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A Workshop Agenda March 2â3, 2015 National Institute of Environmental Health Sciences Building 101, Rodbell ABC 111 T.W. Alexander Drive Research Triangle Park, NC Workshop Objectives: The workshop will explore the role of chemical exposures in the development of obesity through sessions focused on a life span view, possible biologic pathways and environmental influences, and effects of food additives and antibiotics. Speakers will make links between exposure to environmental chemicals and increased incidence of weight gain, glucose tolerance and insulin sensitivity, inflammation, and aspects of metabolic syndrome in animal models and human studies. Two panels at the end of the workshop will provide a chance to discuss opportunities for new research and possible policy actions to address exposure to chemicals associated with the development of obesity. March 2, 2015 8:30 am Welcome and Objectives Frank Loy, LL.B. Roundtable Chair Linda S. Birnbaum, Ph.D., DABT, ATS Roundtable Member Director, National Institute of Environmental Health Sciences 139
140 ENVIRONMENTAL CHEMICAL EXPOSURES AND OBESITY Session 1: Framing the Problem Objectives: Explore the multiple pathways involved in the risk of obesity from two perspectives: public health and environmental health. Discuss how these disciplines intersect and diverge in their focus on the causes of obesity. Set the stage for the discussions to follow. 8:45 am Introduction to Session and Speakers Frank Loy, LL.B. Roundtable Chair 8:50 am Public Health Overview William H. Dietz, Ph.D. (by phone) Director, Sumner M. Redstone Global Center for Prevention and Wellness Milken Institute School of Public Health George Washington University 9:10 am Environmental Health Overview Jerry Heindel, Ph.D. Health Scientist Administrator, Population Health Branch National Institute of Environmental Health Sciences 9:30 am Discussion (20 minutes) Session 2: Life Span View of the Role of Chemical Exposures and Obesity Objective: Provide a life span view of obesity focusing on chemical exposures from pregnancy to childhood to adulthood. 9:50 am Introduction to Session and Speakers Gwen Collman, Ph.D. Director, Division of Extramural Research and Training National Institute of Environmental Health Sciences
APPENDIX A 141 10:00 am The Role of Prenatal Exposure to Persistent Organic Pollutants on Childhood Obesity: Evidence from Epidemiological Studies Damaskini (Dania) Valvi, M.D., M.P.H., Ph.D. Research Fellow, Department of Environmental Health Harvard T.H. Chan School of Public Health 10:30 am Endocrine-Disrupting Chemicals, Onset of Puberty, and Obesity Frank M. Biro, M.D. Director of Research, Adolescent and Transition Medicine Cincinnati Childrenâs Hospital Medical Center Professor, Department of Pediatrics University of Cincinnati College of Medicine 11:00 am Break (20 minutes) 11:20 am OBELIX (OBesogenic Endocrine Disrupting Chemicals: LInking Prenatal EXposure to the Development of Obesity Later in Life): An Integrated Approach to Studying the In Vitro, Clinical, and Epidemiological Effects of Endocrine-Disruptor Exposure Prenatally and in Early Infancy Juliette Legler, Ph.D. (by phone) Professor and Deputy Head, Department of Chemistry and Biology Institute for Environmental Studies Vrije University Amsterdam 11:50 am Discussion (50 minutes) 12:40 pm Lunch Break (60 minutes)
142 ENVIRONMENTAL CHEMICAL EXPOSURES AND OBESITY Session 3: Biologic Pathways and Environmental Influences Objectives: Discuss biologic pathways involved in obesity and how these could be disturbed by environmental chemical exposures. 1:40 pm Introduction to Session and Speakers Henry Anderson, M.D. Roundtable Member State Health Officer Wisconsin Division of Public Health 1:50 pm Identifying Environmental Chemicals to Test for Obesity and Diabetes Outcomes: Clues from Toxcast High-Throughput Screening Data Scott S. Auerbach, Ph.D. Molecular Toxicologist, Biomolecular Screening Branch, National Toxicology Program (NTP) National Institute of Environmental Health Sciences 2:20 pm The Effects of Persistent Organic Pollutants (POPs) on Adipose Tissue Function and Inflammation: In Vitro and In Vivo Models and Studies in Humans Robert Barouki, M.D. Professor University Paris Descartes 2:50 pm Transgenerational Effects of Obesogens: Tributyltin Bruce Blumberg, Ph.D. Professor, Developmental and Cell Biology School of Biological Sciences Professor, Biomedical Engineering The Henry Samueli School of Engineering University of California, Irvine 3:20 pm Break (20 minutes)
