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Suggested Citation:"Front Matter." Institute of Medicine. 1992. Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s. Washington, DC: The National Academies Press. doi: 10.17226/1965.
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ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER

Impact on Diagnosis and Treatment Decisions in the 1990s

A Research Briefing from the Division of Health Sciences Policy

INSTITUTE OF MEDICINE

National Academy Press
Washington, D.C.
1992

Suggested Citation:"Front Matter." Institute of Medicine. 1992. Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s. Washington, DC: The National Academies Press. doi: 10.17226/1965.
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The Institute of Medicine was chartered in 1970 by the National Academy of Sciences to enlist distinguished members of appropriate professions in the examination of policy matters pertaining to the health of the public. In this, the Institute acts under both the Academy’s 1863 Congressional charter responsibility to be an advisor to the federal government, and its own initiative in identifying issues of medical care, research, and education.

Research briefings are an important part of the agreement between the Institute of Medicine and the Howard Hughes Medical Institute to initiate a program of studies that is intended to facilitate the translation of discoveries in basic science into advances for health. Of specific interest in the research briefings are the assessment of current knowledge in a particular field of study, identification of promising areas within that field, and recommendations about future research needs in terms of scientific issues. Although occasional recommendations are made regarding research policy, it is not the purpose of these briefings to advocate increases or decreases in current funding levels or to undertake a prioritization or comparative evaluation of other areas of scientific inquiry. The audience for research briefings is quite broad and includes grant administrators and project officers (government and nongovernment), physicians, science policy analysts, congressional staff, scientists, science journalists, and the interested lay public. Research briefing topics are selected by the Institute of Medicine in consultation with its membership, the IOM Council, and the Board on Health Sciences Policy.

Library of Congress Catalog Card No. 92-60001

International Standard Book Number 0-309-04688-2

Additional copies of this report are available from:
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Printed in the United States of America

The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The image adopted as a logotype by the Institute of Medicine is based on a relief carving from ancient Greece, now held by the Staatlichemuseen in Berlin.

Suggested Citation:"Front Matter." Institute of Medicine. 1992. Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s. Washington, DC: The National Academies Press. doi: 10.17226/1965.
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PANEL FOR THE RESEARCH BRIEFING ON ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER: IMPACT ON DIAGNOSIS AND TREATMENT DECISIONS IN THE 1990s

JANET D. ROWLEY (Co-Chair),

Department of Medicine and of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois

JEFFREY L. SKLAR (Co-Chair),

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts

GARRETT M. BRODEUR,

Division of Hematology/Oncology, St. Louis Children's Hospital, St. Louis, Missouri

WEBSTER K. CAVENEE,

Ludwig Institute-Montreal Branch, Montreal, Quebec, Canada

BEVERLY F. EMANUEL,

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

STANLEY J. KORSMEYER,

Howard Hughes Medical Institute, St. Louis, Missouri

DANIEL PINKEL,

Division of Molecular Cytometry, University of California at San Francisco, San Francisco, California

DENNIS J. SLAMON,

Division of Hematology/Oncology, University of California at Los Angeles, Los Angeles, California

SANFORD A. STASS,

Division of Laboratory Medicine, M.D. Anderson Cancer Center, Houston, Texas

LOUIS C. STRONG,

Division of Pediatrics, M.D. Anderson Cancer Center, Houston, Texas

Rapporteur

JON C. ASTER,

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

Institute of Medicine Staff

DAVID M. TURNER, Project Director,

Research Briefing

RUTH ELLEN BULGER, Director,

Division of Health Sciences Policy

SARAH A. ZIELINSKI, Project Assistant

RITA T. GIBSON, Administrative Assistant

Suggested Citation:"Front Matter." Institute of Medicine. 1992. Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s. Washington, DC: The National Academies Press. doi: 10.17226/1965.
×

Statement of Purpose

Committee for the Research Briefing on Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s

The purpose of this committee was to conduct a research briefing to examine the utilization of genetic techniques for the diagnosis and prognosis of cancer and the impact of this utilization on diagnosis, prognosis, and treatment decisions. Research briefings are sponsored by the Howard Hughes Medical Institute and address three purposes: (1) to highlight a promising and exciting field of medical science; (2) to examine the current status of that field; and (3) to make scientific recommendations about future needs in the field. This research briefing is directed largely toward informing physicians of the rapid advances being made in this field.

Suggested Citation:"Front Matter." Institute of Medicine. 1992. Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s. Washington, DC: The National Academies Press. doi: 10.17226/1965.
×

ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER

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Suggested Citation:"Front Matter." Institute of Medicine. 1992. Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s. Washington, DC: The National Academies Press. doi: 10.17226/1965.
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Suggested Citation:"Front Matter." Institute of Medicine. 1992. Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s. Washington, DC: The National Academies Press. doi: 10.17226/1965.
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Suggested Citation:"Front Matter." Institute of Medicine. 1992. Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s. Washington, DC: The National Academies Press. doi: 10.17226/1965.
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The past 20 years have seen a rapid increase in our understanding of the biology of cancer. And, advances in understanding the genetics of cancer are beginning to have an impact on the clinical management of malignant disease. Many of the genetic changes that underlie malignant transformation of cells and/or that distinguish malignant clones can be used as markers to diagnose, monitor, or characterize various forms of cancer.

The purpose of this volume is to assess the current status of genetic testing in cancer management both from the standpoint of those tests and genetic markers that are presently available and from the perspective of genetic approaches to cancer testing that are likely to have an impact on cancer management in the near future.

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