Tenth Interim Report of the Subcommittee on Acute Exposure Guideline Levels (2004)

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TENTH INTERIM REPORT OF THE SUBCOMMITTEE ON ACUTE EXPOSURE GUIDELINE LEVELS 18 Specific Comment Page 19, line 1. This statement is generic and does not apply specifically to this chemical as implied in this document. COMMENTS ON DICHLORODIMETHYL SILANE At its July 21–23, 2003 meeting, the subcommittee reviewed the AEGL document on dichlorodimethyl silane. The document was presented by Cheryl Bast of Oak Ridge National Laboratory. The subcommittee recommends the following revisions. A revised draft should be reviewed by the subcommittee at its next meeting. General Comment The AEGL values for both chlorosilanes should not be finalized until the AEGL document for HCl is finalized. The HCl AEGL document should be added as a reference and cited at several key places where the derivation is dependent. Specific Comments A 2-week nose-only inhalation study where male and female rats were exposed to dimethyldichloro silane at 15 ppm (nominal) concentration is cited in the ERPG document as reference 11 (Dow-Corning 1993). No effects were observed, and this fact should be added to the document. Although this study does not influence derivation of the AEGLs, it serves as a reference point and would support the conclusions presented in the document. AEGL-2, Page C-3. Delete reference to modifying factor for steepness to be consistent. Page 3, line 24 and page 10, lines 8 and 13. Round LC values to 4 significant figures. Page 4, line 9. The death of one of two animals is formated incorrectly as the fraction 1/2. Page 5, lines 33–34. “Carbon monoxide, carbon dioxide, and silicon oxide fumes may also be produced upon combustion or decomposition of dichlorodimethyl silane.” This statement may be true if the word decomposition is removed. However, this statement is not relevant to the discussion of “Mechanisms of Toxicity” as it relates to AEGLs. The subcommittee suggests removing the word “decomposition” and moving this discussion to the physical properties or to the introduction of the document. Related to the above discussion, the NAC should take a closer look at the references in any mention of combustion products. Phosgene may also be among the combustion products possible with the chlorosilanes.