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Aging in Today's Environment (1987)

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References Aaron, J. E., J. C. Gallagher, J. Anderson, L. Stasiak, E. B. Longton, B. E. Nordin, and M. Nicholson. 1974. Frequency of osteomalacia and osteoporosis in fractures of the proximal femur. Lancet 1:229-233. Abdo, K. M., G. Rao, C. A. Montgomery, M. Dinowitz, and K. Kana- galingam. 1986. Thirteen-week toxicity study of d-alpha-tocopheryl acetate (vitamin E) in Fischer 344 rats. Food Chem. Toxicol. 24:1043- 1050. Abernethy, D. R., J. B. Schwartz, E. L. Todd, R. Luchi, and E. Snow. 1986. Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients. Altered electrocardiographic and hypotensive responses. Ann. Intern. Med. 105 :329-336. Algeo, S., P. E. Fenster, and F. I. Marcus. 1983. Digitalis therapy in the elderb. Geriatrics 38:93-101. Alvarado, J., C. Murphy, and R. Juster. 1984a. Trabecular meshwork cellu- larity in primary open-angle glaucoma and non-glaucomatous normals. Ophthalmology 91:564-579. Alvarado, J., C. Murphy, J. Polansky, and R. Juster. 1981. Age-related changes in trabecular meshwork cellularity. Invest. Ophthalmol. Vis. Sci. 21:714-727. Alvarado J., C. Murphy, R. Juster, and J. Polansky. 1984b. Studies on the pathogenesis of primary open-angle glaucoma: Regional analyses of trabecular meshwork cellularity and dense collagen. Pp. 3-8 in U. Ticho and R. David, eds., Recent Advances in Glaucoma. Amsterdam: Elsevier. Alvares, A. P., S. Kapelner, S. Sassa, and A. Kappas. 1975. Drug metabolism in normal children, lead-poisoned children, and normal adults. Clin. Pharmacol. Ther. 17:179-183. 171

172 REFERENCES Allures, A. P., E. J. Pantuck, K. E. Anderson, A. Kappas, and A. H. Conney. 1979. Regulation of drug metabolism in man by environmental factors. Drug Metab. Rev. 9:185-205. Amdur, M. O. 1986. Air pollutants. Pp. 801-824 in C. D. Klass~en, M. O. Amdur, and J. Doull, ede., Casarett and Doull's Toxicology: The Basic Science of Poisons. 3rd. ed. New York: Macmillan. American Medical Association, Council on Scientific Affairs. 1987. Autopsy: A comprehensive review of current issues. J. AMA 258:364-369. Ames, B. N. 1983. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 221:12501264. Anitschkow, N. 1913. Uber die Veranderungen der Kaninchenaorta bei experimenteller Cholesterinsteatose. Beitr. Pathol. Anat. Allg. Pathol. 56:370404. Anver, M. R., B. J. Cohen, C. P. Lattuada, and S. J. Foster. 1982. Age-associated lesions in barrier-reared male Sprague-Dawley rats: A comparison between Hap: (SD) and Crl:COBStR] CDIRi (SD] stocks. Exp. Aging Res. 8:3-24. ~ _ _, _ _ . Apfelbaum, M. 1978. Adaptation to changes in caloric intake. Proc. Food Nutr. Sci. 2:543-559. Ara~ranis, C. 1969. The use of acetyldigoxin in the aged with congestive heart failure. Geriatrics 24:7S-81. Arnetz, B. B. 1984. The potential role of psychosocial stress on levels of hemoglobin AIC (HbA'C) and fasting plasma glucose in elderly people. J. Gerontol. 39:426-429. Arnetz, B. B., A. Kallner, and T. Theorell. 1982. The influence of aging on hemoglobin Alc tHbAlc). J. Gerontol. 37:648-650. Ashford, N. A. 1986. Policy considerations for human m~nitr~rin`:r in th" workplace. J. Occup. Med. 28:S63-568. ~ l,, ~ · _ Ashley, F., W. B. Kannel, P. D. Sorlie, and R. Masson. 1975. Pulmonary function. Relation to aging, cigarette habit, and mortality. Ann. Intern. Med. 82:730745. Avorn, J. 1986. Increased antidepressant use in patients prescribed beta- blockers. J. Am. Med. Assoc. 255:357-360. Ayesh, R., J. R. Idle, J. C. Ritchie, M. J. Crothers, and M. R. Hetzel. 1984. Metabolic oxidation phenotypes as markers for susceptibility to lung cancer. Nature 312:160170. Bada, J. L., and S. E. Brown. 1980. Amino acid racemization in living mammals: Biochronological applications. I~ends Biochem. Sci. 5~9~:III- V. Bailey, D. W. 1981. Recombinant inbred strains and bilinear congenic strains. Pp. 22~239 in H. L. Foster, J. D. Small, and J. G. Fox, eds., The Mouse in Biomedical Research. New York: Academic Press. Baker, S. R., and M. Rogul, eds. 1987. Environmental Toxicity and the Aging Processes: Proceedings of a Workshop Held in Columbia, Maryland, October 1 and 2, 1985. (Progress in Clinical and Biological Research, Vol. 228) New York: Alan R. Liss, Inc. 139 pp. Baker, G. T. III, M. Jacobson, and G. Mokrynski. 1985. Aging in Drosophila. Pp. 511-578 in V. J. Cristofalo, ea., Handbook of Cell Biology of Aging. Boca Raton, Fla.: Chemical Rubber Company Press, Inc.

REFERENCES 173 Balin, A. K. 1982. Testing the free radical theory of aging. Pp. 137-182 in R. C. Adelman and G. S. Roth, eds., Testing the Theories of Aging. Boca Raton, Fla.: CRC Press, Inc. Barnes, R., and M. Raskind. 1980. Strategies for diagnosing and treating agitation in the aging. Geriatrics 35:111-119. Barr, D. P. 1955. Hazards of modern diagnosis and therapy the price we pay. J. Am. Med. Assoc. 159:1452-1456. Barrows, C. H., Jr., and G. C. Kokkonen. 1977. Relationship between nutrition and aging. Adv. Nutr. Res. 1:253-298. Barrows, C. H., Jr., and G. C. Kokkonen. 1985. Rotifers. Pp. 188-200 in F. A. Lints, ed. Non-mammalian Models for Research on Aging. (Interdisciplinary Topics in Gerontology, Vol. 21) Basel, N.Y.: Karger. Barrows, C. H., Jr., and L. M. Reseeder. 1965. The effect of reduced dietary intake on enzymatic activities and life span of rats. J. Gerontol. 20:60 71. Barter, C. E., and A. H. Campbell. 1976. Relationship of constitutional factors and cigarette smoking to decrease in 1-second forced expiratory volume. Am. Rev. Respir. Dis. 113:305-314. Baskin, S. I., J. Roberts, and B. N. D. Sousa. 1977. Na+ + K+ ATPase and age-dependent digitalis toxicity. Pharmacologist 19:132. Beach, R. S., M. E. Gershwin, and L. S. Hurley. 1981. Nutritional factors and autoimmunity. I. Immunopathology of sine deprivation in New Zealand mice. J. Immunol. 126:1999-2006. Beach, R. S., M. E. Gershwin, and L. S. Hurley. 1982. Nutritional factors and autoimmunity. II. Prolongation of survival of zinc-deprived NZB/W mice. J. Immunol. 128:308-313. Beaty, T. H., B. H. Cohen, C. A. Newill, H. A. Menkes, E. L. Diamond, and C. J. Chen. 1982. Impaired pulmonary function as a risk factor for mortality. Am. J. Epidemiol. 116:102-113. Beaty, T. H., H. A. Menkes, B. H. Cohen, and C. A. Newill. 1984. Risk factors associated with longitudinal change in pulmonary function. Am. Rev. Respir. Dis. 129:660 667. Beauchene, R. E., C. W. Bales, C. S. Bragg, S. T. Hawkins, and R. L. Mason. 1986. Effect of age of initiation of feed restriction on growth, body composition, and longevity of rats. J. Gerontol. 41:13-19. Beebe, G. W. 1979. Reflections on the work of the Atomic Bomb Casualty Commission in Japan. Epidemiol. Revs. 1:184-210. Beebe, G. W., H. Kato, and C. E. Land. 1978. Studies of the mortality of A-bomb survivors. 6. Mortality and radiation dose, 1950-1974. Radiat. Res. 75:138-201. Bell, E. A. 1960. Canavanine in the Leguminosae. Biochem. J. 75:618020. Bell, E., L. F. Marek, D. S. Levinstone, C. Merrill, S. Sher, I. T. Young, and M. Eden. 1978. Loss of division potential in vitro: Aging or differentiation? Science 202:1158-1163. Bellville, J. W., W. H. Forrest, Jr., E. Miller, and B. W. Brown, Jr. 1971. Influence of age on pain relief from analgesics. J. AMA 217:1835-1841. Berg, B. N., and H. S. S;mms. 1960. Nutrition and longevity in the rat. II. Longevity and onset of disease with different levels of food intake. J. Nutr. 71:255-263.

174 REFERENCES Bergman, U., I. Christenson, B. Jansson, and B. E. Wiholm. 1980. Auditing hospital drug utilization by means of defined daily doses per bed-day: A methodological study. Eur. J. Olin. Pharmacol. 17:183-187. Bertel, O., F. R. Bubler, W. Kiowski, and B. E. Lutold. 1980. Decreased beta-adrenoreceptor responsiveness as related to age, blood pressure, and plasma catecholamines in patients with essential hypertension. Hypertension 2:130-138. Bertrand, H. A., F. T. Lynd, E. J. Masoro, and B. P. Yu. 1980a. Changes in adipose mass and cellularity through the adult life of rats fed ad libitum on a life-prolonging restricted diet. J. Gerontol. 35:827-835. Bertrand, H. A., E. J. Masoro, and B. P. Yu. 1980b. Maintenance of glucagon-promoted lipolysis in adipocytes by food restriction. En- docrinology 107:591-595. Besdine, R. W. 1980. Geriatric medicine: An overview. Pp. 135-153 in C. Eisdorfer, ea., Annual Review of Gerontology and Geriatrics. New York: Springer Publishing Co. Beutler, E. 1972. Drug-induced anemia. Fed. Proc. Fed. Am. Soc. Exp. Biol. 31 :141-146. Bierman, E. L. 1985. Arteriosclerosis and aging. Pp. 842-858 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging. 2d ed. New York: Van Nostrand Reinhold Co. Birchenall-Sparks, M. C., M. S. Roberts, J. Staecker, J. P. Hardwick, and A. Richardson. 1985. Effect of dietary restriction on liver protein synthesis in rats. J. Nutr. 115:944-950. Birnbaum, L. S. 1987. Age-related changes in carcinogen metabolism. J. Am. Geriatr. Soc. 35:51-60. Blackwell, B. 1972. The drug defaulter. Clin. Pharmacol. Ther. 13:841-848. Blum, H. F. 1959. Carcinogenesis by Ultraviolet Light. Princeton, N.J.: Princeton University Press. 340 pp. Boethius, G. 1977. Recording the drug prescriptions in county of Jamtland, Sweden. Pattern of drug usage in 16,600 individuals d-tiring 1970-75. Acta Med. Scand. 202:241-251. Boissonneault, G. A., C. E. Elson, and M. W. Pariza. 198ti Net l?ner~r effects of dietary fat on chemically induced mammary carcinogenesi~ in F344 rats. J. Natl. Cancer Inst. 76:335-338. Bolanowski, M. A., R. L. Russell, and L. A. Jacobson. 1981. Quantitative measures of aging in the nematode Cacnorhabdit" cl~anJ: I. Population and longitudinal studies of two behavioral parameters. Mech A~ein~ Dev. 15:279-295. ,¢ _ O _ O Borda, I., H. Jick, D. Slone, B. Dinan, B. Gilman, and T. C. Chalmers. 1967. Studies of drug usage in five Boston hospitals. J. Am. Med. Assoc. 202:506-510. Borkan, G. A. 1978. The Assessment of Biological Age During Adulthood. Doctoral dissertation, Ann Arbor, University of Michigan. (DAI 39/06- A:3682) (University Microfilms No. 78228-61~. Boushey, H. A., M. J. Holtzman, J. R. Sheller, and J. A. Nadel. 1980. Bronchial hyperreactivity. Am. Rev. Respir. Dis. 121:389-413. Bowden, D. M., ed. 1979. Aging in Nonhuman Primates. New York: Van Nostrand Reinhold Co. 393 pp. Boyd, E. M. 1972. Protein Deficiency and Pesticide Toxicity. Springfield, Ill.: Charles C. Thomas. 480 pp.

REFERENCES 175 Bras, G., and M. H. Ross. 1964. Kidney disease and nutrition in the rat. Toxicol. Appl. Pharmacol. 6:247-262. Braverman, I. M., and E. Fonferko. 1982a. Studies in cutaneous aging. I. The elastic fiber network. J. Invest. Dermatol. 78:434-443. Braverman, I. M., and E. Fonferko. 1982b. Studies in cutaneous aging. II. The microvasculature. J. Invest. Dermatol. 78:444-448. Brenner, B. M., T. W. Meyer, and T. H. Hostetter. 1982. Dietary protein intake and the progressive nature of kidney disease. N. Engl. J. Med. 307:652-659. Bristow, M. R., J. W. Mason, M. E. Billingham, and J. R. Daniels. 1978. Doxorubicin cardiomyopathy: Evaluation by phonocardiography, en- domyocardial biopsy, and cardiac catheterization. Ann. Intern. Med. 88:168-175. Brody, J. A. 1983. Limited importance of cancer and of competing risk theories in aging. J. Olin. Exp. Gerontol. 5:141-154. Brody, J. A. 1985. Prospects for an aging population. Nature 315 :463-466. Brody, J. A. 1987. Decreasing mortality and increasing morbidity in the 20th and 21st centuries. Presented at University of Connecticut Symposium and to appear in Philosophy and Medicine Series (in press). Brody, J. A., and P. B. Brock. 1985. Epidemiologic and statistical consider- ations of the United States elderly population. Pp. 3-26 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging. 2d ed. New York: Van Nostrand Reinhold Co. Brooks, A. L., D. K. Mead, and R. F. Peters. 1973. Effect of aging on the frequency of metaphase chromosome aberrations in the liver of the Chinese hamster. J. Gerontol. 28:452-454. Brownlee, M., H. Vlassara, A. Kooney, P. Ulrich, and A. Cerami. 1986. Aminoguanidine prevents diabetes-induced arterial wall protein cross- linking. Science 232:1629-1632. Bruce, S. A. 1982. Regular prescribing in a residential home for elderly for women. Br. Med. J. 284:1235-1237. Bull, D. 1982. A Growing Problem: Pesticides and the Third World Poor. O'cford: Oxfam. Burkitt, D. P. 1982. Diseases of affluence. Pp. 1-7 in J. Rose, ea., Nutrition and Killer Diseases. The E~ects of Dietary Factors on Fatal Chronic Diseases. Park Ridge, N.J.: Noyes. Burnet, M. 1974. Intrinsic Mutagenesis: A Genetic Approach to Aging. New York: Wiley. 236 pp. Burrows, B., M. D. Lebowitz, A. E. Camilli, and R. J. Knudson. 1986. Longitudinal changes in forced expiratory volume in one second in adults. Am. Rev. Respir. Dis. 133:974-980. Bush, P. J., and D. L. Rabin. 1976. Who's using nonpre~cribed medicines? Med. Care 14:1014-1023. Butler, R. N., and M. I. Lewis. 1986. Love and Sex After 40. New York: Harper & Row. 192 pp. Calabrese, E. J. 1986. Age and Susceptibility to Toxic Substances. New York: John Wiley & Sons. 296 pp. Calne, D. B., E. McGeer, A. Eisen, and P. Spencer. 1986. Alzheimer's disease9 Parkinson's disease, and motoneurone disease: Abiotropic in- teraction between ageing and environment? Lancet 2:1067-1070.

