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Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
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B


Workshop Agenda

 

THE ROLE OF OBESITY IN
CANCER SURVIVAL AND RECURRENCE:
A WORKSHOP

 

October 31-November 1, 2011
The Keck Center of the National Academies, Room 100
500 Fifth Street, NW, Washington, DC 20001

DAY 1

8:15 am

Welcome from the IOM National Cancer Policy Forum
Patricia Ganz, University of California, Los Angeles (UCLA), National Cancer Policy Forum Vice Chair

 
8:20 am

Workshop Introduction and Overview
Wendy Demark-Wahnefried, University of Alabama at Birmingham, Workshop Planning Committee Chair

 
8:30 am

Session 1: Role of Obesity and Weight Gain in the Promotion of Various Cancers
Moderator:
Rachel Ballard-Barbash, National Cancer Institute (NCI)

Overview of the role of obesity in cancer risk and progression

–   Susan Gapstur, American Cancer Society

Evidence for the role of obesity in breast cancer progression

–   Pamela Goodwin, Mount Sinai Hospital, University of Toronto

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×
 

Evidence for the role of obesity in prostate cancer progression

–   Elizabeth A. Platz, Johns Hopkins Bloomberg School of Public Health

Obesity, energy balance, and colorectal cancer survivorship

–   Jeffrey Meyerhardt, Dana-Farber Cancer Institute

The impact of weight loss on cancer incidence and mortality

–   Bruce M. Wolfe, Oregon Health & Science University

Correlations of obesity, comorbidity, and treatment:
Implications for survival analysis and interpretation

–   Rachel Ballard-Barbash, NCI

10:30 am

Panel Discussion
Questions:

•  What is the current state of the evidence? What are the evidence gaps?

•  Is the evidence strong enough to recommend weight loss for individuals who are overweight or obese and who are either newly diagnosed with cancer or long-term cancer survivors?

•  Would such an approach be recommended for all survivors or a subset of individuals diagnosed with specific cancers? If the latter, which cancers are those?

•  What is the downside of recommending weight loss to cancer survivors who are overweight or obese given the high incidence of comorbidity in this population?

•  What are the methodological issues for closing the evidence gaps?

•  How do we adjust data on obesity for other factors such as physical activity and diet?

11:15 am Lunch Break

12:15 pm Session 2: Mechanisms by Which Obesity May Influence Cancer Progression
Moderator:
Stephen Hursting, University of Texas at Austin
Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×
 

Overview of mechanisms

–   Nathan Berger, Case Western Reserve University School of Medicine

Increased risk of cancer in obesity and type 2 diabetes

–   Derek LeRoith, Mount Sinai School of Medicine

Growth factor and energy sensing pathways

–   John DiGiovanni, University of Texas at Austin

Hormonal factors in obesity and breast cancer

–   Angela Brodie, University of Maryland

Obesity and breast inflammation: Implications for carcinogenesis

–   Andrew Dannenberg, Weill Medical College of Cornell University

Obesity, stem cells, and cancer

–   Madhuri Kakarala, University of Michigan

Signaling pathway crosstalk/Systems biology

–   Nathan Berger, Case Western Reserve University School of Medicine

2:30 pm

Panel Discussion
Questions:

 

•  What is the evidence to support a role for the various potential mechanisms underpinning the obesity–cancer link?

•  What are the most pressing unanswered questions about mechanistic pathways?

•  What mechanisms are the most viable targets for pharmacologic or other interventions?

•  Are multipronged approaches feasible? Should the focus be on combination therapies and interventions?

•  How easy is it to measure the intermediate biomarkers that have been suggested?

–   For which of these biomarkers are there reliable assays?

–   For which are there limited means to assess specific levels?

–   What barriers exist in determining levels in humans? (e.g., is fresh frozen tissue necessary for assessment?)

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×
3:30 pm

Break

 
3:45 pm

Session 3: Dissecting the Obesity–Cancer Link—Is It Obesity? Energy Balance? Physical Activity?
Moderator: Wendy Demark-Wahnefried, University of Alabama at Birmingham

Overview

–   Wendy Demark-Wahnefried

Mechanistic insights from animal models

–   Stephen Hursting, University of Texas at Austin

Clinical evidence

–   Jennifer Ligibel, Dana-Farber Cancer Center

4:45 pm

Panel Discussion
Questions:

 

•  What is the ultimate driver of the obesity–cancer link?

