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An Assessment of the NIH Women's Health Initiative (1993)

Chapter: Appendix H: NIH-Sponsored Women's Health Studies

« Previous: Appendix G: Women's Health Initiative Committees
Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
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H

NIH-Sponsored Women's Health Studies

The committee asked NIH to provide information about other studies of women's health within NIH. The following charts were developed from the documents provided by the various institutes.

Two charts were developed. The first contains those studies that are funded by more than one institute; the second includes those studies that are single-institute funded.

Those studies marked with an asterisk (*) do not necessarily focus on women, however NIH included them in the response regarding “Women 's Health Studies.” Abbreviations are as follows:

NHLBI

National Heart, Lung, and Blood Institute

NCI

National Cancer Institute

NIDDK

National Institute of Diabetes and Digestive and Kidney Diseases

NINDS

National Institute of Neurological Disorders and Stroke

NIAMS

National Institute of Arthritis and Musculoskeletal and Skin Diseases

NIDR

National Institute Dental Research

NIAAA

National Institute on Alcohol Abuse and Alcoholism

ORMH

Office for Research on Minority Health

Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×

TABLE H-1 WOMEN'S HEALTH STUDIES WITH MULTI-INSTITUTE FUNDING

Study Title

Contributing Institutes

Estimate of Costs by Institute ($)

Period of Study

Number of Subjects

Women's Health Trial: Feasibility Study in Minority Populations

NCI

NHLBI

NIDR

12,300,000

1,106,000

300,000

13,706,000

2 years

2,250

WHT Feasibility Study in Minority Populations: Salivary Study

NIDR (same as above)

300,000 (part of above)

2 years (same as above period)

200 (part of above sample)

Postmenopausal Estrogen/Progestin Interventions (PEPI)

NHLBI

NICHD

NIAMS

NIA

NIDDK

15,187,000

3,535,355

2,025,000

578,000

535,000

21,860,355

10 years

875

Breast Cancer Prevention Trial - Tamoxifen

NCI

NHLBI

NIAMS

65,820,000

7,931,000

2,136,000

75,887,000

7 years

16,000

Study of Osteoporotic Fractures

NIAMS

NIA

32,489,000

14,615,191

47,104,191

11 years

9,700

Efficacy of Estrogen in Hyperprolactinemic Amenorrhea

NIDDK

ORWH

1,043,032

NA

1,043,032

5 years

100

Membrous Lupus Nephropathy

NIDDK

NCI

1,257,000

NA

1,257,000

9 years

16 to date (75% female)

Combination Radioiodine and Adriamycin for Follicular Thyroid Carcinoma

NIDDK

NCI

1,499,000

NA

1,499,000

6 years

22 to date (75% female)

Vitamin E, Betacarotene and Aspirin in Women

NCI

NHLBI

8,474,728

8,348,000

16,822,728

5 years

40,000

Long-Term Outcome of Obesity Treatment in Minority Women

NIDDK

ORMH

3,534,011

6 years

600

Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×

TABLE H-2 WOMEN'S HEALTH STUDIES FUNDED BY SINGLE INSTITUTES

Study Title

Contributing Institute

Estimate of Cost ($)

Period of Study

Number of Subjects

Low Fat Diet and Breast Cancer Reccurrence

NCI

6,729,000

9 years

2,000

Carotene and Retinol Efficiency Trial

NCI

24,707,000+

13 years

17,000 (45% female)

A Dietary Study of the Recurrence of Large Bowel Adenomatoris Polyps

NCI

35,025,000

7 years

2,000 (30% female)

Screening Trial for Prostate, Lung, Colorectal, and Ovarian Cancer

NCI

74,517,000

16 years

148,000 (50% female)

Treatment Strategies for Osteoporosis

NIDDK

380,370

3 years

80

Ursodeoxycholate-Methotrexate for Primary Biliary Cirrhosis Clinical Trial

NIDDK

3,330,368

6 years

NA

Human Zinc Deficiency (MCH)

NIDDK

2,804,751

14 years

80

Low Fat Ad Libitum Diet and Weight Loss

NIDDK

617,246

3 years

118

Biosynthesis, Glycosylation, and Action of Thyrotropin: Clinical Trials of Recombinant TSH

NIDDK

2,008,000

3 years

35 (% female NA)

