Heredity and Development: Second Edition (1972)

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HEREDITY AND DEVELOPMENT i HEREDITY AND DEVELOPMENT 

HEREDITY AND DEVELOPMENT ii 

HEREDITY AND DEVELOPMENT iii Heredity and Development SECOND EDITION JOHN A.MOORE PROFESSOR OF BIOLOGY UNIVERSITY OF CALIFORNIA, RIVERSIDE NEW YORK OXFORD UNIVERSITY PRESS LONDON 1972 TORONTO 

HEREDITY AND DEVELOPMENT iv Copyright © 1957, 1963, 1972 by Oxford University Press, Inc. Library of Congress Catalogue Card Number: 76-161890 Printed in the United States of America 

HEREDITY AND DEVELOPMENT v To Sally Hughes-Schrader 

HEREDITY AND DEVELOPMENT vi 

HEREDITY AND DEVELOPMENT vii Preface Heredity and Development is concerned with concepts in the subsciences of genetics and embryology. The presentation emphasizes the manner in which hypotheses and observations lead to the conceptual schemes that allow us to think in an orderly and satisfying way about the problems involved. I hope that I have written for all persons who are genuinely interested in these mat- ters even though their knowledge of biology may be scant. Experience has shown, however, that Heredity and Development is used primarily in first- year courses in biology in the universities and in one-semester courses in genetics. This second edition differs in many ways from the first. The original 22 chapters have been combined in 12. A new chapter, The Genetics of Man,’ has been added. Those chapters concerned with recent events have been extensively revised. Questions and problems have been provided for many of the chapters. The most important change is that there is now a companion volume, Read- ings in Heredity and Development. The two books are closely integrated but there is a clear division of materials between them. Heredity and Develop- ment deals basically with observations, experiments, and interpretations. Readings consists largely of the great synthetic papers. For example, you can read of E.B.Wilson’s discoveries about sex chromosomes in Heredity and Development and Readings presents his famous lecture to the Royal Society, The Bearing of Cytological Research on Heredity.’ I wish to record once again my indebtedness to those who helped with ear- lier versions of these chapters: Betty Moore, John R.Gregg, Donald McPher- son, Th.Dobzhansky, E.P.Volpe, Lester Barth, Lucena Barth, Francis Ryan, Sally Hughes-Schrader, and Franz Schrader. The new material for this edition has been read in part by Betty Moore and Crellin Pauling. William L.Belser, Kenneth Cooper, and Sally Gall have helped in other ways. John A.Moore Riverside September 1971 

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HEREDITY AND DEVELOPMENT ix Contents Concepts in Genetics Introduction 3 1. Darwin’s Theory of Pangenesis 7 2. The Cellular Basis of Inheritance 19 3. Mendelism 49 4. The Chromosomes and Inheritance 70 5. Morgan and Drosophila 87 6. Genetics—Old and New 140 7. The Substance of Inheritance 152 8. DNA—Structure and Function 167 9. The Genetics of Man 209 Concepts in Embryology Introduction 227 10. A Synopsis of Development of the Amphibian Embryo 229 11. Gastrulation and Organ Formation 242 12. Differentiation 256 13. Developmental Control of Genetic Systems 279 Index 289 

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