National Academies Press: OpenBook
« Previous: Chapter 2
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 48
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 49
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 50
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 51
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 52
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 53
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 54
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 55
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 56
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 57
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 58
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 59
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 60
Suggested Citation:"Chapter 3." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Korean Edition. Washington, DC: The National Academies Press. doi: 10.17226/11385.
×
Page 61

Below is the uncorrected machine-read text of this chapter, intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text of each book. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Y~1 imply ~4~ ~~ ~1~ ~1 ~ ~ +~ ~~ Veterinary Medical Care ~ ~~ ~ ^ - =~7~°n °1°1~1 4°7~ Stile ~~ Prolog ~~ 491 ~9 7~ ] ~ ~ id ~ °~| ~ id ~ ~ o1 'e i? ~1, 0 ~1 Hotel ~ O ~(Surveillance). Z If, I'll. ~ °240~7!'H~ ~~ 11Ho~31 0 ~r~S~p ~~ ~0~. ~°' ~~ ~*=o°1 O off ~1 z1 0 4~ = O ~;~1~ Act O °~d ;~0491A171- 4Q]~ ~E1 w~;~c gqOolitl~~ old ci!5: 491~(ACLAM By. T; B)ol71~ ~e~/~1~(1aboratory animal science and medicine) a: ,~ Argot Hi, *~ ~ 54 ~e] On °\ ~~ of 5L| A!Q1 o1 ~~ TSll ^~ ~~ ~ ! 7 Q3 P| °1 T T4s~lAl7i ohs 0. Own 9.|~;8 Al7~!io3 TO o^1OLt, .~5!| 717J. cam. Sting ~~~ ~AaA1 +~lAlql7n 70~ol'R ^|~0 ~~:76~e row ~o8, Zil7i4;g HAHN S!|At~A47~7t ~~°1°t my. 45A, ~~ ~~ ~ t§ 77t ~ ~ oll711 al Boy ~ ~7~, ~ 79~, 7~178. 71~ owl =] o~iq-Ati~ ~~o° ^1~ ~nOi9R°) Em. 7ii~4~1~1~ 4~r=~7~34 ~~ ttBlqn Sty 01o~of Id. . If, TV (Animal Procurement and Transportation) '= ~~ me 14Et —°48||°t ~~ ~4 {°171~ ~~ +01~ .~ 75 e~71- ~4~Z~ ~A7Oi~ OlT0171~ ~ —Perot Its. r'l~*mm(United State Department of Agriculture:USDA) Class B ~ ~eEl\5T61 ~OO1O1~ 7R~ ?°1 ~ 70 T 7R All ~1 Me °1 51 Al °l—~ ~1, ~A] ol L} =7 °t ~ ~ ~ . '1 ( 7R Al ~ O O ~ C-7 * 31 ~ ~ I ~01~ iF;717.1 . q7-~ T)521 ~~7O1 OAR,—-Aim ~AtoROt ~~ plot 7~8 ~ ~414~ FOR · ~o1 oR~ol0~7 TOJO1 TT°~7her He f a Font ~1 Bed $l71Q1 ~~.° ART °1~ ~ °tAi~(Fish and Wildlife Service)oll Ql°R 73~ °~+ ~~ ~1 7,JAl=~°11 ~01~ 7~1 67 An J 6:i'§ (purpose-bred research animality A(§ol 13ti~yOl.1+ G~ - ~91 Fly oql lR~°4 rho 7!~ ~~0~0t &1-~ 741~ am oit7K on: USDA Class A teal) ^~$2:ol~t ~7~ill5~ fall ~~ DO Stat o7~ by 7i§717~ 0 ;3 Typo ale °e~77OJ ~°11:~. olS Pete 70 ~ ~ ~~ OTT ~~ TV 7e704 ~011 *~81~ . 71 ~~ a: ~ 71 HIM| o1 and 5! rR ED TV! ~(~1 e .: ~ 2o7e7i)S~ ~|T^)oqlAl~ BALM ~Z=r to my. 62

~ 5 ~ Tare ~~ :71 ~t41 1 ~ ~ D By ~ ~ ~~ Tamp BEAT :~1 ~~ D,! A! TV * )! 03 if! 5!1 #1 ~ Q ~ +~1~ ~~ ~ ~73 ~ ~51 ~ e TO ~ ~1 ~ ~ · ~1 ~ ^1 D T e ~;~1 ~ '1 ~ ~ ~ a: ~ ~ ~ Ail °t ;~ °i) T f ~& fig ~ e an ~ ~ ~7~ ot71 By. l Cl ~ ~~°1i T5~1°~ Reilly= ~1~34~1 ~ T He'. ~~ ~l(shipment)^l ZtZ)~ ~ ~~ OF ~\~4 —01 At.~34 OD A(? —~~ ~011~ ~ . ~~ O ~ 1 e ~~ 11 ~ ~ =^] On I4~ 7Dqq Dig ~^1~ ~~ ~iFe741 {0111~ em ~$A14!Q ~1~ ;71 $1811^1 1~T. To ~ 71~7'}521 5~~i71- =~°~. *~71~"D(AWRs) D~ ~7d1~ *~D(International Air Transport Association Live Regulations. IATA. 1995)~ :~ ~D~ FA1~* ~;3 m~°ll tt~J *'m^~ ~°1~.~. ol93ql Cg;~5!1 x01 ° o~1l~o~(PHS, CFR Title 42)ql Q1~3 ~74~ T~q3 =~tl(tuberculin) 7=Alql tt~A1 . ~l~ 71 D 3 ~ 0~ ol °~(CDC 1993). 11~°l(African green. cynomolgus, rhesus)QI ~OD D~ T - ~°1 ,1~(FR 1990: CDC 1991) 2. 311~JaI ~ (Preventive Medicine) ~ o °11 o ~ T~ ~47a ~ ~ ~ ~ ~ - *o| ~ ~3~7d °,] °n ~0~ ~` ~ ~ ~ 0 ~ ~ 0 =~ * 1 ~ . e 0 i] ~! 0 e D O ~ ~ ~ _ ~ ~ ol ~ ~ ~ ~017.~ ~ 7dl 3 ~91 ~ 1 e ~ 3 F~ °~1 ~ 3 8=t iE ~ 7, ip! ~Q 7D ol F34 D~ ~: ~ ~ 7 74 7170 ~3 ql r~, ~7g ig s~ ~i~ ~70, 74 m TF i] 4TT ~o~3 - ~. ~d~. 2-1 7~1Q1. =~, ~i (Ouarantine, Stabilization, and Separation) 74 1~ 1= DTi} ~V~ 71170t ~) 113/oq4i4~7a ~T347( i70~ 1i~7i~71 ~q 59, ~31 7 ~ 14 ~ .71 Q D~ ~ ~70 °1 7D ~ 4 D ~ 1 ~ ~ ~n~ 4t=71~ ~ 7~01~, 4~At~ ~R~ ~T~ - 4~ 78701 D~ ~l~ov 84~6, grc'~ ~70d ~ f o~ °1 °t ~ . 7 7D4 0 7 - 7.~ T~ ~477 0 ~ r40~ o~ T 0 ~7d OD ~0 J) ~ °1~ D T(')tl)~l ~D~ql ~—P1°t ~CI(Butler and others 1995). ~ .7aO~ f40 7-471~ °37~—rq| 7d8T-5>CT3 At~403 °.:Ti~ i51 ~ Oq ~ ~1 ~ ~ ~ llt R °t tl[4. °o3lTr~ 70T f~lovirus!4 mycobacterium74CA 3ilFq' ~7 003iT ~d~q| ~tt ~1l °~}~R~1~ D~~71 ~°~T~(CDC 1991. 1993). Tg3~q~ D 73 J. ~11:4 ^~=°r=~R ~q 7R \017e T ~1~ 7 7R?l~=^oa34 7~3°7~ ~'491 71~03T~ 7e70~T31~. ~ 7~3*~ 70T~ T 38e~~3i43e~ 817dl7;173 $1-oic3 7R5}'~7R~ (Caesarean derivation) f 3'~ °l ~ ( embrYo transfer) ~ R ~o Q~ 73 3'7171 ~ 7ito3 o ~°= Al ~ mE1 =7=q ~tt~ ~tt q763n ~ 3 ~ol.of ~. ~71 ~rql ~oR^1 ~ 0 ~o'4. jR iE3 TE 7,~7t ,4~ 7=A~e31~olT4. OD11~ ~S!| 7~!7Qi~T~R7f 3~71 ~30~ 70T ='J Ti r1^a~qi 907T, 7~ - ,3 ° 3~T| ~E4~ 70T 7e° := ~dq~4 f~ ,°~lT~ 77Q4717 ~ = ~J~ e =~~1 o1~ =471 $17r 7 ~74°f t;:~(71 A11 e ~ ~ ~l ~ QVIT4 ) 7D4 O~ 717 ° O ° ~4 D ~ 1 R ~3 ~ ~e ~ Dql AT§7171 ~ql ~a~ 76,, AD E47= QO30QL;!3, 0~13~ 51~ F~717111[ TO1°! t[T4. F~717J~Q ~1~ fg- 301~3ZE J:~^1 7J. ~F~ At~ =73q| T9l; T]3e f °1T3 II1T>~ ~= 711-1~ D~ A~oo~q~^4, F~7I7J Qn T R t~ ~L ~ ^O C) °I r 1 O T]Q ¢1 ~J O T~] . T] ~ ~V.~q A1 ~ F33~71 7JOI ~ ~ ~ 7;101 63

