National Academies Press: OpenBook
Suggested Citation:"Front Matter." National Research Council. 2006. Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11599.
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EXPLORING THE ROLE OF ANTIVIRAL DRUGS IN THE ERADICATION OF POLIO

WORKSHOP REPORT

Committee on Development of a Polio Antiviral and Its Potential Role in Global Poliomyelitis Eradication

Board on Life Sciences

Division on Earth and Life Studies

NATIONAL RESEARCH COUNCIL OF THE NATIONAL ACADEMIES

THE NATIONAL ACADEMIES PRESS
Washington, D.C.
www.nap.edu

Suggested Citation:"Front Matter." National Research Council. 2006. Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11599.
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THE NATIONAL ACADEMIES PRESS
500 Fifth Street, N.W. Washington, DC 20001

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This study was supported by Contract No. CDC-200-2000-00629 between the National Academy of Sciences and the Centers for Disease Control and Prevention (CDC) and Contract No. HQ/05/076671 between the National Academy of Sciences and the World Health Organization (WHO). The content of this publication does not necessarily reflect the views or policies of the CDC or the WHO, nor does mention of trade names, commercial products or organizations imply endorsement by the U.S. Government.

International Standard Book Number 0-309-10161-1

Cover: Upper left: Three-dimensional image of a poliovirus virion produced using an electron microscope and X-ray crystallography (courtesy of Robert Grant, Stéphane Crainic, and James Hogle, Harvard Medical School). Center: Egyptian stele with the first-known depiction of a polio victim (courtesy of Ny Carlsbert Glyptotek, Copehnagen), superimposed on the genetic sequence of the poliovirus (courtesy of Eckard Wimmer, State University of New York, Stonybrook).

Additional copies of this report are available from the
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Copyright 2006 by the National Academy of Sciences. All rights reserved.

Printed in the United States of America

Suggested Citation:"Front Matter." National Research Council. 2006. Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11599.
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THE NATIONAL ACADEMIES

Advisers to the Nation on Science, Engineering, and Medicine


The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the National Academy of Sciences.


The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Wm. A. Wulf is president of the National Academy of Engineering.


The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Harvey V. Fineberg is president of the Institute of Medicine.


The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy’s purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. Wm. A. Wulf are chair and vice chair, respectively, of the National Research Council.


www.national-academies.org

Suggested Citation:"Front Matter." National Research Council. 2006. Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11599.
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Suggested Citation:"Front Matter." National Research Council. 2006. Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11599.
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COMMITTEE ON DEVELOPMENT OF A POLIO ANTIVIRAL AND ITS POTENTIAL ROLE IN GLOBAL POLIOMYELITIS ERADICATION

SAMUEL L. KATZ (Chair),

Duke University Medical Center, Durham, North Carolina

RAUL ANDINO,

University of California, San Francisco

DIANE JOSEPH-MCCARTHY,

Wyeth Research, Cambridge, Massachusetts

JOHN F. MODLIN,

Dartmouth Medical School, Lebanon, New Hampshire

NEAL NATHANSON,

University of Pennsylvania School of Medicine, Philadelphia

RICHARD J. WHITLEY,

University of Alabama, Birmingham

ECKARD WIMMER,

Stony Brook University School of Medicine, Stony Brook, New York

Staff

ANN H. REID, Study Director

FRANCES E. SHARPLES, Director,

Board on Life Sciences

JOSEPH C. LARSEN, Postdoctoral Research Associate

ANNE F. JURKOWSKI, Program Assistant

Suggested Citation:"Front Matter." National Research Council. 2006. Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11599.
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BOARD ON LIFE SCIENCES

COREY S. GOODMAN (Chair),

Renovis, Inc., South San Francisco, California

ANN M. ARVIN,

Stanford University School of Medicine, Stanford, California

JEFFREY L. BENNETZEN,

University of Georgia, Athens

RUTH BERKELMAN,

Emory University, Atlanta, Georgia

DEBORAH BLUM,

University of Wisconsin, Madison

R. ALTA CHARO,

University of Wisconsin, Madison

DENNIS CHOI,

Merck Research Laboratories, West Point, Pennsylvania

JEFFREY L. DANGL,

University of North Carolina, Chapel Hill

PAUL R. EHRLICH,

Stanford University, Stanford, California

JAMES M. GENTILE,

Research Corporation, Tucson, Arizona

JO HANDELSMAN,

University of Wisconsin, Madison

ED HARLOW,

Harvard Medical School, Boston, Massachusetts

DAVID HILLIS,

University of Texas, Austin, Texas

KENNETH H. KELLER,

University of Minnesota, Minneapolis

RANDALL MURCH,

Virginia Polytechnic Institute and State University, Alexandria

GREGORY A. PETSKO,

Brandeis University, Waltham, Massachusetts

STUART L. PIMM,

Duke University, Durham, North Carolina

JAMES TIEDJE,

Michigan State University, East Lansing

KEITH YAMAMOTO,

University of California, San Francisco

Staff

FRANCES E. SHARPLES, Director

KERRY A. BRENNER, Senior Program Officer

MARILEE K. SHELTON-DAVENPORT, Senior Program Officer

EVONNE P. Y. TANG, Senior Program Officer

ROBERT T. YUAN, Senior Program Officer

ADAM P. FAGEN, Program Officer

ANN H. REID, Program Officer

DENISE GROSSHANS, Financial Associate

ANNE F. JURKOWSKI, Program Assistant

TOVA JACOBOVITS, Program Assistant

Suggested Citation:"Front Matter." National Research Council. 2006. Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11599.
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Acknowledgments

THIS REPORT IS A PRODUCT of the cooperation and contributions of many people. The committee would like to thank all the speakers and participants who attended the Workshop on Development of a Polio Antiviral and Its Potential Role in Global Poliomyelitis Eradication on November 1-2, 2005, and others who provided information and input.

This report has been reviewed in draft form by persons chosen for their diverse perspectives and technical expertise in accordance with procedures approved by the National Research Council’s Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards of objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following for their review of this report:

Craig Cameron, Pennsylvania State University

Walter Dowdle, The Task Force for Child Survival and Development

Christopher D. Earl, BIO Ventures for Global Health

Diane E. Griffin, Johns Hopkins Bloomberg School of Public Health

James M. Hogle, Harvard Medical School

Karla Kirkegaard, Stanford University School of Medicine

Amy K. Patick, Pfizer

Page viii Cite
Suggested Citation:"Front Matter." National Research Council. 2006. Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11599.
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Bert L. Semler, University of California, Irvine School of Medicine

P. Frederick Sparling, University of North Carolina School of Medicine

Although the reviewers listed above have provided constructive comments and suggestions, they were not asked to endorse the conclusions or recommendations, nor did they see the final draft of the report before its release. The review of this report was overseen by Donald S. Burke of the Johns Hopkins Bloomberg School of Public Health and Nicole Lurie of the RAND Corporation. Appointed by the National Research Council, they were responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the author committee and the institution.

Suggested Citation:"Front Matter." National Research Council. 2006. Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11599.
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Suggested Citation:"Front Matter." National Research Council. 2006. Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11599.
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