176 REFERENCES Campbell, A. J., L. McCosh, and J. Reinken. 1983. Drugs taken by a population based sample 65 years and over in New Zealand. N.Z. Med. J. 96:378-380. Campbell, T. C., and J. R. Hayes. 1974. Role of nutrition in the drug- metabolizing enzyme system. Pharmacol. Rev. 26:171-197. Campbell, W. H., R. E. Johnson, R. A. Senft, and D. J. Azevedo. 1977. Treated adverse effects of drugs in an ambulatory population. Med. Care 15:599-608. Carroll, K. K. 1975. Experimental evidence of dietary factors and hol-~one- dependent cancers. Cancer Res. 35 :3374-3383. Cartwright, R. A., R. W. Glashan, H. J. Rogers, R. A. Ahmad, D. Barham- Hall, E. Higgins, and M. A. Kahn. 1982. Role of N-acetyltransferase phenotypes in bladder carcinogenesis. Lancet 2:842-845. Cassidy, M. M., F. G. Lightfoot, L. E. Grau, J. A. Story, D. Kritchevsky, and G. V. Vahouny. 1981. Effect of chronic intake of dietary fibers on the ultrastructural topography of rat jejunum and colon: A scanning electron microscopy study. Am. J. Clin. Nutr. 34:218-228. Cerami, A. 1985. Hypothesis. Glucose as a mediator of aging. J. Am. Geriat. Sac. 33:626-634. Chalmers, J., W. D. Conacher, D. L. Gardner, and P. J. Scott. 1967. Osteomalacia a common disease in elderly women. J. Bone Joint Surg. 49:403-423. Chamberlain, D. A., R. J. White, M. R. Howard, and T. W. Smith. 1970. Plasma digoxin concentrations in patients with Trial fibrillation. Br. Med. J. 3:429-432. Chanutin, A., and E. B. Ferris. 1932. Experimental renal insufficiency produced by partial nephrectomy. I. Control diet. Arch. Intern. Med. 49:767-787. Chapman, R. 1983. Gonadal injury resulting from chemotherapy. Pp. 149- 161 in D. R. Mattison, ea., Reproductive Toxicology. New York: Alan R. Liss. Charlesworth, B. 1980. Evolution in Age-Structured Populations. Cam- bridge: Cambridge Univ. Press. 250 pp. Cheney, K. E., R. K. Liu, G. S. Smith, P. J. Meredith, M. R. Mickey, and R. L. Walford. 1983. The effect of dietary restriction of varying duration on survival, tumor patterns, immune function, and body temperature in BlOC3F1 female mice. J. Gerontol. 38:42~430. Chesky, J. A. 1985. House Ilies. Pp. 66-90 in F. A. Lints, ea., Non- mammalian Models for Research on Aging. (Interdisciplinary Topics in Gerontology, Vol. 21) Basel, N.Y.: Karger. Chien, C. P., E. J. Townsend, and A. Ross-Townsend. 1978. Substance use and abuse among the community elderly: The medical aspect. Addict. Dis. 3:357-372. Clarke, M. G., A. J. Williams, and P. A. Jones. 1981. A psychogeriatric survey of old people's homes. Br. Med. J. 283:1307-1310. Clayson, D. B. 1975. Nutrition and experimental carcinogenesis: A review. Cancer Res. 35:3292-3300. Clinton, S. K., C. R. Truex, and W. J. Visek. 1979. Dietary protein, aryl hydrocarbon hydroxylase and chemical carcinogenesis in rats. J. Nutr. 109:55-62.

REFERENCES 177 Clokey, G. V., and L. A. Jacobson. 1986. The autofluorescent "lipofuscin granulesn in the intestinal cells of Cacnorhabditi~ clegans are secondary lysosomes. Mech. Ageing Dev. 35:79-94. Cluff, L. E., G. L. Thornton, and J. Smith. 1965. Epidemiological study of adverse drug reactions. Trans. Assoc. Am. Physicians 78:255-268. Cokkinos, D. V., G. D. Tsartsalis, E. T. Heimonas, and C. D. Gardikas. 1980. Comparison of the inotropic action of digitalis and isoproterenol in younger and older individuals. Am. Heart J. 100:802-806. Coleman, G. L., W. Barthold, G. W. Osbaldiston, S. J. Foster, and A. M. Jonas. 1977. Pathologic changes during aging in barrier-reared Fischer 344 male rats. J. Gerontol. 32:258-278. Collins, M., and G. M. Rubin. 1984. Structure of chromosomal rearrange- ments induced by the FB transposable element in Drosophila. Nature 308:323-327. Comfort, A. 1963. Effect of delayed and resumed growth on the longevity of a fish (Lebistes reticulates, Peters) in captivity. Gerontologia 8:150-155. Comfort, A. 1979. Ageing: The Biology of Senescence. 3rd ed. New York: Holt Rinehart and Winston, Inc. 414 pp. Conney, A. H., R. Welch, R. Kuntzman, R. Chang, M. Jacobson, A. D. Munro-Faure, A. W. Peck, A. Bye, A. Poland, P. J. Poppers, M. Finster, and J. A. Wolff. 1971. Effects of environmental chemicals on the metabolism of drugs, carcinogens, and normal body constituents in man. Ann. N.Y. Acad. Sci. 179:155-172. Conrad, K., and R. Bressler. 1982. Drug Therapy for the Elderly. St. Louis: C. V. Mosby. Conway, J., R. Wheeler, and R. Sannerstedt. 1971. Sympathetic nervous activity during exercise in relation to age. Cardiovasc. Res. 5:577-581. Cooper, J. W., Jr., and C. G. Bagwell. 1978. Contribution of the consultant pharmacist to rational drug usage in the long-term care facility. J. Am. Geriatr. Soc. 26:513-520. Costa, P. T., Jr., and R. R. McCrae. 1980. Functional age: A conceptual and empirical critique. Pp. 25-50 in S. G. Haynes and M. Feinleib, eds., Proceedings of Second Conference on Epidemiology of Aging, 1977, National Institutes of Health, Bethesda, Md. (NIH Publication No. 80-969) Washington, D.C.: U.S. Government Printing Office. Costa, P. T., Jr., and R. R. McCrae. 1985. Concepts of functional or biological age: A critical view. Pp. 30-37 in R. Andres, E. L. Bierman, and W. R. Hazzard, eds., Principles of Geriatric Medicine. New York: McGraw-Hill Book Co. Crapper, D. R., S. S. Krishnan, and S. Quittkat. 1976. Aluminum, neurofib- rillary degeneration and Alzheimer's disease. Brain 99:67-80. Crowley, C., and H. J. Curtis. 1963. The development of somatic mutations in mice with age. Proc. Natl. Acad. Sci. USA 49:62~628. Crowley, J. J., B. J. Cusak, S. G. Jue, J. R. Koup, and R. E. Vestal. 1986. Induction of theophylline metabolish by phenytoin is unaltered by aging. (Abstract) Clin. Res. 34:396A. Cummings, J., D. F. Benson, and S. LoVerme, Jr. 1980. Reversible dementia: Illustrative cases, definition, and review. J. Am. Med. Assoc. 243:2434- 2439.

178 REFERENCES Cummings, S. R., J. L. Kelsey, M. C. Nevitt, and K. J. O'Dowd. 1985. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol. Rev. 7:178-208. Curtis, H. J., and K. Miller. 1971. Chromosome aberrations in liver cells of guinea pigs. J. Gerontol. 26:292-293. Cusack, B. J., and M. J. Denham. 1984. Nutritional status and drug disposition in the elderly. Pp. 71-91 in D. A. Roe, ea., Drugs and Nutrition in the Geriatric Patient. New York: Churchill Livingstone. Dalderup, L. M., and Visser, W. 1969. Influence of extra sucrose in the daily food on the life-span of Wistar albino rats. Nature 222:105~1052. Das, M., D. R. Bickers, and H. Mukhtar. 1986. Epidermis: The major site of cutaneous benzota~pyrene and benzo~a~pyrene-7,8-diol metabolism in neonatal BALB/c mice. Drug Metab. Dispos. 14:637-642. Davis, R., and C. W. Leathers, eds. 1985. Behavior and Pathology of Aging in Rhesus Monkeys. New York: Alan R. Liss. Davis, T. A., C. W. Bales, and R. E. Beauchene. 1983. Differential effects of dietary caloric and protein restriction in the aging rat. Exp. Gerontol. 18:427-435. DeBethizy, J. D., J. M. Sherrill, D. E. Rickert, and T. E. Hamm, Jr. 1983. Effects of pectin-containing diets on the hepatic macromolecular covalent binding of 2,6-dinitro-~3H]toluene in Fischer-344 rats. Toxicol. Appl. Pharmacol. 69:369-376. Dion, K., E. Berscheid, and E. Walster. 1972. What is beautiful is good. J. Pers. Soc. Psychol. 24:285-290. Divoll, M., D. J. Greenblatt, D. R. Abernethy, and R. I. Shader. 1982. Cimetidine impairs clearance of antipyrine and desmethyldiazepam in the elderly. J. Am. Geriatr. Soc. 30:684-689. Doll, R. 1978. An epidemiological perspective of the biology of cancer. Cancer Res. 38:3573-3583. Doll, R., and R. Peto. 1978. Cigarette smoking and bronchial carcinoma: Dose and time relationships among regular smokers and lifelong non- smokers. J. Epidemiol. Community Health 32:303-313. Doll, R., and R. Peto. 1981. The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst. 66:1191-1308. Doppelt, S. H., R. M. Neer, M. Daly, L. Gourret, A. Schiller, and M.F. Holick. 1983. Vitamin-D Deficiency and osteomalacia in patients with hip fractures. Orthop. Trans. 7:512-513. Dresdale, A., R. O. Bonow, R. Wesley, S. T. Palmeri, L. Barr, D. Mathison, T. D'Angelo, and S. A. Rosenberg. 1983. Prospective evaluation of doxorubicin-induced cardiomyopathy resulting from postsurgical adju- vant treatment of patients with soft tissue sarcomas. Cancer 52:51-60. Duffy, F. H., J. L. Burchfiel, P. H. Bartels, M. Gaon, and V. M. Sim. 1979. Long-term effects of an organophosphate upon the human electroen- cephalogram. Toxicol. Appl. Pharmacol. 47:161-176. Duggan, D. E., A. F. Hogans, K. C. Kwan, and F. G. McMahon. 1972. The metabolism of indomethacin in man. J. Pharmacol. Exp. Ther. 181:563-575. Durand, A. M., M. Fisher, and M. Adams. 1964. Histology in rats as influenced by age and diet. Arch. Pathol. 77:268-277.

REFERENCES 179 Durand, A., M. Fisher, and M. Adams. 1968. The influence of type of dietary carbohydrates. Effect on histological findings in two strains of rats. Arch. Pathol. 85:318-324. Enjeti, S., B. Hazelwood, S. Permutt, H. Menkes, and P. Terry. 1978. Pulmonary function in young smokers. Male-female differences. Am. Rear. Respir. Dis. 118:667~76. Esser, K., and B. Bockelman. 1985. Fungi. Pp. 231-246 in F. A. Lints, ea., Non-Mammalian Models for Research on Aging. (Interdisciplinary Topics in Gerontology, Vol. 21) Basel, N.Y.: Karger. Evans, M. J., and G. Freeman. 1980. Morphological and pathological effects of NO2 on the rat lung. Pp. 243-265 in S. D. Lee, ea., Nitrogen Oxides and Their Effects on Health. Ann Arbor, Mich.: Ann Arbor Science Publishers. Evans, D. A. P., K. A. Manley, and V. A. McKusick. 1960. Genetic control of isoniazid metabolism in man. Br. Med. J. 2:485-491. Everitt, A. V. 1973. The hypothalamic-pituitary control of aging and age- related pathology. Exp. Gerontol. 8:265-277. Everitt, A. V. 1982. Nutrition and the hypothalamic pituitary influence on aging. Pp. 245-256 in G. B. Moment, ea., Nutritional Approaches to Aging. Boca Raton, Fla.: CRC Press. Everitt, A. V., B. D. Porter, and M. Steele. 1981. Dietary, caging and temperature factors in the aging of collagen fibers in rat tail tendon. Gerontology 27:37-41. Everitt, A. V., N. J. Seedsman, and F. Jones. 1980. The effects of hypophy- sectomy and continuous food restriction, begun at age 70 and 400 days, on collagen aging, proteinuria, incidence of pathology and longevity in the male rat. Mech. Ageing Deer. 12:161-172. Fanestil, D. D., and C. H. Barrows, Jr. 1965. Aging in the rotifer. J. Gerontol. 20:462-469. Fanger, P. O. 1972. Thermal Comfort: Analysis and Applications in Envi- ronmental Engineering. Copenhagen: Danish Technical Press. 244 pp. Farah, F., W. Taylor, M. D. Rawlins, and O. James. 1977. Hepatic drug acetylation and oxidation: Effects of aging in man. Br. Med. J. 2:155- 156. Feeney-Burns, L., and M. R. Ellersieck. 1985. Age-related changes in the ultrastructure of Bruch's membrane. Am. J. OpEthalmol. 100:686-697. Feinleib, M., and J. Luoto. 1984. Longevity of nonsmoking men and women. Public Health Rep. 99:223. Fernandes, G., E. J. Yunis, D. G. Jose, and R. A. Good. 1973. Dietary influence on antinuclear antibodies and cell-mediated immunity in NZB mice. Int. Arch. Allergy Appl. Immunol. 44:770-782. Fernandes, G., E. J. Yunis, J. Smith, and R. A. Good. 1972. Dietary influence on breeding behavior, hemolytic anemia, and longevity in NZB mice. Proc. Soc. Exp. Biol. Med. 139:1189-1196. Fernandes, G., P. Friend, E. J. Yunis, and R. A. Good. 19?8. Influence of dietary restriction on immunologic function and renal disease in (NZB X NZW)F~ mice. Proc. Natl. Acad. Sci. USA 75:150~1504.

180 REFERENCES Filion, A.-M., and M. Laughrea. 1985. Translation fidelity in the brain, liver, and hippocampus of the aging Fischer 344 rat. Pp. 257-262 in R. S. Sohal, L. S. Birnbaum, and R.G. Cutler, eds., Molecular Biology of Aging: Gene Stability and Gene Expression. (Aging Series, Vol. 29) New York: Raven Press. Finch, C. E., and P. W. Landfield. 1985. Neuroendocrine and autonomic functions in aging mammals. Pp. 567-594 in C. E. Finch and E. L. Schneider, eds., Handbook of Biology of Aging. 2d ed. New York: Van Nostrand Reinhold Co. Fire, A. 1986. Integrative transformation of Caenorhabditis elegans. EMBO J. 5:2673-2680. Fleisch, J. H. 1981. Age-related decrease in beta adrenoreceptor activity of the cardiovascular system. Trends Pharmacol. Sci. 2:377-339. Fletcher, C. M. 1976. The Natural History of Chronic Bronchitis and Emphysema. An Eight-Year Study Of Early Chronic Obstructive Lung Disease in Working Men in London. New York: Oxford University Press. 272 pp. Flower, S. S. 1931. Contributions to our knowledge of the duration of life in vertebrate animals. Part V. Mammals. Proc. Zool. Soc. London 1:145-234. Flynn, M. A. 1984. Problems in nutritional management of the elderly. Pp. 307-314 in H. J. Armbrecht, J. M. Prendergast, and R. M. Coe, eds., Nutritional Intervention in the Aging Process. New York: Springer- Verlag. Forsum, E., P. E. Hillman, and M. C. Nesheim. 1981. Effect of energy restriction on total heat production, basal metabolic rate, and specific dynamic action of food in rats. J. Nutr. 111:1691-1697. Fowle, J. R., III. 1984. Workshop Proceedings: Approaches to Improving the Assessment of Human Genetic Risk Human Biomonitoring. Re- port No. EPA-600/9-84-016. Washington, D.C.: U.S. Environmental Protection Agency, Office of Health and Environmental Assessment. 59 pp. "Available from National Technical Information Service, Springfield, Va., as PB85-1030183. Francis, A. A., W. H. Lee, and J. D. Regan. 1981. The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals. Mech. Ageing Dev. 16:181-189. Freer, C. B. 1985a. Old myths. Lancet 1:268-269. Freer, C. B. 1985b. Study of medicine prescribing for elderly patients. Br. Med. J. 290:1113-1115. French, C. E., R. H. Ingram, J. A. Uram, G. P. Barron, and R. W. Swift. 1953. The influence of dietary fat and carbohydrate on growth and longev~ity in rats. J. Nutr. 51:329-339. Fridovich, I. 1977. Oxygen radicals, hydrogen peroxide, and oxygen toxicity. Pp. 239-277 in W. A. Pryor, ea., Free Radicals in Biology, Vol. 1. New York: Academic Press. Friedman, D. B., and T. E. Johnson (in press). A mutation in the ayc-1 gene in Cacnorhabdilw clegans lengthens life and reduces hermaphrodite fertility. Genetics.