^1~J (Drozdowicz and others 1990: Jelinek 1971: Landi and others 1982; Prasad and others 1978; Sanhouri and others 1989; Tuli and others 1995; Wallace 1976). ~~7~k9] 7=-to~ =~ ~~ 'TV 0 ~ 0~ ~~ Din Isis, 8a~7q Joule T71 Ids ~~ 3~ 73~7t ~7~ t,3~ 7~ 9$~°13 T88P4. ~T~7(cubicle), Elrll~ ~ ~(laminar flow) ^1'$~7'1. ANTE 73tj3~714 *3,017l, otol9~B,3~olEl ~ 7~T03 ~ fR<!~ T 71~ 03~ ~ ': ~1 C3,1~ ~ ~~ ~ -~-~ol 7r~l'~ tb i~ ~ ~ Twirl 8S ~~ ~1 ;7 ~3 ~ T ~ ~ 70 T. ~ ~$ ~e°~3~1 Alit ~~ *91 *gee ~1-$8J +£ °~1~ ~Z1Ll owl ~~ ~ ~ o\1 [13~blC~ —~.~ to O e! t31tS~ ~tdilyi7.1 =7114 ~t37Jo3 0 ~ 73 if tb~j3~lEtS Hi. . ~~ O Al 79 D~Ol D~7~1 O 01~ *eA|71 ~ IT 1~. ~.$ 4 q3 are ~~$ol bets Olaf TV = O Bordetella bronchiseptica~ e ~ei:71qjA.l ~~J 7JquJ~ *t3J50~77l~ 71~q aft ADO ~371 Is °e°~(Manning and others 1984). O ~81 1 ~ <~ ~((D~17;3~), °1-=ii17~7il Tee ~ 01~1017~31 TM]* 0372~e o 7474 73 1 h}~93olot Off. 431`F em Idol ~03 simian hemorrhagic fever(Palmer and others 1968)QI (!wol D~qT7~ t3PlZl~ (simian immu -nodeficiency virus)94 AT (Hirsch and others 1991: Murphey-Corb and others 1986). °~7t °o~=q3~1~ I! 74ODO~71DJ o~lol ~q3, A1 ~t-s ~J~. O ~e 71qq]A1 *ip3~ ~(~)ol*~;: 7~ ^~$501~ 70$7t di] 4135 ~d ~i~l ~wol (Saimiri sciureus) ~ Herpesvirus tamarinusql ~F~e3 7ci$ 7ett'7J0D~ ~Ett1171~, Herpesvirus tamarinus7f we41P1 9clwol(Aotus trivirgatus)(Hunt and Melendez 1966), °eT P=~(marmoset)32t E[Di?4 (tamarine: Saguinus oedipus 5. nigricollis) (Holmes and others 1964: Meluick and others l964)qR 7.~5101 7,1DO7SO,] ~7,40=ts~ ~te~4 T ~o~Tr1 ~ol td°t351°l rS~51 Pl~a~ ~i5R71 ~ 70$. ~e ~o°lEt $° ~7~° ~ ,°|~ oR3s e - D,, S(t—Q1 8~°Ifx<!°= 3~0l~l_(sialodacryo denitis virus), atm^51 7J0=t3Pl~l^(hepatitis virus). ~ 71~3 Pasteurella multoada, 99+ol(Pl71~L ~r: macaque species)=l Cercopithecine herpesvirus I (~t~5 Herpesvirus simiae) D' ~71QI Mycoplasma hyopneumoniae7t ~. 2 - 2 ~e~391 7~A|. 7.3~ 7;1~33 ~Z| (Surveillance, Diagnosis, Treatment, and Control of Disease) . ~= ~ 7etso3, ~sR ~ 0l<}8a~51 =5~ "O ° ~lt33~ T °] ~ ~ AtZl =Io5R ~it!~1°iot isJ~ 71~7¢ ° ~ ol51 ~° ~° ~R°1 °|T°173,°! O!71DJ~ T~ 3~71~ ~o1 ot_~ ~3X3~7~ 7,3~01 °J. 703$~ q~ \1 7tm ~J~ sRof ~ol ~QlAt4~qlAl At$3,a 70$ rO~ 7~\ 733~11ql ~ °e~Z4°~) ~o1 03~ 70 $~ 71~. ~! ~D ~ ~ ~ ~°R 74 rS ~ql ~ ~J ~ ~D ~ ~ ^~ ~ f o ~ ~ 7lr=7~ ~ 71 F T ~ - 7et307D~^l9t 71~ql 7A7,JT~ tb~t3t3 e 37ef7= ° ~ mDl~s~ 1 ~. 4 7171 ~ ~ ~5L] 64