APPENDIX A 143 3:40 pm Effects of Perinatal Exposure to BPA on Obesity and Metabolic Disease Later in Life Beverly Rubin, Ph.D. Associate Professor of Integrative Physiology and Pathobiology Sackler School of Graduate Biomedical Sciences Tufts University 4:10 pm Effects of Environmental Chemicals on Energy Metabolism and Insulin Secretion Barbara Corkey, Ph.D. Zoltan Kohn Professor Boston University School of Medicine 4:40 pm Panel Discussion (50 minutes) 5:30 pm Adjourn for the Day March 3, 2015 8:30 am Welcome Back and Introduction Lynn Goldman, M.D., M.S., M.P.H. Roundtable Vice-Chair Dean, Milken Institute School of Public Health George Washington University Session 4: Nutrients, Food Additives, Antibiotics Objective: Present research on how antibiotics and agents in our food, such as high-fructose corn syrup and artificial sweeteners, may play a role in the development of obesity. 8:40 am Introduction to Session and Speakers Lynn Goldman, M.D., M.S., M.P.H. Roundtable Vice-Chair
144 ENVIRONMENTAL CHEMICAL EXPOSURES AND OBESITY 8:50 am Infectobesity: Obesity of Infectious Origins Nikhil V. Dhurandhar, Ph.D. (by phone) Chair, Department of Nutritional Sciences Texas Tech University 9:20 am Antibiotics and Obesity Charles Bailey, M.D., Ph.D. (by phone) Assistant Professor of Clinical Pediatrics, Divisions of Hematology & Oncology Childrenâs Hospital of Philadelphia 9:50 am Sugar and Obesity Ayca Erkin-Cakmak, M.D., M.P.H. Clinical Research Associate University of California, San Francisco 10:20 am Noncaloric Sweeteners and Obesity Kristina Rother, M.D., M.H.Sc. Chief, Diabetes, Endocrinology, and Obesity Branch National Institute of Diabetes and Digestive and Kidney Diseases 10:50 am Panel Discussion (50 minutes) 11:40 am Lunch Break (60 minutes) Session 5: Research Needs Objective: Identify opportunities for new research directions based on the discussions at the workshop. 12:40 pm Introduction to Session and Discussants Harold Zenick, Ph.D. Roundtable Member Former Director of the Office of Research and Development National Health and Environmental Effects Research Laboratory U.S. Environmental Protection Agency
APPENDIX A 145 12:50 pm Discussants: Linda S. Birnbaum, , Ph.D., DABT, ATS Roundtable Member Suzette M. Kimball, Ph.D. Roundtable Member (by phone) Acting Director, U.S. Geological Survey John M. Rogers, Ph.D. Director, Toxicity Assessment Division National Health and Environmental Effects Research Laboratory U.S. Environmental Protection Agency Nikhil V. Dhurandhar, Ph.D. (by phone) President, Obesity Society 1:20 pm Panel Discussion (60 minutes) Session 6: Policy Solutions Objective: Discuss possible actions to reduce exposure to chemicals associated with the development of obesity. 2:20 pm Introduction to Session and Discussants Faiyez Bhojani, M.D. Roundtable Member Chief Medical Officer, Global Manufacturing and Chemicals Royal Dutch Shell 2:30 pm Discussants: Jeanne Conry, M.D. (by phone) Assistant Physician-in-Chief, Kaiser Permanente Past President, American Congress on Obstetrics and Gynecology
146 ENVIRONMENTAL CHEMICAL EXPOSURES AND OBESITY Judy LaKind, Ph.D. (by phone) President, LaKind Associates, LLC Adjunct Associate Professor, Department of Epidemiology and Public Health University of Maryland School of Medicine Sheela Sathyanarayana, M.D., M.P.H. Associate Professor, Departments of Pediatrics and Environmental and Occupational Health Sciences University of Washington Member, Council on Environmental Health American Academy of Pediatrics Sonya Lunder, M.P.H. Senior Analyst Environmental Working Group 3:00 pm Panel Discussion (50 minutes) 3:50 pm Closing Remarks Frank Loy, LL.B Roundtable Chair 4:00 pm Adjourn