REFERENCES 181 Friedman, Z., V. Whitman, M. J. Maisels, W. Berman, Jr., K. H. Marks, and E. S. Vesell. 1978. Indomethacin disposition and indomethacin- induced platelet dysfunction in premature infants. J. Clin. Pharmacol. 18:272-279. Fries, J. F. 1980. Aging, natural death, and the compression of morbidity. N. Engl. J. Med. 303:130-135. Fries, J. F. 1983. The compression of morbidity. Milbank Mem. Fund Q. 61 :397-419. Farukawa, T., M. Inoue, F. Ka; iya, H. Inada, S. Takasugi, S. E`ukni, H. Takeda, and H. Abe. 1975. Assessment of biological age by multiple regression analysis. J. Gerontol. 30:422-434. Gachalyi, B., A. Vas, P. Hajos, and A. Kaldor. 1984. Acetylator phenotypes: Eject of age. Eur. J. Clin. Pharmacol. 26:43-45. Gallant, J. 1981. Error catastrophe theory of cellular senescence. Pp. 373- 381 in R. T. Schimke, ea., Biological Mechanisms in Aging. (NIH Publication No. 81-2194) Washington, D.C.: U.S. Government Printing Office. Gardner, D. E., F. J. Miller, E. J. Blommer, and D. L. Coffin. 1979. Influence of exposure mode on the toxicity of NO2. Environ. Health Perspect. 30:23-29. Gardner, P., and L. E. Cluff. 1970. The epidemiology of adverse drug reactions. A review and perspective. Johns Hopkins Med. J. 126:77-87. Garrettson, L. K., and P. G. Dayton. 1970. Disappearance of phenobarbital and diphenylhydantoin from serum of children. Clin. Pharmacol. Ther. 11 :674-679. Garruto, R. M., D. C. Gaidusek, and K. M. Chen. 1980. Amyotrophic lateral sclerosis among Chamorro migrants from Guam. Ann. Neural. 8:612-619. Garry, P., and W. Hunt. 1986. Biochemical assessment of vitamin status in the elderly: Ejects of dietary supplement intakes. Pp. 117-137 in M. L. Hutchinson and H. N. Munro, eds., Nutrition and Aging. New York: Academic Press. Garry, P. J., J. S. Goodwin, W. C. Hunt, E. M. Hooper, and A. G. Leonard. 1982a. Nutritional status in a healthy elderly population: Dietary and supplemental intakes. Am. J. Clin. Nutr. 36:319-331. Garry, P. J., J. S. Goodwin, and W. C. Hunt. 1982b. Nutritional status in a healthy elderly population: Riboflavin. Am. J. Clin. Nutr. 36:902-909. Garry, P. J., J. S. Goodwin, W. C. Hunt, and B. A. Gilbert. 1982c. Nutritional status in a healthy elderly population: Vitamin C. Am. J. Clin. Nutr. 36:332-339. Gerrard, J. W., D. W. Cockcroft, J. T. Mink, D. J. Cotton, R. Poonawala, and J. A. Dosman. 1980. Increased nonspecific bronchial reactivity in cigarette smokers with normal lung function. Am. Rev. Respir. Dis. 122:577-581. Gerstenblith, G., H. A. Spurgeon, J. P. Froehlich, M. L. Weisfeldt, and E. G. Lakatta. 1979. Diminished isotropic responsiveness to ouabain in aged rat myocardium. Circ. Res. 44:517-523. Gibaldi, M., and D. Perrier. 1982. Pharmacokinetics. 2d ed. New York: Marcel Dekker. 494 pp.

182 REFERENCES Gilchrest, B. A. 1979. Relationship between actinic damage and chronologic aging in keratinocyte cultures of human skin. J. Invest. Dermatol. 72:219-223. Gilchrest, B. A. 1980. Prior chronic sun exposure decreases the lifespan of human skin fibroblasts in vitro. J. Gerontol. 35:537-541. Gilchrest, B. A. 1984. Skin and Aging Processes. Boca Raton, Fla.: CRC Press. 120 pp. Gilchrest, B. A., J. S. Staff, and N. A. Soter. 1982a. Chronologic aging alters the response to ultraviolet-induced inflammation in human skin. J. Invest. Dermatol. 79:11-15. Gilchrest, B., G. F. Murphy, and N. A. Soter. 1982b. Effect of chrono- logic aging and ultraviolet irradiation on Langerhans cells in human epidermis. J. Invest. Dermatol. 79:85-88. Gilchrest, B., G. Szabo, E. Flynn, and R. M. Goldwyn. 1983. Chronologic and actinically induced aging in human facial skin. J. Invest. Dermatol. 80(Suppl.~:81s-85s. Giles, H. G., S. M. MacLeod, J. R. Wright, and E. M. Sellers. 1978. Influence of age and previous use on diazepam dosage required for endoscopy. Can. Med. Assoc. J. 118:513-514. Gillette, J. R. 1971. Factors affecting drug metabolism. Ann. N.Y. Acad. Sci. 179:43-66. Glenner, G. G. 1982. Alsheimer's disease (senile dementia): A research update and critique with recommendations. J. Am. Geriatr. Soc. 30:59- 62. Good, R. A., A. West, and G. Fernandes. 1980. Nutritional modulation of immune responses. Fed. Proc. Fed. Am. Soc. Exp. Biol. 39:3098-3104. Goodrick, C. L. 1978. Body weight increment and length of life: The effect of genetic constitution and dietary protein. J. Gerontol. 33:184-190. Goodrick, C. L., D. K. Ingram, M. A. Reynolds, J. R. Freeman, and N. L. Cider. 1983. Differential effects of intermittent feeding and voluntary exercise on body weight and lifespan in adult rats. J. Gerontol. 38:36-45. Goodwin, J. S., J. M. Goodwin, and P. J. Garry. 1983. Association between nutritional status and cognitive functioning in a healthy elderly population. J. Am. Med. Assoc. 249:2917-2921. Gotto, A. M., Jr. 1986. Treatment of hyperlipidemia. Am. J. Cardiol. 57:1 lG-16G. Goyer, R. A. 1986. Toxic eEects of metals. Pp. 582-635 in C. D. Klaassen, M. O. Amdur, and J. Doull, eds., Casarett and Doull's Toxicology: The Basic Science of Poisons. 3rd ed. New York: Macmillan. Graf, R. J., J. B. Halter, and D. Porte. 1978. Glycosolated hemoglobin in normal subjects and subjects with maturity onset diabetes. Evidence for a saturable system In man. Diabetes 27:834-839. Graham, J. A., and A. M. Kligman. 1985. Physical attractiveness, cosmetic use and self-perception. Int. J. Cosmet. Sci. 7:85-97. Greenblatt, D. J., E. M. Sellers, and R. I. Shader. 1982. Drug disposition In old age. N. Engl. J. Med. 306:1081-1088. Grove, G. L., R. M. Lavker, E. Hoelzle, and A. M. Kligman. 1981. Use of nonintrusive tests to monitor age-associated changes in human skin. J. Soc. Cosmet. Chem. 32:15-26. Guariglia, P., and C. Abrahams. 1985. The impact of autopsy data on DRG reimbursement. Hum. Pathol. 16:1184-1186.

REFERENCES 183 Guigoz, Y., and H. N. Munro. 1985. Nutrition and aging. Pp. 878-893 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging, 2d ed. New York: Van Nostrand Reinhold Co. Guttmann, D. 1978. Patterns of legal drug use by older Americans. Addict. Die. 3:337-356. Hall, M. R. P. 1982. Drug interactions in the elderly. Gerontology 28(Suppl. 1~:18-24. Harman, D. 1978. Free radical theory of aging: Nutritional implications. Age 1:145-152. Harman, D. 1981. The aging process. Proc. Natl. Acad. Sci. USA 78:7124- 7128. Harrison, Y. E., and W. L. West. 1971. Stimulatory effect of charcoal-broiled ground beef on the hydroxylation of 3,4-benspyrene by enzymes in rat liver and placenta. Biochem. Pharmacol. 20:2105-2108. Harrison, D. E., J. R. Archer, and C. M. Astle. 1984. Effects of food restriction on aging: Separation of food intake and adiposity. Proc. Natl. Acad. Sci. USA 81:1835-1838. Hart, R. W., and R. B. Setlow. 1974. Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc. Natl. Acad. Sci. USA 71:2169-2173. Hausman, P. B., and M. E. Weksler. 1985. Changes in the immune response with age. Pp. 414-432 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging. 2nd ed. New York: Van Nostrand Reinhold Co. Hayes, A. W., ed. 1982. Principles and Methods of Toxicology. New York: Raven Press. 750 pp. Haydick, L. 1965. The limited in vitro lifetime of human diploid cell strains. Hap. Cell. Res. 37:614036. HayBick, L. 1974. The strategy of senescence. Gerontologist 14:37-45. Hayllick, L. 1979. The cellular basis for biologic aging. Pp. 159-186 in C. E. Finch and L. Hayllick, eds., Handbook of the Biology of Aging. New York: Van Nostrand Reinhold Co. Hayflick, L., and P. S. Moorhead. 1961. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25:585~21. Hazzard, W. R. 1983. Clinical rationales for the inclusion of geriatrics in medical education. Pp. 23-52 in Proceedings of the Regional Institute on Geriatric and Medical Education. Washington, D.C.: Association of American Medical Colleges. Heaney, R. P., J. C. Gallagher, C. C. Johnston, R. Neer, A. M. Parfitt, and G. D. Whedon. 1982. Calcium nutrition and bone health in the elderly. Am. J. Clin. Nutr. 36:98~1013. Hegner, D. 1980. Age-dependence of molecular and functional changes in biological membrane properties. Mech. Ageing Dev. 14:101-118. Helen Keller International, Inc. 1986. To Restore Sight: The Global Conquest of Cataract Blindness. New York: Helen Keller International, Inc. 58 pp. Helmkamp, J. C., E. O. Talbott, and H. Margolis. 1984. Occupational noise exposure and hearing loss characteristics of a blue-collar population. J. Occup. Med. 26:885-891. Higgins, M. W., and J. B. Keller. 1970. Predictors of mortality in the adult population of Tecumseh. Arch. Environ. Health 21:418-424.

184 REFERENCES Higgins, M. W., 3. B. Keller, M. Becker, W. Howatt, J. R. Landis, H. Rotman, J. G. Weg, and I. Higgins. 1982. An index of risk for obetructi~re airways disease. Am. Rev. Respir. Dis. 125:144-151. Higginson, J. 1969. Present trends in cancer epidemiology. Pp. 4075 in J. F. Morgan, ea., Proceedings of the Eighth Canadian Cancer Conference, Honey Harbour, Ontario, 1968. Toronto: Pergamon Press. Hill, M., R. MacLennan, and K. Newcombe. 1979. Letter to the editor: Diet and large-bowel cancer in three socioeconomic groups in Hong Kong. Lancet 1:436. Holick, M. F. 1986. Vitamin D requirements for the elderly. Olin. Nutr. 1986. 5:121-129. Hoover, R., and J. F. Fraumeni, Jr. 1973. Risk of cancer in renal-transplant recipients. Lancet 2:55-57. Horn, P. L., M. S. Turker, C. E. Ogburn, C. M. Di~teche, and G. M. Martin. 1984. A cloning assay for 6-thioguanine resistance provides evidence against certain somatic mutational theories of aging. J. Cell. Physiol. 121:309-315. Hornig, D. F. (in press) Conclusions, Chapter 20. In J. Brain, ea., Variations in Susceptibility to Toxic Agents in the Air: Identification, Mechanisms, and Policy Implications. Baltimore, Md.: Johns Hopkins University Press. Hostetter, T. H., J. L. Olson, H. G. Rennke, M. A. Venkatachalam, and B. M. Brenner. 1981. Hyperfiltration in remnant nephrons: A potentially adverse response to renal ablation. Am. J. Physiol. 241:F85-F93. Houston, A. 1979. Drug use in Southampton hospitals. MCFM Thesis cited by C. M. Castleden and C. F. George. 1984. Prescription for the elderly. Pp. 71-98 in K. O'Malley, ea., Clinical Pharmacology and Drug Treatment in the Elderly. Edinburgh: Churchill Livingstone. Hruza, Z., and Chvapil, M. 1962. Collagen characteristics in the skin, tad! tendon and lungs in experimental atherosclerosis in the rat. Physiol. Bohemoslav. 11 :423-429. Hucker, H. B., A. G. Zacchei, S. V. Cox, D. A. Brodie, and N. H. R. Cantwell. 1966. Studies on the absorption, distribution and excretion of indomethacin in various species. J. Pharmacol. E5cp. Ther. 153:237- 249. Hurwitz, N. 1969. Predisposing factors in adverse reactions to drugs. Br. Med. J. 1:536-539. Hypertension Detection and Follow-up Program Cooperative Group. 1987. Educational level and 5-year all-cause mortality in the hypertension detection and follow-up program. Hypertension 9:641-646. Hypertension Detection and Follow-up Program Cooperative Research Group. 1985. Mortality findings for stepped-care and referred-care participants in the Hypertension Detection and Follow-up Program, stratified by other risk factors. Prev. Med. 14:312-335. Inamizu, T., N. Kinohara, M. P. Chang, and T. Makinodan. 1986. Frequency of 6-thioguanine-resistant T cells is inversely related to the declining T-cell activities in aging mice. Proc. Natl. Acad. Sci. USA 83:2488-2491. Ingle, L., T. R. Wood, and A. M. Banta. 1937. A study of longevity, growth, reproduction and heart rate in Daphnia longispina as influenced by limitations in quantity of food. J. Exp. Zool. 76:325-352.