At 3 ~ 44 ~~ AiDd D' ~~ ~~ Be, 7o9^47~0J ANTES ol~O1 °le 70$, 7~ T~1~7A 7.1 il 7( 7~ Al of ol Till 7a T A| ~ ~ ~ Al ~ ~ ~1 ° 0t ~~ ~ D ~ ~ J' ~~ ~ ~2'0 AM 767d~ ~~ I, DROP ARIA 7~17t 7~0D~1(oil Oo~7d '°nA1 Mycobactenum tuberculosis)°ll ~ I CA~o1 ~~ ~ ~.0 If, 7.1 Dig ~~ ~704 ~0] al ~ 1 7171 gem hero Bird 7-J~ ~ Al ~ rid ~ ~ ~~ +~ Ol~Joll~l ~*~= 7> 2'ololo~ Add' (gross) Melt, (microscopic) Owe ODES rOd6l~ trout DRAW GUAM };~:l,~ot~ ~8A~ 7AJ~ A1~1~7F —~7~ ~21~ =~ 87 ~e T°~ ~ ~ 7;1 ~ ~ ~ AJ ~ ~ f ~ At~ Ad~ ~ 7e 7C ~O~ Ot ~J~ A~ ~d ~ 7il ~ 7~ ~ ° 71 ~ i~17A O i~ ~^e~~ Ot ~D] 7~ ~D °11 0 <! =~ T71 ~ ~ il i ~ o V D e ~_ 71e IllA9~ 7JCD, ~isl ~°l61^ 7~0V(T~ A 7J~) 4!!^l'8(conventional) 3{t7~45!1 AeAl~onA1 7'1T ~A98tA1=], ~dRi~l°~(barrier)~ ~ =~O1~ ~7-AdO1 ~t 7,4$, 8~7g rO~ '~r(specific pathogen-free:SPF) 11 7.1 ~9q Aa AJ31 ol -~-~ $q ~ ^2 ·2n ~ ~ ~A1 ~ ~ A| ~ c|1 A1 ~ D| A9 ~ 7D V ol 2 o ~ ~A~ 7108~ - ~ DJO~^ A3~, Ol~4 ~ ~ C~m ~o e ~ I le v °D~IIS1 ~1i3~ Sendai virus, Kilham rat virus. mouse hepatitis virus, IymPhocytic choriomeningitis virus, Mycoplasma pulmonis~ c f ~°1~(NRC 1991a,b). ~ 704 _i~ ~ eql ~Et~ ;3~7= ~ 7=, A2 71$~54 == 704 7~1~03 7VL0VQ] O'~ -OD7~1ql ~]~ Al~`J~ E ~g] OtCg~: =* 7v~°J~o1 ~7~1 r 7J7d7=A1 Te] _ ~7c;l ~70 rOdgdi! T~R ^4A1 rr~ *Zi8~ 7v~ovcR74=' 7] 66~. ~ 1 1_ v ~ 4101~ T 4 rOl~e ~7O7vAtol~ ~R~r8°~ - 7~rS~84 D~ * 7~94(polYmerase chain reaction: PCR)= ol~ofe DNA ~AA~T 7J° 511 7v\°v, ~0~ ol~ rO~ e ° °v Ado,~ - ~ ~r iD~ ~ 70A ·4 ~j~ql 7~70t 7 oR°) ~ z~ol^'^Oi ~OOt(transplantable tumor), hYbridoma. cell line =~ 71 Ao4~717R(biOIOgic material)~. ~7lTr ~olEl^(murine virus)91 ~(source)°C~ A1 ^~A1~4 °°=A17e T Al~(Nicklas and others 1993). DiT' 0d7nAaA~(.MAP), ;~e ~7'4^]A~(RAP) D~ 69^E1 ~inAgA~(HAp) Z=A}e A]4~7nA4~ otOiElf OOV ~El13~e~R ~7A0l=C~(de Souza and Smith 1989: NRC 1991c) ~4~oR u`~ 3. ~ ~ *1*1 (Surgery) f9i~7g 74~. 7~9d ~i~$. T~7~74~ ~7A 717~1~. ~=Z1 v~( °eP~~ 43 CCE5~ ;4Zo4 ~°d ~91 At~47A AdE' TrqR tRi}~4' T~Et~ ~7m x171~' ~J r ~°~= . (T-T A ~— rD$T,, TCo~, Q1;?T7 71711 ) olE1~ 9*4=Q] 74 °C~° elf g-7e7~5q —T~T7,99~T ATT4S41= rOC4~0R DIE} rTOo~ot7R LT~. T~711~qR [R~ D ~ ;^ie 7 71 T:~ 7,`1~AlAl e 7~ Ati - ^a 7D~^l7v ° ~ f~ 7e~54 Ao ~7>T- A@* ~04 7r~(Brown and Schofield 1994: Brown and others 1993). 7A7e~ +~°l A]~o4~ 7AAlq~ 3jl70U~~7> ~A15a T 01~ 4~T 4~7=i49l A1~7~0J 3J74IrJ §c33 7~7t olTO4~740t ~rT. ~ it 1 ~71UI~ U~~7O°1 Utig7~71L} 9:R~I T~ AAA1 J(°R~ ~ ,. J71~ ~I, o~ Ts~), $A~!7A C ec ~4~.S~ rmcAl~F 37248R0f ~— Ti~71~ J70A17a 70$ 7a4;4qR ~R~ §o371~ ~1~ AJ'ERO) 0~, ~rO °~,n L~EtL+' olA] *Uod 65

~~ ~~ x~ ~~ ~IJ (clinical morbidity) =~ ~q~1F(mortalitY)°ll T7|6~i olvd dials] 71~Q ~R~R6 of i.~, T~7, ! ~ ~ >11 A! TED ^1 Al 91 ~5!1x~, Utah At. TSARS. Tam 3~. ~~| [2 $!T71* ~~ T~ED1~1 ~~ T~!°1 ~0~6loi U~(Cunliffe-Beamer 1993) TF7~ Te8A1 °Iq ~ Ott :;il*°:~ TF°Il Del $~ ~D19} arm. TF01 6361 He Am 71 ~ 9~. TF7~ - *~1 717~7t, TOT ~ig°~ ~6R 3~0~6'ot ma. (Brown and Schofield 1994). W 9i7~ 7e~01 ~1I~DII '21~ °~ SdDO1 IS T $]F §~4 . ~ 17]714 ~qq~11~ °9 ° ~ T °~ ~e\!Q ~ 7g ° TF7;~°l1 6Dl~a7,lR'3~ eTO4~,~ 710| 7~7ei~ ~ol ~e T ,J,~(Klement and others 1987). ~ 61~ T~TF~ ~l8D06~ 7DT ~^D>~ A1.~ ~81-7i1 ~°~ T~ ,°~}~q- T~T~D3 . =~ ~ ~7~41 D . ~7~7e78sil i~ ^3~. 715~ 7A7e7J At~ E~7] O] 71 6a. '~-6=A1 ~ *6~$i26~ E'94 7D 840 At~ ¢~ 7iL01 TF ° ~',R, ~ T 01 1; ~ °,.!+ ~ =*Al-71- ~ol ~02;~(Chaffee 1974: Wingfield 1979). ~F^e~1 TF Q ~eA|ol~; SIT~ A12~ ~D$1~ 71~] — 77cT~. ~ ;;1~ =~ T ~Ff FoR ~7~ oR~ ea~. Ati~TFofl ~i~ ~ At~ DRT84' ~a~. r~l701 Q~: 7 73191 E:iT TF1~ 40,R~ Ja Sl ~ ~ 71~ 7.~01 °11 ~ -7 ~ ~ ~ ~ °11 ~ol i,7. *~~ O ~ ~ 7t °~lq 747~ 71 FT~°I| 61IT~ TF~ 7.1 ~!A1 ~ 711~ _v~ . 2;P a R ~! Bi~ 71~toll ~°1 ~a T ^1~(ASR 1989). iFw51~o~709~(PHS Policy):il ~F_ 71~D(AWRs)~ T~= ~eAIBl~ ~T7~7( 7 TF71~D°11 ER~ 7~7aiiJ 7~7~ Q] tl7'~ 0 ~59 ~7ad ~ $1 ~:~ (]ACuc) ol|A1 =~7d, ~ ,7, 0~ °aD~ ° ~ TT7a7~1'°1 ~* ERTF~ (TF~ ~TF!:I~. ~a~D~7coll ~* ~a . f F~I 3R`~! TF~ ~1~V *,R'~\t T ti. r8~a~S Tw(major survival surgery) . ~1170~ ~71~ ~A171~. ~J'7q70 ~,_ ~ai;7m 71~o9| ~a7a7m 701~0R~ *A4Al71~ f Fe~ `4~( 7R ~F, 7R ~F. 7R T9i~. ~7 - 71~. A>7| 7e~F) +^a~ f F (minor survival surgery)~ il|70~ ~Al-717.l ~11 °~7J9] ~J7,R,7d ~o~vJ~ *~ 501.71L| otoR i~o,R,~g *=rt71 °~ fF7 i~(~o~ ~ 04 ~. ·5~77OII 71*,R~ ~ 74174 ~ ~! ig71~ =~. +~°V~ ~o,R~Al ~ 0~77OJ f f F ~ -25- ]'p—F t9 ~ ~ ~71 ~2Q ~7.1otollA1 ~e^1 ~ |7~1 ~ 0~71o51 Ti ~7451 71 T 7778 =58 ~49 7t 545 Q 05~. ~ 70~70 ^1 F°1 ~ Q] E':~* 7 ER ~ O ~ A1 Sa 71 ~. _ 70F~ Tit~ 70 T T~77 ° ~ ~e^| =5. Dl~a. (nonsurvival) f F°llA1~ ~ ~o|A1 ~!;471 7,]01 C~l—~Al.A174ot . I o. fF~ ~A1~ 70$. ~ 7ol0RA1 °,~ 7= 71~=Q~ VJ~:A1 I4~ ~.o~ o] ~14~ 4 FT81 . 711~81~. fF7t fF7~7DI~ 7~850t 17 4 F71T fFT$] ~ D7~7R *718Rof ~(SIattum and others 1991). Ttl~7 ° v~C ~ °J°R —7 7~01 fF~77Ddo1 °T~ R4~ ~°~ o31= ~r~. S4T RA1 Al$~7, £oF~ fF°R°) ~._ 70T o£F~ fF4I~ ol <£,~ 7,JC] £=o'7 ~ ~q~D~ ~? f °,AO~, 01~7.tA47t ~71 C~ +~ °~q ol5i 7iL0 g~0 =7 °J~R D1 ~T 7D ¢7d 0J ~] 71 7t ~= ~ 5°~ fFT 0~03~ ~ '= ~ 5~ °~7a f 7^1~ 7~ 7~ ~ ~7 al 41~71 $i o~ +52| ~47d ~1~o1 ~e hA °5P] Ti;{+F 71 ~A .° r~| ^o~ ° °v ° ~l ~t!— ~7 7V~^A| -71 7l $1 iS~ °l *~c!~(culiliffe —Beamer 1993). TF7~7Z~. 717 +£7 TF~ ^4~71 (t£o ~ 7Q~ 7j`~ Q7A~ o1 F f °~l~(Schonholtz 1976) . T~f F 71~3 ~ fF~1°' OD e~ ~ ~£ T~D~ 401~ ~73aQ =59~ ~(Belkin 1992: McWilliams 1976). 7 °~T~ 7104 66

