron nonacarbonyl and carbon monoxide or burn to ferric oxide. In the event of a release, what is the most likely compound to which the public will be exposed? If it is a decomposition product of the parent material and not iron pentacarbonyl, there is no reason to derive an AEGL for iron pentacarbonyl. This issue point needs to be resolved. How is iron pentacarbonyl produced and used in industrial plants? Is it consumed on site in an inert atmosphere? Is it transported to refineries and blended in gasoline? How is it used in making iron cores? Iron pentacarbonyl may also be used in making computer hard disk memory components, but the document suffers from the fact that the industrial use and handling practices for this material are given little attention.

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