REFERENCES 185 Ingman, S. R., I. R. Lawson, P. G. Pierpsoli, and P. Blake. 1975. A survey of the prescribing and administration of drugs in a long-term care institution for the elderly. J. Am. Geriatr. Soc. 23:309-316. Institute of Medicine and National Research Council. 1985. America's Aging: Health in an Older Society. Committee on an Aging Society. Washington, D.C.: National Academy Press. 241 pp. International Agency for Research on Cancer. 1982. Formaldehyde. Pp. 345- 389 in IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Some Industrial Chemicals and Dyestuff~. Vol. 29. Lyon, France: IARC. Iselius, L., and D. A. P. Evans. 1983. Formal genetics of isoniazid metabolism in man. Clin. Pharmacokinet. 8:541-544. Iwasaki, K., C. A. Gleiser, E. J. Masoro, and B. P. Yu. 1986. Dietary protein and chronic nephropathy in the rat. Fed. Proc. Fed. Am. Soc. Exp. Biol. 45:829. Jensen, O. M., and A. M. Bolander. 1980. Trends in malignant melanoma of the skin. World Health Stat. Q. 33:2-26. Jick, H. 1974. Drugs—remarkably non-toxic. N. Engl. J. Med. 291:824-828 Johannsen, W. 1909. Elemente der exakten Erblichkeitslehre. Jena, Ger- many: Fisher. Johnson, T. E. 1984. Analysis of the biological basis of aging in the nematode, with special emphasis on Cacnorhabditis plenary. Pp. 5093 in D. H. Mitchell and T. E. Johnson, eds., Invertebrate Models in Aging Research. Boca Raton, Fla.: CRC Press, Inc. Johnson, T. E. 1987. Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 84:3777-3781. Johnson, T. E., and N. L. Foltz. 1987. Aging in Cacnorhab~ illegal: Update 1986. Pp. 37-47 in M. R. Rothstein, ea., Annual Review of Biological Research in Aging. Vol. 3. New York: Alan R. Liss. Johnson, T. E., and V. J. Simpson. 1985. Aging studies in Cacr~orhabdilw elegant and other nematodes. Pp. 481-495 in V. J. Cristofalo, ea., Handbook of Cell Biology of Aging. Boca Raton, Fla.: CRC Press, Inc. Joint American Medical Association-American Nursing Association Task Force. 1983. The Improvement of Health Care of the Aged Chronically Ill. Kansas City, Mo.: American Medical Assoc.-American Nursing Assoc. Joseph, J. A., J. Whitaker, G. S. Roth, and D. K. Ingram. 1983. Life-long dietary restriction affects striatially-mediated behavioral responses in aged rate. Neurobiol. Aging 4:191-196. Kador P. F., Y. Akagi, and J. H. Kino~hita. 1985. Diabetic cataracts in animal models: Prevention and reversibility with aldose reductase inhibitors. Diabetic Med. 2:194-197. Kaiko, R. F. 1980. Age and morphine analgesia in cancer patients with postoperative pain. Clin. Pharmacol. Ther. 28:823-826. Kalchthaler, T., E. Coccaro, and S. Lichtiger. 1977. Incidence of polyphar- macy in a long-term care facility. J. Am. Geriatr. Soc. 25:308-313. Kalu, D. N., R. Cockerham, B. P. Yu, and B. A. Roos. 1983. Lifelong dietary modulation of calcitonin levels in rats. Endocrinology 113:201~2016.

186 REFERENCES Kalu, D. N., R. R. Hardin, R. Cockerham, B. P. Yu, B. K. Norling, and J. W. Egan. 1984. Lifelong food restriction prevents senile osteopenia and hyperparathyroidism in F344 rats. Mech. Age lug Dev. 26:103-112. Kannel, W. B. 1985. Hypertension and aging. Pp. 859~877 in C. E. Finch and E. L. Schneider, ed$., Handbook of the Biology of Aging. 2d ed. New York: Van Nostrand Reinhold Co. Kannel, W. B., W. P. Castelli, T. Gordon, and P. M. McNamara. 1971. Serum cholesterol, lipoproteins, and the risk of coronary heart disease: The Framingham Study. Ann. Intern. Med. 74:1-12. Kaplan, J. G. 1980. Neurotoxicity of selected biological toxins. Pp. 631~48 in P. S. Spencer and H. H. Schaumburg, edit., Experimental and Clinical Neurotoxicology. Baltimore: Williams & Wilkins. Kappas, A., A. P. Alvares, K. E. Anderson, E. J. Pantuck, C. B. Pantuck, R. Chang, and A. H. Conney. 1978. Effect of charcoal-broiled beef on antipyrine and theophylline metabolism. Clin. Pharmacol. Ther. 23:445-450. Kappas, A., K. E. Anderson, A. H. Conney, and A. P. Alvares. 1976. Influ- ence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Clin. Pharmacol. Ther. 20:6434i53. Karch, F. E., and L. Lasagna. 1975. Adverse drug reactions. A critical review. J. Am. Med. Assoc. 234:12301241. Katzman, R., and R. D. Terry. 1983. Normal aging of the nervous system. Pp. 15-50 in R. Katzman and R. D. Terry, eds., The Neurology of Aging. Philadelphia: F. A. Davis. Kauffman, R. E., D. W. Shoeman, S. H. Wan, and D. L. Azarnoff. 1972. Absorption and excretion of clindamycin-2-phosphate in children after intramuscular injection. Clin. Pharmacol. Ther. 13:704-709. Kayser, J., J. Neumann, and J. Lavollay. 1972. Effete favorables exerces sur la longevity du rat Wistar per divers types de restrictions vitaminiques. C. R. Acad. Sci., Serie D 274:3593-3596. Kellaway, G. S., and E. McCrae. 1973. Intensive monitoring for adverse drug effects in patients discharged from acute medical wards. N. Z. Med. J. 78:525-528. Kiecolt-Glaser, J. K., R. Glaser, D. Williger, J. Stout, G. Messick, S. Sheppard, D. Ricker, S. C. Romisher, W. Briner, G. Bonnell, and R. Donnerberg. 1985. Psychosocial enhancement of immunocompetence in a geriatric population. Health Psychol. 4:25-41. Kiel, J. E., J. F. F`inklea, R. L. Pietsch, and R. H. Gasden. 1969. A pesticide use survey of urban households. Agric. Chem. 24:10-12. Kirkwood, T. B. L. 1985. Comparative and evolutionary aspects of longevity. Pp. 27-44 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging, 2d ed. New York: Van Nostrand Reinhold Co. Kitagawa, T., O. Hino, K. Nomura, and H. Sugano. 1984. Dose-response studies on promoting and anticarcinogenic effects of phenobarbital and DDT in the rat hepatocarcinogenesis. Carcinogenesis 5:1653-1656. Klaassen, C. D., M. O. Amdur, and J. Doull, eds. 1986. Casarett and Doull's Toxicology: The Basic Science of Poisons. 3rd ed. New York: Macmillan. 974 pp. Klebanoff, S. J. 1980. Oxygen metabolism and the toxic properties of phagocytes. Ann. Intern. Med. 93:480-489.

REFERENCES 187 Klein, L. E., P. S. German, and D. M. Levine. 1981. Adverse drug reactions among the elderb: A reassessment. J. Am. Geriatr. Soc. 29:525-530. Klein, L. E., P. S. German, D. M. Levine, E. R. Feroli, Jr., and J. Ardery. 1984. Medication problems among outpatients. A study with emphasis on the elderly. Arch. Intern. Med. 144:1185-1188. Klein, U., M. Klein, H. Sturm, M. Rothenbuhler, R. Huber, P. Stucki, I. Gikalov, M. Keller, and R. Hoigne. 1976. The frequency of adverse drug reactions as dependent upon age, sex and duration of hospitalization. Int. J. Clin. Pharmacol. Biopharm. 13:187-195. Kligman, A. M. 1969. Early destructive effect of sunlight on human skin. J. Am. Med. Assoc. 210:2377-2380. Kligman, A. M. 1979. Perspectives and problems in cutaneous gerontology. J. Invest. Dermatol. 73:3046. Kligman, L. H., F. J. Akin, and A. M. Kligman. 1982. Prevention of ultraviolet damage to the dermis of hairless mice by sunscreens. J. Invest. Dermatol. 78:181-189. Kligman, L. H., F. J. Akin, and A. M. Kligman. 1985. The contributions of UVA and UVB to connective tissue damage in hairless mice. J. Invest. Dermatol. 84:272-276. Kohn, R. R. 1982. Cause of death in very old people. J. Am. Med. Assoc. 247:2793-2797. Kokkonen, G. C., and C. H. Barrows. 1985. The effect of dietary vitamin, protein and intake levels on the life span of mice of different ages. Age 8:13-18. Kripke, M. L. 1974. Antigenicity of marine skin tumors induced by ultraviolet light. J. Natl. Cancer Inst. 53:1333-1336. Kritchevsky, D., M. M. Weber, and D. M. Klurfeld. 1984. Dietary fat ver- sus caloric content in initiation and promotion of 7,12-dimethylbenz~a)- anthracene-induced mammary tumorigenesis in rate. Cancer Res. 44:3174-3177. Kuramoto, K.? S. Matsushita, J. Mifune, M. Sakai, and M. Murakami. 1978. Electrocardiographic and hemodynamic evaluations of isoproterenol test in elderly ischemic heart disease. Jpn. Circ. J. 42:955-960. LaBella, F. S. 1965. Structure of collagen from human tendon as influenced by age and sex. J. Gerontol. 20:54-59. LaDu, B. N. 1972. Pharmacogenetic~: Defective enzymes in relation to reactions to drugs. Ann. Rev. Med. 23:453-468. Lakatta, E. G. 1985a. Health, disease, and cardiovascular aging. Pp. 73-104 in Institute of Medicine and National Research Council, Committee on an Aging Society, eds., America's Aging: Health in an Older Society. Washington, D.C.: National Academy Press. Lakatta, E. G. 1985b. Heart and circulatione Pp. 377-413 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging. 2d ed. New York: Van Nostrand Reinhold Co. Lakatta, E. G. 1986. Diminished beta-adrenergic modulation of cardiovascu- lar function in advanced age. Cardiol. Clin. 4:185-200. Lancaster, H. O., and J. Nelson. 1957. Sunlight as a cause of melanoma: A clinical survey. Med. J. Aust. 1:452-456. Lane, R. J., and P. A. Routledge. 1983. Drug-induced neurological disorders. Drugs 26:124-147.

188 REFERENCES Langer, E. J., and J. Rodin. 1976. The effects of choice and enhanced per- sonal responsibility for the aged: A field experiment in an institutional setting. J. Pers. Soc. Psychol. 34:191-198. Langer, E. J., J. Rodin, P. Beck, C. Weinman, and L. Spitzer. 1979. Environmental determinants of memory improvement in late adulthood. J. Pers. Soc. Psychol. 37:2003-2013. Langford, H. G., J. Stamler, S. Wassertheil-Smoller, and R. J. Prineas. 1986. All-cau~e mortality in the Hypertension Detection and Follow-up Program: Findings for the whole cohort and for persons with less severe hypertension, with and without other traits related to risk of mortality. Prog. Cardiovascular Dis. 29~3, Suppl. 1~:2054. Langston, J. W. 1985. MPTP neurotoxicity: An overview and characteriza- tion of phases of toxicity. Life Sci. 36:201-206. Laouari, D., C. Kleinknecht, M. C. Gubler, and M. Brayer. 1983. Adverse effect of proteins on remnant kidney: Dissociation from that of other nutrients. Kidney Int. [Suppl.] 16:S248-S253. Laragh, J. H., and M. S. Pecker. 1983. Dietary sodium and essential hypertension: Some myths, hopes, and truths. Ann. Intern. Med. 98:735-743. Larson, E. B., B. V. Reifier, H. J. Featherstone, and D. R. English. 1984. Dementia in elderly outpatients: A prospective study. Ann. Intern. Med. 100:417-423. Laudenslager, M. L., S. M. Ryan, R. C. Drugan, R. L. Hyson, and S. F. Maier. 1983. Coping and immunosuppression: Inescapable but not escapable shock suppresses lymphocyte proliferation. Science 221:568-570. Lavker, R. M. 1979. Structural alterations in exposed and unexposed aged skin. J. Invest. Dermatol. 73:59 66. Lawson, D. H., and H. Jick. 1976. Drug prescribing in hospitals: An international comparison. Am. J. Public Health 66:644-648. Leaf, A. 1982. Long-lived populations: Extreme old age. J. Am. Geriatr. Soc. 30:485-487. Learoyd, B. M. 1972. Psychotropic drugs and the elderly patient. Med. J. Aust. 1:1131-1133. Lefrak, E. A., J. Pitha, S. Rosenheim, and J. A. Gottlieb. 1973. A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32:302- 314. Leopold, A. C. 1978. The biological significance of death in plants. Pp. 101-114 in J. A Behnke, C. E. Finch, and G. B. Moment, eds., The Biology of Aging. New York: Plenum. Leto, S., G. C. Kokkonen, and C. H. Barrows. 1976. Dietary protein, life- span, and biochemical variables in female mice. J. Gerontol. 31:144-148. Leveille, P. J., R. Weindruch, R. L. Walford, O. Bok, and J. Horwitz. 1984. Dietary restriction retards age-related loss of gamma crystalline in the mouse lens. Science 224:1247-1249. Levin, P., J. K. Janda, J. A. Josenh. D. K Tn~r:~m zing fib. ~ Rack 1981. Dietary restriction retards the age-associated loss of rat striatal dopaminergic receptors. Science 214:561-562. Levy, M., D. Kletter-Hemo, I. Nir, M. Eliakim. 1977. Drug utilization and adverse drug reactions in medical patients. Comparison of two periods, 196072 and 1973-76. Isr. J. Med. Sci. 13:1065-1072. ~ —7 ~ o _ _ ~ ~ ~ V ^^—

REFERENCES 189 Lewin, R. 1986. Age factors loom in Parkinsonian research. Science 234:120 1201. Lewis, S. E., D. F. Goldspink, J. G. Phillips, B. J. Merry, and A. M. Holehan. 1985. The effects of aging and chronic dietary restriction on whole body growth and protein turnover in the rat. Exp. Gerontol. 20:253-263. Liepa, G. U., E. J. Masoro, H. A. Bertrand, and B. P. Yu. 1980. Food restriction as a modulator of age-related changes in serum lipids. Am. J. Physiol. 238:E253-E257. Lijinsky, W., and P. Shubik. 1964. Benzota~pyrene and other polynuclear hydrocarbons in charcoal-broiled meat. Science 145:53-55. Lindell, T. J. 1982. Current concepts: III. Molecular aspects of dietary modulation of transcription and enhanced longevity. Life Sci. 31:625- 635. Lindeman, R. D., J. Tobin, and N. W. Shock. 1985. Longitudinal studies on the rate of decline in renal function with age. J. Am. Geriatr. Soc. 33:278-285. Lindop, P. J., and J. Rotblat. 1961. Long-term eRects of a single whole-body exposure of mice to ionizing radiations. I. Lifte-shortening. Proc. R. Soc. London, Ser. B 154:332-349. Lints, F. A., ed. 1978. Genetics and Aging. (Interdisciplinary Topics in Gerontology, Vol. 14) Basel, N.Y.: Karger. Lints, F. A. 1984. Insects. In D. H. Mitchell and T. E. Johnson, eds. Invertebrate Models in Aging Research. Boca Raton, Fla.: CRC Press. L;nts, F. A. 1985a. Drosophila. Pp. 91-119 in F. A. Lints, ea., Non- Mammalian Models for Research on Aging. (Interdisciplinary Topics in Gerontology, Vol. 21) Basel, N.Y.: Karger. Lints, F. A. 1985b. Insects. Pp. 140169 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging. 2d ed. New York: Van Nostrand R~inhold. Lints, F. A., ed. 1985c. Non-Mammalian Models for Research on Aging. (Interdisciplinary Topics in Gerontology, Vol. 21) Basel, N.Y.: Karger. 288 pp. Lloyd, T. 1984. Food restriction increases life span of hypertensive animals. Life Sci. 34:401-407. Loeb, J., and J. H. Northrop. 1917. On the influence of food and temperature upon the duration of life. J. Biol. Chem. 32:103-121. London, E. D., S. B. Waller, A. T. Ellis, and D. K. Ingram. 1985. Effects of intermittent feeding on neurochemical markers in aging rat brain. Neurobiol. Aging 6:199-204. London, G. M., M. E. Safar, Y. A. Weiss, and P. L. Milliez. 1976. Isopro- terenol sensitivity and total body clearance of propranolol in hyperten- sive patients. J. Clin. Pharmacol. 16:174-182. Lorber, J. 1975. Good patients and problem patients: Conformity and deviance in a general hospital. J. Health Soc. Behav. 16:213-225. Lott, R. S. 1983. Neurologic disorders. Pp. 1103-1162 in M. A. Koda- Kimble, B. S. Katcher, and L. Y. Young, eds., Applied Therapeutics for Clinical Pharmacists. 3rd ed. San Francisco: Applied Therapeutics, Inc. Loub, W. D., L. W. Wattenberg, and D. W. Davis. 1975. Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants. J. Natl. Cancer Inst. 54:985-988.