~ 3 ~ Tact ~~ 9 ~ ~ f In ~~ t31~! At. 7tl ~ ~ f XT#I ~ ~ ~ zip, Knoll tll ~ =131 (Hofmann 1979), +~ few. Off And, Dais fF~91 ~3~ Z='e fF7-i old crop =~31(Chamberlain and Houang 1984: Pereira and others 1990: Schonholtz 1976), 717. Amp, ~llMlm°~3F3'4 Dd~(Kagan 1992b) ~ 71~3 7~0 ~ ° - Me fF711391 °l§(AYliffe 1991: Kagan 1992a: Ritter and Marmion 1987: Schofield 1994: Whyte 1988)°1 ~~fw71~oll :!. ~~ ~91 ~~ ~Ao3°ll ~71~ ·~703 ·Da~6 o ^~iql388ot ~h4(Schofieid 1994). ~°rtD3~34 7~D3~°1 °l'J7~0~] '30~ol~. ~~ ~171~ PAR ~~ ~ o1 °lTol~le71 ~4°~]o5~°~°t eJ~(Berg 1993). §°3~ ~~4~4it73~ ^~64 AT ~8J ~ 17JF 7134°Lr °|~ 71~. AT~ ~°13' ~TA ~°3f(saline)~ All~ °ir tT~. °et R~ ^4~ital(sterilant)~;: o~l=1 ~O'~ ^3~73,1~ °t']~(Rutala 1990) 01 ~7a 0 ~ °1r~ o3§:l~p~o1 °~5L ~ ~ ~F5~ ~ ° tt P ~ ~1 ~'~61 0~!709~17~1 °~ S] ·~ (lACUC) O13~ ~ on3 ~0~ 7~1 ~°~ ~ 733 T. D1 Ae~ 71 ~1 T~+F ~ ~ 7~ O3 ~ ~ t~ A1 ~e ql ~ n,~ ^1 ~'87n °Lr tl~ T18 m~St1 A1l ~ ° 0 71 O-D 2~ Dn 7'Fq3' 3~4 ~133 ~ }~' 71 D n ~ q3' fF^l~ ~ io]7l o~ ~ ~ tt ~r3' ° ~ +~ L]OL~ 0 ~3 87,1t4~ 7~3OLL ~1:} (AORN 1982: Bartiey 1993). 7gm°131 ~ ~ ~1°~ TF~1° ~q*~L f~ ~ . ~ 7ee 7DT. 4Fe~ ~Aa~ TFF $1i~b3 At8~71 7il t~1 ~79~ ~th ~! *7.1 iL1 7~ 0 r t ~. A4I ~D tt f F ~ L] E1 ~ ~ ~ 7q] ql cR ~ 7A 7~ ~ T~ e f F~ ~o o 7 ~ o ~D F ~04 T~. 51- ~ ^0 ~ 5!F ~D ~ 71 w54 7D~D4 ~ O Ao ZO~O 34 gE'91 rD 7~7~ ~ L] E1 29 °11 ~ ~D ~ ~ 701^° ~R~ -71~ ;!61 ~9ol~, Cl~ ~oR 5~74O~ ~DR °tr71~ T ~ ~o~ ~71 70L81F ~1~ ~ T °I~(Dardai and Heavner 1987). ~ =~°~ rc1~- fF ~r<£—~r~Ol~ :;LAD p^5!t 70L~ 7~ ~e~71~. TFo oql Rt ~ I *54 ~o~47A 7=f^D~ 710~: ~789l 057.17t ~. ~t~oq 7JOo'~1 fw'~ o;4 0~77e34 TqR D oF rl~ f ~e a|~7~71 ~° A°~ ~ 38~ t~ - ol °~71~ f °~ 7~1~71 7RAI~IM ~l~(Beamer 1972: BradDeld and others 1992: Cunliffe -Beamer 1990: Waynforth 1980. 1987). °~UJ7~0~l ~I~3D4I-~741F TF91 70$0R ~ ~ e7~T$~ ~ TF8ol. ~f~ ~FF ~Alq3~ 717~1~ T 01 051 7~L~BJ f w7e7~lQ~ TL~ =~70~ 7~71M ,°~],olA1 3~ ~o4Al121 TF~ t4~7 _~ ~= T~ 71~F ~D~L f ~l~(Brown 1994: Cunliffe-Beamer 1993). ~e71~ fF°I] tt~ C1~ ~ f~71Y1°1 ~OD0174 +7R~ol ~I~(Cunliffe-Beamer 1983. 1993). 0e~7= 0 ~ Aa~'L O`~=OR At*~71 $181<i *7~1~e ~70~ ~ 7D°R~1 ~ o~ i] o 7 ~ o oL o L 7L D Lo A 7L 7~1 D. n ~3!S ~7151 1~ 1|A1 fFtiR r ~h 1 . ~1~ D <3f91 ~ o ~ o D O ~ ~ '~1 ~eA1ol ~ ^}e °e~ ~+F51 ~+Fe ~§F52l~ °~703oll~1 ~|~ ~o7 f g 7~ 71 t3 ~e ~^ OO 73 ~71 °~Lre ~71~o||~ ~ Ae~1 2~.L f ~ ~7~Lo3 ^1 f F~ 70 $o4~ ~F21 7170~3t *712 $]—°R 7 7e~ T~71LD. 7.~7D7q| 76~74l Di4q7n5!] At4 0,~ ~F5!1 717034 =7.|°0 o2~)F D17.|71 Dle $~D°~|7~ ~7|7001317} :~L R ot~ —1~L~ D] 7104~1 °~ii[! i~3330— fF~ ~ fFDoLY=O1 TJe^1 ~-~ 7.~° °~Lq~ f F7-4~ ~ f F 4 ~L]E1~D ~ ~. tt~(care) ~ 7l~7O~54 ~D774 °1B1(! ~3T ~ T 2a~ 7~°1 5.371~ ~ ~ ~R81 71F ~E! ~7~5T 4T~ ~ ~ f F T #~7F 7~7e61 ~ D {t tt8~. f F T (~ ~O ~ ~ ~ ~ )FF~ ~ ~ 5~ ~ f F ~ ~1 5t~ ~ 71F01~. e0UJ SLL]E1~ ~ 70L~= Xt§0~ ~ ~ 7~71°§ ~ ~ ~ ~53 f F ~ ~ ~71~T 67

