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Phthalates and Cumulative Risk Assessment: The Tasks Ahead (2008)

Chapter: Appendix A: Statement of Task

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Suggested Citation:"Appendix A: Statement of Task." National Research Council. 2008. Phthalates and Cumulative Risk Assessment: The Tasks Ahead. Washington, DC: The National Academies Press. doi: 10.17226/12528.
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Page 141

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Appendix A Statement of Task A National Research Council committee will evaluate human health risks and the potential for conducting a cumulative risk assessment for phthalate es- ters. The committee will review critical scientific data and address questions related to human relevance of experimental data, modes of action, exposure in- formation, dose-response assessment, and the potential for cumulative effects. In its evaluation, the committee will consider the strengths and weaknesses of cu- mulative assessment approaches. The committee will provide recommendations to EPA on conducting a cumulative risk assessment on phthalate chemicals, including additional research needed. The committee shall consider the applica- bility of its recommendations for conducting cumulative risk assessment for other chemical classes. 141

Next: Appendix B: Biographic Information on the Committee on Health Risks of Phthalates »
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People are exposed to a variety of chemicals throughout their daily lives. To protect public health, regulators use risk assessments to examine the effects of chemical exposures. This book provides guidance for assessing the risk of phthalates, chemicals found in many consumer products that have been shown to affect the development of the male reproductive system of laboratory animals.

Because people are exposed to multiple phthalates and other chemicals that affect male reproductive development, a cumulative risk assessment should be conducted that evaluates the combined effects of exposure to all these chemicals. The book suggests an approach for cumulative risk assessment that can serve as a model for evaluating the health risks of other types of chemicals.

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