National Academies Press: OpenBook
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

Rapid Medical
Countermeasure
Response to
Infectious Diseases

Enabling Sustainable Capabilities
Through Ongoing Public- and
Private-Sector Partnerships

Workshop Summary

Theresa Wizemann, Megan Reeve Snair, and Jack Herrmann,
Rapporteurs

Forum on Medical and Public Health Preparedness
for Catastrophic Events

Forum on Drug Discovery, Development, and Translation

Forum on Microbial Threats

Board on Health Sciences Policy

Board on Global Health

Institute of Medicine

images

THE NATIONAL ACADEMIES PRESS

Washington, DC

www.nap.edu

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

THE NATIONAL ACADEMIES PRESS • 500 Fifth Street, NW • Washington, DC 20001

This activity was supported by contracts between the National Academy of Sciences and the American College of Emergency Physicians; American Hospital Association; Association of State and Territorial Health Officials; Centers for Disease Control and Prevention (Contract No. 200-2011-38807, TO #30); Department of Defense (Contract No. HT0011-11-P-0186); Department of Defense, Uniformed Services University of the Health Sciences (Contract No. HT9404-12-1-0022); Department of Health and Human Services’ Administration for Children and Families (Contract No. HHSP2332014001533P); Department of Health and Human Services’ National Institutes of Health: National Institute of Allergy and Infectious Diseases, National Institute of Environmental Sciences, National Library of Medicine (Contract No. HHSN26300007 [Under Base 1 #HHSN263201200074I]); Department of Health and Human Services’ Office of the Assistant Secretary for Preparedness and Response (Contract No. HHSO100201000021P); Department of Homeland Security, Office of Health Affairs (Contract No. HSHQDC-13-J-00384 [Under Base 1 #HSHQDC-11-D-00009]); Department of Transportation’s National Highway Traffic Safety Administration (Contract No. DTNH22-10-H-00287); Department of Veterans Affairs (Contract No. 101-G09041); Food and Drug Administration (Contract No. HHSF22301027T [Under Base Contract DHHS-8598]); Infectious Diseases Society of America; Martin, Blanck & Associates; Merck Research Laboratories (Contract No. APA-2014-1666); National Association of Chain Drug Stores; National Association of County and City Health Officials; National Association of Emergency Medical Technicians; Novartis Vaccines and Diagnostics, Inc.; Pharmaceutical Research and Manufacturers of America; Robert Wood Johnson Foundation; Target Corporation; and Trauma Center Association of America. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.

International Standard Book Number-13: 978-0-309-37861-1
International Standard Book Number-10: 0-309-37861-3
DOI: 10.17226/21809

Additional copies of this workshop summary are available for sale from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.

Copyright 2016 by the National Academy of Sciences. All rights reserved.

Printed in the United States of America

Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2016. Rapid medical countermeasure response to infectious diseases: Enabling sustainable capabilities through ongoing public and private-sector partnerships: Workshop summary. Washington, DC: The National Academies Press.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

images

The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Ralph J. Cicerone is president.

The National Academy of Engineering was established in 1964 under the charter of the National Academy of Sciences to bring the practices of engineering to advising the nation. Members are elected by their peers for extraordinary contributions to engineering. Dr. C. D. Mote, Jr., is president.

The National Academy of Medicine (formerly the Institute of Medicine) was established in 1970 under the charter of the National Academy of Sciences to advise the nation on medical and health issues. Members are elected by their peers for distinguished contributions to medicine and health. Dr. Victor J. Dzau is president.

The three Academies work together as the National Academies of Sciences, Engineering, and Medicine to provide independent, objective analysis and advice to the nation and conduct other activities to solve complex problems and inform public policy decisions. The Academies also encourage education and research, recognize outstanding contributions to knowledge, and increase public understanding in matters of science, engineering, and medicine.