,~ ~~ x/~ ~~ Em D~1 ~q~Zlol ~1* +91oR°f Em. ~1~ _ 71°n ~° ~~ ~717F °~ Poll TO ~~ 7.~7t ~~ of omit Am. Deborah ~~ ~°d ~R¢Q~72. ^ =4 ¢1t 71~. Tow ma' DEN ~°~°R ~R°R ~ -Sol tt~J~ 71~°101; Am. Tom 7~! ~72 Otto ° $1isJ 707§ T_(FBR 1987) . ~J~1 ~2 °4711e=~ TOl f~727R M91 tt61 =4 7a72~ 918~ 71291 ~71g ~~ T7F ~7! ~~ ~ ~ °ill 1: ~7 l] El So 01 ~ ~79 O i!! JJ ~1 £1 ;A1~ °~ ° ~ 71 ~ ~ ~1 71 ~°~ ~ :'l HI AIR . T~$ ~— ~E|LR~ =~ ~ 7003 T~T~ ~El. ~CR(~. banda~,lng). ~ITS!1 ~2~(~) ~ 2~, ~5R~ 7R71 =°n T~ 71~ol°t ~ ~(UFAW 1989) 4 ££, 7:!~, ~1~ (Pain, Analsesia. and Anesthesia) f~4~^ ~91 ~f7~01 $~ '2~1~ f~oll ~uJ~d ~ R~ ~ ~(~) °1 i~ 7,gi'7= 0 ~ ~7= 011 ^~} ° :~71 ~ ~ 7~=Mo o1 J ~— 7~ ° ~ mE1 71 °J ~ = *~z54 °.] 70 ~ ~ D21'~. ~ 70 iS3 ~ ~ ~ o|| ~J9 i5~ =~ ° ~ 7§ ol1 ^1 ~ u~ol~ ~—O2O~ f oAA~ 7~1~ $~1~ ~1311!1~ 8~- Ee D4 ^5 1 ~ ~ °~! ol D] ~!4 7~1 °~ ~ t0 $ 0A 7§ IS~ f ~rel ~ e D4 _ S) ~~ ~ o i j! ~7 f 7JC|, T4~1 ^2~ol|A1 D}~781!4 79~701s~ 7~79i~ ^~8 ~Ei7~47~ ~r~ I 1 9~ r~q~l~ ~ D4 ~ 7=~7~1~ 7037 (Recognition and Alleviation of Pain and Distress in Laboratory Animals: NRC 1992)l ol~ ~ol tt~ 71 tJ 7~ 0] ~ D~ ~r~ 72Ol1 i~l~ ;~o3 ~ 71- 71 ~5;i ol ~tti(T ~ A D ) . ~ 11 '1 ~ ~5~1 71 ~ ~ ~ 7Aa ~:°1 7474 ~E1~R ~ D ~rg . D °lrl(Hughes and Lang 1983: Soma 19874. ~r°n ~ ~°ll ~q~ Y~ - o1 ~OO~7l ~1~o4(Breazile 1987: Morton and Griffiths 1986; Wright and others 1985) ~°~8J *~°n~1 ~ ~70~ 71~ Z~7~1 °~, ^~1~ ~D8, 3il ^~ ~=olL~ °a~ Y]~ D3l70~7~0` Ql~Oll] 7^~^11. YlOl~o 7~° 79201 ~o tR ~ 2 T ~r°l ~ ~a~ ~91 71 ~; ~ °1 §~ f Mr](NRC 1992) ~6 31 ~ ~= :~ ~ ~ At O=~ `~ At2=' ~¢ ~ r~rO] A,] ~ ~, ~ ~ =,) ^a ~847~ 71 ~ oil DRm$ il~8R°t ii~ 79°l~(Dresser 1988; Dubner 1987: Kitchen and others 1987). L'J7~0~ ~ol^~ol ~0 71~7i °~6374 0171 ,°~71~1 ~-~ 1 ~ °~== 70$0R~ ^1~40|7nA1 ~= of 71~ f~7~717t ~°IlAl~ ~ °171~ f 7-1~ - 70~ f °,l~(lRAC 1985). 0,~5~ tE~47AoJ D~8 ~AotA1-7l7Al °= ~ OD~7~ 0|~79o] ~ 7^1~ Dg D}~Y~Y~ ' of71 $18il^1 71T7~ ~17~iQ +8R°1 ~. 71~^1191 f~1 ~ f~ T +~T$5!1 71~7t ~r°~2 f AA~. *~' O`~EO. ~9:1 SoERQ~ 70~, =~7<A, 7 (tql ~R ~ ~ ~ 471154 ~, +~r^1 7J. ~ql tR ~ o47n 91 0,~73 Ao, ~ ol ~a q ~7= 72 ~ 1 fs~Q ~ ~ 2 D ql ~R Q~tm2 703TS~ Z~°l ID;Q S] ~-'ql ~ R °4~154 . 2 71 ~ ~ ~ ~ ~ ~ ~ ut#1 ~ 70 $, 70A 2 ~ 71 ~71 ~ °1 0 Q - 71~ °] oQo}D~ ~o,3Dl~7A,15g o, 7,gAO~ A~~ 3~r2= ~°] ~ T M~ 7170A7c], ~0,~711(anxiolytics). ~l70~71~781( neuromuscular blocking agent) 14 7ttQ °4741~ 79~731~ =1-~1707} °1~ ~;r~=Q 7037=A17l7l *0r] =6 T~r91 °4~11 · 7~ 71~701~ Dt~7A.l5lt ~—otO] Aio4\t f OM~ <170~7-~731(~ 68