190 REFERENCES Lower, G. M., Jr., and M. S. Kanarek. 1982. Risk, susceptibility and the epidemiology of proliferative neoplastic disease: Descriptive vs. mechanistic approaches. Med. Hypotheses 9:33-49. Luckinbill, L. S., R. Arking, M. J. Clare, W. C. Cirocco, and S. A. Buck. 1984. Selection for delayed senescence in Drosophila melanogaster. Evolution 38:996-1003. Ludwig, F. C., and E. J. Masoro, Eds. 1983. The measurement of biological age. Exper. Aging Res. 9:219-255. Lumley, L. E., S. R. Walker, C. G. Hall, N. Staunton, and P.R. Grob. 1986. The under-reporting of adverse drug reactions seen in general practice. Pharmaceut. Med. 1:205-212. Mackay, I. R. 1977. Changes in human lymphocyte activity with age. Pp. 75-80 in I. R. Mackay, ea., Multidisciplinary Gerontology: A Structure for Research in Gerontology in a Developed Country. (Interdisciplinary Topics in Gerontology, Vol. 11) Basel, N.Y.: Karger. Macklem, P. T. 1972. Obstruction in small airways. A challenge to medicine. Am. J. Med. 52:721-724. MacLaughlin, J., and M. F. Holick. 1985. Aging decreases the capacity of human skin to produce vitamin D3. J. Clin. Invest. 76:1536-1538. MacMahon, B. 1971. Epidemiological considerations in staging of HodgLin's disease. Cancer Res. 31:1854-1857. Maeda, H., C. A. Gleiser, E. J. Masoro, I. Murata, C. A. McMahan, and B. P. Yu. 1985. Nutritional influences on aging of Fischer 344 rats: II. Pathology. J. Gerontol. 40:671-688. Magnus, K. 1977. Incidence of malignant melanoma of the skin in the five Nordic countries: Significance of solar radiation. Int. J. Cancer. 20:477-485. Malinow, M. R., E. J. Bardana, Jr., B. Pirofi~ky, S. Cra~ig, and P. McLaughlin. 1982. Systemic lupus erythematosus-like syndrome in monkeys [ed alfalfa sprouts: Role of a nonprotein amino acid. Science 216:415-417. Manton, K. G. 1980. Sex and race specific mortality diRerentials in multiple cause of death data. Gerontologist 20:480-493. Manton, K. G., S. S. Poss, and S. Wing. 1979. The black/white mortality crossover: Investigation ^ aging. Gerontologist 19:291-300. ~rom tne perspecti~re of the components of Martin, G. M. 1979. Genetic and evolutionary aspects of aging. Fed. Proc. Fed. Am. Soc. Exp. Biol. 38:1962-1967. Martin, G. M., C. A. Sprague, and C. J. Epstein. 1970. Replicative life-span of cultivated human cells: Effects of donor's age, tissue, and genotype. Lab. Invest. 23:86-92. Martin, G. M., A. C. Smith, D. J. Ketterer, C. E. Ogburn, and C. M. Disteche. 1985. Increased chromosomal aberrations iI1 first metaphases of cells isolated from the kidneys of aged mice. Isr. J. Med. Sci. 21 :296-301. Martin, G. M., C. A. Sprague, T. H. Norwood, and W. R. Pendergrass. 1974. Clonal selection, attentuation and differentiation in an in vitro model of hyperplasia. Am. J. Pathol. 74:137-154. Mas, X., J. R. Laporte, M. E. Frati, L. Busquet, J. M. Arnau, L. Ibanez, E. Seculi, D. Capella, and G. Arbones. 1983. Drug prescribing and use among elderly people in Spain. Drug Intell. Clin. Pharm. 17:378-382. o

REFERENCES 191 Masoro, E. J. 1980. Mortality and growth characteristics of rat strains commonly used in aging research. Exp. Aging Res. 6:219-233. Masoro, E. J. 1985. Nutrition and aging A current assessment. J. Nutr. 115:842-848. Masoro, E. J., B. P. Yu, and H. A. Bertrand. 1982. Action of food restriction in delaying the aging process. Proc. Natl. Acad. Sci. USA 79:42304241. Masoro, E. J., C. Compton, B. P. Yu, and H. Bertrand. 1983. Temporal and compositional dietary restrictions modulate age-related changes in serum lipids. J. Nutr. 113:88~892. Matsumura, G., A. Herp, and W. Pigman. 1966. Depolymerization of hyaluronic acid by autoxidants and radiations. Radiat. Res. 28:735- 752. Mattison, D. R. 1985. Clinical manifestations of ovarian toxicity. Pp. 100 130 in R. Dixon, ea., Target Organ Toxicity: Gonads (Reproductive and Genetic Toxicity). New York: Raven Press. Mattison, D. R., and G. T. Ross. 1983. Laboratory methods for evaluat- ing and predicting specific reproductive dysfunctions: Oogenesis and ovulation. Pp. 217-246 in V. R. Vouk and P. J. Sheehan, eds., Meth- ods for Assessing the Effects of Chemicals on Reproductive Functions. New York: Wiley. McCarron, D. A. 1985. Is calcium more important than sodium in the pathogenesis of essential hypertension? Hypertension 7:607027. McCarter, R., E. J. Masoro, and B. P. Yu. 1982. Rat muscle structure and metabolism in relation to age and food intake. Am. J. Physiol. 242:RS9-R93. McCarter, R., E. J. Masoro, and B. P. Yu. 1985. Does food restriction retard aging by reducing the metabolic rate? Am. J. Physiol. 248:E488-E490. Me Cay, C. M., and M. F. Crowell. 1934. Prolonging life span. Sci. Mon. 39:405-414. Mc Cay, C. M., M. F. Crowell, and L. A. Maynard. 1935. The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutr. 10:63-79. McClain, R. M., and J. M. Rohrs. 1985. Potentiation of the teratogenic effects and altered disposition of diphenylhydantoin in mice fed a purified diet. Toxicol. Appl. Pharmacol. 77:86-93. McClearn, G. E., J. R. Wilson, and W. Meredith. 1970. The use of isogenic and heterogenic stocks in behavioral research. Pp. 3-22 in G. Li~dzey and D. D. Thiessen, eds., Contributions to Behavioral Genetic A~alysis: The Mouse as a Prototype. New York: Appleton-Century-Crofts. McGeer, P. L., E. G. McGeer, and J. S. Susuki. 1977. Aging and extrapyra- midal function. Arch. Neurol. 34:33-35. McGill, H. C., Jr. 1977. Atherosclerosis: Problems in pathogenesis. Athero- sclerosis Revs. 2 :27~5. McLean, P., A. M. Gonzalez, M. Sochor, and J. S. Hothersall. 1985. Lens metabolism and cellular effects of aldose reductase. Diabetic Med. 2:189-193. Medawar, P. B. 1952. An Unsolved Problem in Biology. London: H. K. Lewis. (Reprinted in The Uniqueness of the Individual. 1957. London: Methuen.)

192 REFERENCES Medina, D., H. W. Lane, and C. M. Tracey. 1983. Selenium and mouse mammal tumorigenesis: An investigation of possible mechanisms. Cancer Res. 43:2460s-2464s. Melmon, K. L. 1971. Prevent able drug reactions~auses and cures. N. Engl. J. Med. 284:1361-1368. Menkes, H. A., T. H. Beaty, B. H. Cohen, and G. Weinmann. 1985. Nitrogen washout and mortality. Am. Rev. Respir. Dis. 132:115-119. Merry, B. J., and A. M. Holehan. 1979. Onset of puberty and duration of fertility in rats fed a restricted diet. J. Reprod. Fertil. 57:253~259. Merry, B. J., and A. M. Holehan. 1985. In vivo DNA synthesis in the dietary restricted long-lived rat. Exp. Gerontol. 20:15-28. Miller, G.H., and D. R. Gerstein. 1983. The life expectancy of nonsmoking men and women. Public Health Rep. 98:343-349. Mirvish, S.S. 1981. Inhibition of the formation of carcinogenic N-nitroso compounds by ascorbic acid and other compounds. Pp. 557-587 in J. H. Burchenal and H. F. Oettgen, eds., Cancer: Achievements, Challenges, and Prospects for the 1980's. Vol. 1. New York: Grune and Stratton. Mitch, W. E. 1984. The influence of the diet on the progression of renal insufficiency. Annul Rev. Med. 35:249-264. Mitchell, D. H., and T. E. Johnson, Eds. 1984. Invertebrate Models in Aging Research. Boca Raton, Fla.: CRC Press. 195 pp. Model, D. 1985. Smoker's face: An underrated clinical sign? Br. Med. J. 291:176~1762. Moise, T. S., and A. H. Smith. 1927. The effect of high protein diet or the kidneys. Arch. Pathol. 4:53~542. Monnier, V. M., and A. Cerami. 1981. Nonenzymatic browning in viva: Possible process for aging of long-lived proteins. Science 211:491-493. Monnier, V., R. R. Kohn, and A. Cerami. 1984. Accelerated age-related browning of human collagen in diabetes mellitus. Proc. Natl. Acad. Sci. USA 81:583-587. Montagna, W., and K. Carlisle. 1979. Structural changes in aging human ~km. J. Invest. Dermatol. 73:47-53. Mortensen, H. B., and C. Christophersen. 1983. Glucosylation of human haemoglobin A in red blood cells studied in vitro. Kinetics of the formation and dissociation of haemoglobin Al c. Clin. Chim. Acta 134:317-326. Mortimer, A. M. 1985. Discussion paper: Perspectives on the status of autopsy. In Institute of Medicine, ea., Report of Ad Hoc Advisory Committee on Autopsy Policy. Washington, D.C.: National Academy of Sciences. Mostardi, R. A., N. R. Woebkenberg, D. L. Ely, M. Conlon, and G. Atwood. 1981. The University of Akron study on air pollution and human health effects. II. Effects on acute respiratory illness. Arch. Environ. Health 36:250-255. Movshovitz, M., and B. Modan. 1973. Role of sun exposure in the etiology of malignant melanoma: Epidemiologic inference. J. Natl. Cancer Inst. 51 :777-779. Mullen, J. B. M., B. R. Wiggs, J. L. Wright, J. C. Hogg, and P. D. Pare. 1986. Nonspecific airway reactivity in cigarette smokers. Relationship to airway pathology and baseline lung function. Am. Rev. Respir. Dis. 133:120-125.

REFERENCES 193 Mulroy, R. 1973. Iatrogenic disease in general practice: Its incidence and effects. Br. Med. J. 2:407-410. Multiple Risk Factor Intervention Trial Research Group. 1982. Multiple Risk Factor Intervention Trial: Risk factor changes and mortality results. J. Am. Med. Assoc. 248:1465-1477. Multiple Risk Factor Intervention Trial Research Group. 1986. Relationship between baseline risk factors and coronary heart disease and total mortality in the Multiple Risk Factor Intervention Trial. Prev. Med. 15:254-273. Munkres, K. D. 1985. The role of genes, antioxidants, and antioxygenic enzymes in aging of Neurospora: A review. In L. W. Oberley, ea., Superoxide Drsmutases, Vol. III, Pathological States. Boca Raton, Fla: CRC Press, Inc. Murasaki, G., T. V. Zenser, B. B. Davis, and S. M. Cohen. 1984. Inhibi- tion by aspirin of N-~4-~5-nitro-2-furyl)-2-thiasolyl] formamide-induced bladder carcinogenesis and enhancement of forestomach carcinogenesis. Carcinogenesis 5:53-55. Murdoch, J. C. 1980. The epidemiology of prescribing in an urban general practice. J.R. Call. Gen. Pract. 30:593-602. Nakagawa, I., and Y. Masana. 1971. Effect of protein nutrition on growth and life span in the rat. J. Nutr. 101:613020. Nam, C. B., N. L. Weatherby, and K. A. Ockay. 1978. Causer of death which contribute to the mortality cros~over effect. Soc. Biol. 25:30~314. Naraha~hi, T., ed. 1984. Cellular and Molecular Neurotoxicology. New York: Raven Press. 304 pp. National Center for Health Statistic~ (NCHS). 1978a. Advance R~port- Final Mortality Statistics 1976. (Monthly Vital Statistics Report, Vol. 26, No. 12, Suppl. 2) Wa~hington, D.C.: U.S. Government Printing Office, March 1978. National Center for Health Statistic~ (NCHS). 1978b. Facts of Life and Death. (DHEW Pub. No. (PHS) 79-1222.) Washington, D.C.: U.S. Government Printing Office. Nat~onal Center for Health Statistics (NCHS). 1981a. Characteristics of Nursing Home Resident~ Health Status and Care Received: National Nursing Home Survey, United States. (Vital and Health Statistics, Series 13, No. 59) DHHS Pub. No. (PHS) 81-1712. Washington, D.C.: U.S. Government Printing Office. National Center for Health Statistics (NCHS). l981b. Health, United States, 1981. DHHS Pub. No. (PHS) 82-1232. Washington, D.C.: U.S. Gov- ernment Printing Office. National Center for Health Statistics (NCHS). 1981c. Prevalence of Selected Impairments by Age and Sex, United States. 1981. (Vital and Health Statistics Series 10, Data from the National Health Interview Survey), Washington, D.C.: U.S. Government Printing Office. National Center for Health Statistics (NCHS). 1982. Death rates for the elderly decline substantially. In Health: United States, 1982. DHHS Pub. No. (PHS) 83-1232. Washington, D.C.: U.S. Government Printing Office. National Center for Health Statistics (NCHS). 1983. Americans Needing Help to Function at Home. (Advance Data from Vital and Health Statistics, No. 92) Washington, D.C.: U.S. Government Printing Office.

194 REFERENCES National Center for Health Statistics (NCHS). 1985a. Vital Statistics of the United States, 1980, V. 2, Mortality. Washington, D.C.: U.S. Government Printing Office. National Center for Health Statistics (NCHS). 1985b. Vital Statistics of the United States, 1982. Vol. II., Sec. 6, Life Tables. Pub. No. (PHS) 85-1104. Washington, D.C.: U. S. Government Printing Office. 14 pp. National Center for Health Statistics (NCHS). 1986a. Health United States. 1985. DHHS Pub. No. (PHS) 86-1232. Washington, D.C.: U.S. Gov- ernment Printing Office. 174 pp. National Center for Health Statistics (NCHS). 1986b. Aging in the eighties, preliminary data from the Supplement on Aging to the National Health Interview Survey, United States, January-June 1984. (Advance Data from Vital and Health Statistics. No. 115) DHHS Pub. No. (PHS) 86-1250. Washington, D.C.: U.S. Government Printing Office. National Center for Health Statistics (NCHS). 1986c. Advance Report of Final Mortality Statistics, 1984. (Monthly Vital Statistics Report. Vol. 35, No. 6, Suppl. 2) DHHS Pub. No. (PHS) 86-1120. Washington, D.C.: U.S. Government Printing Office. National Research Council (NRC). 1972. The Effects on Populations of Exposure to Low Levels of Ionizing Radiation. Washington, D.C.: National Academy of Sciences, National Research Council. 217 pp. National Research Council (NRC). 1980a. Recommended Dietary Allow- ances. 9th rev. ed. Washington, D.C.: National Academy of Sciences. 185 pp. National Research Council (NRC). 1980b. The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: 1980. Committee on the Biological Effects of Ionizing Radiation. Washington, D.C.: National Academy Press. 524 pp. National Research Council (NRC). 1981a. Indoor Pollutants. Washington, D.C.: National Academy Press. 537 pp. National Research Council (NRC). 1981b. Mammalian Models for Research on Aging. Washington, D.C.: National Academy Press. 587 pp. National Research Council (NRC). 1982. Diet, Nutrition, and Cancer. Washington, D.C.: National Academy Press. National Research Council (NRC). 1985. Models for Biomedical Research. A New Perspective. Washington, D.C.: National Academy Press. 180 PP. National Research Council (NRC). 1986. Environmental Tobacco Smoke: Measuring Exposures and Assessing Health Effects. Washington, D.C.: National Academy Press. 337 pp. National Research Council (NRC). (in press) Committee on Biologic Markers. Oversight Document. Neely, E., and M. L. Patrick. 1968. Problems of aged persons taking medications at home. Nurs. Res. 17:52-55. Nero, A. V., M. B. Schwehr, W. W. NazaroR, and K. L. Revzan. 1986. Dis- tribution of airborne radon-222 concentrations in U.S. homes. Science 234:992-997. Newberne, P. M., and A. E. Rogers. (in press) The role of nutrients in cancer causation. In Y. Hayashi et al., eds., Proceedings of the Princess Takamatsu Symposium, Tokyo, Nov. 12-14, 1985. Tokyo: Japan Science Society Press and Utrecht: VNU Science Press.

