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Issues in Risk Assessment (1993)

Chapter: Appendix B Workshop Program

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Suggested Citation:"Appendix B Workshop Program ." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
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Appendix B
Workshop Program

Thursday, November 8, 1990

8:30

Welcome: Donald Mattison, University of Pittsburgh Committee Vice-Chairman

8:35

Introduction and Objectives: Richard Griesemer, NIEHS Workshop Chairman

8:45

Biological Factors in Two-Stage Models

 

Presenter: Alfred Knudson, Fox Chase Cancer Center

9:30

Discussant: Robert Maronpot, NIEHS

9:50

Questions and Comments

10:10

Break

10:30

Two-Stage Clonal Expansion Model of Carcinogenesis

 

Presenter: Suresh Moolgavkar, Fred Hutchinson Cancer Research Center

11:15

Discussants: James Wilson, Monsanto; Robert Sielken, Sielken, Inc.; Todd Thorslund, Clement Associates, Inc.

12:00

Questions and Comments

Suggested Citation:"Appendix B Workshop Program ." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
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12:15

Lunch

1:15

Application of the Two-Stage Model to Animal Data

 

Presenter: Samuel Cohen, University of Nebraska Medical Center

2:00

Discussants: William Farland, EPA; Carl Barrett, NIEHS

2:30

Questions and Comments

2:45

General Discussion

 

Leader: Richard Griesemer, NIEHS

 

Issues:

 

• The scientific basis for two-stage models of carcinogenesis.

• Can two-stage models of carcinogenesis adequately represent biological processes that may involve a variety of mechanisms?

• The implications for the design of rodent bioassays.

• The implications for health risk assessment.

3:30

Adjourn

Suggested Citation:"Appendix B Workshop Program ." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
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Page 233
Suggested Citation:"Appendix B Workshop Program ." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
×
Page 234
Next: Appendix C Workshop Federal Liaison Group »
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The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume.

The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures.

The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.

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