Obesity Treatment: Self-Management vs. Dependence Models

NIDDK

653,062

3 years

240

Modification of Director and Renal Disease *

NIDDK

59,020,000

10 years

855

Cardiovascular Health Study

NHLBI

63,370,000

6 years

5,201 (43% female)

Women's Health Study

NHLBI

8,348,000

5 years

41,600

Trial of Antioxidant Therapy of Cardiovascular Disease in Women (part of WHS)

NHLBI

3,122,000

5 years

8,000

Nurses's Health Study

NHLBI

2,762,000

13 years

121,700

Calcium for Preeclampsia Prevention

NHLBI

2,000,000

3 years

4,500

Cardiovascular Risk Factors and Menopause

NHLBI

2,207,000

4 years

550

Maintenance Psychotherapy in Recurrent Depression

NHLBI

3,800,000

5 years

180

Atherosclerosis Risk in Communities *

NHLBI

102,689,000

14 years

16,000 (% female NA)

NHLBI Growth and Health Study

NHLBI

16,645,000

9 years

2,379

Estrogen Effects on Cognition in Turner Syndrome

NINDS

1,209,014

9 years

2,379

Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×

Women's Estrogen for Stroke Trial

NINDS

5,205,657

5 years

652

Genetic Epidemiology of Epilepsy *

NINDS

600,000

6 years

2,501 (46% female)

Incidence and Prevalence of Epilepsy *

NINDS

800,000

6 years

3,000 (50% female)

Rochester Diabetic Neuropathy Study

NINDS

3,744,698

9 years

380 (50% female)

Felbamage Concentration Response Trial *

NINDS

3,922,358

2 years

140 (50% female)

Genetic Epidemiology of Familial Epilepsy *

NINDS

1,449,561

10 years

340 (50% female)

Rectal Diazepam in Acute Repetitive Seizures *

NINDS

3,034,621

3 years

144 (47% female)

Remacemide Inpatience Seizure Evaluation Trial * (RISE)

NINDS

1,741,641

3 years

60 (33% female)

Control Study of Value of BMT for Storage Diseases *

NINDS

2,196,210

5 years

165 (50% female)

National Acute Spinal Cord Injury Study *

NINDS

6,609,929

17 years

495 (15% female)

Stroke Prevention in Atrial Fibrillation *

NINDS

14,799,368

9 years

3,400 (35% female)

Warfarin Aspirin Recurrent Stroke Study *

NINDS

25,875,696

5 years

1,920 (% female NA)

Brain Resuscitation Clinical Trial *

NINDS

3,379,284

14 years

2,500 (33% female)

North American Carotid Endarterectomy Trial *

NINDS

22,461,790

11 years

2,800 (% female NA)

Randomizes Trial of Tirilizad in Acute Stroke *

NINDS

1,124,130

2 years

700 (% female NA)

Phase II-B Randomized Controlled Study of Tissue Plasminogen Activator for Acute Ischemic Stroke *

NINDS

6,921,909

4 years

400 (% female NA)

Randomized Trial of ORG 10172 in Acute Ischemic Stroke and Data Management Center *

NINDS

9,532,046

5 years

1,800 (40% female)

Asymptomatic Carotid Artery Stenosis Collaborative Study *

NINDS

13,389,265

11 years

1,500 (35% female)

Studies of the Natural History and Response to Therapy in Multiple Sclerosis Using MRI *

NINDS

2,408,919

NA

38 (66% female)

Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×

New alcohol problems and disorder: 11 year ECA follow-up *

NIAAA

311,680

3 years

867 (62% female)

Biological markers of alcohol consumption among women

NIAAA

67,486

NA

60

Secondary prevention of alcohol problems in women

NIAAA

147,259

2 years

NA (100% female)

Alcohol use among teenagers and infant outcome

NIAAA

126,829

NA

600

Effect of prenatal alcohol use on pediatric outcome

NIAAA

82,088

9 years

650

Neuroendocrine effects of alcohol on puberty *

NIAAA

135,866

NA

NA

Alcohol effects in postmenopausal women

NIAAA

240,368

NA

NA

Fetal alcohol exposure and female reproductive function *

NIAAA

210,781

NA

NA

Impact of labeling and education on antenatal drinking

NIAAA

169,689

NA

14,500

Fetal alcohol exposure --From mechanism to prevention: protecting the next pregnancy *