REFERENCES 195 Newberne, P. M., and V. Suphakarn. 1983. Nutrition and cancer: A review, with emphasis on the role of vitamins C and E and selenium. Nutr. Cancer 5:107-119. Newberne, P. M., G. Charnley, K. Adams, M. Cantor, D. Roth, and V. Supharkarn. 1986. Gastric and oesophageal carcinogenesis: Models for the identification of risk and protective factors. Food Chem. Toxicol. 24:1 111-11 19. Nichols, W. W., and D. G. Murphy, eds. 1977. DNA Repair Processes. Miami, Fla.: Miami Symposium Specialists. 286 pp. Niewoekner, D. E., J. Kleinerman, and D. B. Rice. 1974. Pathologic changes in the peripheral airways of young cigarette smokers. New Engl. J. Med. 291:755-758. Nolan, L., and K. O'Malley. 1987a. Excessive prescribing for the elderly? J. Am. Geriatr. Soc. (In press) Nolan, L., and K. O'Malley. 1987b. Increased sensitivity of the elderly to adverse drug reactions? J. Am. Geriatr. Soc. (In press) Nohl, H. and D. Hegner. 1978. Do mitochondria produce oxygen radicals in viva? Eur. J. Biochem. 82:563-567. Nolen, G. A. 1972. Effect of various restricted dietary regimens on the growth, health and longevity of albino rats. J. Nutr. 102:1477-1493. Nooden, L. D., and J. E. Thompson. 1985. Aging and senescence in plants. Pp. 105-127 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging. 2d ed. New York: Van Nostrand Reinhold Co. Nordin, B. E., P. J. Heyburn, M. Peacock, A. Horsman, J. Aaron, D. Marshall, and R. G. Crilly. 1980. Osteoporosis and osteomalacia. Clin. Endocrinol. Metab. 9:177-205. Norkin, S. A. 1966. Lipid nature of ceroid in experimental nutritional cirrhosis. Arch. Pathol. 82:259-266. O'Dell, B. L., R. T. Jessen, L. E. Becker, R. T. Jackson, and E. B. Smith. 1980. Diminished immune response in sun-damaged skin. Arch. Dermatol. 116:550561. Olson, R.D., R. C. Boerth, J. G. Gerber, and A. S. Nies. 1981. Mechanism of adriamycin cardiotoxicity: Evidence for oxidative stress. Life Sci. 29:1393-1401. O'Malley, K., T. G. Judge, and J. Crooks. 1980. Geriatric clinical pharma- cology and therapeutics. Pp. 158-181 in G. Avery, ea., Drug Treatment. 2d ed. Sydney: Adis Press. Omdahl, J. L., P. J. Garry, L. A. Hunsaker, W. C. Hunt, and J. S. Goodwin. 1982. Nutritional status in a healthy elderly population: Vitamin D. Am. J. Clin. Nutr. 36:1225-1233. Omenn, G. S., and A. G. Motulsky. 1978. aEco-Genetics~: Genetic variation in susceptibility to environmental agents. P. 83 in B. H. Cohen, A. M. Lilienfeld, and P. C. Huang, eds., Genetic Issues in Public Health and Medicine. Springfield, Ill.: Charles C. Thomas. Omenn, G. S., and H. V. Gelboin, eds. 1984. Genetic Variability in Response to Chemical Exposure. Banbury Report 16. Cold Spring Harbor: Cold Spring Harbor Laboratory. 421 pp. Orgel, L. E. 1963. The maintenance of the accuracy of protein synthesis and its relevance to aging. Proc. Natl. Acad. Sci. USA 49:517-521.

196 REFERENCES Orgel, L. E. 1970. The maintenance of the accuracy of protein synthesis and its relevance to ageing: A correction. Proc. Natl. Acad. Sci. USA 67:1476. Ostrom, J. R., E. R. Hammarlund, D. B. Christensen, J. B. Plein, and A. J. Kethley. 1985. Medication usage in an elderly population. Med. Care 23:157-164. Paffenbarger, R. S. 1979. Proceedings of the Conference on the Decline in Coronary Heart Disease Mortality. NIH Pub. No. 79-1610, pp. 298-311. Washington, D.C.: U.S. Government Printing Office. Paffenbarger, R. S., Jr., R. J. Brand, R. I. Sholts, and D. L. Jung. 1978. Energy expenditure, cigarette smoking, and blood pressure level as related to death from specific diseases. Am. J. Epidemiol. 108:12-18. Paffenbarger, R. S., Jr., R. T. Hyde, A. L. Wing, and C. H. Steinmets. 1984. A natural history of athleticism and cardiovascular health. J. Am. Med. Assoc. 252:491-495. Paget, G. E., and P. G. Lemon. 1965. The interpretation of pathology data. Pp. 382-405 in W. E. Ribelin and J. B. McCoy, eds., Pathology of Laboratory Animals. Springfield, Ill.: Charles C. Thomas. Palmer, L., L. Bertilsson, G. Alvan, M. Orme, F. Sjoqvi~t, and B. Holmstedt. 1974. Indomethacin: Quantitative determination in plasma by mass fragmentography including pilot pharmacokinetics in man. Pp. 91-97 in H. J. Robinson and J. R. Vane, eds., Prostaglandin Synthetase Inhibitor~. New York: Raven Press. Pantuck, E. J., C. B. Pantuck, W. A. Garland, B. H. Min. L. W. Wattenberg, K. E. Anderson, A. Kappas, and A. H. Conney. 1979. Stimulatory effect of brussels sprouts and cabbage on human drug metabolism. Clin. Pharmacol. Ther. 25:88-95. Pantuck, E. J., K.-C. Hsiao, W. D. Loub, L. W. Wattenberg, R. Kuntzman, and A. H. Conney. 1976. Stimulatory effect of vegetables on intestinal drug metabolism in the rat. J. Pharmacol. Exp. Ther. 198:278-283. Parkin, D. M., C. R. Henney, J. Quirk, and J. Crook~. 1976. Deviation from prescribed drug treatment after discharge from hospital. Br. Med. J. 2:686 688. Paulsen, O., and L. G. Nilsson. 1985. Distribution of acetylator phenotype in relation to age and sex in Swedish patients. A retrospective study. Eur. J. Clin. Pharmacol. 28:311-315. Paykel, E. S., R. Fleminger, and J. P. Watson. 1982. Psychiatric side effects of antihypertensive drugs other than reserpine. J. Clin. Psychopharma- col. 2:14-39. Pearl, R. 1928. The Rate of Living. New York: Knopf. 185 pp. Pearson, M. W., and C. J. C. Roberts. 1984. Drug induction of hepatic enzymes in the elderly. Age Aging 13:313-316. Pelkonen, O., E. H. Kaltiala, T. K. Larmi, and N. T. Karki. 1973. Com- parison of activities of drug-metabolizing enzymes in human fetal and adult liver~. Clin. Pharmacol. Ther. 14:840846. Perera, F. P., and I. B. Weinstein. 1982. Molecular epidemiology and carcinogen-DNA adduct detection: New approaches to studies of human cancer causation. J. Chronic. Dis. 35:581~00. Perl, D. P., and A. R. Brody. 1980. Alsheirner's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science 208:297-299. · _% ~. - .. . . . . ~ .

REFERENCES 197 Perl, D. P., D. C. Gajdusek, R. M. Garruto, R. T. Yanagihara, and C. J. Gibbs. 1982. Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism with dementia of Guam. Science 217:1053-1055. Peto, K., and R. Doll. 1984. Keynote Address: The control of lung cancer. Pp. 1-19 in M. Mizell and P. Correa, eds., Lung Cancer: Causes and Prevention. Proceedings of the International Lung Cancer Update Conference, New Orleans, La., March 3-5, 1983. Deerfield Park, Fla.: Verlag Chemie International. Peto, R., F. J. Roe, P. N. Lee, L. Levy, and J. Clack. 1975. Cancer and ageing in mice and men. Br. J. Cancer 32:411-426. Petrakis, N. L., V. L. Ernster, and M. C. King. 1982. Breast, pp. 855-870. In D. Schottenfeld and J. F. Fraumeni, Jr., Ede. Cancer Epidemiology and Prevention. Philadelphia: W. B. Saunders Co. Pollard. M.. P. H. Luckert. P.H.. and G. Ye Pan. 1984. Inhibition of intestinal tumorigenesis in methylazoxymethanol-treated rats by dietary restriction. Cancer Treat. Rep. 68:405-408. Pongor, S., P. C. Ulrich, F. A. Bencsath, and A. Cerami. 1984. Aging of proteins: Isolation and identification of a fluorescent chromaphore from the reaction of polypeptides with glucose. Proc. Natl. Acad. Sci. USA 81 :2684-2688. Porta, E. A. 1980. Nutritional factors and aging, pp. 55-119. In R. B. Tobin and M. A. Mehlman, Eds. Advances in Modern Human Nutrition. Park Forest South, Illinois. Pathotox Publishers, Inc. Porta, E. A., N. S. Joun, and R. T. Nitta. 1980. Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. I. Lifespan, serum biochemical parameters and pathological changes. Mech. Ageing Dev. 13:1-40. Procacci, P., M. Della Corte, M. Zoppi, S. Romano, M. Maresca, and M. Voegelin. 1974. Pain thresshold measurement in man. P. 105 in J. J. Bonica, P. Procacci, and C. Pagoni, eds., Recent Advanccs on Pain: Pathophysiology and Clinical Aspects. Springfield, Ill.: Charles C. Thomas. Pruitt, A. W., P. G. Dayton, and J. H. Patterson. 1973. Disposition of diazoxide in children. Clin. Pharmacol. Ther. 14:73-82. Purkerson, M. L., P. E. Hoffsten, and S. Klahr. 1976. Pathogenesis of the glomerulopathy associated with renal infarction in rats. Kidney Int. 9:407-417. Rane, A., and F. Sjoqvist. 1972. Drug metabolism in the human fetus and newborn infant. Pediatr. Clin. North Am. 19:37-49. Raskind, M. A., M. Kitchell, and C. Alvarez. 1978. Bromide intoxication in the elderly. J. Am. Geriatr. Soc. 26:222-224. Rawlings, J. L., and P. A. Frisk. 1975. Pharmaceutical services for skilled nursing facilities in compliance with federal regulations. Am. J. Hosp. Pharm. 32:905-908. Ray, W. A., C. F. Federspiel, and W. Schaffner. 1980. A study of antipsy- chotic drug use in nursing homes: Epidemiologic evidence suggesting misuse. Am. J. Public Health 70:485-491. Reaven, E., D. Wright, C. E. Mondon, R. Solomon, H. Ho, and G. M. Reaven. 1983. E~ect of age and diet on insulin secretion and insulin action in the rat. Diabetes 23:175-180. , ,

198 REFERENCES Reddy, B. S., T. Narisawa, D. Vukusich, J. H. Weisburger, and E. L. Wynder. 1976. Effect of quality and quantity of dietary fat and dimethylLydrazine in colon carcinogenesis in rats. Proc. Soc. Exp. Biol. Med. 151:237-239. Ruddy, B. S., L. A. Cohen, G. D. McCoy, P. Hill, J. H. Wei~burger, and E. L. Wynder. 1980. Nutrition and its relationship to cancer. Adv. Cancer Res. 32:237-345. Reff, M. E., and E. L. Schneider, eds. 1982. Biological Markers of Aging. NIH Publication No. 82-2221. Washington, D.C.: U.S. Government Printing Office. 252 pp. Reidenberg, M. M., M. Levy, H. Warner, C. B. Coutinho, M. A. Schwartz, G. Yu, and J. Cheripko. 1978. Relationship between diazepam dose, plasma level, age, and central nervous system depression. Clin. Pharmacol. Ther. 23:371-374. Rensberger, B. 1976. Bad prescriptions kill thousands a year. The New York Times, January 28. Retherford, R. D. 1972. Tobacco smoking and the sex mortality differential. Demography 9:203-216. Richardson, A., and H. T. Cheung. 1982. Current concepts: I. The relationship between age-related changes in gene expression, protein turnover, and the responsiveness of an organism to stimuli. Life Sci. 31 :605-613. Ricketts, W. G., M. C. Birchenall-Sparks, J. P. Hardwick, and A. Richardson. 1985. Effect of age and dietary restriction on protein synthesis by isolated kidney cells. J. Cell. Physiol. 125:492-498. Riggs, B. L., and L. J. Melton III. 1986. Involutional osteoporosis. N. Engl. J. Med. 314:1676-1686. Riley, M. W. 1981a. Health, behavior, and aging. Pp. 25-39 in Institute of Medicine, ea., Interim Report No. 5. Health and Behavior: A Research Agenda. Washington, D.C.: National Academy Press. Riley, V. 1981b. Psychoneuroendocrine influences on immunocompetence and neoplasia. Science 212:1100-1109. Roberts-Thomson, I. C., S. Whittingham, U. Youngchaiynd, amd I. R. Mackay. 1974. Ageing, immune response, and mortality. Lancet 2:368- 370. Rodeheffer, R. J., G. Gerstenblith, L. C. Becker, J. L. Fleg, M. L. Weis- feldt, and E. G. Lakatta. 1984. Exercise cardiac output is maintained with advancing age in healthy human subjects: Cardiac dilatation and increased stroke volume compensate for a diminished heart rate. Circulation 69:203-213. Rodin, J. 1986. Aging and health: Effects of the sense of control. Science 233:1271-1276. Roe, D. A. 1985. Drug eEects on nutrient absorption, transport, and metabolism. Drug Nutr. Interact. 4:117-135. Rogers, A. E., and P. M. Newberne. 1971. Diet and adatoxin Bl toxicity in rats. Toxicol. Appl. Pharmacol. 20:113-121. Rose, M. R. 1984. Laboratory evolution of postponed senescence in Droso- phila melanogaster. Evolution 38:1004-1010. Roskos, K. V., R. H. Guy, and H. I. Maibach. 1986. Percutaneous absorption in the aged. Pp. 455-465 in B. A. Gilchrest, ea., The Aging Skin. (Dermatologic Clinics Vol. 4, No. 3) Philadelphia: W. B. Saunders Company.

