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Health Implications of Perchlorate Ingestion (2005)

Chapter: Appendix C Participants at Public Sessions

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Suggested Citation:"Appendix C Participants at Public Sessions." National Research Council. 2005. Health Implications of Perchlorate Ingestion. Washington, DC: The National Academies Press. doi: 10.17226/11202.
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Page 213
Suggested Citation:"Appendix C Participants at Public Sessions." National Research Council. 2005. Health Implications of Perchlorate Ingestion. Washington, DC: The National Academies Press. doi: 10.17226/11202.
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Page 214
Suggested Citation:"Appendix C Participants at Public Sessions." National Research Council. 2005. Health Implications of Perchlorate Ingestion. Washington, DC: The National Academies Press. doi: 10.17226/11202.
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Page 215

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Appendix C Participants at Public Sessions October 27, 2003 – Washington, DC Persons who made formal presentations Paul Anastas, Office of Science and Technology Policy Jonathan Borak, Yale University Olga Dominguez, National Aeronautics and Space Administration William Farland, U.S. Environmental Protection Agency, Office of Research and Development Karen Guevara, U.S. Department of Energy, Office of Environmental Management Annie Jarabek, U.S. Environmental Protection Agency, Office of Research and Development Desmond Lugg, National Aeronautics and Space Administration David Mattie, U.S. Department of Defense, Air Force Research Laboratory Dan Rogers, U.S. Department of Defense, Air Force Legal Services Agency Jennifer Sass, Natural Resources Defense Council Tom Schneider, Office of Senator Dianne Feinstein Jonathan Tolman, Senate Committee on Environment and Public Works Terry Troxell, Food and Drug Administration, Office of Plant and Dairy Foods and Beverages Persons who made comments at the open microphone session John Gibbs, Kerr-McGee Shared Services Company Hank Giclas, Western Growers Association 213

214 Health Implications of Perchlorate Ingestion Larry Ladd, Community Advisory Group for Aerojet Superfund Site Issues, Rancho Cordova, California Steven Lamm, Consultants in Epidemiology and Occupational Health Richard Pleus, Intertox December 12, 2003 – Irvine, CA Persons who made formal presentations Rebecca Clewell, CIIT Centers for Health Research Christopher De Rosa, Agency for Toxic Substances and Disease Registry Janice Juraska, University of Illinois–Urbana-Champaign Harold Schwartz, University of California–Irvine Douglas Wolf, U.S. Environmental Protection Agency, Environmental Carcinogenesis Division December 13, 2003 – Irvine, CA Persons who made formal presentations Jonathan Borak, Yale University F. Robert Brush, San Diego State University Patricia Buffler, University of California–Berkeley Kenneth Crump, Environ Kirby C. Donnelly, Texas A&M University Andrea Elberger, University of Tennessee Health Sciences Center Matthew Hagemann, Soil/Water/Air Protection Enterprise Steven C. Lewis, ExxonMobil Biomedical Sciences Richard Pleus, Intertox Sam Sanderson, University of Nebraska Medical Center David Ting, California Environmental Protection Agency, Office of Environmental Health Hazard Assessment Douglas Wahlsten, University of Alberta Persons who made comments at the open microphone session William Campbell, Tohono O'Odham Nation Water Resources Todd Croft, Nevada Division of Environmental Protection Bill Gedney, Southern California Water Company

Appendix C 215 Dan Guth, Boeing Company Gary Praglin, Engstrom, Lipscomb & Lack Harold Schwartz, University of California–Irvine Renee Sharp, Environmental Working Group Lenny Siegel, Center for Public Environmental Oversight James Strock, Council on Water Quality May 24, 2004 – Woods Hole, MA Persons who made formal presentations Jonathan Borak, Yale University William Farland, U.S. Environmental Protection Agency, Office of Research and Development John Gibbs, Kerr-McGee Corporation Curtis Klaasen, University of Kansas Medical Center William Mendez, ICF Consulting, Inc. David Ting, California Environmental Protection Agency, Office of Environmental Health Hazard Assessment Persons who made comments at the open microphone session Dan Guth, Boeing Company Steven Lamm, Consultants in Epidemiology and Occupational Health James Strock, Council on Water Quality Carol Rowan West, Massachusetts Department of Environmental Protection

Next: Appendix D Sensitivity of Perchlorate-Induced Iodide Uptake Inhibition to Serum Iodide Concentrations »
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Perchlorate—a powerful oxidant used in solid rocket fuels by the military and aerospace industry—has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by inhibiting the uptake of iodide by the thyroid. Thyroid hormones are critical for normal growth and development of the central nervous system of fetuses and infants. This report evaluates the potential health effects of perchlorate and the scientific underpinnings of the 2002 draft risk assessment issued by the U.S. Environmental Protection Agency (EPA).

The report finds that the body can compensate for iodide deficiency, and that iodide uptake would likely have to be reduced by at least 75% for months or longer for adverse health effects, such as hypothryroidism, to occur. The report recommends using clinical studies of iodide uptake in humans as the basis for determining a reference dose rather than using studies of adverse health effects in rats that serve as EPA’s basis. The report suggests that daily ingestion of 0.0007 milligrams of perchlorate per kilograms of body weight—an amount more than 20 times the reference dose proposed by EPA—should not threaten the health of even the most sensitive populations.

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