~3~$~ pancuronium)~ THAI D~|~ T°1°~ .°11~ i; ~A1O11 ~ Am ~ Q D!141~17171 ~~ AI81i oll£ ,1~(Klein 1987). °1~1~ °~,4,201 +~°1~ old ~~ ~~ TIED on ~~ 70$, r(D1 ~ I D!~AD£~ ~~ ~ O]D1 T~°1 AT~17n Em. ~61 7't=|7078~ ~~(~ AD ~°~ D~4)~ ~~ DL~AD£~ ~~ is| =; Aim D\!°e a$'DI^o 0~21l(paralyzing agents)7f Al—'8 70$. ID *~.° ~~74(blOCking agent)°~ol D1~1711~ A>~ *-'my —~1 ~~= ~71~ ~ Aft. ~~D°1 (NRC 1992). 141 4. ~1 ~ ~~ 01QI°~I£ ~~ I41°~ ~°1 ~y01 io$£ D6 (NRC 1992: SPinelli 1990). Oko4A1 06~ .4~ ~Lo1, A070~7.~1~. ~¢ 707~A171~1 ~r-~. °17~= ~°1 ~76 ai D~ ~ ol °~ ~ ~°J e 7m ' eQ Di H1 A1 71 . rl| ol §~ ~. ~ 70] ~o tR ~ TT ~ ( 0~4 '~) AJ70AJ~ 0~ ~88 7~7e81 ~71~°1 ~A]o~ ~o\|~| ~e T£ ~, ~ L D^D >'-eDR~~ ~Aio| o,,1~ AO~eRo~lAl Py~41 ~ o~ q~n] ~ ~o1 ~A~ 70$ °R~ Ali~£ o1S~ 7lQ 0~7;n~ D>DI~ DR M~eQ 70~D~ 7?0~ °e\~74 °471 ~°n qlI1~ 70$o4£ ~7'1w ~70~71 ~88 ~(IACUC)7t ^~ol ~o47~8h4°) ~(NRC 1992: Van Sluyters and Oberdorfer 1991). 5 oJe~t (Euthanasia) ot~r4q;~ ~ol~ M~P1A°1 D^~ T~Ag AOTE8~ AiDoleQ $e~ ~_e ~e ~o1~ eg~o1~ oJe,jAt ~eQ rt993~ n1= ~Ts~l~;]Ll O]e4AtA17,1 ~ ~ MA (1993 Report of the AVMA Panel on Euthanasia: AVMA 1993 ~:~ ~T91 7R7D~)2 ~ ~0t ~. ~Q1. ~a ~Q A(~ ~R°II~ 3~847, ~7A ~717y ~c rO ~8 ol; ~Jr~ oJe4A} ~ ~1 ~'A 70qADQ rO 7~e 71 ~ 0 i~A1 ~ 0, ~ T . ~ J ~ E' .1 ~71 ~ r iS1 D1 4~1 51~ ~ , i13q ARDO; eQ ,$£~= crrem A83~1 ^0 H1 7~°4 Ap T 511~ ~rRe! Q£0terl1 ^~!!g',_ A17~i ~rii o~tr~O404 5!1~ 71~ ~~-?-~7A~ ld el" o. JeAi e8D7~°4 r0~ o]7,jAO~ 7,~0~7~4 ~o1 ~-]lS3010t ~= OJqA1~ =~91 DiA1D4 ~741°11A1 018!473~ 71~7R. 717097~ ~e ~. AI~D _~ T~ 114 ~I=+ 707=A171A1 ~ 70$ A,~4~ T O~Ae ~0l~ AJ~RAg ~ ~7q 7e'}Aote4, ~o,lg] =171 =0~ 7~01 0J8~A 747.1 Ql ^1 eQ2 ;~5 e °n ~AI D ° '4' ~ ~ol 0I£7 °~ D4 ~Q D~Qe 4 ~= T~ Al on °J—~A ~ ~^D~Z T 01 O Dq T~ o`3zjL7,}7} AJ^~ 7e~=e ~r~ T °~r; ~e ~g ~ol|7J1 ~= T7~1 ';), ~ o ~ AeA1gROt ~r~ OeT~ 70$ ~] ~ ~n ~ ~ ~ ~o~°1 T~ A] ~e' ~ ~q 7i ~ ~33 T on q~r| . 1 Z1 ~ 1 I z ~ oll oJe~ A18aA1 r'l~ ~Q~ ~i~lZI T;~1 .°iserj(AVMA 1993). °~q 9~ $1 ~ ~ 78 ~ 711 A ~ ~ ~ ~= eQ ~ ~ ~ 06 ~ ~ 7A °n ~z~ 7~ 7 r4, 0i)~J7A0~ ~Z17 ~(70T~.r. ~T. ~§ ~5~1 ~)~ ~0104 TX~7'~('4~1F 7il~, 141 ~o ~°iD(~74|. COz )7i ~Q32~. ~z1~ eT _~3~ n le ~7 J ~Z-q. o~q| ~Z404X~ ~T$O1 r4~1~ T ~r'l oJe~ ee ~Q Sr1~1(IACUC)71 7'D§0~ TOJ~O]°t ~1 °Jaite ~ ~oll^1 ~q~Q~Z1~ °.~4~t ~,°1| - ~ 7~01 T8&4~04oj o~DB 7,~7 o1~ 0J';:7A0,.! ~?q 0 ~ ~A|~rT ^fDo~ ~70eQ oJat4At !~ ~oll^1 ~aro~$ 69

{!D~1 ~61~ ii~1 ~1? I J 71 ~ ~~ 71i~ 71 o7~171~ I T JO —~°1 Moliere ~ ~~ T9lAl ,.~T7~71 ~~ J_ At A171~r~ :po] ~ 7,~—, ~ ~ 79 0 ~ o~te4At~ ~A1 ~71 ~ 02 ^1- 51~ ~~ 7,JA174 *~7t BEAD ~ 70 $, 70~17= 0 e! of ~~ 73$ tool ,oJr- (Arluke 1990: NRC 1992: Rollin 1986: Wolfle 1985). 7J~£7~71 ~87,~ 64 ~a°~ 0Jes4Ay 0~] Elf TO ~ a 7a 0 ;! Olaf T 0.1 lo_ 7.1~ 7a O £ 0~7.1~ al °1 of Wry 70

~ 3 ~ TO ~~ ~~ Arluke, A. 1990. Uneasiness among laboratory technicians. Lab. Anim. 1 9(4) :20-39. AORN (Association of Operating Room Nurses). 1982. Recommended Practices for traffic patterns in the surgical suite. Assoc. OPer Room Ours. J 15(4):750-758. ASR (Academy of Surgical Research).1989. Guidelines for training in surgical research in animals. J. invest Surg. 2:263-268. Ayliffe, G. A. J .1991. Role of the environment of the operating suite in surgical wound infection. Rev. Inf. Dis. 13(Suppl 10):S800-804. AVMA (American Veterinary Medical Association). 1993. Report of the AVMA Panel on euthanasia. J. Am. Vet. Med. Assoc. 202(2):229-249. Banley, J. M. 1993. Environmental control: OPeretins room air quality. Todavs O. R. Nurse 15(5):11-18. Beamer, T. C. 1972. Pathological changes associated with ovarian transplantation. Pp. 104 in The 44th Annual Report of the Jackson Laboratory, Bar Harbor, Maine: Jackson Laboratory. Belkin, N. J. 1992. Barrier materials, their influence on surgical wound infections. Assoc. Over. Room Nurs. J. 55(6): 1521-1528. Berg, J. 1993. Sterilization. PP. 124-129 in Textbook of Small Animal Surgery, 2nd ed., D. Slatter, ed. Philadelphia: W. B. Saunders. Bradfield, J. F., T. R. Schachtman, R. M. McLaughlin, and E. K. Steffen. 1992. Behavioral and physiological effects of inepparent wound infection in rats. Lab. Anim. Sci. 42(6):572-578. Breazile, J. E. 1987. Physiologic basis and consequences of distress in animals. J. Am. Vet. Med. Assoc. 191(10):1212-1215. Brown, M. J. 1994. Aseptic surgery for rodents. PP. 67-72 in Rodents and Rabbits: Current Research issues, S. M. Niemi, J. S. Venable, and H. N. Guttman, eds. Bethesda, Md.: Scientists Center for Animal Welfare. Brown, M. J., and J. C. Schofield. 1994. Perioperative care. PP. 79-88 in Essentials for Animal Research: A Primer for Research Personnel. B. T. Bennett, M. J. Brown, and J. C. Schofield, eds. Washington, D.C.: National Agricultural Librarv. Brown. M. J., P. T. Pearson, and F. N. Tomson 1993. Guidelines for animal surgery in research and teaching. Am. J. Vet. Res. 54(9):1544-1559. Butler, T. M.. B. G. Brown, R. C. Dysko. E. W. Ford, D. E. Hoskins, H. J. Klein, J. L . Levin. K. A. Murray, D. P. Rosenberg, J. L. Southers. and R. B. Swenson. 1995. Medical management. PP. 255-334 in Nonhuman Primates in Biomedical Research: Biologv and Management, B. T. Bennett. C. R. Abee, and R. Hendrickson, eds. San Diego, Calif.: Academic Press. CDC (Centers for Disease Control and Prevention). 1991. Update: Nonhuman Primate importation. MMWR. October9,1991. CDC (Centers for Disease Control and Prevention). 1 993. Tuberculosis in imported nonhuman primates-United States, June 1990-May 1993. MMWR, July 30, 1993. Vol. 42, no.29. CFR (Code of Federal Regulations) Title 42. PHS, HHS, Subchapter F(lmportations), Section 71.53 (Nonhuman primates). Chaffea, V. W. 1974. 71