Learn more about the National Academies of Sciences, Engineering, and Medicine at www.national-academies.org.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

WORKSHOP PLANNING COMMITTEE1

RICHARD HATCHETT (Co-Chair), Biomedical Advanced Research and Development Authority, Department of Health and Human Services, Washington, DC

MONIQUE MANSOURA (Co-Chair), Novartis Vaccines and Diagnostics, Cambridge, MA

PHYLLIS ARTHUR, Biotechnology Industry Organization, Washington, DC

MARK FEINBERG, Merck & Co., Inc., West Point, PA

THOMAS INGLESBY, UPMC Center for Health Security, Baltimore, MD

ALI KHAN, College of Public Health, University of Nebraska Medical Center, Omaha, NE

MICHAEL KURILLA, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

JOSEPH LARSEN, Biomedical Advanced Research Development Authority, Department of Health and Human Services, Washington, DC

CARMEN MAHER, Office of Counterterrorism and Emerging Threats, Food and Drug Administration, Silver Spring, MD

MICHAEL OSTERHOLM, Center for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, MN

TARA O’TOOLE, In-Q-Tel, Inc., Arlington, VA

GERALD PARKER, Center for Innovation in Advanced Development & Manufacturing, Texas A&M University Health Science Center, Bryan, TX

ANDREW PAVIA, Infectious Disease Society of America, Salt Lake City, UT

JOHN REX, AstraZeneca, Waltham, MA

IOM Staff

BRUCE M. ALTEVOGT, Forum Director (until May 2015)

JACK HERRMANN, Forum Director (since May 2015)

___________________

1Institute of Medicine planning committees are solely responsible for organizing the workshop, identifying topics, and choosing speakers. The responsibility for the published workshop summary rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

CHRISTOPHER J. DEFEO, Program Officer

MEGAN REEVE SNAIR, Program Officer

ASHLEY OTTEWELL, Research Associate

ALEX REPACE, Senior Program Assistant

ANDREW M. POPE, Director, Board on Health Sciences Policy

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

FORUM ON MEDICAL AND PUBLIC HEALTH
PREPAREDNESS FOR CATASTROPHIC EVENTS1

DAN HANFLING (Co-Chair), UPMC Center for Biosecurity, Bethesda, MD

SUZET M. MCKINNEY (Co-Chair), Illinois Medical District Commission, Chicago, IL

ROY L. ALSON, American College of Emergency Physicians, Winston-Salem, NC

KATHRYN BRINSFIELD, Office of Health Affairs, Department of Homeland Security, Washington, DC

SUSAN COOPER, Regional Medical Center, Memphis, TN

BROOKE COURTNEY, Office of Counterterrorism and Emerging Threats, Food and Drug Administration, Washington, DC

DAVID T. DYJACK, National Association of County and City Health Officials, Washington, DC

BRUCE EVANS, National Association of Emergency Medical Technicians, Upper Pine River Fire Protection District, Bayfield, CO

JULIE L. GERBERDING, Merck Vaccines, Merck & Co., Inc., West Point, PA

LEWIS R. GOLDFRANK, New York University School of Medicine, New York

JOHN L. HICK, Hennepin County Medical Center, Minneapolis, MN

PAUL E. JARRIS, Association of State and Territorial Health Officials, Arlington, VA

LISA G. KAPLOWITZ, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC

MICHAEL G. KURILLA, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

EMILY LORD, Healthcare Ready, Washington, DC

DONALD M. LUMPKINS, Federal Emergency Management Agency, Department of Homeland Security, Washington, DC

JAYNE LUX, National Business Group on Health, Washington, DC

LINDA M. MACINTYRE, American Red Cross, San Rafael, CA

___________________

1Institute of Medicine forums and roundtables do not issue, review, or approve individual documents. The responsibility for the published workshop summary rests with the workshop rapporteurs and the institution.

Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

MONIQUE K. MANSOURA, Novartis Vaccines and Diagnostics, Inc., Cambridge, MA

NICOLE MCKOIN, Target Corporation, Furlong, PA

AUBREY K. MILLER, National Institute of Environmental Health Sciences, Bethesda, MD

MATTHEW MINSON, Texas A&M University, College Station

JOHN OSBORN, Mayo Clinic, Rochester, MN

TARA O’TOOLE, In-Q-Tel, Arlington, VA

ANDREW T. PAVIA, Infectious Diseases Society of America, Salt Lake City, UT

STEVEN J. PHILLIPS, National Library of Medicine, Bethesda, MD

ALONZO PLOUGH, Robert Wood Johnson Foundation, Princeton, NJ

LEWIS J. RADONOVICH, Department of Veterans Affairs, Washington, DC

STEPHEN C. REDD, Centers for Disease Control and Prevention, Atlanta, GA

MARY J. RILEY, Administration for Children and Families, U.S. Department of Health and Human Services, Washington, DC

SARA ROSZAK, National Association of Chain Drug Stores, Arlington, VA

KENNETH W. SCHOR, Uniformed Services University of the Health Sciences, Bethesda, MD

ROSLYNE SCHULMAN, American Hospital Association, Washington, DC

RICHARD SERINO, Harvard School of Public Health, Boston, MA

DAVID J. SMITH, Department of Defense, Washington, DC

MARGARET VANAMRINGE, The Joint Commission, Washington, DC

W. CRAIG VANDERWAGEN, Martin, Blanck & Associates, Alexandria, VA

JENNIFER WARD, Trauma Center Association of America, Las Cruces, NM

JOHN M. WIESMAN, Washington State Department of Health, Tumwater, WA

GAMUNU WIJETUNGE, National Highway Traffic Safety Administration, Washington, DC

MATTHEW K. WYNIA, Center for Bioethics and Humanities, University of Colorado Denver, Aurora, CO

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

IOM Staff

BRUCE M. ALTEVOGT, Forum Director (until May 2015)

JACK HERRMANN, Forum Director (since May 2015)

MEGAN REEVE SNAIR, Program Officer

ASHLEY OTTEWELL, Research Associate

ALEX REPACE, Senior Program Assistant

ANDREW M. POPE, Director, Board on Health Sciences Policy

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

FORUM ON DRUG DISCOVERY, DEVELOPMENT, AND
TRANSLATION1

RUSS ALTMAN (Co-Chair), Stanford University, CA

STEVEN GALSON (Co-Chair), Amgen Inc., Thousand Oaks, CA

MARGARET ANDERSON, FasterCures, Washington, DC

HUGH AUCHINCLOSS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

CHRISTOPHER AUSTIN, National Center for Advancing Translational Sciences, Bethesda, MD

ANN BONHAM, Association of American Medical Colleges, Washington, DC

LINDA BRADY, National Institute of Mental Health, National Institutes of Health, Bethesda, MD

GAIL CASSELL, Harvard Medical School Department of Social and Global Medicine (Visiting), Carmel, IN

ANDREW DAHLEM, Eli Lilly & Co., Indianapolis, IN

JAMES DOROSHOW, National Cancer Institute, Bethesda, MD

JEFFREY DRAZEN, New England Journal of Medicine, Boston, MA

HARRY GREENBERG, Stanford University School of Medicine, CA

LYNN HUDSON, Critical Path Institute, Tucson, AZ

S. CLAIBORNE JOHNSTON, Dell Medical School at the University of Texas, Austin

JACK KEENE, Duke University Medical Center, Durham, NC

RUSTY KELLEY, Burroughs Wellcome Fund, Research Triangle Park, NC

RONALD KRALL, University of Pittsburgh, Steamboat Springs, CO

FREDA LEWIS-HALL, Pfizer, Inc., New York, NY

BRIGGS MORRISON, AstraZeneca, Summit, NJ

BERNARD MUNOS, InnoThink Center for Research in Biomedical Innovation, Indianapolis, IN

ELIZABETH (BETSY) MYERS, Doris Duke Charitable Foundation, New York, NY

JOHN ORLOFF, Baxter BioScience, Deerfield, IL

RAJESH RANGANATHAN, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD

___________________

1Institute of Medicine forums and roundtables do not issue, review, or approve individual documents. The responsibility for the published workshop summary rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

