An ad hoc planning committee will organize and conduct a public workshop to examine the process for evaluating evidence for genomic applications. The workshop goal is to evaluate how evidence for genomic applications is gathered and assessed for clinical decision making, reimbursement decisions, and guideline development in the absence of an ideal information base. The workshop will also address how evidence is evaluated for determining what secondary genome sequencing information should be returned to patients. Current models will be evaluated to advance discussions among diverse stakeholder groups which may include academic researchers, industry and professional society representatives, clinicians, patients, payers, and laboratory test developers. The planning committee will develop the workshop agenda, select speakers and discussants, and moderate the discussions. An individually authored summary of the workshop will be prepared by a designated rapporteur in accordance with institutional policy and procedures.