~1~7~1 Gage Attic ~~ Ale Surgery of laboratory animals. PP. 233-247 in Handbook of Laboratory Animal Science, Vol. 1, E. C. MelbY, Jr. and N. H. Altman, ads. Cleveland, Ohio: CRC Press. Chamberlain, G. V., and E. Houang. 1984. Trial of the use of masks in gynecological operating theatre. Ann. R. Coil. Suro. 66(6):432-433. Cunliffe-Beamer, T. L. 1983. Biomethodology and surgical techniques. Pp. 419-420 in The Mouse in Biomedical Research, Vol. 111, Normative Biology. Immunoloov and Husbandry. H. L. Foster, J. D. Small and J. G. Fox, eds. New York: Academic Press. Cunliffe-Beamer, T. L. 1990. Surgical Techniques. PP. 80-85 in Guidelines for the Well-Being of Rodents in Research, H. N. Guttman, ed. Bethesda, Md.: Scientists Center for Animal Welfare. Cunliffe-Baamer, T. L. 1993. Applying principles of aseptic surgery to rodents. AWIC Newel. 4(2):3-6. Dardai, E., and J. E. Haavner. 1987. Respiratory and cardiovascular effects of halothane, isoflurane and enflurane delivered via a Jackson-Rees breathing system in temperature controlled and uncontrolled rats. Meth. Find. EXP. Clin. Pharmacol. 9(11):717-720. de Souza, M., and A. L. Smith. 1989. Comparison of isolation in call culture with conventional and modified mouse antibody Production tests for detection of marine viruses. J. Clin. Microbial. 27:185-187. DOI (Department of the interior). Endangered and threatened wildlife and plants (50 CFR 17.11), U.S. Fish and Wildlife Service. Dresser, R. 1988. Assessing harm and justification in animal research: Federal policy opens the laboratory door. Rutgers Law Rev. 450(3):723-795. Drozdowicz, C. K., T. A. Bowman, M. L. Webb, and C. M. Lang. 1990. Effect of in-house transport on murine Plasma corticosterone concentration and blood lymphocyte populations. Am. J. Vet. Res. 51:1841-1846. Dubner, R. 1987. Research on Pain mechanisms in animals. J. Am. Vat. Mad. Assoc. 191(10):1273-1276. FBR (Foundation for Biomedical Research). 1987. Surgerv: Protecting your animals and your atudv. PP. 19-27 in The Biomedical investigator's Handbook for Researchers Using Animal Models. Washington, D.C.: Foundation for Biomedical Research. FR (Federal Register) 1990. CDC, HHS. Requirement for a special Permit to import cvnomolous, African green, or rhesus monkeys into the United States. Vol. 55. no. 77, April 20, 1990. Hirsch. V. M., P. M. Zack. A. P. Vogel, and P. R. Johnson. 1991. Simian immunodeficiency virus infection of macaques: End-stage disease is characterized by wide spread distribution of Proviral DNA in tissues. J. Infect, Dia. 163:976-988. Hofmann, L. S. 1979. Preoperative and operative patient management. PP 14-22 in Small Animal Surgery, An Atlas of Operative Technique, W. E. Wingfiald and C. A. Rawlings, eds. Philadelphia: W.B. Saunders. Holmes. A. W., R. G. Caldwell, R. E. Dadmon. and F. Dainhardt. 1964. Isolation and characterization of a new herpes virus. J. Immunol. 92:602-610 Hughes H. C., and C. M. Lang. 1983. Control of pain in dogs and cats. Pp. 207-216 in Animal Pain: Perception and Alleviation, R. L. Kitchell and H. H. Erickson, eds. Bethesda, Md.: American Physiological Society. 72

;~ 3 ~ To ~~ ~~ Hunt, R. D., and L. V. Melendez. 1966. Spontaneous herpes-T infection in the owl monkev (Aotus trivirsatus). Pathol. Vet. 3:1-26. IATA (International Air Transport Association). 1995. IATA Live Animal Regulations, 22nd edition. Montreal. Quebec: international Air Transport Association. IRAC (Interagency Research Animal Committee). 1985. U.S. Government Principles for Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. Federal Register, May 20, 1985. Washington, D.C.: Office of Science and TechnoloOv Policy. Jelinek, V. 1971. The influence of the condition of the laboratory animals employed on the experimental results. PP. 110-120 in Defining the Laboratory Animal.. Washington, D.C.: National Academy of Sciences. Kagan, K. G. 1992a. Aseptic technique. Vet. Tech. 13(3):205-210. Kagan, K. G. 1992b. Care and sterilization of surgical equipment Vet. Tech. 13(1):65-70. Kitchen. H.. A. Aronson. J. L. Bittle, C. W. McPherson. D. B. Morton, S. P. Pakes, B. Rollin, A. N. Rowan, J. A. Sechzer, J. E. VanderliP, J. A. Will, A. S. Clark, and J. S. GloYd. 1987. Panel report of the colloquium on recognition and alleviation of animal Pain and distress. J. Am. Vet. Med. Assoc. 191(10):1186-1191. Klein, L. 1987. Neuromuscular blocking agents. PP. 134-153 in Principles and Practice of Veterinary Anesthesia, C. E. Short, ad. Baltimore, Md.:Williams & Wilkins. Clement, P., P. J. del Nido. L. Mickleborough, C. MacKay, G. Klement, and G. J. Wilson. 1987. Techniques and postoperative management for successful cardiopulmonary bypass and oPen-heant surgery in dogs. J. Am. Vet. Med. Assoc. 1 90 (7): 869-874. Landi, M. S., J. W. Kreider, C. M. Lang, and L. P. Bullock. 1982. Effects of shipping on the immune function in mice. Am. J. Vet. Res. 43:1654-1657. Manning, P. J., J. E. Wagener. and J. E. Harkness. 1984. Biology and diseases of guinea Pigs. In Laboratorv Animal Medicine. J. G. Fox. B. J. Cohen. and F. M. Loew, eds. San Diego: Academic Press. McWilliams, R. M. 1976. Divided responsibilities for operating room asePSiS: The dilemma of technology. Med. Instrum. 10(6):300-301 Melnick, F. L., M. Midulla, I. Wimberly, J. G. Barrera-Oro, and B. M. Levy. 1964. A new member of the herpes virus group isolated from South American marmosets. J. Immunol. 92:596-601. Morton, D. B., and P. H. M. Griffiths. 1985. Guidelines on the recognition of pain, distress and discomfort in exPerimental animals and an hYPothesis for assessment. Vet. Rec. 116:431-436. Murphey-Corb, M., L. N. Martin. S. R. S. Rangan, G. B. Baskin, B. J. Gormus, R. H. Wolf. W. A. Andes, M. West, and R. C. Montelaro. 1986. Isolation of an HTLV-111-related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic managabeys. Nature 321 :435-437. Nicklas, W., V. Kraft. and 8. Meyer. 1993. Contamination of transPlantable tumors, cell lines, and monoclonal antibodies with rodent viruses. Lab. Anim. Sci. 43:296-299. NRC (National Research Counci8. 1991a. Barrier ProGrams. PP. 17-20 in Infectious Diseases of Mice and Rats. A report of the institute of Laboratory 73

