Appendix B
Example Report Outlines for Future SMAC and SWEG Documents
OUTLINE FOR NEW CHEMICALS
- Physical and Chemical Properties
- Occurrence, Source, and Use on Spacecraft
- Toxicokinetics
- Toxicodynamics and Mechanism of Action
- Toxicity Summary
- Literature Search Strategy (summary of databases, dates, search terms, etc.)
- Acute Toxicity
- Human
- Animal
- Short-Term Toxicity
- Human
- Animal
- Subchronic Toxicity
- Human
- Animal
- Chronic Toxicity
- Human
- Animal
- Interaction with Other Chemicals
- Spaceflight Effects
- Rationale for Acceptable Concentrations
- Description of How Each SMAC/SWEG Was Derived (to include detailed justification of the selection of health end points, key studies, point of departure, and uncertainty factors)
- Exposure Standards Set by Other Organizations
- Research Recommendations
OUTLINE FOR UPDATING CHEMICAL GUIDELINES
- Occurrence, Source, and Use on Spacecraft
- Summary of Original Approach to Setting SMACs or SWEGs
- New Data
- Literature Search Strategy (databases, dates, search terms, etc.)
- Toxicokinetics
- Toxicodynamics and Mechanism of Action
- Acute Toxicity
- Short-Term Toxicity
- Subchronic Toxicity
- Chronic Toxicity
- Interaction with Other Chemicals
- Spaceflight Effects
- Rationale for Revision to the Original SMACs or SWEGs
- Description of Revisions to Each SMAC/SWEG (to include detailed justification of the selection of health end points, key studies, point of departure, and uncertainty factors)
- Exposure Standards Set by Other Organizations
- Research Recommendations
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