REFERENCES 199 Ross, M. H. 1969. Aging, nutrition and hepatic enzyme activity patterns in the rat. J. Nutr. 97(Suppl. I, Part II):563-602. Ross, M., and G. Bras. 1965. Tumor incidence patterns and nutrition in the rat. J. Nutr. 87:245-260. Ross, M., and G. Bras. 1973. Influence of protein under- and over-nutrition on spontaneous tumor prevalence in the rat. J. Nutr. 103: 944-963. Rothstein, M. 1982. Biochemical Approaches to Aging. New York: Academic Press. 314 pp. Rubner, M. 1908a. Das Problem der Lebensdauer und Seine Beziehungen sun Wachstum und Ernahrung. Munich: Oldenbourg. Rubner, M. 1908b. Problems des Wachstums und der Lebensdauer. Mitt. Gesch. Med. Naturwiss. 7:58-81. Rudzinska, M. A. 1952. Overfeeding and lifespan in Tokophyra infusionum. J. Gerontol. 7:544-548. Russell, R. L., and L. A. Jacobson. 1985. Some aspects of aging can be studied easily in nematodes. Pp. 128-145 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging. 2d ed. New York: Van Nostrand Reinhold Co. Sacher5 G. A. 1977. Life table modification and life prolongation. Pp. 582- 628 in C. E. Finch and L. Hayllick, eds., Handbook of the Biology of Aging. New York: Van Nostrand Reinhold Co. Sacher, G. A. 1979. Energy metabolism and thermoregulation in old age. ASHRAE Trans. 85:775-783. Salem, S. A. M., P. Rajjayabun, A. M. M. Shepherd, and I. H. Stevenson. 1978. Reduced induction of drug metabolism in the elderly. Age Ageing 7:68-73. Sapeika, N. 1978. Pharmacodynamic action of natural food. Pp. 115-123 in R. Trnhaut and R. Ferrando, eds., World Review of Nutrition and Dietetics. Vol. 29. Toxicology and Nutrition. Basel, N.Y.: Karger. Sapolsky, R. M., and T. M. Donnelly. 1985. Vulnerability to stress-induced tumor growth increases with age in rats. Role of glucocorticoids. En- docrinology 117:662~66. Sapolsky, R. M., L. C. Krey, and B. S. McEwen. 1983a. Corticosterone receptors decline in a site-specific manner in the aged rat brain. Brain Res. 289:235-240. Sapolsky, R. M., L. C. Krey, and B. S. McEwen. 1983b. The adrenocortical stress-response in the aged male rat: Impairment of recovery from stress. Exp. Gerontol. 18:5504. Sapolsky, R. M., L. C. Krey, and B. S. McEwen. 1986a. The adrenocortical axis in the aged rat: Impaired sensitivity to both fast and delayed feedback inhibition. Neurobiol. Aging 7:331-335. Sapolsky, R. M., L. C. Krey, and B. S. McEwen. 1986b. The neuroen- docrinology of stress and aging: The glucocorticoid cascade hypothesis. Endocr. Rev. 7:284-301. Sasaki, S., and T. Kasuga. 1981. Life-shortening and carcinogenesis in mice irradiated neonatally with X rays. Radiat. Res. 88:313-325. Savage, E. P., T. J. Keefe, H. W. Wheeler, L. Mounce, L. Helwic, F. Applehans, E. Goes, T. Goes, G. Mihlan, J. Rench, and D. K. Taylor. 1981. Household pesticide usage in the United States. Arch. Environ. Health 36:304-309.

200 REFERENCES Saxton, J. A., Jr., and G. C. Kimball. 1941. Relation to nephrosi~ and other diseases of albino rats to age and to modifications of diet. Arch. Pathol. 32:951-965. Schaie, K. W., and S. L. Willis. 1986. Adult Development and Aging, 2d ed. Boston: Little, Brown and Co. Schaumburg, H. H., J. Kaplan, A. Windebank, N. Vice, S. Rasmus, D. Pleasure, and M. J. Brown. 1983. Sensory neuropathy from pyridoxine abuse: A new megavitamin syndrome. New Engl. J. Med. 309:445-448. Schimke, R. T., S. W. Sherwood, A. B. Hill, and R. N. Johnston. 1986. O,rerreplication and recombination of DNA in higher eukaryotes: Po- tential consequences and biological implications. Proc. Natl. Acad. Sci. USA 83:2157-2161. Schmucker, D. L. 1978. Age-related changes in drug disposition. Pharmacol. Rev. 30:445-456. Schmucker, D. L. 1985. Aging and drug disposition: An update. Pharmacol. Rev. 37:133-148. Schmucker, D. L., and R. K. Wang. 1987. Characterization of monkey liver microsomal NADPH cytochrome C(P-450) reductase as a function of aging. Drug Metab. Dispos. 15:225-232. Schneider, E. L., and J. A. Brady. 1983. Aging, natural death, and the compression of morbidity: Another view. N. Engl. J. Med. 309:854-856. Schneider, E. L., and J. D. Reed. 1985. Modulations of aging processes. Pp. 45-76 in C. E. Finch and E. L. Schneider, ede., Handbook of the Biology of Aging. 2d ed. New York: Van Nostrand Reinhold Co. Schneider, E. L., and Y. Mitsui. 1976. The relationship between in vitro cellular aging and in vitro human age. Proc. Natl. Acad. Sci. USA 73:3584-3588. Schulz, R. 1976. Effects of control and predictability on the physical and psychological well-being of the institutionalized aged. J. Pers. Sac. Psychol. 33:563-573. Schulz, R. 1980. Aging and control. Pp. 261-277 in M. E. P. Seligman and J. Garber, eds., Human Helplessness: Theory and Applications. New York: Academic. Schwartz, D., M. Wang, L. Zeitz, and M. E. Goss. 1962. Medication errors made by elderly, chronically ill patients. Am. J. Public Health 52:2018-2029. Segal, J. L., J. F. Thompson, and R. A. Floyd. 1979. Drug utilization and prescribing patterns in a skilled nursing facility: The need for a rational approach to therapeutics. J. Am. Geriatr. Soc. 27:117-122. Segall, P. E. 1979. Interrelations of dietary and hormonal effects in aging. Mech. Ageing. Dev. 9:515-525. Seidl, L. G., G. F. Thornton, J. W. Smith, and L. E. Cluff. 1966. Studies on the epidemiology of adverse drug reactions. III. Reactions in patients on a general medical service. Bull. Johns Hopkins Hosp. 119:290315. Shafrir, E., and J. H. Adler, 1984. Effect of long-term sucrose diet on the reproduction and survival of spiny mice (Acomys cahirinus). Nut r. Res. (N.Y.) 4:495-501. Shakman, R. A. 1974. Nutritional influences on the toxicity of environmental pollutants: A review. Arch. Environ. Health 28:105-113. Shapiro, J. A., Ed. 1983. Mobile Genetic Elements. New York: Academic Press. 688 pp.

REFERENCES 201 Shaw, S. M., and L. J. Opit. 1976. Need for supervision in the elderly receiving long-term prescribed medication. Br. Med. J. 1:505-507. Shay, H., M. Gruenstein, and M. B. Shimkin. 1964. Effect of casein, lactalbumin, and ovalbumin on 3-methylcholanthrene-induced mammary carcinoma in rats. J. Natl. Cancer Inst. 33:243-253. Shimamura, T., and A. B. Morrison. 1975. A progressive glomerulo-sclerosis occurring in partial five-sixths nephrectomized rats. Am. J. Pathol. 79:95-106. Shock, N. W. 1977. Systems integration. Pp. 639061 in C. E. Finch and L. Haydick, eds., Handbook of the Biology of Aging. New York: Van Nostrand Reinhold Co. Siegel, J. S., and C. M. Taeuber. 1986. Demographic perspectives on the long-lived society. Daedalus 115~1~:77-117. Silverberg, A. B. 1984. Carbohydrate metabolism and diabetes in the aged. Pp. 191-208 in H. J. Armbrecht, J. M. Prenderga~t, and R. M. Coe, eds., Nutritional Intervention in the Aging Process. New York: Springer- Verlag. Silberberg, M., and R. Silberberg. 1955. Diet and life span. Physiol. Rev. 35:347-362. Silverstein, A. 1982. Neurological Complications of Therapy. Mt. Kisco N.Y.: Futura Publishing Co. Sinclair, H. M., 1982. Essential fatty acids and chronic degenerative diseases. Pp. 69-83 in J. Rose, ea., Nutrition and Killer Diseases: The ERects of Dietary Factors on Fatal Chronic Di~eases. Park Ridge, N.J.: Noyes. Sipes, I. G., and A. J. Gandolfi. 1986. Biotransformation of toxicants. Pp. 64-98 in C. D. Klaassen, M. O. Amdur, and J. Doull, eds., Casarett and Doull's Toxicology: The Basic Science of Poisons. 3rd ed. New York: Macmillan. Skegg, D. C., R. Doll, and J. Perry. 1977. Use of medicines in general practice. Br. Med. J. 1 :1561-1563. Skillrud, D. M., K. P. Offord, and R. D. Miller. 1986. Higher risk of lung cancer in chronic obstructive pulmonary disease. A prospective, matched, controlled study. Ann. Intern. Med. 105:503-507. Sklar, L. S., and H. Anisman. 1979. Stress and coping factors induence tumor growth. Science 205:513-515. Skoll, S. L., R. J. August, and G. E. Johnson. 1979. Drug prescribing for the elderly in Saskatchewan during 1976. Can. Med. Assoc. J. 121:1074-1081. Smidt, N. A., and E. G. McQueen. 1972. Ad~rerse reactions to drugs: A comprehensive hospital in-patient survey. N.Z. Med. J. 76:397-401. Smith, J. G., Jr., E. A. Davidson, W. M. Sams, Jr., and R. D. Clark. 1962. Alterations in human dermal connecti~re tissue with age and chronic sun damage. J. Invest. Dermatol. 39:347-350. Smith, W. M., T. M. Vogt, C. C. Ireland, and D. Black. 1985. Resources in geriatric drug research. Drug Inf. J. 19:421-427. Smithard, D. J., and M. J. Langman. 1978. The effect of ~ritamin 5Up- plementation upon antipyrine metabolism in the elderly. Brit. J. Clin. Pharmacol. 5:181-185. Smith-Sonneborn, J. 1984. Protozoan aging. Pp. 1-14 in D. H. Mitchell and T. E. Johnson, eds., Invertebrate Models in Aging Research. Boca Raton, Fla.: CRC Press, Inc.

202 REFERENCES Smith-Sonneborn, J. 1985a. Aging in unicellular organisms. Pp. 79-104 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging. 2d ed. New York: Van Nostrand Reinhold Co. Smith-Sonneborn, J. 1985b. Genome interactions in the pathology of aging Protozoa. Pp. 453-479 in V. J. Cristofalo, ea., Handbook of Cell Biology of Aging. Boca Raton, Fla.: CRC Press, Inc. Smith-Sonneborn, J. 1985c. Protozoa. Pp. 201-230, in F. A. Lints, ea., Non- Mammalian Models for Research on Aging. (Interdisciplinary Topics in Gerontology, Vol. 21) Basel, N.Y.: Karger. Sohal, R. S. 1981. Metabolic rate, aging and lipofuscin. Pp. 303-316 in R. S. Sohal, ea., Age Pigments. Amsterdam: Elsevier/North Holland. Sohal, R. S., and M. C. McArthur. 1985. Cellular aspects of aging in insects. Pp. 497-509 in V. J. Cristofalo. ea.. Handbook of Cell Bic~lc`~r of Aa~in~r Boca Raton, Fla.: CRC Press. Inc. 7 7 =~ ~ ~ Sohal, R. S., and R. G. Allen. 1986. Relationships between oxygen metabolism, aging and development. Pp. 117-160 in W. A. Pryor, ea., Advances in Free Radical Biology and Medicine. Vol. 2. Elmsford, N.Y.: Pergamon Press. ~ ~ 1 ~ ~ ~ A_~ ~ .. bokoloH, L. 1978. Occult osteomalacia in American (U.S.A.) patients with fracture of the hip. Am. J. Surg Pathol. 2:21-30. Soliman, M. H. 1985. Tribolium. Pp. 120-141 in F. A. Lints, ea., Non- Mammalian Models for Research on Aging. Basel, N.Y.: Karger. Sotaniemi, E., and I. P. Palva. 1972. The use of polypharmaceutical drug therapy in a medical ward. Ann. Clin. Res. 4:158-164. Spencer, P. S., and J. Ochoa. 1981. The mammalian peripheral nervou~ system in old age. Pp. 35-103 in J. G. Johnson, Jr., ea., Aging and Cell Structure. New York: Plenum Press. Spencer, P. S., C. M. Beaubernard, M. C. Bischoff-Fenton, and T. L. Kurt. 1985. Clinical and experimental neurotoxicity of 2-t-buivla~n 2 hvArr`~`r 5-methylhexane. Ann. Neurol. 17:28-32. ~ ~a~ —~~ ~ ~ ——~~ __ __~ Spencer, P. S., P. B. Nunn, J. Hugon, A. C. Ludolph, S. M. Ross, D. N. Roy, and R. C. Robertson. 1987. Guam amyotrophic lateral sclerosis- parkinsonism-dementia linked to a plant excit ant neurotoxin. Science 237:517-522. Spoor, A. 1967. Presbycusis values in relation tc, nni~?-incl,,~H h`~rina 1 Int. Audiology 6:48-57. Spradling, A. C., and G. M. Rubin. 1982. Transposition of cloned P elements into Drosophila germ line chromosomes. Science 218:341-347. Stasse-Wolthuis, M. 1981. InDuence of dietary fibre on cholesterol metabolism and colonic function in healthy subjects. World Rev. Nutr. Diet 36:10 140. Stohs, S. J., W. A. Al-Turk, and C. R. Angle. 1982. Glutathione S- transferase and glutathione reductase activities in hepatic and extra- hepatic tissues of female mice as a function of age. Biochem. Pharmacol. 31:21 13-21 16. Strickland, P. T. 1986. Photocarcinogenesis by near-ultraviolet (UVA) radi- ation in Sencar mice. J. Invest. Dermatol. 87:272-275. Strickland, S., and M. J. Sawey. 1980. Studies on the effect of retinoids on the differenatiation of teratocarcinoma stem cells in vitro and in vivo. Dev. Biol. 78:76-85.

REFERENCES 203 Stuchlikov, E., M. Juricova-Horakova, and Z. Deyl. 1975. New aspects of dietary eject of life prolongation in rodents. What is the role of obesity in aging? Exp. Gerontol. 10:141-144. Sulston, J. E., E. Schierenberg, J. G. White, and J. N. Thomson. 1983. The embryonic cell lineage of the nematode CacnorhabdRu ciegane. Dev. Biol. 100:64-119. Tannenbaum, A. 1945. The dependence of tumor formation on the composi- tion of the calorie-restricted diet as well as on the degree of restriction. Cancer Res. 5 :610625. Taylor, J. R., V. P. Calabre~e, and R. Blanke. 1979. Organochlorine and other insecticides. Pp. 391-456 in P. J. Vinken and G. W. Bruyn, eds., Handbook of Clinical Neurology. Intoxication of the Nervous System. Pt. 1. Amsterdam: North-Holland Publ. Co. Thiers, B. H., J. C. Maize, S. S. Spicer, and A. B. Cantor. 1984. The effect of aging and chronic sun exposure on human Langerhans cell populations. J. Invest. Dermatol. 82:223-228. Tielsch J. M., R. M. Royall, H. A. Quigley, J. D. Gottsch, and A. Sommer. 1986. Baltimore Eye Survey: Design and Preliminary Results. Invest. Ophthalmol. Vis. Sci. 27~3, suppl.~:44. Till, J. E., E. A. McCulloch, and L. Siminovitch. 1964. A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells. Proc. Natl. Acad. Sci. USA 51:29-36. Tomassi, G., and V. Silano. 1986. An assessment of the safety of tocopherols as food additives. Food Chem. Toxicol. 24:1051-1061. Tomlinson, B. E., and D. Irving. 1977. The numbers of limb motor neurons in the human lumbosacral cord throughout life. J. Neuroi. Sci. 34:213- 219. Toth, B., and K. Patil. 1983. Enhancing effect of vitamin E on marine intenstinal tumorigenesis by 1,2-dimethylLydrazine dihydrochloride. J. Natl. Cancer Inst. 70:1107-1111. Traeger, A., H. Noschel, and J. Zaumseil. 1973. Zur pharmakokinetik van Indomethazin bei Schwangeren, kreibenden und deren Neugelborenen. Zentralbl. Gynakol. 95:635~41. Trainor, K. J., D. J. Wigmore, A. Chrysostomou, J. L. Dempsey, R. Seshadri, and A. A. Morley. 1984. Mutation frequency in human lymphocytes increases with age. Mech. Ageing Dev. 27:83-86. Trang, J. M., J. Blanchard, K. A. Conrad, and G. G. Harrison. 1982. The effect of vitamin C on the pharmacokinetics of caffeine in elderly men. Am. J. Clin. Nutr. 35:487-494. Tso, M. O. 1985. Pathogenetic factors of aging macular degeneration. Ophthalmology 92:628~35. Tuckers S. M., R. L. Mason, and R. E. Beauchene. 1976. Influence of diet and feed restriction on kidney function of aging male rats. J. Gerontol. 31 :264-270. Tulloch, A. J. 1981. Repeat prescribing for elderly patients. Br. Med. J. 282:1672-1675. Twum-Barima, Y., T. Finnigan, A. I. Habash, R. D. T. Cape, and S. G. Carruthers. 19&4. Impaired enzyme induction by rifampicin in the elderly. Br. J. Clin. Pharmacol. 17:595-597. United Nations. 1984. United Nations Demographic Yearbook. (ST/ESA/ SPAT/SEA R/14) New York: United Nations.