Elm Animal Resources Committee on infectious Diseases of Mice and Rats. Washington, D C: National Academy Press NRC (National Research Council) 1991b individual disease agents and their effects on research. PP 31-258 in infectious Diseases of Mice and Rats. A report of the institute of Laboratory Animal Resources Committee on Infectious Diseases of Mice and Rats. Washington, D C: National Academy Press. NRC (National Research Council). 1991c. Health Surveillance Programs. Pp. 21-27 in infectious Diseases of Mice and Rats A report of the institute of Laboratory Animal Resources Committee on infectious Diseases of Mice and Rats Washington, D C: National Academy Press. NRC (National Research Council). 1992. Recognition and Alleviation of Pain and Distress in Laboratory Animals. A report of the institute of Laboratory Animal Resources Committee on Pain and Distress in Laboratory Animals. Washington, D. C.: National AcademY Press Palmer, A E. A M Allen, N. M Teuraso, and A Skelokov. 1968. Simian hemorrhagic fever 1 Clinical and ePizootiologic aspects of an outbreak among quarantined monkeys Am J. Trop, Med. HY9. 17:404-412. Pereira, L. J. G. M. Lee, and K. J. Wade. 1990 The effect of surgical handwashing routines on the microbial counts of operating room nurses. Am J. Inf Control. 18(6):354-364. PHS (Public Health Service). 1996. Public Health Service Policy on Humane Care and Use of Laboratory Animals Washington, D C: U S Department of Health and Human Services, 28 Do [PL 99-158, Health Research Extension Act. 19853 Prasad, S., B R Gatmaitan, and R C O'Connell 1978. Effect of a conditioning method on general safety test in guinea Pigs Lab. Anim. Sci. 28(5) :591-593. Ritter, M. A., and P. Marmion 1987 The exogenous sources and controls of microorganisms in the operating room Orthopedic Nursing 7(4):23-28 Rollin, B 1986. Euthanasia and moral stress IN Loss, Grief and Care, R. DeBellis. ed Binghamton, N Y.: Haworth Press. Rutaln, W. A. 1990. APIC guideline for selection and use of disinfectants. Am. J. Inf. Control 18(2):99-117 Sanhouri A. A, R. S. Jones, and H. Dobson. 1989. The effects of different types of transportation on plasma cortisol and testosterone concentrations in male goats. Br. Vet J 145:446-450 Schofield, J C 1994. Principles of aseptic technique PP 59-77 in Essentials for Animal Research: A Primer for Research Personnel, B T Bennett, M J. Brown, and J C. Schofield, eds. Washington. D C.: National Agricultural LibrarY Schonholtz, G. J 1976 Maintenance of aseptic barriers in the conventional operating room J. Bone and Joint Surg. 58-A(4):439-445. Slattum, M M., L. Maggio-Price, R. F. DiGiacomo, and R. G. Russell. 1991. Infusion-related sepsis in dogs undergoing acute cardiopulmonary surgery Lab Anim Sci 41(2):146-150. Soma, L R. 1987. Assessment of animal Pain in experimental animals Lab Anim Sci. 37:71-74. Spinelli, J. 1990. Preventive suffering in laboratory animals Pp. 231-242 in 74

~3 ~$~ The Experimental Animal in Biomedical Research. Vol. I: A Survey of Scientific and Ethical issues for investigators. B. Rollin and M. Kesel, eds. Boca Raton, F a: CRC Press. Tuli, J. S.,J. A. Smith, and D. B. Morton. 1995. Stress measurements in mice after transportation. Lab. Anim. 29:132-138. UFAW (Universities Federation for Animal Welfare).1989. Surgical procedures. Pp.3-15 in Guidelines on the Care of Laboratory Animals and Their Use for Scientific Purposes ill. London: Universities Federation for Animal Welfare. Van SluYters, R. C., and M. D. Oberdorfer, eds. 1991. Preparation and Maintenance of Higher Mammals During Neuroscience Experiments. Report of National institute of Health Workshop. NIH No. 91-3207. Bethesda, Md.:National institutes of health. Wallace, M. E. 1976. Effect of stress due to deprivation and transport in different genotypes of house mouse. Lab. Anim. (London) 10(3):335-347. Waynforth, H. B. 1980. Experimental and Surgical Technique in the Rat. London: Academic Press. 104 PP. Wevnforth, H. B. 1987. Standards of surgery for experimental animals. Pp. 311-312 in Laboratory Animals: An introduction for New Experimenters, A, A. Tuffery, ed. Chichester: Wiley-lnterscience. Whyte, W. 1988. The role of clothing and drapes in the operating room. J. Hosp. Inf. 11(SUPPI C):2-17, Wingfield, W. E. 1979. Surgical Principles. PP. 1-3 in Small Animal Surserv. An Atlas of Operative Techniques, W. E. Wingfield and C. A. Rewlings, ads. Philadelphia: W. B. Saunders. Wolfle, T. L. 1985. Laboratory animal technicians: Their role in stress reduction and human-comPanion animal bonding. Vet. Clin. N. Am. Small Anim. Pract. 15(2):449-454. Wright, E. M., K. L. Marcella, and J. F. Woodson. 1985. Animal pain: Evaluation and control. Lab Anim. 14(4):20-36, 75

Next: Chapter 4 »
Guide for the Care and Use of Laboratory Animals -- Korean Edition Get This Book
×
Buy Paperback | $47.00
MyNAP members save 10% online.
Login or Register to save!
  1. ×

    Welcome to OpenBook!

    You're looking at OpenBook, NAP.edu's online reading room since 1999. Based on feedback from you, our users, we've made some improvements that make it easier than ever to read thousands of publications on our website.

    Do you want to take a quick tour of the OpenBook's features?

    No Thanks Take a Tour »
  2. ×

    Show this book's table of contents, where you can jump to any chapter by name.

    « Back Next »
  3. ×

    ...or use these buttons to go back to the previous chapter or skip to the next one.

    « Back Next »
  4. ×

    Jump up to the previous page or down to the next one. Also, you can type in a page number and press Enter to go directly to that page in the book.

    « Back Next »
  5. ×

    To search the entire text of this book, type in your search term here and press Enter.

    « Back Next »
  6. ×

    Share a link to this book page on your preferred social network or via email.

    « Back Next »
  7. ×

    View our suggested citation for this chapter.

    « Back Next »
  8. ×

    Ready to take your reading offline? Click here to buy this book in print or download it as a free PDF, if available.

    « Back Next »
Stay Connected!