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Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2015. Examining a Developmental Approach to Childhood Obesity: The Fetal and Early Childhood Years: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21782.
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Appendix A

Workshop Agenda

Institute of Medicine and National Research Council
Food and Nutrition Board and Board on Children, Youth, and Families
Examining a Developmental Approach to Childhood Obesity:
The Fetal and Early Childhood Years
Planning Committee on Understanding the Dynamic Relationship
Between Biology, Environment, and Early Childhood Development on
Risk of Obesity

February 26–27, 2015
Keck Building, Room 100
The National Academies
500 Fifth Street, NW
Washington, DC

WORKSHOP OBJECTIVES

  • Identify epigenetic-mediated relationships between exposure to risk factors during sensitive periods of development (gestation through age 3) and subsequent obesity-related health outcomes.
  • Explore the science around periods of plasticity and potential reversibility of obesity risk in the context of early childhood development.
  • Examine the translation of epigenetic science to guide early childhood obesity prevention and intervention to reduce obesity risk.
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2015. Examining a Developmental Approach to Childhood Obesity: The Fetal and Early Childhood Years: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21782.
×

DAY 1

8:00–8:45 a.m.

Registration

Introduction and Opening Remarks

8:50 a.m.

Welcome

 

Shari Barkin, William K. Warren Family Foundation Chair in Medicine and Professor of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt University

9:00 a.m.

Opening Remarks

 

David M. Klurfeld, National Program Leader, Human Nutrition, Agricultural Research Service, U.S. Department of Agriculture

 

Sandra Hassink, Medical Director, Institute for Healthy Childhood Weight, American Academy of Pediatrics

 

Jamie Bussel, Program Officer, Robert Wood Johnson Foundation

Session 1: The Role of Epigenetics in Pediatric Obesity—Conceptual Overview

 

Moderated by Matthew Gillman, Harvard School of Public Health

9:30 a.m.

Fundamentals of Epigenetics

 

Robert Waterland, Baylor College of Medicine

9:50 a.m.

Conceptual Model of Epigenetic Influence on Obesity Risk

 

Andrea Baccarelli, Harvard School of Public Health

Session 2: Etiology and Causal Inference

 

Moderated by Karen Lillycrop, University of Southampton

10:10 a.m.

Epigenetic Mechanisms for Obesity Risk

 

Jacob Friedman, University of Colorado, Denver

10:30 a.m.

The Role of Disparity in the Origins of Obesity Risk

 

Linda Adair, University of North Carolina at Chapel Hill

10:50 a.m.

Fathers’ Early Contribution to the Birth of the Child: The Role of Paternal RNAs

 

Stephen Krawetz, Wayne State University

11:10 a.m.

Maternal Influences on Offspring’s Epigenetics and Later Body Composition

 

Caroline Relton, Newcastle University

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2015. Examining a Developmental Approach to Childhood Obesity: The Fetal and Early Childhood Years: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21782.
×

11:30 a.m.

Q & A with Participants

12:00 p.m.

Break for Lunch

Session 3: Opportunities for Intervention and Prevention

 

Moderated by Leann Birch, University of Georgia

1:00 p.m.

Developmental Plasticity—Sensitive Periods and Risk of Obesity

 

Karen Lillycrop, University of Southampton

1:20 p.m.

Maternal Health and Diet’s Effect on Offspring’s Metabolic Functioning

 

Kevin Grove, Novo Nordisk

1:40 p.m.

Early Infant Rapid Weight Gain and the Epigenetics of Leptin

 

Marie-France Hivert, Harvard Medical School

2:00 p.m.

Therapies to Reverse Metabolic Disturbances Arising as a Consequence of Developmental Programming

 

Mark Vickers, University of Auckland

2:20 p.m.

Panel Discussion with Speakers

 

Moderated by Leann Birch, University of Georgia

2:40 p.m.

Break

3:00 p.m.

The Microbiome and Our Genome

 

William Nierman, J. Craig Venter Institute

3:20 p.m.

The Epigenetics of the Microbiome

 

Meredith Hullar, Fred Hutchinson Cancer Research Center

3:40 p.m.

Toxic Stress and Its Role in Childhood Obesity

 

Antonio Convit, Nathan Kline Institute for Psychiatric Research

4:00 p.m.

Panel Discussion with Speakers

4:30 p.m.

Concluding Remarks

 

Shari Barkin, Monroe Carell Jr. Children’s Hospital at Vanderbilt University

DAY 2

8:50 a.m.

Welcome and Summary from Day 1

 

Shari Barkin, Monroe Carell Jr. Children’s Hospital at Vanderbilt University

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2015. Examining a Developmental Approach to Childhood Obesity: The Fetal and Early Childhood Years: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21782.
×

Session 4: Real-World Application

 

Moderated by Debra Haire-Joshu, Washington University in St. Louis

9:00 a.m.

Early Exposure Events and Obesity-Related Outcomes

 

Aryeh Stein, Emory University

9:20 a.m.

Messages to Women About Epigenetics and Childhood Obesity

 

Sarah Richardson, Harvard University

9:40 a.m.

Theory to Policy

 

Matthew Gillman, Harvard Pilgrim Health Care Institute

10:00 a.m.

Theory to Clinical Practice

 

Shari Barkin, Monroe Carell Jr. Children’s Hospital at Vanderbilt University

10:20 a.m.

Panel Discussion with Speakers

Session 5: Data Gaps and Future Directions

 

Moderated by Esa Davis, University of Pittsburgh Medical Center

10:40 a.m.

Facilitated Discussion on Data Gaps and Future Research

 

Invited Speakers from Days 1 and 2

11:00 a.m.

Facilitated Discussion on Opportunities and Challenges in Epigenetics Research

 

Judith Hall, University of British Columbia

11:30 a.m.

Chair’s Summary and Final Thoughts

 

Shari Barkin, Monroe Carell Jr. Children’s Hospital at Vanderbilt University

12:00 p.m.

Adjourn Meeting

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2015. Examining a Developmental Approach to Childhood Obesity: The Fetal and Early Childhood Years: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21782.
×
Page 147
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2015. Examining a Developmental Approach to Childhood Obesity: The Fetal and Early Childhood Years: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21782.
×
Page 148
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2015. Examining a Developmental Approach to Childhood Obesity: The Fetal and Early Childhood Years: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21782.
×
Page 149
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2015. Examining a Developmental Approach to Childhood Obesity: The Fetal and Early Childhood Years: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21782.
×
Page 150
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Recent scientific evidence points to the origins of childhood obesity as an outcome of the dynamic interplay of genetic, behavioral, and environmental factors throughout early development, with a compelling body of evidence suggesting that both maternal and paternal nutritional and other exposures affect a child's risk of later obesity. The burgeoning field of epigenetics has led researchers to speculate that many of the observed associations between early developmental exposures and later risk of childhood obesity are mediated, at least in part, through epigenetic mechanisms.

To explore the body of evolving science that examines the nexus of biology, environment, and developmental stage on risk of childhood obesity, the Institute of Medicine and the National Research Council convened a workshop in February 2015. The workshop focused on the prenatal period, infancy, and early childhood and addressed evidence from both animal and human studies. Workshop objectives were to (1) identify epigenetic-mediated relationships between exposure to risk factors during sensitive periods of development (gestation through age 3) and subsequent obesity-related outcomes; (2) explore the science around periods of plasticity and potential reversibility of obesity risk in the context of early childhood development; and (3) examine the translation of epigenetic science to guide early childhood obesity prevention and intervention to reduce obesity risk. This report summarizes the information presented and discussed at the workshop.

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