204 R~FE=3NCES U.S. Bureau of the Census. 1984. Demographic and Socioeconomic Aspects of Aging in the United States. (Current Population Reports, Series P-23, No. 138) Washington, D.C.: U.S. Government Printing Office. 159 pp. U.S. Environmental Protection Agency (EPA). 1986. Air Quality Criteria for Osone and Other Photochemical Oxidants. EPA/600/8-84-020AF. Research Triangle Park, N.C.: U.S. Environmental Protection Agency, Environmental Criteria and Assessment Once. 5 vole. U.S. Interagency Staff Group on Carcinogens. 1986. Chemical carcinogens: A review of the science and its associated principles. Environ. Health Perspect. 67:201-282. U.S. National Advisory Eye Council (NAEC). 1983. Report of the Glaucoma Panel. In Vision Research: A National Plan, 1983-1987, vol. 2, pt. 4, pp. 15-16. (NIH Publication No. 83-2469) Washington, D.C.: U.S. National Eye Institute. U.S. National Cancer Institute. 1980. Bioassay of Selenium Sulfide (Gavage) for Possible Carcinogenicity (CAS No. 7446-34-6~. (NCI-CG-TR-194) Bethesda, Md.: U.S. NCI and Research Triangle Park, N.C.: National Toxicology Program. 119 pp. U.S. National Institute for Occupational Safety and Health (NIOSH). 1981. Formaldehyde: Evidence of Carcinogenicity. (Current Intelligence Bul- letin 34) Washington, D.C.: U.S. Government Printing Office. 15 pp. U.S. National Institute of Environmental Health Sciences (NIEHS). 1977. Human Health and the Environment Some Research Needs. Report of the Second Task Force for Research Planning in Environmental Health Science. (DHEW Publication No. NIH 77-1277) Washington, D.C.: U.S. Government Printing Office. 498 pp. U.S. National Institute of Environmental Health Sciences (NIEHS). 1984. Human Health and the Environment Some Research Needs. Report of the Third Task Force for Research Planning in Environmental Health Science. (NIH Publication No. NIH 86-1277) Washington, D.C.: U.S. Government Printing Office. 407 pp. U.S. National Institutes of Health (NIH). 1984. Biochemical and Cellular Markers of Chemical Exposure and Preclinical Indicators of Disease. Pp. 203-267 in U.S. NIH, ea., Human Health and the Environment: Some Research Needs, 3. Report of the Third Tack Force for Research Planning in Environmental Health Science. Washington, D.C.: U.S. Government Printing Office. U.S. Office of Technology Assessment (OTA). 1985. Technology and Aging in America. Washington, D.C.: U.S. OTA. 496 pp. U.S. Public Health Service (PHS). 1968. The Health Consequences of Smok- ing. A Public Health Service Review, 1967, revised. Washington, D.C.: U.S. Government Printing Office. 227 pp. U.S. Senate Special Committee on Aging. 1986. Aging America: Trends and Projections, 1985-86 Edition. Washington, D.C.: U.S. Government Printing Office. 129 pp. Unverferth, D. V., R. D. Magorien, C. V. Leier, and S. P. Balcerzak. 1982. Doxorubicin cardiotoxicity. Cancer Treat. Rev. 9:14~164. Upton, A. C., 1977. Pathobiology. Pp. 513-535 in C.E. Finch and L. Hayllick, eds., Handbook of the Biology of Aging. New York: Van Nostrand Reinhold.

REFERENCES 205 Urbach, F., J. H. Epstein, and P. D. Forbes. 1974. Ultraviolet carcinogenesis: Experimental, global, and genetic aspects. Pp. 250283 in M. A. Pathak, L. C. Harber, M. Seiji, and A. Kukita, ede., Sunlight and Man: Normal and Abnormal Photobiologic Responses. Tokyo: University of Tokyo Press. van Brummelen, P., F. R. Bubler, W. Kiowski, and F. W. Amann. 1981. Age-related decrease in cardiac and peripheral vascular responsiveness to isoprenaline: Studies in normal subjects. Clin. Sci. 60:571-577. Vandenbroucke, J. P. 1985. Survival and expectation of life from the 1400's to the present. Am. J. Epidemiol. 122:1007-1016. Vesell, E. S. 1969. Recent progress in pharmacogenetics. Adv. Pharmacol. Chemother. 7:1-52. Vesell, E. S., ed. 1971. Drug metabolism in man. Ann. N. Y. Aced. Sci. 179:1-755. Vesell, E. S. 1973. Advances in pharmacogenetics. Prog. Med. Genet. 9:291-367. Vesell, E. S. 1980. Why individuals vary in their response to drugs. Trends in Pharmacological Sciences 1:340351. Vesell, E. S. 1982a. Dynamically interacting genetic and environmental fac- tors that affect the response of developing individuals to toxicants. Pp. 107-124 in V. R. Hunt, M. K. Smith, and D. Worth, eds., Environmen- tal Factors in Human Growth and Development. (Banbury Report 11) Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory. Vesell, E. S. 1982b. On the significance of host factors that affect drug disposition. Clin. Pharmacol. Ther. 31:1-7. Vesell, E. S. 1984. New directions in pharmacogenetics. Introduction. Fed. Proc. Fed. Am. Soc. E'cp. Biol. 43:23102325. Vesell, E. S. (in press) Pharmacogenetics, Chapter B. In T. E. Gram and L. J. King, eds., The Biochemical Toxicology of Environmental Agents. 2d ed. Vol. 1. New York: Elsevier. Vestal, R. E. 1985. Clinical pharmacology. Pp. 424-443 in R. Andres, E. L. Bierman, and W. R. Hazzard, eds., Principles of Geriatric Medicine. New York: McG raw-Hill. Vestal, R. E., and G. W. Dawson. 1985. Pharmacology and aging. Pp. 744-819 in C. E. Finch and E. L. Schneider, eds., Handbook of the Biology of Aging. 2d ed. New York: Van Nostrand Reinhold Co. Vestal, R. E., A. J. Wood, and D. G. Shand. 1979. Reduced beta- adrenoreceptor sensitivity in the elderly. Clin. Pharmacol. Ther. 26:1B1- 186. Vestal, R. E., S. G. Jue, and B. J. Cusack. 1985. Increased risk of adverse drug reactions in the elderly: Fact or myth? Pp. 97-104 in K. O'Malley and J. L. Waddington, eds., Therapeutics in the Elderly. (International Congress Series No. 677) Amsterdam: Elsevier Science Publishers B.V. Vestal, R. E., B. J. Cusack, G. D. Mercer, G. W. Dawson, and B. K. Park. 1987. Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men. J. Pharmacol. Exp. Ther. 241:488-500. Vestal, R. E., E. A. McGuire, J. D. Tobin, R. Andres, A. H. Norris, and E. Mezey. 1977. Aging and ethanol metabolism. Clin. Pharmacol. Ther. 21 :343-354.

206 REFERENCES Veterans' Administration Cooperative Study Group on AntiLypertensive Agents. 1967. Effects of treatment on morbidity in hypertension. J. Am. Med. Assoc. 202:1028-1034. Veterans' Administration Cooperative Study G roup on Antihypertensive Agents. 1970. Effects of treatment on morbidity in hypertension. J. Am. Med. Assoc. 213~7~:1143-1152. Visintainer, M. A., J. R. Volpicelli, and M. E. Seligman. 1982. Tumor rejection in rats after inescapable or escapable shock. Science 216:437- 439. Vollmer, W. M., L. R. Johnson, and A. S. Buist. 1985. Relationship of response to a bronchodilator and decline in forced expiratory volume in one second in population studies. Am. Rev. Respir. Dis. 132:1186-1193. Van Hoff, D. D., M. W. Layard, P. Basa, H. L. Davis, Jr., A. L. Hoff, M. Rozencweig, and F. M. Muggie. 1979. Risk factors for doxorubicin- induced congestive heart failure. Ann. Intern. Med. 91:710717. Voss, K. H., E. J. Masoro, and W. Anderson. 1982. Modulation of age- related loss of glucagon-promoted lipolysis by food restriction. Mech. Ageing Dev. 18:135-149. Wald, N. J. 1976. Mortality from lung cancer and coronary heart-disease in relation to changes in smoking habits. Lancet 1:136-138. Waldorf, D. S., R. F. Willkens, and J. L. Decker. l9B8. Impaired delayed hypersensitivity in an aging population: Association with antinuclear reactivity and rheumatoid factor. J. Am. Med. Assoc. 203:831-834. Waldron, I. 1976. Whv do women liars lr~n~r~r then m~n47 S:~^ In; Marl 10:349-362. O ———~^ _~^ · A s Walford, R. L. 1986. The 120-Year Diet. New York: Simon and Schuster. Warner, H. R., R. N. Butler, R. L. Sprott, and E. L. Schneider, eds. 1987. Modern Biological Theories of Aging. New York: Raven Press. 324 pp. Watson, A. F., and E. Mellanby. 1930. Tar cancer in mice. II. The condition of the skin where modified by external treatment or diet, as a factor in influencing the cancerous reaction. Br. J. Exp. Pathol. 11:311-322. Wattenberg, L. W. 1971. Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer. Effect of diet on benzpyrene hydroxylase activity. Cancer 28:99-102. Wattenberg, L. W. 1972. Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenoloic antioxidants and ethoxyquin. J. Natl. Cancer Inst. 48:1425-1430. Weindruch, R. 1985. Aging in rodents fed restricted diets. J. Am. Geriatr. Soc. 33:125-132. Weindruch, R., and R. L. Walford. 1982. Dietary restriction in mice beginning at 1 year of age: Effect on life-span and spontaneous cancer incidence. Science 215:1415-1418. Weindruch, R., B. H. Devens, H. V. Raff, and R. L. Walford. 1983. Influence of dietary restriction and aging on natural killer cell activity in mice. J. Immunol. 130:993-996. Weinshilboum, R. M. 1984. Human pharmacogenetics: Introduction. Fed. Proc. Fed. Am. Soc. Exp. Biol. 43:2295-2297. Weintraub, M. 1984. A different view of patient compliance in the elderly. Pp. 43-50 in R. E. Vestal, ea., Drug Treatment in the Elderly. Sydney: ADIS Health Science Press.

REFERENCES 207 Weintraub, M., W. Y. Au, and L. Lasagna. 1973. Compliance as a determi- nant of serum digoxin concentration. J. Am. Med. Aspic. 224:481-485. Weisbroth, S. H. 1974. Neoplastic diseases. Pp. 331-375 in S. H. Weisbroth, R. E. Flatt, and A. L. Kraus, eds., The Biology of the Laboratory Rabbit. New York: Academic Press. Weksler, M. E. 1986. Biological basis and clinical significance of immune senescence. Pp. 57-67 in I. Grossman, ea., Clinical Geriatrics. 3rd ed. New York: J. B. Lippincott Co. Welling, P. 1985. Nutrient effects on drug metabolism and action in the elderly. Drug Nutr. Interact. 4:173-207. Welsch, C. W., M. Goodrich-Smith, C. K. Brown, and N. Crowe. 1981. Enhancement by retinyl acetate of hormone-induced mammary tumori- genesis in female GR/A mice. J. Natl. Cancer Inst. 67:935-938. Wiberg, G. S., H. L. Trenholm, and B. D. Coldwell. 1970. Increased ethanol toxicity in old rats: Changes in LD50, in Vito and in vitro metabolism, and liver alcohol deLydrogenase activity. Toxicol. Appl. Pharmacol. 16:718-727. Wiberg, G. S., J. M. Samson, W. B. Maxwell, B. B. Coldwell, and H. L. Trenholm. 1971. Farther studies on the acute toxicity of ethanol in young and old rats: Relative importance of pulmonary excretion and total body water. Toxicol. Appl. Pharmacol. 20:22-29. Williams, G. C. 1957. Plelotropy, natural selection and the evolution of senescence. Evolution 11:398-411. Williams, J. R., P. S. Spencer, S. M. Stahl, J. F. Borzelleca, W. Nichols, E. PEtzer, E. J. Yunis, R. Carchman, J. W. Opishinski, and R. A. Walford. 1987. Interactions of aging and environmental agents: The toxicological perspective. Pp. 81-135 in S. R. Baker and M. Rogul, eds., Environmental Toxicity and the Aging Processes. (Progress in Clinical and Biological Research, Vol. 228) New York: Alan R. Liss, Inc. Wills, T. A. 1978. Perceptions of clients by professional helpers. Psychol. Bull. 85:968-1000. Wollenberger, A., J. Jehl, and M. L. Karsh. 1953. Influence of age on the sensitivity of the guinea pig and its myocardium to ouabain. J. Pharmacol. Exp. Ther. 108:52-60. Woodhouse, K. W., E. Mutch, F. M. Williams, M. D. Rawlins, and O. F. W. James. 1984. The effect of age on pathways of drug metabolism in human liver. Age Ageing 13:328-334. World Health Organization (WHO). 1977. Oxides of Nitrogen (Fn=;r~n mental Health Criteria 4) Geneva: WHO. 79 pp. World Health Organization (WHO). 1980. Noise. (Environmental Health Criteria 12) Geneva: WHO. 103 pp. World Health Organization (WHO). 1985. Statistics Annual 1985. Geneva: WHO. Yin, F. C., H. A. Spurgeon, H. L. Greene, E. G. Lakatta, and M.L. Weisfeldt. 1979. Age-associated decrease in heart rate response to isoproterenol in dogs. Mech. Ageing Dev. 10:17-25. Yin, F. C., M. L. Weisfeldt, and W. R. Milaor. 1981. Role of Sortie input impedance in the decreased cardiovascular response to exercise with aging in dogs. J. Clin. Invest. 68:28-38. _ ~ _ , ~ _ . _

208 REFERENCES Yu, B. P., E. J. Masoro, and C. A. McMahan. 1985. Nutritional influencer on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics. J. Gerontol. 40:657~70. Yu, B. P., H. A. Bertrand, and E. J. Masoro. 1980. Nutrition-aging influence of catecholamine-promoted lipolysis. Metab. Olin. Exp. 29:438-444. Yu, B. P., E. J. Masoro, I. Murata, H. A. Bertrand, and F. T. Lynd. 1982. Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, growth, lean body mass and disease. J. Gerontol. 37:13~141.

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