ROBERT RATNER, American Diabetes Association, Alexandria, VA

MICHAEL ROSENBLATT, Merck & Co., Inc., Kenilworth, NJ

MICHAEL SEVERINO, AbbVie Inc., North Chicago, IL

ELLEN SIGAL, Friends of Cancer Research, Washington, DC

LANA SKIRBOLL, Sanofi, Washington, DC

MURRAY STEWART, GlaxoSmithKline, Collegeville, PA

BRIAN STROM, Rutgers, the State University of New Jersey, Newark

JANET TOBIAS, Ikana Media, New York, NY

JOHN WAGNER, Takeda Pharmaceuticals, Cambridge, MA

JOANNE WALDSTREICHER, Johnson & Johnson, New Brunswick, NJ

CARRIE WOLINETZ, National Institutes of Health, Bethesda, MD

JANET WOODCOCK, Food and Drug Administration, Silver Spring, MD

IOM Staff

ANNE CLAIBORNE, Forum Director

CHRISTOPHER J. DEFEO, Program Officer

REBECCA ENGLISH, Program Officer

EMILY BUSTA, Associate Program Officer

KATHRYN HOWELL, Senior Program Assistant

ANDREW M. POPE, Director, Board on Health Sciences Policy

Page xiii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

BOARD ON GLOBAL HEALTH1

THOMAS C. QUINN (Chair), National Institute of Allergy and Infectious Disease and Johns Hopkins University School of Medicine

JO IVEY BOUFFORD, New York Academy of Medicine

GARY DARMSTADT, Stanford School of Medicine

JACOB A. GAYLE, Medtronic Foundation

GLENDA E. GRAY, South African Medical Research Council

MARGARET A. HAMBURG, National Academy of Medicine

STEPHEN W. HARGARTEN, Medical College of Wisconsin

CLARION JOHNSON, ExxonMobil

ALAN I. LESHNER, American Association for the Advancement of Science (Emeritus)

GUY H. PALMER, Washington State University

ANNE C. PETERSEN, University of Michigan

DAVID VLAHOV, University of California, San Francisco, Schools of Nursing and Medicine

IOM Staff

PATRICK KELLEY, Board Director

___________________

1Institute of Medicine boards do not review or approve individual reports and are not asked to endorse conclusions and recommendations. The responsibility for the content of the reports rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

Reviewers

This workshop summary has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published workshop summary as sound as possible and to ensure that the workshop summary meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the process. We wish to thank the following individuals for their review of this workshop summary:

PHYLLIS A. ARTHUR, Biotechnology Industry Organization

KENNETH W. BERNARD, (Retired) World Health Organization

THOMAS J. BOLLYKY, Council on Foreign Relations

MANON COX, Protein Sciences Corporation

JULIE GERBERDING, Merck & Co., Inc.

TARA O’TOOLE, In-Q-Tel, Inc.

Although the reviewers listed above have provided many constructive comments and suggestions, they did not see the final draft of the workshop summary before its release. The review of this workshop summary was overseen by LESLIE Z. BENET, University of California, San Francisco. He was responsible for making certain that an independent examination of this workshop summary was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this workshop summary rests entirely with the rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
×

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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2016. Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21809.
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Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary Get This Book
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Emerging infectious disease threats that may not have available treatments or vaccines can directly affect the security of the world's health since these diseases also know no boundaries and will easily cross borders. Sustaining public and private investment in the development of medical countermeasures (MCMs) before an emerging infectious disease becomes a public health emergency in the United States has been extremely challenging. Interest and momentum peak during a crisis and wane between events, and there is little interest in disease threats outside the United States until they impact people stateside.

On March 26 and 27, 2015, the Institute of Medicine convened a workshop in Washington, DC to discuss how to achieve rapid and nimble MCM capability for new and emerging threats. Public- and private-sector stakeholders examined recent efforts to prepare for and respond to outbreaks of Ebola Virus Disease, pandemic influenza, and coronaviruses from policy, budget, and operational standpoints. Participants discussed the need for rapid access to MCM to ensure national security and considered strategies and business models that could enhance stakeholder interest and investment in sustainable response capabilities. This report summarizes the presentations and discussions from this workshop.

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