NIAAA

186,102

NA

NA

Biological risk factors in relatives of alcoholic women

NIAAA

328,648

NA

NA

Hb-associated acetaldehyde --A marker of fetal alcohol exposure *

NIAAA

57,211

NA

NA

Alcoholism and family interaction *

NIAAA

475,739

NA

300 (17% female)

Hispanic drinking and intra-family violence *

NIAAA

699,615

NA

800 (% female NA)

Genetic epidemiology --Alcohol abuse in eating disorders

NIAAA

399,993

NA

147

A twin/family study of alcohol dependence in women

NIAAA

157,151

2 years

2,503 (app 70% female)

Alcohol use and HIV-related risky sex among adolescents *

NIAAA

110,486

2,676 (50% female)

5 years

Frequent heavy drinking and marital violence in newlyweds *

NIAAA

194,716

1 year

4,000 (50% female)

Experimental study of alcohol and marital aggression *

NIAAA

145,044

NA

440 (50% female)

Alcoholism and family history in women

NIAAA

174,599

NA

60

A twin study of female alcoholism and related disorders

NIAAA

762,450

App 20 years

2,400 (75% female)

Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×

Family history of alcoholism and premenstrual symptoms

NIAAA

165,104

1 year

NA

Biobehavioral studies of alcohol problems in women

NIAAA

141,098

NA

NA

Alcohol and the menstrual cycle -- Biobehavioral studies

NIAAA

355,400

NA

NA

Mother's alcohol problems and children's victimization *

NIAAA

305,567

NA

App 1,000 (50% female)

Alcohol, breathing, and sleep -- Age and gender effects *

NIAAA

166,745

NA

NA

Cognitive and psychosocial recovery in alcoholic subtypes *

NIAAA

181,903

2 years

240 (50% female)

Longitudinal twin-family studies -- Use and abuse of alcohol *

NIAAA

298,897

12,500

5 years (% female NA)

Problem drinking by future MDs *

NIAAA

190,951

NA

NA

Drinking, drug use and unsafe sex among gay and bisexual couples *

NIAAA

180,414

NA

NA

Maternal alcohol and lactational immune transfer

NIAAA

194,052

NA

NA

Interpersonal skills of adult children of alcoholics *

NIAAA

103,300

NA

240 (% female NA)

Dietary ethanol and initiation of DMBA tumorigenesis

NIAAA

124,602

NA

NA (100% female)

Characteristics of homeless women and their children *

NIAAA

301,844

NA

1,200 (% female NA)

Neurobehavioral aspects of fetal alcohol exposure *

NIAAA

895,954

NA

NA

Health beliefs and alcohol use in pregnant women

NIAAA

79,649

NA

200

Psychosocial correlates of adolescent driving behavior *

NIAAA

225,156

NA

5,000

Alcohol and stress -- Interactive effects *

NIAAA

123,328

NA

NA

Problem drinking in women --A national survey follow-up

NIAAA

456,729

10 years

NA

Effects of alcohol in human ovarian cell function

NIAAA

168,224

NA

NA

Time-dependent effect of alcohol on spontaneous abortion

NIAAA

34,560

NA

5,300

Vulnerability factors and adolescent drinking *

NIAAA

172,191

2 years

3,190 (% female NA)

Behavioral risk for AIDS among alcoholics *

NIAAA

215,327

NA

1,500 (% female NA)

Children of alcoholics risk in young adults -- A longitudinal sibling design *

NIAAA

143,713

NA

12,686 (% female NA)

Primary care alcohol screens --Patient sex and ethnicity *

NIAAA

74,750

2 years

1,350 (66% female)

Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×
Page 117
Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×
Page 118
Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×
Page 119
Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×
Page 120
Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×
Page 121
Suggested Citation:"Appendix H: NIH-Sponsored Women's Health Studies." Institute of Medicine. 1993. An Assessment of the NIH Women's Health Initiative. Washington, DC: The National Academies Press. doi: 10.17226/2271.
×
Page 122
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The National Institutes of Health Women's Health Initiative (WHI) is the largest research study ever funded by NIH ($625 million over 14 years) and is designed to test strategies to prevent cardiovascular disease, breast cancer, and osteoporotic fractures—leading causes of death, disability, and decreased quality of life for older women. Although the WHI has already begun, serious questions remain about its design, cost, and the likelihood that it can answer the questions it asks. This book evaluates whether the effort can be justified scientifically.

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