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Suggested Citation:"Appendix F: Acronym List." Institute of Medicine and National Research Council. 2015. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/21666.
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Appendix F


Acronym List

ABSL

animal biosafety level

ACE-2 receptor

Angiotensin-converting enzyme 2

APHIS

Animal and Plant Health Inspection Service

BARDA

Biomedical Advanced Research and Development Authority

BMBL

Biosafety in Microbiological and Biomedical Laboratories

BSAT

Biological Select Agents and Toxins

BSL

biosafety level

CDC

U.S. Centers for Disease Control and Prevention

cDNA

complementary deoxyribonucleic acid

CoV

coronavirus

CRISPR

clustered regularly interspaced short palindromic repeats

DNA

deoxyribonucleic acid

DURC

dual use research of concern

EID

Emerging Infectious Diseases

FBI

Federal Bureau of Investigation

Suggested Citation:"Appendix F: Acronym List." Institute of Medicine and National Research Council. 2015. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/21666.
×

GAO

Government Accountability Office

GOF

gain-of-function

HA

hemagglutinins

HAE

human airway epithelial

HEPA

high-efficiency particulate arrestance

HPAIV

highly pathogenic avian influenza viruses

IACUC

Institutional Animal Care and Use Committees

IBC

Institutional Biosafety Committee

IOM

Institute of Medicine

IRI

Influenza Research Institute (at the University of Wisconsin-Madison)

JCVI

J. Craig Venter Institute

LAI

Laboratory Acquired Infection

mAb

monoclonal antibody

MERS

Middle East respiratory syndrome

NA

neuraminidase

NAS

National Academy of Sciences

NIAID

National Institute of Allergy and Infectious Diseases

NIH

National Institutes of Health

NSABB

National Science Advisory Board for Biosecurity

NRC

National Research Council

PLoS

Public Library of Science

PPE

personal protective equipment

PPP

potential pandemic pathogens

RNA

ribonucleic acid

SARS

severe acute respiratory syndrome

SGVI

Synthetic Genomics Vaccines

SL-CoV

SARS-like CoV

S&T

science and technology

UPMC

University of Pittsburgh Medical Center

USDA

U.S. Department of Agriculture

USG

U.S. Government

USNRC

U.S. Nuclear Regulatory Commission

Suggested Citation:"Appendix F: Acronym List." Institute of Medicine and National Research Council. 2015. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/21666.
×

UW

University of Wisconsin-Madison

WHO

World Health Organization

Suggested Citation:"Appendix F: Acronym List." Institute of Medicine and National Research Council. 2015. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/21666.
×

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Suggested Citation:"Appendix F: Acronym List." Institute of Medicine and National Research Council. 2015. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/21666.
×
Page 123
Suggested Citation:"Appendix F: Acronym List." Institute of Medicine and National Research Council. 2015. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/21666.
×
Page 124
Suggested Citation:"Appendix F: Acronym List." Institute of Medicine and National Research Council. 2015. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/21666.
×
Page 125
Suggested Citation:"Appendix F: Acronym List." Institute of Medicine and National Research Council. 2015. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/21666.
×
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On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, the United States government launched a one-year deliberative process to address the continuing controversy surrounding so-called "gain-of-function" (GOF) research on respiratory pathogens with pandemic potential. The gain of function controversy began in late 2011 with the question of whether to publish the results of two experiments involving H5N1 avian influenza and continued to focus on certain research with highly pathogenic avian influenza over the next three years. The heart of the U.S. process is an evaluation of the potential risks and benefits of certain types of GOF experiments with influenza, SARS, and MERS viruses that would inform the development and adoption of a new U.S. Government policy governing the funding and conduct of GOF research.

Potential Risks and Benefits of Gain-of-Function Research is the summary of a two-day public symposia on GOF research. Convened in December 2014 by the Institute of Medicine and the National Research Council, the main focus of this event was to discuss principles important for, and key considerations in, the design of risk and benefit assessments of GOF research. Participants examined the underlying scientific and technical questions that are the source of current discussion and debate over GOF research involving pathogens with pandemic potential. This report is a record of the presentations and discussion of the meeting.

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