•  Are the relationships between physical activity and energy restriction in cancer similar to those in other diseases such as cardiovascular disease, or does cancer represent a different model?

•  What model systems and research methodologies could help us sort out the various contributions to the obesity–cancer link?

•  What is needed for effective clinical studies?

•  If we are able to discern the factors most influential in cancer promotion, would that necessarily change medical practice?

•  How might we best break the obesity–cancer link?

 
5:15 pm

Wrap-up, Day 1

 
5:30 pm

Adjourn Day 1

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×

DAY 2

8:30 am

Session 4: Tying It All Together
Moderator: Pamela Goodwin, University of Toronto

 

Overview of weight loss interventions for obese adults

–   Thomas Wadden, University of Pennsylvania

Physical activity interventions in cancer survivors: What works?

–   Kerry Courneya, University of Alberta

Evidence from diet and weight loss studies for cancer survivors: What works?

–   Cheryl Rock, University of California, San Diego

Interventions in cancer survivors; issues and challenges in this population

–   Anne McTiernan, University of Washington

When do we have enough evidence to intervene in cancer patients?

–   Patricia Ganz, UCLA

10:30 am

Panel Discussion
Opening statements by:
Kate Murphy, Fight Colorectal Cancer
Diana Dyer, CancerRD.com


Questions:

 

•  When is there enough evidence to warrant intervention?

•  What interventions are effective? What is the evidence?

•  When is the teachable moment?

•  What are the mechanics of intervention: Who, when, where, how, and what?

•  Which interventions are likely to be the most cost-effective?

•  What barriers stand in the way of broad dissemination on interventions?

11:30 am

Lunch Break

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×
12:00 pm

Session 5: Reactions and Panel Discussion—What Are the Policy and Research Implications?
Moderators: Martin Murphy, CEO Roundtable on Cancer and Patricia Ganz, UCLA

 

Lori Minasian, Division of Cancer Prevention, NCI
Linda Nebeling, Division of Cancer Control and Population Sciences, NCI
Jo Anne Zujewski, Division of Cancer Treatment and Diagnosis, NCI
Edward Partridge, American Cancer Society and University of Alabama at Birmingham
Dean Brenner, American Society of Clinical Oncology and University of Michigan

Questions:

•  What are the research needs and goals to advance understanding of this topic?

•  What resources and infrastructures are needed to accomplish the research goals?

•  What is needed for effective interdisciplinary research in this area?

•  What policy changes do you suggest to reduce obesity-related cancer incidence and mortality?

•  What are the obstacles to implementing such policy changes? How could those obstacles be overcome?

•  How can we work with other medical fields to accomplish common goals?

1:00 pm

Closing Remarks—Wendy Demark-Wahnefried

 
1:10 pm

Adjourn

Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×
Page 85
Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×
Page 86
Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×
Page 87
Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×
Page 88
Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×
Page 89
Suggested Citation:"Appendix B: Workshop Agenda." Institute of Medicine. 2012. The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13348.
×
Page 90
Next: Appendix C: Speaker Biographies »
The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary Get This Book
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Recent research suggests that obesity and excess weight can play a prominent role in the incidence and progression of various cancers. Obesity results from an energy imbalance - that is, energy intake that is higher than energy expenditure - could also influence the growth of cancers. Recognizing the impact that current findings on obesity and cancer could have on future cancer prevention and care, the National Cancer policy Forum (NCPF) of the Institute of Medicine (IOM) help a 2-day workshop on "The Role of Obesity in Cancer Survival and Recurrence," in Washington, DC, on October 31 and November 1, 2011.

The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary reviews each presenter's latest clinical evidence on the obesity-cancer link and the molecular mechanisms that might explain that link. Clinicians, researchers, cancer survivors, and policy makers also discussed potential interventions to counter the effects of obesity on cancer, and research and policy measures needed to stem the rising tide of cancer mortality predicted by an increasingly overweight and older population worldwide.

The Role of Obesity in Cancer Survival and Recurrence: Workshop Summary explores the complex web of molecular mechanisms that underlie the obesity-cancer link, the ways to design future studies to acquire the information needed to guide patient care, what to advise cancer patients about weight loss, diet, exercise, and other measures to reduce their risk of cancer progression or recurrence and policy suggestions related to research, education, and dissemination of the findings on obesity and cancer.

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